Aging & Longevity
500 peer-reviewed studies indexed
Revisiting the associations between cooking oils and survival among older people in China: A nationwide, community-based, prospective cohort study.
Cooking with lard was associated with significantly longer CVD-specific survival compared to vegetable oils among older adults in China (TR=1.44, 95% CI: 1.08-1.91).
The effects of extracellular matrix degradation mediated by chronic inflammation in aged skin on the structure and function of eccrine sweat glands.
The activation of the IL-1β-MMP-1 inflammatory pathway in aging may contribute to eccrine sweat gland dysfunction and structural disruption by degrading type I and type II collagen surrounding the glands.
The Relationship Between Task-Related Aperiodic EEG Activity, Neural Inefficiency and Verbal Working Memory in Younger and Older Adults.
Flatter aperiodic exponents were associated with less efficient neural processing, and older adults flexibly modulate their aperiodic exponent during retention to support working memory performance.
IL-18 Binding Protein, a biomarker of strength maintenance after surgery but reduced physical performance in age-related sarcopenia.
IL-18 binding protein associates with maintenance of strength after surgery but is negatively associated with muscle strength and physical performance in men with age-related sarcopenia, consistent with known effects of IL-18BP ligands on mitochondrial function.
The stories of the ageing population in Luton, United Kingdom on their experience of periodontal diseases healthcare.
The interaction of cultural beliefs, systemic barriers, and psychosocial variables affects the oral health of older Indian adults in Luton, with periodontal treatment tending to be reactive and symptomatic with little preventive treatment.
Trajectories of cognitive decline before and after new-onset loneliness: The English Longitudinal Study of Ageing.
Incident loneliness is associated with accelerated cognitive decline after, but not before, the event, with the onset of loneliness marking a critical inflection point associated with a subsequent acceleration in cognitive decline.
Age-dependent changes in the transverse carpal ligament and median nerve: a cadaveric histological and biomechanical study.
The TCL stiffens and becomes structurally disorganized with advancing age, paralleled by degenerative changes in the median nerve, which may predispose elderly individuals to a higher risk of carpal tunnel syndrome.
HIV Infection as an Independent Factor Accelerating Epigenetic Ageing in Men Treated with Integrase Inhibitors: A Case-Control Study.
HIV infection is an independent factor causing global DNA hypomethylation and increased DNMT1 expression and thus accelerating epigenetic ageing in men successfully treated with INSTI-based cART.
Hippocampal subfield thickness and shape analysis in examining the impact of TDP-43 in primary age-related tauopathy.
Geometry-based morphometric analysis revealed that PART with TDP-43 exhibited thinner left subiculum and CA1 with curvature deformations in left CA1 and CA2/3 relative to PART without TDP-43, demonstrating different patterns of hippocampal thinning and curvature associated with TDP-43 co-pathology in primary age-related tauopathy.
Interstride Variation in EEG Power Spectra of Younger and Older Adults Walking at a Range of Gait Speeds.
Interstride variability in EEG alpha and beta power lessened with faster walking speeds and was lower in older adults than younger adults, suggesting that older adults' reduced automaticity of gait may be unrelated to electrical brain activity.
Plasma Biomarkers of Senescence in Cholestatic Liver Disease: A Signature of Risk Stratification and Progression.
This is the first study to define a plasma SASP biomarker signature associated with cholestatic liver disease, with analytes that track disease stage and represent both mechanistic indicators and potential clinical trial endpoints.
Social capital and subjective well-being among older adults: The mediating role of loneliness and the moderating role of optimism.
Loneliness mediates the relationship between social capital and subjective well-being in older adults, accounting for 45.1% of bonding and 50.5% of bridging social capital associations, while optimism negatively moderates the social capital–loneliness pathway.
Digital Inclusion Pathways for Older Chinese Adults in the Context of Active Aging: Secondary Analysis of 2023 China Longitudinal Aging Social Survey Data.
Digital inclusion promoted active aging indirectly, by expanding social engagement and enhancing mental health, thereby improving overall health status, with policy implications for prioritizing digital skills over access alone.
The Onset of Empty Nest Increases Subjective Well-Being Amongst Middle-Aged and Older Adults: Longitudinal National Evidence From Thailand, 2015-2022.
