Aging & Longevity
500 peer-reviewed studies indexed
Repeated proliferative events ameliorate age-associated accumulation of DNA damage in HSPCs.
Repeated blood withdrawals equivalent to clinical blood donation clear DNA damages without impacting the functioning of HSPCs.
"We are left alone": A qualitative study of life satisfaction of older adults in rural Nepal.
Older adults in rural Nepal struggled to thrive as they navigated filial discrepancies amid youth out-migration and a changing economic context, connecting low life satisfaction to political, religious, and social dynamics while relying on tradition to cope with situations outside their control.
Sub-Networks of the Brain R2 Structural Connectome Integrity Matrix (SCIM) and Older Adult Cognitive and Motor Functioning.
Factor analyses of a structural connectome integrity matrix (R2) in older adults revealed four Sub-Networks differentially associated with baseline and longitudinal cognitive and motor functioning, providing an approach to assessing aging structural connectome integrity.
Demographic and biosocial determinants of beneficial trends in older adult cognition in the USA and England: the role of cohort succession.
Improvements in cognitive functioning between 2004 and 2018 in older US and English adults were largely driven by cohort succession increasing average educational attainment, though increases in psychological conditions, diabetes, and divorce emerged as detrimental counteracting factors.
Regional correlates of tau pathology and synaptic function in primary age-related tauopathy.
In primary age-related tauopathy, oligomeric and fibrillar tau are associated with a shift toward synaptic inhibition predominantly within the hippocampus, with proteomic correlates implicating vesicle trafficking pathways as mediators of tau oligomer-associated alterations in synaptic function.
Brain Age Estimation on T2-FLAIR Scans for Application to Multiple Sclerosis.
Brain age predictions relying on T2-FLAIR scans are as accurate as those derived from T1-weighted scans and could be used as an easily obtainable biomarker of MS severity and progression in clinical practice.
The impact of cognitive impairment and low muscle mass on all-cause mortality among older adults in China: An empirical analysis based on CLHLS cohort data.
The coexistence of cognitive impairment and low muscle mass was associated with a substantially increased risk of all-cause mortality (HR 2.54, 95% CI: 2.11–3.05), particularly among women and individuals younger than 80 years, underscoring the importance of comprehensive geriatric assessment in aging populations.
Polygenic Associations Between Motor Behavior, Neuromotor Traits, and Active Music Engagement in Four Cohorts.
Polygenic scores for faster walking pace were associated with higher amounts of active music engagement across four independent cohorts, suggesting a shared genetic architecture between motor function and active music engagement.
Age-related differences in brain activity despite matched cognitive performance: A moderated-mediation analysis.
Despite matched cognitive performance between younger and older adults, moderated-mediation analysis of fMRI data revealed age-related differences in brain activity supporting upregulation, reorganization, and suppression as mechanisms, suggesting the need to expand the cognitive reserve and resilience framework to include neural suppression as a potential mechanism of healthy cognitive aging.
Re: "Ageism and the feminization of old age: A systematic review".
Gendered late-life vulnerabilities reflect cumulative life-course disadvantage, with older women showing higher depression risk and older men showing higher suicide risk, reinforcing review-based policy implications.
Influence of age on speech-in-noise and spatial processing abilities in middle-aged adults.
Among middle-aged adults with self-reported normal hearing, cognitive function (MoCA) emerged as the strongest predictor of speech-in-noise ability, while the older subgroup (51-60 years) exhibited reduced spatial advantage and significantly lower MoCA scores.
AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia.
AMPK phosphorylates Ser1157 at the C terminus of HCN4, decreasing its membrane expression and contributing to altered electrophysiological properties of cardiac pacemaker cells, with constitutive AMPK activation in aged mice correlating with increased intrinsic bradycardia.
Poliumoside attenuates endothelial senescence and atherosclerosis by regulating MKRN2-mediated autophagy via the PI3K/AKT/ mTOR pathway.
Poliumoside attenuates autophagy dysfunction in senescent HUVECs by inhibiting the PI3K/AKT/mTOR pathway via MKRN2, providing a potential therapeutic strategy for cellular senescence and atherosclerosis.
Multi-trajectories of intrinsic capacity and their impact on incident disability in community-dwelling older adults in Japan.
