Cardiac arrests occurring at home, in patients over 80, in female patients, in non-medical events, and in urban settings were associated with a lower likelihood of bystanders performing chest compressions, while emergency service arrival within 15 minutes increased the probability of receiving chest compressions.
Key Findings
Results
Only a minority of cardiac arrest events managed by lay bystanders received resuscitation maneuvers.
A total of 12,066 out-of-hospital cardiac arrest events were analyzed from the Lombardy region emergency medical system between 1 July 2024 and 30 June 2025.
Of the 12,066 events, only 4,233 were assisted by laypeople.
The study notes that 'in approximately half of cases of witnessed OHCA, bystanders do not initiate resuscitation maneuvers.'
Results
Cardiac arrests occurring at home were associated with a substantially lower likelihood of bystanders performing chest compressions.
Home location was associated with an odds ratio of 0.33 (95% CI: 0.28–0.39) for receiving chest compressions.
This represented the strongest negative predictor among the location and contextual factors examined.
The finding was derived from a logistic regression model applied to the full dataset of lay-bystander-assisted events.
Results
Patients over 80 years old were associated with a markedly lower likelihood of receiving bystander chest compressions.
Age over 80 was associated with an odds ratio of 0.40 (95% CI: 0.35–0.45) for receiving chest compressions.
This was among the strongest negative predictors identified in the logistic regression model.
The authors describe the age-related gap as 'significant,' warranting greater attention in BLS-D educational materials.
Results
Female patients were less likely to receive bystander chest compressions compared to male patients.
Female sex was associated with an odds ratio of 0.80 (95% CI: 0.70–0.91) for receiving chest compressions.
The authors describe this sex-related gap as 'noteworthy,' prompting calls for greater attention to educational material in BLS-D courses.
The sex disparity was identified as a factor that dispatch centers should consider when providing pre-arrival instructions.
Results
Non-medical events were associated with a lower likelihood of bystanders performing chest compressions.
Non-medical events were associated with an odds ratio of 0.44 (95% CI: 0.37–0.51) for receiving chest compressions.
This was identified as a significant predictor in the logistic regression model.
The specific definition of 'non-medical events' is described in the context of the event classification used by the Lombardy emergency medical system.
Results
Urban settings were associated with a lower likelihood of bystanders performing chest compressions.
Urban setting was associated with an odds ratio of 0.60 (95% CI: 0.51–0.71) for receiving chest compressions.
This finding was counterintuitive relative to assumptions about greater bystander availability or training in urban areas.
Urban setting was one of five factors negatively associated with bystander CPR performance in the logistic regression model.
Results
Emergency medical service arrival within 15 minutes was associated with an increased probability of the patient receiving chest compressions.
EMS arrival within 15 minutes was associated with an odds ratio of 1.31 (95% CI: 1.14–1.51) for receiving chest compressions.
This was the only factor in the logistic regression model positively associated with bystander chest compression performance.
The authors suggest this finding should be considered by dispatch centers when providing pre-arrival instructions.
Conclusions
The authors recommend specific communication training for dispatch centers and targeted revision of BLS-D educational materials based on identified predictors.
The authors call for dispatch centers to consider age, sex, location, and event type when providing pre-arrival CPR instructions to laypeople.
The authors state that 'specific communication training should be developed' for critical pre-arrival phases.
The authors note that 'communication in these critical phases should be the subject of further study.'
What This Means
This research analyzed over 12,000 out-of-hospital cardiac arrest cases in the Lombardy region of Italy over one year to understand why bystanders often skip performing CPR (cardiopulmonary resuscitation) when someone collapses. Of those cases where ordinary people (not medical professionals) were present, the study used statistical modeling to identify which situations made it more or less likely that a bystander would actually start chest compressions before emergency services arrived.
The study found several factors that made bystanders less likely to perform CPR: the cardiac arrest happened at home, the patient was older than 80 years, the patient was female, the event occurred in an urban area, or the event was classified as non-medical. Conversely, when emergency services arrived within 15 minutes, bystanders were somewhat more likely to have performed chest compressions — possibly because dispatcher instructions prompted action. The gaps related to patient age and sex were highlighted as especially concerning, since survival from cardiac arrest is strongly linked to receiving immediate CPR regardless of who the patient is.
This research suggests that training programs (BLS-D courses) and emergency dispatch protocols may need to be updated to specifically address these disparities. For example, dispatchers could be trained to recognize when a caller may be hesitant to perform CPR on an elderly person or a woman, and provide more targeted guidance. The findings point to the need for better communication strategies during the critical minutes before ambulances arrive, and the authors call for further research into how these conversations can be improved to save more lives.
Stirparo G, Ticozzi E, Merigo G, Magliocca A, Bodina A, Marconi G, et al.. (2026). When Bystanders Skip CPR: Insights from a Retrospective Study.. Medicina (Kaunas, Lithuania). https://doi.org/10.3390/medicina62081524