Triglyceride-Glucose Index and Incident Stroke in Elderly Patients with Type 2 Diabetes: A Retrospective Cohort Study.

About 5% of elderly patients with T2DM developed CT-confirmed incident stroke over roughly 4.7 years of follow-up.

• The cohort included 1024 patients aged ≥60 years with T2DM at a provincial tertiary care center in Northern Thailand.
• 51 patients (5.0%) developed incident stroke.
• Mean follow-up was 4.7 years; the primary outcome was computed tomography-confirmed stroke during a 5-year follow-up.

Higher TyG index quartiles were associated with less favorable metabolic profiles.

• The TyG index was calculated from baseline fasting triglyceride and fasting plasma glucose levels and categorized into quartiles.
• The abstract does not give the specific metabolic variables that differed across quartiles.

Stroke-free survival did not differ significantly across TyG index quartiles.

• Kaplan-Meier survival analysis was used to compare stroke-free survival across quartiles.
• The abstract reports 'no significant differences in stroke-free survival' across TyG quartiles.

The TyG index was not independently associated with incident stroke in multivariable Cox models, whether analyzed as quartiles or as a continuous variable.

• Cox proportional hazards models adjusted for age, sex, hypertension, and smoking status.
• Hazard ratios with 95% confidence intervals were estimated.
• No significant independent association was found in either categorical or continuous analyses.

The authors conclude the TyG index has limited prognostic utility for stroke risk prediction in elderly patients with T2DM.

• This contrasts with prior evidence linking the TyG index to stroke in general populations.
• Evidence on the TyG index's prognostic value for incident stroke in elderly T2DM patients had previously been limited.