Four distinct intrinsic capacity trajectories were identified among community-dwelling Japanese older adults, and after accounting for mortality as a competing risk, all declining patterns showed higher disability risks than non-declining ones, with time-varying relationships highlighting the importance of IC-pattern-based assessments and targeted interventions.
Research on aging-friendly design risk assessment model based on non-parametric estimation.
A risk assessment model integrating non-parametric estimation, wavelet analysis, and prudence evaluation effectively identifies high-risk design zones and recommends parameters (button width ≥ 16 mm, font size ≥ 14pt, response delay ≤ 500 ms) that significantly reduce misoperation rates and task time while improving user satisfaction and safety for elderly users.
Digital Futures in an Ageing Society: Frontline Perspectives on Sociotechnical Imaginaries in Swedish Eldercare.
Care professionals in Swedish eldercare maintain persistent techno-optimism and techno-determinism despite regular experiences of technological malfunction, a phenomenon explained by the analytical concepts 'tech love goggles' and 'the magic leap,' which obscure immediate needs of workers and older care recipients.
Maternal Age at Childbirth and Offspring Cognitive Function in Middle and Older Age: A Longitudinal Cohort Study.
Advanced maternal age (>35 years) is associated with poorer offspring cognitive performance at baseline in middle and older age, with an effect size of -0.223 SD in the fully adjusted model, though no significant difference in the rate of cognitive decline was observed across maternal age groups.
Integration of Multi-Omics and Machine Learning Identifies TGFB1 and SERPINE1 as Biomarkers of Vascular Smooth Muscle Cell Senescence in Intracranial Aneurysms.
Integration of multi-omics data, machine learning, and experimental validation identified TGFB1 and SERPINE1 as robust biomarkers of senescence-associated VSMCs in intracranial aneurysms, showing high diagnostic accuracy (AUC > 0.75) and upregulation in IA tissues.
Cardiovascular Risk Indices Differentially Linked to Hippocampal Subfield Volumes: A Comparison Between Younger and Older Adults.
Cardiovascular risk indices show age-dependent, subfield-specific associations with hippocampal volumes, with the subiculum showing greater sensitivity and age moderating the relation between all indices and subiculum volume except waist-to-hip ratio.
Life expectancy in stomach cancer survivors adjusted for blood-test-based frailty: insights into biological aging.
FI-Lab-defined frailty was associated with significant life expectancy loss in stomach cancer survivors, particularly in male, middle-aged survivors with early-stage stomach cancer, with frail patients having 1.4-fold higher risk of cancer and non-cancer mortality.
Celastrol Targets Hsc70-Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis.
Celastrol surpasses benchmark senolytics ABT-263 and fisetin in potency by disrupting an Hsc70-Bim-CHIP complex to stabilize Bim and trigger intrinsic apoptosis in senescent cells, extends Drosophila lifespan, mitigates organ fibrosis in mice, and a β-galactosidase-activated prodrug (CeGal) preserves efficacy while markedly reducing systemic toxicity.
Non-contact radar assessment of One-Legged Stand Test for fall risk in aging.
FMCW radar accurately detects OLST transitions and captures wobble signatures linked to neuromuscular control and fall risk, establishing proof-of-concept for non-contact radar assessment of balance in older adults.
Social perceptions, age stereotypes, and health behaviours: an economic and public health perspective from China.
More favourable perceptions of ageing are strongly associated with higher levels of preventive care, physical activity, and social participation, with about one quarter of this association linked to an indirect pathway through lower endorsement of negative stereotypes, and these relationships are further shaped by provincial discourse on ageing and urban-rural inequalities.
Household mold exposure and arthritis in older Chinese adults: evidence from the Chinese Longitudinal Healthy Longevity Survey (CLHLS).
Mold exposure was associated with higher odds of arthritis in older Chinese adults (OR = 1.36, 95% CI: 1.08–1.71), with drinking status significantly modifying this relationship, and analgesic use was additionally found to be associated with arthritis.
The Limits of Predicting Individual-Level Longevity: Insights From the U.S. Health and Retirement Study.
Using 12 statistical and machine learning models and more than 150 predictors from the U.S. Health and Retirement Study, individual-level lifespan prediction achieves relatively high discriminative performance but fails to account for most lifespan heterogeneity at the individual level, with consistent inequalities in mortality predictability across sociodemographic groups.
