Cardiovascular

Timeliness of Emergency Care for Intracerebral Hemorrhage Compared With Acute Ischemic Stroke.

TL;DR

In this cohort study of patients with acute stroke, patients with ICH arrived at the ED faster but were less likely to achieve care targets than patients with AIS.

Key Findings

Among 195,659 EMS-transported stroke patients across 195 GWTG-Stroke hospitals, ICH patients presented with substantially greater stroke severity than AIS patients.

  • The cohort included 31,464 patients with ICH and 164,195 with AIS admitted from January 1, 2015, to June 30, 2024.
  • Median (IQR) NIHSS score was 14 (6-23) for ICH vs 6 (2-13) for AIS (absolute standardized difference, 0.694).
  • Median (IQR) age of the full cohort was 74.0 (63.0-83.0) years; 97,978 (50.1%) were female.

After adjustment for patient demographics only, ICH was associated with higher odds of door-to-ED physician assessment within 10 minutes compared with AIS.

  • Demographic-adjusted aOR, 1.08; 95% CI, 1.02-1.14.
  • Models were sequentially adjusted for demographics, then medical history and presenting factors, then hospital characteristics.

The association for door-to-ED physician assessment within 10 minutes reversed after adjusting for medical history, presenting factors (including NIHSS), and hospital characteristics, with ICH having lower odds than AIS.

  • Fully adjusted aOR, 0.94; 95% CI, 0.89-0.99.

The same pattern was seen for door-to-initial brain imaging order within 20 minutes: ICH had higher odds after demographic adjustment but lower odds after full adjustment.

  • Demographic-adjusted aOR, 1.09; 95% CI, 1.02-1.16.
  • Fully adjusted aOR (medical history and hospital characteristics), 0.91; 95% CI, 0.85-0.97.

Median last known well to arrival time increased over the study period for both AIS and ICH.

  • AIS: increased 32.5% (151 to 200 minutes; P < .001).
  • ICH: increased 34.3% (108 to 145 minutes; P < .001).
  • ICH patients had shorter last-known-well-to-arrival times than AIS patients (patients with ICH arrived at the ED faster).

Rates of EMS prenotification largely remained stable over time for both ICH and AIS.

  • Temporal trends of prehospital care metrics were examined across the 2015-2024 study period.

Patients with ICH arrived faster but were less likely to meet ED care targets, which the authors say needs addressing given emerging hyperacute ICH therapies and bundled care models.

  • Prehospital metrics (eg, EMS prenotification) and ED metrics (eg, door to ED physician assessment, door to brain imaging order) were assessed.
  • Authors state that addressing these differences is essential to optimizing acute stroke outcomes.

What This Means

This study compared how quickly people with two types of stroke received emergency care: bleeding in the brain (intracerebral hemorrhage, or ICH) and stroke caused by a blocked blood vessel (acute ischemic stroke, or AIS). It used data on nearly 196,000 patients who came by ambulance to 195 U.S. hospitals between 2015 and 2024. ICH patients were generally much sicker on arrival and reached the hospital sooner after last being seen well. Despite arriving faster, ICH patients were somewhat less likely to be seen by an emergency physician within 10 minutes or to have brain imaging ordered within 20 minutes once differences in patient and hospital characteristics, including stroke severity, were accounted for. Before that full adjustment, ICH patients appeared slightly more likely to meet these targets. Over the decade, the time from last known well to arrival got longer for both stroke types by about a third, and ambulance prenotification of hospitals stayed roughly flat. This research suggests that emergency care for ICH may lag behind care for ischemic stroke, even though ICH patients arrive quickly. As new fast-acting ICH treatments and coordinated care approaches emerge, the authors suggest that closing these gaps could help improve outcomes. This was an observational study, so it shows associations rather than causes.

Have a question about this study?

Citation

Royan R, Ikeaba U, Alhanti B, Stamm B, Mac Grory B, Prabhakaran S, et al.. (2026). Timeliness of Emergency Care for Intracerebral Hemorrhage Compared With Acute Ischemic Stroke.. JAMA network open. https://doi.org/10.1001/jamanetworkopen.2026.39429