The relationship between lipid accumulation products and non-alcoholic fatty liver disease among adults in the North of Iran: a cross-sectional study.

Each unit increase in LAP score was associated with a 1.8% increase in the odds of NAFLD in the adjusted model.

• Cross-sectional study conducted in the second stage of the Amol Cohort Study with n=3,120 participants in North Iran.
• NAFLD was confirmed using ultrasound imaging.
• The association was statistically significant (P < 0.001) after multivariate logistic regression adjustment.
• A parallel 1.6% increase in odds of hepatic steatosis index (HSI) was also found per unit change in LAP score (P < 0.001).

Participants in the second tertile of LAP had significantly higher odds of NAFLD and elevated HSI compared to those in the first tertile.

• For NAFLD: OR = 2.042, 95% CI: 1.578–2.642, P < 0.001.
• For HSI: OR = 1.765, 95% CI: 1.283–2.428, P < 0.001.
• These estimates were derived from the adjusted multivariate logistic regression model.
• The first tertile of LAP served as the reference category.

Participants in the highest (third) tertile of LAP had the greatest odds of NAFLD and elevated HSI compared to the first tertile.

• For NAFLD: OR = 3.607, 95% CI: 2.665–4.880, P < 0.001.
• For HSI: OR = 3.406, 95% CI: 2.282–5.083, P < 0.001.
• A dose-response pattern was observed across LAP tertiles, with odds increasing from the second to the third tertile.
• All estimates were from the adjusted multivariate logistic regression model.

The LAP index was calculated using waist circumference and triglyceride levels, and the study utilized both LAP and hepatic steatosis index (HSI) as measures of adiposity and hepatic steatosis.

• LAP values were obtained using corresponding equations incorporating waist circumference and triglyceride concentration.
• HSI values were similarly derived using a corresponding equation.
• NAFLD diagnosis was confirmed by ultrasound imaging.
• The study was cross-sectional and conducted as part of the second stage of the Amol Cohort Study (n = 3,120).

The LAP index, which reflects adiposity and lipid metabolism, was evaluated as a predictor of NAFLD in an Iranian population.

• The study was conducted in the North of Iran as part of the Amol Cohort Study.
• The LAP index is described as providing insights into the relationship between adiposity and lipid metabolism.
• The study sample consisted of 3,120 adult participants.
• Multivariate logistic regression was performed to examine relationships between LAP tertiles and both NAFLD and HSI.