Accelerated senescence in sulfur mustard-exposed individuals: Evidence from oxidative DNA damage, telomere shortening, and dietary inflammatory index.
SM exposure, coupled with pro-inflammatory dietary patterns, accelerates cellular aging through oxidative damage and inflammation, with telomere shortening, OGG1, and p16 expression signifying SM-induced damage while 8-oxo-dG levels can indicate disease severity.
Brief mind-body exercise in high-latitude aging: reduced sedentarism and domain-specific cognitive/social benefits.
A brief, indoor, regionally adapted mind-body exercise program is feasible and produces a meaningful profile of benefits, including reduced sedentarism, selective enhancement of executive-visuospatial function, and increased empathy, in older people living at high southern latitudes.
GDF-11, GDF-15, Jag-1, and leptin in neuronal-derived extracellular vesicles as aging-related biomarkers to identify individuals at risk of Alzheimer's dementia: A pilot study.
A minimal nEV-derived panel including lower GDF-11 and higher GDF-15, Jag-1, and Leptin discriminated AD from controls and was associated with MRI-determined cortical atrophy in regions vulnerable to AD, with nEV biomarkers more accurately reflecting brain pathology than those measured in plasma.
The Tuned Cortex: Convergent Expertise-Related Structural and Functional Remodeling across the Adult Lifespan.
Experts in bird identification showed lower mean diffusivity in frontoparietal and posterior cortical areas compared to novices, with these same regions showing selective functional engagement for less familiar stimuli, suggesting convergent structural remodeling and functional tuning in service of expert performance across the lifespan.
Age-related cerebello-thalamo-cortical white matter degradation and executive function performance across the lifespan.
Age-related degradation of cerebello-thalamo-cortical white matter connectivity is associated with poorer executive function performance in an age-dependent fashion, with higher diffusivity metrics linked to lower EF scores in older but not younger adults.
Relationship between personality, memory complaints and episodic memory in young, middle-aged and older adults.
Associations between episodic memory performance, memory complaints, and personality traits (openness and neuroticism) differed by age group, with complaints reflecting actual performance in young adults, neuroticism driving complaints in middle-aged adults, and openness associated with better performance while complaints were unlinked to performance or personality in older adults.
High-density lipoprotein cholesterol and cognitive impairment: A U-shaped relationship in China's aging population.
A U-shaped association was observed between HDL-C levels and cognitive scores in older Chinese adults, with a turning point at 67.43 mg/dL, such that both very low and very high HDL-C were associated with lower cognitive scores.
Task-dependent cognitive effects of intermittent theta-burst stimulation across the adult lifespan.
iTBS of the DLPFC influences cognition in a task-dependent manner, reducing reaction times in attention and working memory tasks across all participants and improving working memory accuracy with a right hemisphere advantage, while effects on sequence learning and inhibition were not demonstrated.
17-β-Estradiol Protects Chondrocytes From Senescence and Ameliorates Osteoarthritis Progression via ERα-AKT-FOXO4 Pathway.
E2 contributes to the alleviation of chondrocyte senescence through the ERα-AKT-FOXO4 signalling pathway and ameliorates OA progression in a rat model, offering a novel therapeutic approach for controlling chondrocyte senescence.
Developmental trajectories of reading and neural substrates: a lifespan perspective on Chinese reading.
Age-related brain-reading relationships shift from cortical thinning correlating with better reading in children and young adults to positive associations in older adults, indicating a transition from neural pruning to compensatory mechanisms in Chinese reading across the lifespan.
Neutralizing hepatic apolipoprotein E enhances aged bone fracture healing.
ApoE increases with age and causes poor fracture healing by inhibiting Wnt/β-catenin signaling through Lrp4, and neutralizing ApoE with an antibody treatment resulted in fracture calluses with 35% more bone deposition in aged wildtype mice.
Fine motor function deficits in the 5xFAD mouse model of Alzheimer's disease.
9-month 5xFAD mice exhibited the most impaired performance at each motor assay in an age-dependent manner, suggesting that accumulation of AD-related pathology affects motor function, extending even to fine motor skills.
