TL;DR
Ultrasound-derived tibia-fascia angle difference (ΔTFA) showed a significant linear correlation with intracompartmental pressure and achieved moderate diagnostic accuracy (AUC 0.716) as a noninvasive screening tool for high compartment pressure in tibial plateau fractures.
Key Findings
Results
ΔTFA demonstrated a significant linear correlation with intracompartmental pressure after adjustment for confounders.
Multivariable linear regression yielded β = 1.74 mmHg/°, 95% CI: 1.07–2.41, Padj < 0.001
Spearman correlation showed a moderate monotonic association: ρ = 0.545, 95% CI: 0.395–0.667, P < 0.001
TFA was measured bilaterally using B-mode ultrasound by blinded operators
Invasive ICP served as the reference standard
Results
ΔTFA achieved moderate diagnostic accuracy for detecting high compartment pressure (ICP > 30 mmHg).
AUC of 0.716 (95% CI: 0.621–0.812) for detecting HCP defined as ICP > 30 mmHg
Optimal cutoff was ΔTFA ≥ 4.9°
Sensitivity at optimal cutoff was 86.5%
Specificity at optimal cutoff was 52.9%
Methods
The study enrolled 105 patients with closed tibial plateau fractures at a tertiary trauma center.
This was an observational study design
All patients had closed tibial plateau fractures
TFA was measured bilaterally using B-mode ultrasound
Operators performing ultrasound measurements were blinded
Discussion
The high sensitivity but limited specificity of ΔTFA supports its use as a screening tool rather than a standalone diagnostic test.
Sensitivity of 86.5% supports screening utility to avoid missed cases of high compartment pressure
Specificity of 52.9% indicates a notable false-positive rate
Authors noted that 'specificity limitations warrant complementary confirmatory tests'
The authors describe ΔTFA as providing 'moderate diagnostic accuracy as a screening tool for HCP'
Conclusions
The authors concluded that ΔTFA integration into trauma workflows could enhance early risk stratification, particularly for high-energy fractures.
ΔTFA was described as a 'rapid, operator-friendly method for noninvasive ICP estimation'
Potential benefit was highlighted specifically for high-energy fractures
The method is positioned as complementary to, not replacing, confirmatory tests
Current noninvasive diagnostics for ACS were characterized as lacking 'clinical practicality and reliability'
Have a question about this study?
Citation
Zhang H, Li L, Jia H, Wang H, Dong Q, Guo J, et al.. (2026). Ultrasound-derived tibia-fascia angle for noninvasive assessment of intracompartmental pressure in tibial plateau fractures.. PloS one. https://doi.org/10.1371/journal.pone.0344990
Copy