Use of the Human Activity Profile to evaluate functional performance in chronic venous insufficiency: A validity study.

The Human Activity Profile (HAP) correlated significantly with ankle dorsiflexion range of motion as measured by the Weight Bearing Lunge Test.

• Correlation coefficient r = 0.606, p < 0.001
• This was the strongest physical performance correlation observed in the study
• Sample consisted of 50 patients with CVI (mean age 65.7 ± 11.5 years, CEAP 1 to 6)
• Cross-sectional study design

HAP correlated significantly with calf muscle strength and endurance as measured by the Heel-Rise Test.

• Correlation with HRT repetitions: r = 0.457, p = 0.001
• Correlation with HRT execution time: r = 0.427, p = 0.002
• Both repetitions and time components of the HRT showed statistically significant associations with HAP scores

HAP correlated significantly with lower limb strength and endurance as measured by the Sit-to-Stand Test.

• Correlation with STS5 (5-repetition Sit-to-Stand): r = -0.430, p = 0.002
• Correlation with STS60 (60-second Sit-to-Stand): r = 0.450, p = 0.001
• The negative correlation with STS5 reflects that lower time to complete 5 repetitions indicates better performance

HAP correlated significantly with health-related quality of life as assessed by the CIVIQ-14 questionnaire.

• Correlation coefficient r = -0.631, p = 0.002
• This was the strongest overall correlation observed in the study
• The negative direction indicates that higher HAP scores (better functional performance) were associated with lower CIVIQ-14 scores (better quality of life)

Participants in the highest HAP group demonstrated significantly better performance on multiple functional tests compared to lower HAP groups.

• Significant between-group differences were found for WBLT, HRT (both repetitions and time), and STS60 (p < 0.05)
• Participants were stratified into HAP groups for this comparison
• No significant between-group difference was reported for handgrip strength or calf circumference in this comparison

HAP scores differed significantly between patients with mild CVI and those with severe CVI when the sample was stratified by CEAP classification.

• Mild CVI defined as CEAP ≤ 3; severe CVI defined as CEAP ≥ 4
• Statistically significant difference in HAP score: p = 0.037
• This finding supports the discriminant validity of the HAP for distinguishing functional levels across CVI severity stages
• CEAP classifications ranged from 1 to 6 in the study sample

The study population consisted of 50 patients with chronic venous insufficiency across a wide range of disease severity.

• Mean age 65.7 ± 11.5 years
• CEAP classifications ranged from 1 to 6
• Cross-sectional study design
• Patients were assessed using HAP, WBLT, HRT, STS (5-rep and 60-sec), handgrip dynamometry, CIVIQ-14, and calf circumference measurement