Cardiovascular

Urinary Bisphenol A Levels Are Associated with Vascular Injury in Mexican Patients with Coronary Artery Disease.

Guerrero-Meza F, Alcocer-Gamba M, et al. • International journal of molecular sciences • 2026

PubMed 42942065 DOI 10.3390/ijms27209295
TL;DR

Our findings support uBPA levels are associated with vascular injury in Mexican patients with coronary artery disease.

Key Findings

Results

Patients with obstructive coronary disease had higher urinary BPA levels than patients with non-obstructive disease.

  • OD patients had uBPA of 3.46 ± 2.04 ng/mL versus 1.25 ± 1.08 ng/mL in NOD patients.
  • The study evaluated 89 patients aged 30-85 years who underwent quantitative coronary angiography and SYNTAX score assessment.
  • Patients were classified as obstructive (OD) or non-obstructive (NOD) disease; groups were compared using Welch's t-test and ANOVA.
Results

Urinary BPA levels differed according to the extent of coronary involvement, including the number of diseased arteries and diseased artery segments.

  • uBPA differed by number of diseased arteries and by number of diseased artery segments (ANOVA-based comparisons).
  • uBPA was positively associated with number of diseased arteries and diseased artery segments in correlation analysis.
Results

Urinary BPA was positively associated with angiographic measures of coronary disease severity.

  • Positive associations were reported with SYNTAX score and percentage of stenosis.
  • Analyses included correlation analysis and adjusted multiple linear regression.
Results

Urinary BPA was positively associated with the vascular injury biomarkers MMP-2 and MMP-9.

  • MMP-2 and MMP-9 were measured alongside VCAM-1 as vascular injury biomarkers.
  • The abstract reports positive associations of uBPA with MMP-2 and MMP-9, but does not report an association of uBPA with VCAM-1.
Results

Urinary BPA was positively associated with standard modifiable cardiovascular risk factors (SMuRFs) and negatively associated with HDL cholesterol.

  • The abstract reports a positive association with SMuRFs and a negative association with HDLc.
  • Lipid profile was assessed in all patients.
Results

SYNTAX score was associated with vascular injury biomarkers and low HDL cholesterol.

  • SYNTAX score was associated with MMP-2, MMP-9, and VCAM-1.
  • SYNTAX score was also associated with low HDLc levels.

What This Means

This study looked at whether exposure to bisphenol A (BPA), a chemical found in some plastics and food packaging that can disrupt hormones, is linked to heart artery disease in Mexican patients. Eighty-nine adults had their coronary arteries imaged and scored for disease severity, and BPA was measured in their urine along with cholesterol, traditional risk factors, and blood markers of blood-vessel injury (VCAM-1, MMP-2, MMP-9). Patients with blocked (obstructive) coronary arteries had about three times higher urinary BPA on average (3.46 ng/mL) than those without significant blockages (1.25 ng/mL). Higher BPA was also linked to more diseased arteries and segments, greater narrowing, higher disease-severity scores, higher levels of MMP-2 and MMP-9 (markers of vessel injury and tissue remodeling), more traditional risk factors, and lower HDL ("good") cholesterol. This research suggests BPA exposure may be associated with vascular injury and more severe coronary disease, beyond classic risk factors. However, this was an observational study in a small group, so it shows associations rather than proving that BPA causes heart disease, and larger studies would be needed to confirm the findings.

Have a question about this study?

Presence or severity of Hashimoto's thyroiditis does not influence basal calcitonin levels: observations from CROHT biobank.
Journal of endocrinological investigation • 2022

HT patients of all disease stages preserve Ct production as healthy individuals and there is no need for Ct measurements...
Approach to the Patient: Safety of Growth Hormone Replacement in Children and Adolescents.
The Journal of clinical endocrinology and metabolism • 2022

rhGH therapy has been used for more than 3 decades and data are largely reassuring, yet we still have much to learn abou...
Extended Absorption of Liothyronine from Poly-Zinc-Liothyronine: Results from a Phase 1, Double-Blind, Randomized, and Controlled Study in Humans.
Thyroid : official journal of the American Thyroid Association • 2022

PZL possesses the necessary properties to achieve a much improved T3 pharmacokinetic profile, with ~30% lower Cmax that...
Lipoprotein subtypes after testosterone therapy in transmasculine adolescents.
Journal of clinical lipidology • 2022

Testosterone appears to be a major contributor to differences in lipoprotein profiles, a surrogate for cardiovascular di...
Long-term testosterone undecanoate treatment in the elderly testosterone deficient male: An observational cohort study.
Andrology • 2022

Long-acting testosterone undecanoate treatment in elderly testosterone-deficient patients required more frequent dose ad...
Society for Endocrinology guidelines for testosterone replacement therapy in male hypogonadism.
Clinical endocrinology • 2022

The Society for Endocrinology commissioned a multidisciplinary guideline to provide all care providers with a comprehens...

Citation

Guerrero-Meza F, Alcocer-Gamba M, Núñez-Urquiza J, Vera-Urquiza R, Montalvo-Ramos A, Ahumada-Solórzano S, et al.. (2026). Urinary Bisphenol A Levels Are Associated with Vascular Injury in Mexican Patients with Coronary Artery Disease.. International journal of molecular sciences. https://doi.org/10.3390/ijms27209295