Aging & Longevity
500 peer-reviewed studies indexed
How We Sleep, How We Move, How Long We Expect to Live: An Integrative Review of Lifestyle Behaviors and Subjective Life Expectancy.
Sleep quality and physical activity form the core behavioral components of a dynamic system shaped by dietary behavior and psychological well-being, with subjective life expectancy positioned as a key psychological link between lifestyle behaviors and longevity.
Accelerated aging mediates the association between fecal incontinence and mortality: Evidence from the National Health and Nutrition Examination Survey.
Accelerated aging partially mediated the association between fecal incontinence and all-cause mortality, with phenotypic age acceleration accounting for 9.56% of the effect of fecal incontinence on all-cause mortality in a US population cohort.
Drought and cognitive function in older adults: results from the Mexican health and aging study.
Longer drought exposure was negatively related with Verbal Learning and Verbal Recall performance over time but exhibited an inverse U-shaped association with Verbal Fluency among Mexican adults aged 50+, and these associations were not explained by nutrition or mental health covariates.
ZNF384-Driven Fibulin-1 Exacerbates Vascular Stiffness via TGF-β/Smad3-Mediated Senescence and Fibrosis.
Fbln1 exacerbates vascular stiffness through ZNF384-mediated transcriptional activation and TGF-β/Smad3-dependent ECM/senescence pathways, and targeting Fbln1 or its regulators may offer therapeutic strategies for age-related vascular pathologies.
A Multidomain Lifestyle Intervention Is Associated With Improved Functional Trajectories and Favorable Changes in Epigenetic Aging Markers in Frail Older Adults: A Randomized Controlled Trial.
A 6-month multidomain lifestyle intervention (nutritional supplement and supervised exercise) in frail older adults was associated with reduced frailty, improved physical function, reduced DNAm PhenoAge, and preserved telomere length compared with habitual care, suggesting potential geroprotective effects.
Air Pollution and the Progression of Physical Function Limitations and Disability in Aging Adults.
Air pollution, particularly PM2.5, PM10-2.5, and NO2, was associated with greater hazards of transitioning toward physical disability and lower odds of recovery, suggesting that air pollution may affect the progression of physical disability and hinder recovery in later life.
Urolithin A Attenuates Aging-Induced Liver Injury by Inhibiting Nur77 Ubiquitination and Degradation.
Urolithin A stabilizes Nur77 by inhibiting MDM2-mediated ubiquitination and degradation, thereby alleviating hepatic aging-associated inflammation in D-galactose-induced macrophage senescence and mouse liver aging models.
Striatal dopamine and skeletal muscle energy metabolism in older adults.
Striatal dopamine in the limbic subregion, but not other subregions, was positively associated with greater skeletal muscle mitochondrial ATP production capacity in vivo in older adults, independent of multiple confounders.
Testicular ageing as a central hallmark of male senescence: characteristics, molecular mechanisms and emerging therapeutic strategies.
Testicular ageing is a defining feature of male senescence marked by progressive structural deterioration and declining steroidogenic and spermatogenic capacity, and although lifestyle, pharmacological, and stem-cell-based interventions show promise, their clinical applicability remains limited.
Periodic Therapeutic Phlebotomy Mitigates Systemic Aging Phenotypes by Promoting Bone Marrow Function.
Periodic therapeutic phlebotomy exerts anti-aging effects by restoring bone marrow function and mitigating aging phenotypes, subsequently driving peripheral blood functional restoration in D-galactose-induced aging models.
Di-n-butyl phthalate induces NF-κB-mediated senescence-associated secretory phenotype to promote epithelial proliferation, epithelial-mesenchymal transition, and benign prostatic hyperplasia.
Di-n-butyl phthalate induces NF-κB-mediated senescence-associated secretory phenotype to promote epithelial proliferation, epithelial-mesenchymal transition, and benign prostatic hyperplasia through IL-8/CXCR2 signaling.
Alzheimer's Disease Pathologies Affect Dopaminergic Neural Mechanisms of Memory.
AD pathological processes acutely alter the mechanisms by which elevated dopamine synthesis supports optimal memory performance, disrupting and even reversing relationships between dopamine synthesis, memory, and temporal lobe activation in older adults.