The onset of empty nest was positively associated with positive affect in both men and women, and with greater life satisfaction in women, amongst middle-aged and older adults in Thailand from 2015 to 2022.
Age prediction of contributors to two-person DNA mixtures via deconvolution of autosomal DNA methylation profiles.
Autosomal DNAm profiles from two-person DNA mixtures can be successfully deconvoluted when one contributor is known, enabling age prediction accuracy comparable to single-source samples except at low suspect-to-victim ratios (1:4 and 1:10).
Five energy metabolism pathways show distinct regional distributions and lifespan trajectories in the human brain.
Using curated gene sets and whole-brain transcriptomics, five fundamental energy metabolic pathways show consistent divergence between primarily energy-producing and anabolic pathways across the cortex, exhibit unique relationships with cellular and laminar organization, and display distinct developmental trajectories from fetal stage to adulthood.
Magnetic resonance spectroscopy in hospitalised older people shows age and delirium-specific metabolic changes.
Delirium in hospitalised older people is characterised by elevated brain glutamate concentration in parietal white matter as measured by MRS, which could cause excitotoxic brain injury and contribute to post-delirium cognitive decline.
Senescence markers in peripheral blood mononuclear cells in pediatric drug-resistant epilepsy.
We observed no evidence of established stress-induced premature or replicative senescence in drug-resistant epilepsy patients, however elevated proinflammatory cytokines and high p21/p16 expression may suggest ongoing seizures cause cellular stress which could increase susceptibility to senescence over time.
Targeting Senescence: Tianma Granule Inhibits Colorectal Cancer Progression by Modulating miR-29a-5p/P53 Signaling in the Tumor Microenvironment.
Tianma granule (TMG) remodels the chemotherapy-induced senescence-associated tumor microenvironment and suppresses colorectal cancer progression by modulating the miR-29a-5p/P53 axis, enhancing apoptosis in senescent cells, and counteracting S-TME-mediated tumor growth and metastasis.
Future Care Planning for Ageing Adults With Intellectual Disabilities: Family Caregiver Perspectives in Thailand.
Most Thai families caring for older relatives with intellectual disabilities lack concrete future plans, relying on informal family care due to limited services, financial constraints and cultural values.
Features of Mitochondrial Dynamics Changes in Large Pyramidal Neurons of the Human Motor Cortex during Aging.
Aging in the human motor cortex is associated with enhanced mitochondrial fragmentation in large pyramidal neurons, evidenced by decreased TOMM20 and Opa1 staining intensity and increased Drp1 staining intensity, possibly linked to dysfunction in mitochondrial fusion.
Update of the Novara Cohort Study (NCS): protocol evolution of a population-based longitudinal study on ageing in Northern Italy - cohort profile.
The Novara Cohort Study (NCS) is a population-based longitudinal cohort in Northern Italy designed to investigate biological, psychological, and social factors influencing ageing, with approximately 1000 participants enrolled as of mid-2025 and a target of at least 10,000 participants for long-term follow-up.
Retention and longitudinal change in Insight 46, an intensive neuroscience sub-study of the 1946 British birth cohort.
In Insight 46, a neuroscience sub-study of the 1946 British birth cohort, 88% retention was achieved over 2.5 years, with β-amyloid positivity, female sex, and older age associated with lower odds of retention, while cognitive and clinical changes over follow-up have implications for the interpretation and generalisability of longitudinal ageing research.
Disrupting the Senescence-Associated Secretory Phenotype-M1Macrophage Feedback Loop in Synovitis Using Dual Nano-Switches To Restore Joint Homeostasis.
A dual nanomedicine platform combining synovium-targeting liposomes delivering senolytics and M2 macrophage-derived exosomes disrupted the senescence-inflammation feedback loop in osteoarthritis, achieving 73.53% synovitis index reduction and 75.00% OARSI score reduction in rat OA models.
Age-related differences in memory organization: How depth of processing and learning intention affect free recall and temporal contiguity.
Deeper processing improves overall recall across age groups, but the organization of recall differs with age and learning intention, with younger adults showing disrupted temporal contiguity under deep intentional processing while older adults maintained stable temporal organization across conditions.
