The Level of Ischemia-Modified Albumin in Healthy Individuals of Different Age Groups.

IMA levels were elevated in elderly individuals compared to the other two age groups.

• Three age groups were compared: healthy young (18-49 years), middle-aged (51-68 years), and elderly and older (73-99 years) people.
• IMA content was measured using the albumin cobalt binding assay.
• The difference in IMA content between elderly individuals and the other age groups was statistically significant (p < 0.05).

IMAR (IMA/albumin ratio) was also elevated in elderly individuals compared to the other two age groups.

• IMAR was calculated as IMA divided by serum albumin concentration.
• The difference in IMAR between the elderly group and the other age groups was statistically significant (p < 0.01).
• The significance level for IMAR (p < 0.01) was stronger than for IMA alone (p < 0.05).

A positive correlation was established between IMA levels and age in the total group of volunteers.

• The correlation coefficient between IMA and age was r = 0.308 (p < 0.05).
• The analysis was performed across the total group of volunteers spanning ages 18-99 years.

A positive correlation was established between IMAR and age in the total group of volunteers.

• The correlation coefficient between IMAR and age was r = 0.412 (p < 0.01).
• The correlation for IMAR (r = 0.412) was stronger than for IMA alone (r = 0.308).
• The analysis was performed across the total group of volunteers spanning ages 18-99 years.

Oxidative modification of serum albumin increases with age in healthy individuals.

• IMA is described as an oxidative stress marker in serum.
• The study included healthy individuals across four age categories: young (18-49 years), middle-aged (51-68 years), elderly, and older (73-99 years).
• Both IMA and IMAR showed age-dependent increases, supporting the conclusion that albumin oxidative modification accumulates with aging.