Psychosocial stressors, accelerated biological aging, and multiple morbidities: Evidence from an age-diverse sample.
When modeling multiple psychosocial stressors simultaneously, financial strains and everyday discrimination emerged as more consistent predictors of accelerated epigenetic aging and poorer health outcomes than adverse childhood experiences or stressful life events, with stressor effects more pronounced for mental health than physical health or biological aging.
Understanding Care Worker Well-Being and Job Satisfaction: The Influence of Intergenerational Contact and Aging Anxiety.
Care workers who experienced more positive contact with residents were less anxious about their own aging, with psychological concerns mediating effects on subjective well-being and fear of old people mediating effects on job satisfaction.
Methylmalonic Acid, an Aging-Associated Metabolite, Accelerates Intervertebral Disc Degeneration by Inducing Disc Vascularization via the CCL7/JAK2-STAT3/VEGF Signaling Axis.
Methylmalonic acid (MMA), an aging-associated metabolite, accelerates intervertebral disc degeneration by inducing disc vascularization via the CCL7/JAK2-STAT3/VEGF signaling axis, and lenvatinib, a VEGF receptor inhibitor, delayed IVDD progression as a rescue strategy.
The Nrf2-SLPI axis in aging and its role in the pathophysiology of pulmonary Mycobacterium avium complex disease.
Age-related reductions in Nrf2 activity and SLPI expression contribute to poor outcomes in pulmonary MAC disease, and targeting the Nrf2-SLPI axis may represent a novel therapeutic approach for elderly patients.
Can dual-task high-velocity exercise training improve cognitive function in older adults? Secondary analysis of an 18-month cluster randomized controlled trial.
Dual-task functional power training (DT-FPT) may improve cognitive domains critical for functional independence in older retirement living residents, with genotype potentially influencing these outcomes.
Distinct epigenetic aging in sporadic and hereditary neuroendocrine neoplasms.
Epigenetic age and age acceleration analysis demonstrate distinct patterns in sporadic and hereditary NEN, suggesting lower impact of epigenetic alteration or DNA aging in the pathogenesis of hereditary NEN.
Depression and Cognitive Outcomes: Linking the Mayo Clinic Study of Aging and Rochester Epidemiology Project.
Depression was associated with increased risk for incident MCI (HR=1.37) and dementia (HR=1.33), lower baseline cognitive scores in most domains, and longitudinal cognitive decline, with only antidepressant users showing significantly increased risk for MCI and dementia in sensitivity analyses.
Circulating Metabolites Treat Human TMJ-OA by Eliminating Senescent Chondrocytes via the C1QBP/C1q/p14ARF Axis.
Autologous circulating extracellular vesicles (C-EVs) significantly enhanced condylar bone regeneration and alleviated TMJ-OA symptoms in a randomized clinical trial by eliminating senescent chondrocytes via the C1QBP/C1q/p14ARF axis.
When Testosterone Fades: Leydig Cell Aging Shaped by Environmental Toxicants, Metabolic Dysfunction, and Testicular Niche Crosstalk.
Declining Leydig cell steroidogenesis is shaped by environmental endocrine-disrupting chemicals, metabolic dysfunction, and testicular aging, which converge on impaired organelle quality control, oxidative stress, and senescence-associated remodeling to compromise androgen production and male reproductive health.
Rethinking immune studies: population-level immune variations and the path forward.
A meta-analysis across 3 large, diverse cohort studies found consistent and significant associations between 20 immune cell subtypes, 3 cell ratios, and sociodemographic variables including age, sex, race/ethnicity, and socioeconomic status, with CMV emerging as a major contributor to immune composition variation.
Exposure to polycyclic aromatic hydrocarbons and aging acceleration: Unraveling the underlying mechanisms and the role of AKT1 via integrative methods.
PAHs exposure was associated with aging acceleration, and AKT1 as a possible target molecule was involved, with individuals carrying high-risk genotypes and high OH-PAHs exposure being susceptible to accelerated aging.
Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus.
Intranasal hiPSC-NSC-EVs therapy in late middle age can effectively diminish proinflammatory microglial transcriptome and signalling cascades that drive neuroinflammaging in the hippocampus, contributing to better brain function in old age.