Do JST-IC Trajectories Truly Capture Aging Processes? A Need to Reconsider What the Trajectories Represent.
JST-IC-based trajectories may represent mixed trait-change constructs shaped by cognitive reserve, digital literacy, and cohort-specific exposures rather than primarily reflecting aging-related decline.
Visuo-spatial attention in younger and older adults: comparing performance on a series of computer-based tasks.
Older adults had significantly slower response times compared to younger adults across all tasks, but accuracy was largely comparable, with increasing task demands having a greater impact on older adults' performance.
Social connections are differentially related to subjective age and physiological age acceleration amongst older adults.
Weak social connections (living alone, low social integration, low social support) are risk factors for accelerated physiological age but do not have a statistically significant association with older subjective age amongst adults aged 50+.
Exploring neural correlates of automated speech-based cognitive markers through resting-state functional connectivity in aging and at-risk Alzheimer's disease.
Digital speech-based assessments may have limited current utility for detecting functional connectivity alterations in at-risk individuals, with only one speech feature (SVF temporal cluster switching) surviving correction for multiple comparisons, associated with greater language network connectivity in the left middle temporal gyrus.
Echoes of childhood trauma: the relationship between adverse childhood experiences, brain structure, and mental health in aging adults.
ACEs showed strong evidence of association with mental health symptoms in mid- to late adulthood and were associated with dose-dependent regional grey matter volume reductions in limbic and frontal regions, though hypothesized mediation by hippocampus, amygdala, and dorsolateral prefrontal cortex morphology was not confirmed.
[Influences of aged male parents on learning ability of offspring in SD rats and intervention effect of Wuzi Yanzong Pills based on miR-34a-5p/SIRT1 signaling pathway].
Wuzi Yanzong Pills can improve testicular spermatogenesis and sperm quality in aged rats, thereby enhancing offspring's learning and memory performance by regulating miR-34a-5p expression to delay spermatogenic cell senescence via miR-34a-5p mediated intergenerational transmission.
Differential Gene Expression in Human Hippocampus With Aging.
Transcriptomic analysis of human hippocampal samples identifies differentially expressed genes between young and old adults linked to inflammation, DNA repair, and neural activity, and identifies RAD23B as a putative biomarker and regulator of cell aging in the brain with negative correlation of mRNA and protein expression with age.
Effect of bedrest on the human gut and oral microbiome: implications for frailty.
Inactivity-associated changes to the human microbiome during head-down tilt bedrest are associated with the early stages of frailty development, and exercise may serve as an effective countermeasure against these effects.
AGNES-AGing NEphropathy study-a prospective cohort of older patients with advanced chronic kidney disease.
In older patients with advanced CKD, comorbidity burden and beta-blocker use were associated with an increased risk of death, whereas ACEI/ARB use was linked to a lower likelihood of both dialysis initiation and death.
The CFP macromolecule attenuates senescent liver sinusoidal endothelial cell-driven activation of hepatic stellate cells.
CFP (encoding properdin), a macromolecular regulatory protein, was identified as a senescence marker highly expressed in liver sinusoidal endothelial cells that is downregulated in a stage-dependent manner during MASH-fibrosis, and CFP overexpression attenuates senescent LSEC-driven activation of hepatic stellate cells by reducing TGF-β1 secretion.
PDP1 drives hepatocellular carcinoma progression by regulating senescence through the cAMP/Ca2+ signaling pathway.
PDP1 drives senescence-associated malignant progression in HCC by linking glycolytic regulation, histone lactylation, and DNA methylation to the control of ADCY5 expression and subsequent cAMP/Ca2+ signaling, underscoring its potential as a therapeutic target.
Chronic IL-21 exposure reshapes pulmonary environment, elevating risk of respiratory diseases.
Age-related elevation of IL-21 levels may be a key driver of pulmonary dysfunction in the elderly, inducing pro-inflammatory states, cellular senescence, altered macrophage lipid metabolism, and impaired antiviral responses in the lungs.
The Brain Resilience Study protocol: Building a dataset of the biological and sociocultural factors affecting brain health in older adults.