Upskilling in Healthy Longevity Medicine and Its Association With Physicians' Implementation Intent and Self-Reported Clinical Confidence: Cross-Sectional Observational Study.
Accredited education in healthy longevity medicine is associated with enhanced confidence in HLM knowledge, increased clinical engagement with HLM practices, and a shift in aging-related care paradigms among physicians.
Noradrenergic innervation across brain regions is altered by aging and by disease progression in a mouse model of Alzheimer's disease neuropathology.
APP transgenic mice displayed region-specific alterations in hippocampal noradrenergic fiber density that followed distinct age-related trajectories, and these alterations were not associated with amyloid-β plaque load and occurred in the absence of neuronal loss or Aβ plaques in the locus coeruleus.
Impact of age and slope angle on the motion between the body's center of mass and center of pressure during downhill walking.
Older adults exhibit significantly higher frontal inclination angles and rates of change at contralateral heel-strike during downhill walking, suggesting increased lateral postural demand and greater fall risk compared to young adults.
Mammalian mitochondrial DNA accumulates insertions and deletions with age in energetically demanding tissues.
Using highly accurate duplex sequencing, de novo insertion and deletion mtDNA mutations accumulate rapidly with age in somatic tissues with high energetic demand (brain and skeletal muscle) or high proliferation (liver), but in oocytes indels accumulate slower with age than nucleotide substitutions or do not accumulate at all.
Prefrontal cortex connectivity during right and left hand dexterity tests in younger and older adults.
Functional connectivity of the PFC evaluated by fNIRS differed in Older versus Younger adults, and age and non-dominant hand required more connectivity but did not lead to improved task efficiency.
Age differences in endocannabinoid tone are ameliorated after recent cannabis use.
Older adults exhibited lower baseline endocannabinoid levels than younger adults, but acute cannabis use produced broad endocannabinoid elevations across all age groups, with larger increases in AEA and DEA specifically in older adults.
Cultural Engagement Is Related to Decelerated Physiological Age: Doubly Robust Estimations in a National Cohort Study.
Cultural engagement was related to lower physiological age cross-sectionally and 4 and 8 years later in older adults, with an average treatment effect of -2.17 years (95% CI -3.48 to -0.86), consistent across all three types of cultural activity explored.
Elucidate senescence-related gene signature and immune infiltration landscape in abdominal aortic aneurysm.
This study identified four senescence-related diagnostic biomarkers (IL6, ETS1, TDO2, and TBX2) for abdominal aortic aneurysm through transcriptomic analysis of public databases, revealing their associations with immune cell infiltration, AAA subtypes, and confirming their expression changes in a murine AAA model.
Leg strength and neural activation deficits in older adults with multiple sclerosis.
Neuromuscular function deficits in older adults with MS are largely attributed to impaired neural activation without significant differences in muscle quality compared with controls.
Effects of aging on host responses in gingival crevicular fluid in natural gingivitis.
The inflammatory profiles of young and elder cohorts with natural gingivitis are distinct, with the aged periodontium characterized by higher susceptibility to disease and diminished healing capacity, while the young cohort demonstrated lower disease susceptibility and more robust tissue turnover.
Deep Learning-Based Structural Brain Age Estimation in Bipolar Disorder and Schizophrenia: A Single-Site Pilot Study.
SZ and BD exhibit elevated Brain-PAD early in adulthood with greater heterogeneity than healthy controls, with frontotemporal regions contributing prominently to brain-age predictions, supporting Brain-PAD as a group-level marker of apparent brain aging.
Grief or Relief? Dyadic loneliness and biological health after mid-to-late life widowhood.
Deceased dyadic partner's pre-loss loneliness was associated with lower (healthier) post-loss levels of Cystatin C and triglycerides among recently widowed adults, suggesting that removal of a lonely partner as a 'stress generator' via widowhood may be associated with improved biological health following loss.
Thrombospondin 1-CD47 Signalling Modulates Vascular Smooth Muscle Cell Senescence in Chronic Kidney Disease.
IS and TSP1 promote VSMC senescence through CD47-dependent ERK1/2 and AhR signalling, and CD47 deletion protects against CKD-induced vascular remodelling, suggesting that CD47 blockade may represent a novel therapeutic strategy to mitigate vascular complications in CKD.