Associations of Dietary Decanoic Acid Intake With Cognitive Function in the Elderly and the Mediating Effects of Hypertension and Diabetes: An Analysis From NHANES 2011-2014.
Dietary decanoic acid intake is positively associated with global cognitive function in older adults, with hypertension and diabetes partially mediating this relationship, accounting for 27.53% and 24.33% of the total effect, respectively.
Transplantation of Mitochondria isolated from iPSC-MSCs mitigates doxorubicin-induced cardiomyopathy by inhibiting cardiomyocyte senescence.
Transplantation of mitochondria isolated from iPSC-MSCs improved cardiac function in a mouse model of doxorubicin-induced cardiomyopathy by alleviating cardiomyocyte senescence via improved metabolic function.
Associations Between 40-Year Trajectories of BMI and Proteomic and Epigenetic Aging Clocks: Deciphering Nonlinearity and Interactions.
BMI at age 18 and ~60 years and changes in BMI over 40 years were associated with increased biological aging for most aging estimates, with statistical evidence of nonlinearity found in about one-third of significant associations, mostly observed for proteomic clocks.
Integrative transcriptomic profiling links telomere dysfunction to cGAS-STING activation in heart failure signatures in mice and humans.
Telomere dysfunction in heart failure engages innate immune signaling via the cGAS-STING pathway, with direct relevance to human heart failure across species and etiologies.
The impact of social engagement on the mental health development of older adults: A 10-year longitudinal study.
Social engagement was positively associated with life satisfaction and negatively associated with depression in older adults over a 10-year period, with both life satisfaction and depression following nonlinear (quadratic) trajectories over time.
Estrogen Receptor-Phytoestrogen Interactions in Health and Aging: A Review on Estrogen Receptor Vascular Actions with Proof-of-Concept Data.
Estrogen supports macronutrient utilization, adipose regulation, bone density, and endothelial function, and GPER agonism enhances both contractile and vasodilatory responses in female but not male rat aortas, providing mechanistic evidence of sex-specific vascular estrogen signaling.
Man Enough to Care: Intersections of Masculinities, Care, and Aging.
Men in nursing appear 'man enough to care,' with their practices both reinforcing and challenging the gender order through two contrasting strategies: adapting hegemonic masculinity to incorporate caring elements, and re-masculinizing care through relationality, emotional openness, and rejection of dominance.
Sex differences in cognitive function trajectories and influencing factors in older adults: A machine learning study based on CHARLS and HRS.
XGBoost machine learning models identified education as the top influencing factor for cognitive function trajectories across all groups, with family factors mattering more in China, U.S. medical and endowment insurance having stronger effects, and sex-specific differences linked to external social networks for men versus family responsibilities and community environments for women.
Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives.
The contemporary testosterone decline represents a complex, multifactorial public health issue requiring integrated approaches to preserve hormonal and systemic health.
Elevating Circulating L-Kynurenine Promotes Frailty in Aging Mice.
PGC1α overexpression in skeletal muscle mitigates the exacerbation of physical frailty induced by elevated circulating L-Kyn in aging mice, in part through increased skeletal muscle capacity for L-Kyn metabolism due to PGC1α-induced increase in muscle KAT expression.
UBE3A-mediated mH2A1 Ubiquitination activates TERT transcription to promote senescence resistance in pancreatic cancer.
The UBE3A/mH2A1/TERT axis enhances the anti-senescence capacity of pancreatic cancer cells and drives malignant progression, suggesting that UBE3A may serve as a novel therapeutic target for pancreatic cancer.
Earthquake and Aging: Quality of Life and Its Determinants Among Older Persons After the Al-Haouz Earthquake in Morocco.
Older persons in Al Haouz still face impaired quality of life six months after the earthquake, especially those with significant losses or low social support, with PTSD, housing damage, and loss of a relative independently associated with lower quality of life.
Digital literacy, work participation, and active aging: evidence on older adults' employment and well-being in China.
Higher levels of digital literacy are significantly associated with a higher likelihood of employment among older adults in China, with digital application skills exhibiting the largest marginal effect, operating through pathways of improved aging attitudes, strengthened social capital, and alleviated grandchild care burden.
Randomized phase 2b dose-escalation trial of stem cell therapy with laromestrocel for aging frailty.
