Gut Microbiome
417 peer-reviewed studies indexed
Indole-3 Acetate Limits Dysbiosis-Driven Diastolic Failure via Hcrt Neurons.
Hypertensive gut dysbiosis reduces indole-3 acetic acid, which normally suppresses hypothalamic hypocretin neuron overactivation and sympathetic overdrive, and restoring indole-3 acetic acid signaling via the aryl hydrocarbon receptor mitigates cardiac concentric hypertrophy and diastolic dysfunction.
Intermittent fasting inhibits Tp53-driven glioma through gut microbiota-mediated methionine-m6A regulation.
Intermittent fasting inhibits Tp53-driven glioblastoma progression through gut microbiota-mediated alterations in methionine sulfoxide production, which regulates m6A modification and suppresses the TGF-β signaling pathway in a tumor subtype-dependent manner.
Alcohol consumption in metabolic dysfunction-associated steatotic liver disease (MASLD): understanding the gut-liver crosstalk for clinical translation.
Alcohol in combination with a Western diet synergistically exacerbated steatotic liver disease through disruption of the intestinal barrier, LPS-mediated TLR4 hepatic inflammation, and impaired CPT-1 lipid oxidation, with gut microbiota changes in DUAL-fed mice showing similarities to dysbiosis in MASLD patients who consumed alcohol.
Bacterial constipation: Mucin-degrading intestinal commensal bacteria cause constipation.
Cooperative degradation of colonic mucins by two commensal bacteria, Akkermansia muciniphila and Bacteroides thetaiotaomicron, reduces lubrication and induces fecal dehydration leading to constipation, with bacterial sulfatase activity identified as a key mechanistic target.
Characterisation of the gut-lung axis microbiome in clinically stable patients with chronic obstructive pulmonary disease.
The gut and lung microbiomes in patients with COPD are distinct, but both clinically relevant as both present bacterial associations with airflow limitation, exacerbation history, and inhaled corticosteroid use.
The role of gut microbes in production of aromatic carboxaldehydes.
A stable isotope dilution mass spectrometry method was developed to quantify aromatic carboxaldehydes from all four aromatic amino acids in feces, revealing that gut microbes produce these metabolites, that antibiotic depletion reduces fecal levels of I3A, 4HBA, BA, and 4IA, and that individuals with Crohn's disease have lower fecal levels of I3A and 4HBA relative to non-IBD controls.
Soluble MAdCAM-1 as a biomarker in metastatic renal cell carcinoma.
Soluble MAdCAM-1 levels above 180 ng/ml were associated with significantly improved progression-free survival and overall survival in metastatic renal cell carcinoma patients across three independent cohorts, with low sMAdCAM-1 linked to immunosuppressive gut microbiota dominated by Enterocloster species.
Gut microbiota-derived isovaleric acid alleviates atrial fibrillation by suppressing GSDME-dependent pyroptosis.
Gut microbiota-derived isovaleric acid (IVA), produced by Ruminococcus gnavus from dietary leucine, alleviates atrial fibrillation by activating GPR109A on atrial cardiomyocytes and suppressing IL-6/STAT3 signaling and GSDME-dependent pyroptosis.
Impact of Helicobacter pylori infection on gut and intratumoral microbiome and its association with immunotherapy response in gastrointestinal cancer.
H. pylori infection significantly affects the structure and functional activity of gut and intratumoral microbiome in gastric cancer, and incorporating H. pylori infection status into microbiome-based prediction models improved the accuracy of predicting immunotherapy outcomes.
The impact of an oral purified microbiome therapeutic on the gastrointestinal microbiome.
Higher-dose VOS (VOWST) in phase 3 was associated with improved engraftment and significantly altered microbial composition, diversity, bile acid profiles, and short-chain fatty acids consistent with durable prevention of recurrent C. difficile infection.
Gut-derived succinic acid potentiates high-altitude-related spermatogenesis dysfunction.
High-altitude exposure increases intestinal Clostridium symbiosum colonization, which impairs spermatogenesis through succinic acid production that activates GPR91/TRPV4/Ca2+ signaling in testicular macrophages, driving inflammatory polarization and spermatogenic cell apoptosis.
Genetic relationships between the gut microbiota and prostate cancer: Mendelian randomization combined with bioinformatics analysis.
Mendelian randomization analysis identified 16 gut bacteria causally linked to prostate cancer (7 risk-increasing, 9 protective), and bioinformatics analysis identified five feature genes (PLCL1, VSNL1, ROR2, NRXN3, and TEAD1) used to construct a nomogram for predicting prostate cancer risk.
Gut mucosal mycobiome profiling in Crohn's disease uncovers an AMP-mediated anti-inflammatory effect of Cladosporium sphaerospermum.
Cladosporium sphaerospermum is depleted in the ileal mucosa of Crohn's disease patients and counteracts intestinal inflammation partly through adenosine 5'-monophosphate (AMP) production, upregulating epithelial cell junctions and Wnt signalling pathway.
Microbial metabolite FAD mobilizes adipocyte lipid remodeling to enhance cancer immunotherapy efficacy.
A microbiota-adipose axis shapes antitumor immunity whereby microbial FAD mobilizes adipocyte lipid remodeling via FADS2 to enhance PUFA synthesis, increasing CD8+ T cell cytotoxicity and improving immune checkpoint blockade efficacy.
Microbiota-induced T cell plasticity enables immune-mediated tumour control.
A single gut commensal bacterium (SFB) imprints T cell plasticity by inducing intestinal TH17 cells that convert to TH1-like cells within tumours sharing SFB antigen, enabling anti-PD-1-mediated tumour control through enhanced CD8+ T cell recruitment and effector function.
Infertility and the microbiota.
Dysbiosis of reproductive tract and gut microbiota triggers infertility through mechanisms including bacterial ecological ratio imbalances, immune system dysregulation, inflammatory responses, and effects on signaling pathways, with microbiota offering significant capacity for diagnosis, prognosis, and treatment of infertility-associated reproductive disorders.
Ketogenic diet alleviates septic lung injury via microbial gut-lung axis.
Ketogenic diet alleviates sepsis-induced lung injury through a microbial-gut-lung axis whereby gut bacteria convert oleic acid into azelaic acid, which promotes neutrophil apoptosis and expands MerTK+ alveolar macrophages via PPAR-γ activation to enhance efferocytosis and resolution of lung injury.