Transitioning from Anti-aging to Skin Activation: Limiting Cellular Fatigue and Senescence for Skin Longevity.

A multicenter dermatoporosis trial among 400 participants showed a 20-40% reduction in trans-epidermal water loss (TEWL).

• Study enrolled 400 participants across multiple centers
• TEWL reduction ranged from 20-40%
• TEWL was used as a primary endpoint to assess barrier function
• Data were generated from a multicenter dermatoporosis trial, a randomized controlled trial, and specific cohorts of sensitive skin patients

Hydration levels increased by 80% based on corneometer readings among study participants.

• Hydration was measured using corneometer readings
• An 80% increase in hydration was observed
• This was among the 400 participants in the multicenter trial
• Hydration was listed as one of the primary study endpoints

Skin thickness increased by 5% as measured by ultrasound in study participants.

• Ultrasound measurements were used to assess skin thickness
• A 5% rise in skin thickness was recorded
• Skin thinning (dermatoporosis) was the primary condition being addressed
• Structural remodeling of the extracellular matrix (ECM) was a component of the intervention

Dermo-epidermal junction (DEJ) integrity improved in 83% of treated subjects compared to 17% of controls.

• DEJ integrity was assessed using LC-Optical Coherence Tomography (LC-OCT)
• 83% of subjects showed improved DEJ integrity versus 17% of controls
• DEJ assessment was a key study endpoint
• This finding was observed in the randomized controlled trial component of the study

Preclinical ex vivo models demonstrated decreases in fibroblast senescence levels and activation of the JAG/NOTCH pathway.

• Fibroblast senescence levels were reduced in ex vivo preclinical models
• Activation of the JAG/NOTCH pathway was observed
• Study endpoints included senescent markers, cytokine profiles, and biomarkers of cellular renewal
• These preclinical findings supported the clinical data from the human trials

The skin activation strategy combines ECM and DEJ remodeling, barrier restoration, hydration enhancement, and senescent cell reduction to improve functional skin resilience.

• The approach is described as 'Skin Activation' as a dermatologic strategy for promoting skin longevity
• It is supported by clinical and preclinical evidence
• The strategy targets structure, function, and cellular energy and renewal
• This represents a shift from a 'broad anti-aging focus to a more targeted skin activation approach'