The Brain Resilience Study (BRS) protocol integrates multimodal biological and cognitive measures with rich demographic, psychosocial, and lifestyle data to create an open resource for studying resilience to dementia in 1000+ adults aged 50 and older.
Relative Telomere Length in Leukocytes as a Potential Biomarker of Male Idiopathic Infertility.
Men with idiopathic infertility exhibited a significantly shorter relative telomere length reduced by approximately 40% in comparison with fertile controls, suggesting ongoing genomic instability likely driven by oxidative stress-mediated DNA damage.
Medial temporal lobe atrophy is associated with age and pathologies, especially small vessel disease.
Age and white matter hyperintensities (WMH) emerged as the most prominent factors associated with medial temporal lobe atrophy (MTA), with WMH mediating 32-41% of the association between age and MTA, and an age-independent MTA cut-off performed comparably to previously published age-adjusted cut-offs.
Relationships between fine memory discrimination and tau burden in two independent cohorts of older adults.
Poorer fine memory discrimination on the Mnemonic Similarity Task was associated with higher tau burden (PET and CSF) across two independent cohorts of older adults, supporting its potential as an adjunctive, accessible screening measure associated with underlying tau pathology.
The relationship between social interaction patterns and cognitive trajectory in older adult: evidence from ELSA.
Face-to-face social interaction was associated with greater stability and less decline in orientation and executive function among older adults, while no significant associations were found between social interaction patterns and memory trajectories.
Spatial amyloid-informed multimodal brain age as an early marker of Alzheimer's-related vulnerability and risk stratification.
An amyloid-informed multimodal brain age gap (BAG) model captures convergent AD-related pathology, biomarker alterations, and cognitive vulnerability beyond amyloid burden alone, supporting its value for individualized risk stratification and prevention-focused assessment.
Age-associated chemokine receptor expression profiles in human peripheral blood monocyte subsets predict cardiovascular disease risk.
Aging is associated with distinct changes in monocyte chemokine receptor expression that relate to CAD severity, identifying age- and disease-associated monocyte immune features that may contribute to CAD progression.
Texas Card Sorting Test: a Brief Test of Executive Functioning with Age-Adjusted Norms and External Validation.
The Texas Card Sorting Test demonstrated validity and feasibility as a brief measure of executive functioning that can accurately discriminate between normal aging and dementia, with an AUC of 0.912 and classification accuracy of 84% for normal controls versus Alzheimer's disease clinical syndrome.
Sex Disparities in the Processes Underlying Aging: Mitochondrial DNA Copy Number Associations with Dynapenia, 25-Hydroxyvitamin D3 Levels and Quality of Life in Older Adults.
This study identified a marginally significant positive correlation between serum 25(OH)D3 levels and mtDNA-CN in older adults (r = 0.210; p = 0.010), which did not persist after Bonferroni correction, and found sex-specific associations whereby lower mtDNA-CN was linked to muscle weakness, mobility problems, and self-care difficulties in women but not men.
Global functional connectivity of cognitive control networks predicts task-switching performance in older adults.
Greater integration of the CCN, DMN, and SMN, as measured by global functional connectivity, is associated with better task-switch performance under increasing working memory demands in older adults.
Age-related changes of multi-parametric quantitative imaging across the adult lifespan in the lumbar vertebra.
The proposed DFA-MEGRE method enables multi-parametric quantitative imaging of the lumbar spine and demonstrates age-related quadratic changes in all five quantitative parameters (PD, T1, R2*, PDFF, and QSM) across the adult lifespan.
Antigen-specific TH17 cells offset the age-related decline in durable T cell immunity.
Durable vaccine efficacy with aging relies on antigen-specific TH17 cells that compensate for CD8+ T cell defects, as the adjuvanted component vaccine selectively enhanced TH17 CD4+ T cells and prevented their conversion into regulatory T cells through lipid metabolic regulation.
Enhancing peripheral scene recognition through spatial frequency training: Behavioral evidence from macular degeneration and healthy aging.
Repeated spatial frequency training improved peripheral scene recognition in macular degeneration patients, particularly for low spatial frequency scenes, and also benefited older controls viewing through artificial scotomas, supporting the potential of perceptual training for visual rehabilitation in MD and normal aging.