Laromestrocel infusion results in clinically meaningful, dose- and time-dependent increases in the 6-min walk test compared with placebo, identifying a stem cell therapy approach for the management of patients with hypomobility and other features of aging frailty.
Sialic acid-responsive Parabacteroides is linked to gut barrier integrity in older adults.
In older adults, Parabacteroides is linked to intestinal barrier integrity and responds to mucin-associated sialic acid, supporting a model wherein host-derived glycans foster barrier-protective microbes to promote healthy aging.
Biological age acceleration associated with mental and behavioural disorders: Evidence from the UK biobank cohort.
Mental and behavioural disorders are observationally and robustly linked to accelerated biological ageing, with a dose-response by comorbidity, and genetic evidence supports potential causal roles for depression, insomnia, and anxiety in promoting ageing.
Age-Associated Metabolomic Changes in Human Spermatozoa.
Advancing age disrupts sperm 'metabolostasis' (metabolite homeostasis essential for normal function), compromising their physiological integrity and fertilization competence, with 137 potential aging-sperm biomarkers identified with AUC = 1.
FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3.
FGF21 inhibits nucleus pulposus cell senescence and delays intervertebral disc degeneration by activating SIRT1-mediated FOXO3 deacetylation and enhancing PINK1-Parkin pathway-dependent mitophagy.
Accelerated biological aging and the dynamic transitions of stroke and dementia: A multi-state trajectory analysis.
BAA was associated with the initial onset of stroke, dementia, and mortality, whereas its associations with later progression to comorbidity were not evident, suggesting that BAA may be most informative for identifying early vulnerability before clinical disease onset.
Personalized functional topography-based multisite brain age prediction modeling reveals divergent neurodevelopment in major depression.
Using individualized functional topography-based brain age prediction in 1,105 MDD patients and 1,065 healthy controls, two patient subgroups with divergent neurodevelopmental profiles—positive or negative brain age gaps—were identified, each showing distinct network alterations, clinical symptoms, gene expression patterns, and antidepressant treatment responses.
p16Ink4a-Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway.
p16Ink4a-positive hepatocytes accumulate in zone 3 during CCl4-induced liver injury, exhibit senescent characteristics, drive liver fibrosis through activation of the LIFR signaling pathway via CTF1/LIF ligands, and their selective elimination ameliorates fibrosis through suppression of hepatic stellate cell activation.
Oxymatrine Alleviates Atherosclerosis by Regulating Macrophage Senescence via the SIRT1-P53 Signaling Pathway.
Oxymatrine alleviates atherosclerosis by stabilizing SIRT1 and enhancing its activity to promote P53 deacetylation, ubiquitination, and degradation, thereby delaying macrophage senescence-induced foam cell formation.
Synovial macrophage rhoa protects against osteoarthritis by suppressing YAP/IL-17C mediated chondrocyte senescence.
Macrophage-specific RhoA deletion exacerbates osteoarthritis by activating a novel YAP/CCN2-IL-17C axis that induces chondrocyte senescence via PI3K/AKT/mTOR, revealing a previously unrecognized protective role for macrophage RhoA in joint homeostasis.
Superenhancer-mediated ferroptosis in age-related hearing loss: cochlear epigenomics.
Reduced binding of Sp1 to the Fth1 superenhancer triggered hair cell ferroptosis and the progression of age-related hearing loss, suggesting that manipulating superenhancer sites and inhibiting ferroptosis may offer novel therapeutic strategies for treating ARHL.
Effects of exhaustive and/or strenuous exercise on aging-related molecular and physiological biomarkers: a systematic review and meta-analysis.
Exhaustive and/or strenuous exercise is associated with adverse shifts in aging-related molecular and physiological biomarkers, including shortened telomere length, increased 8-OHdG, upregulated IL-6, and reduced VO₂max, and these effects appear dose-dependent.
EIF4A3-Induced Circular RNA circSnd1 Promotes Muscle Atrophy and Muscle Ageing by Stabilizing EEF1A1.
CircSnd1 is upregulated in multiple muscle atrophy models and aged muscle, and promotes muscle atrophy and ageing by stabilizing EEF1A1 through FAT10-mediated competition with ubiquitin, while its repression ameliorates multiple types of muscle atrophy.