Dietary Supplements

Treatment and tracking algorithm for iron deficiency anaemia among children and adolescents- a policy informed evidence- based framework for India.

TL;DR

The authors developed two evidence-based algorithms, one for mild and one for moderate-to-severe iron deficiency anaemia in children and adolescents aged 6 months to 18 years, to provide an operational approach to strengthen anaemia management and follow up within the Anaemia Mukt Bharat programme. They state that these algorithms need field validation in different settings.

Key Findings

Two treatment and tracking algorithms were developed for iron deficiency anaemia in children and adolescents aged 6 months to 18 years: one for mild anaemia and one for moderate-to-severe anaemia.

  • The algorithms cover treatment initiation, follow up, response assessment, and guidance on subsequent steps.
  • They were intended to support clinical decision-making, improve adherence and follow up, and strengthen implementation of the Anaemia Mukt Bharat (AMB) programme.
  • They were developed by consolidating findings from guideline review and systematic literature searches, then refined through expert consultation.

The algorithms suggest haemoglobin measurement as the first-line test for identifying anaemia, with serum ferritin and C-reactive protein (CRP) reserved for non-responders.

  • Serum ferritin and CRP are used for children who do not respond to initial treatment.
  • Systematic literature searches addressed diagnostic thresholds for serum ferritin and CRP.

The development methodology combined guideline appraisal, targeted systematic searches, and expert consultation.

  • National and international guidelines and consensus statements were reviewed.
  • Methodological quality of the guidelines was appraised using the AGREE II tool.
  • Systematic searches addressed serum ferritin and CRP thresholds, iron supplementation dosage and frequency, and dosing strategies.
  • Findings were consolidated into algorithms and refined through expert consultation.

The work was motivated by implementation gaps in the AMB 'test, treat and track' strategy, including suboptimal coverage of biweekly IFA supplementation in children aged 6-59 months.

  • Challenges named include limited coverage, poor adherence, workforce shortages and inconsistent follow up.
  • Recent programme monitoring data indicated suboptimal coverage of biweekly iron and folic acid (IFA) supplementation among children aged 6-59 months.
  • This underscored the need for a standardised treatment and tracking algorithm.

The authors conclude the algorithms offer an evidence-based operational approach to improve continuity of care and reduce variability in practice, but require field validation.

  • The algorithms are intended for AMB programme settings.
  • The authors state that the algorithms need field validation in different settings.
  • No implementation or outcome data are reported in the abstract.

What This Means

India's Anaemia Mukt Bharat programme aims to test children and adolescents for anaemia, treat them, and track their progress. In practice, this has been hampered by low coverage of iron supplements, poor adherence, too few health workers, and inconsistent follow up. Programme data show that coverage of twice-weekly iron and folic acid supplements in children aged 6-59 months is lower than hoped. To help, the authors reviewed national and international guidelines, checked their quality with a standard tool (AGREE II), searched the literature on key questions such as blood test thresholds and iron dosing, and refined the results with expert input. The product is two step-by-step algorithms, one for mild anaemia and one for moderate-to-severe anaemia, covering starting treatment, follow up, checking response, and deciding next steps. Haemoglobin is the first test used to identify anaemia. Ferritin and CRP, which help show iron stores and inflammation, are suggested for children who do not respond to treatment. This research suggests that a standardised pathway could reduce variation in how anaemia is managed and improve continuity of care in the programme. However, the algorithms have not yet been tested in real-world settings, so their effect on outcomes is unknown. The authors say they need field validation in different settings.

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Citation

Bansal P, Chandiok K, Shah D, Chandra J, Kulkarni B, Yadav K, et al.. (2026). Treatment and tracking algorithm for iron deficiency anaemia among children and adolescents- a policy informed evidence- based framework for India.. The Indian journal of medical research. https://doi.org/10.25259/IJMR_1502_2026