Aging & Longevity
500 peer-reviewed studies indexed
Differential associations of cataracts with somatic and cognitive-affective symptoms of depression: longitudinal findings from the English Longitudinal Study of Ageing.
Cataracts are independently associated with increased risk of incident depressive symptoms in older adults, particularly somatic manifestations, suggesting that timely cataract treatment may represent a potential intervention point for mitigating depressive symptoms in aging populations.
How Does Multimorbidity Affect Self-Rated Health Among Older Adults in India: Mediating Role of Social, Functional and Behavioural Factors.
Functional health parameters such as limitations in ADL and IADL, mobility restrictions, sleep problems, pain, and poor health care utilisation are potential mediators in the relationship between multimorbidity and self-rated health among older adults in India.
Unhooking the past: Early-life exposure to hookworm eradication and later-life longevity.
Early-life exposure to the Rockefeller Sanitary Commission's hookworm eradication campaign in the American South during the 1910s increased old-age longevity by approximately 1.3 months for a one-standard-deviation increase in county-level treatment intensity.
Computational discovery and prioritization of ribose-5-phosphate isomerase A as a mitochondrial target for reversing senescence in mesenchymal stem cells.
A bioinformatic pipeline identified ribose-5-phosphate isomerase A (RPIA) as a mitochondrial hub gene upregulated in aged mesenchymal stem cells, predicting senescence with high accuracy and suppressing osteogenic potential, proposing RPIA as a novel therapeutic target for osteoporosis.
Interpretable Machine Learning with SHAP Identifies Key Biomarkers in a Multi-Factorial Spectrum of Age-Related Neurological and Metabolic Conditions.
A gradient boosting model with SHAP analysis identified iron, transferrin, and glucose as key stable biomarkers with synergistic interactions in classifying age-related neurological and metabolic conditions, achieving F1-scores between 0.87 and 0.96 across five clinical classes.
Disability severity transitions in the community-dwelling Swiss ageing population: secondary analysis of the Swiss version of the Survey of Health, Ageing and Retirement in Europe (SHARE) using multistate models.
Multimorbidity and higher disease burden increase the risk of transitioning to higher disability severity states and death in community-dwelling Swiss adults aged 50+, with age and sex also significantly associated with disability severity transitions.
Trichosanthes kirilowii extract alleviated liver fibrosis and acute myocardial infarction by inhibiting VCAN to restrain monocyte senescence: Insights from bioinformatic analyses and experimental validation.
Trichosanthes kirilowii extract exerts bifunctional protection against liver fibrosis and AMI by targeting VCAN-mediated monocyte senescence.
Evaluating the Preparedness of Speech-Language Pathologists Enrolled in a Graduate Programme in South India to Serve the Ageing Population: A Survey Study.
Speech-language pathologists enrolled in a graduate programme in South India reported being only moderately prepared for assessment and management of communication and swallowing disorders in the ageing population, highlighting the need for specialised curriculum content and training.
Self-perception of depressive symptoms, self-reported medical diagnosis, and associated factors: findings from the Brazilian Longitudinal Study of Aging, 2019-2021.
The prevalence of self-reported physician-diagnosed depression among Brazilian older adults was 12.2%, independently associated with female sex, lower schooling, and physical inactivity, while self-perceived depressive symptoms showed an even higher prevalence of 15.6%, reinforcing the need for a hybrid approach combining self-report with objective methods.
Strategy and Motivation, Rather Than Fatigue, Drive Age-Related Differences in Sustained Attention Performance: Evidence for Decoupled Beta-Band Oscillations.
Strategy and motivation, rather than fatigue, drive age-related differences in sustained attention performance, reflected in decoupled beta-band oscillatory signatures.
Changes in pneumococcal vaccine coverage in the Canadian Longitudinal Study on Aging (CLSA): An analysis based on the 2018-2021 follow-up 2 survey.
Pneumococcal vaccine coverage among Canadian adults aged 65 and older enrolled in the CLSA increased by only 2% between 2015-2018 and 2018-2021, and no changes were observed among those under the age of 65 with underlying conditions.
Reduced retinal microvascular density in patients with mixed connective tissue disease: an exploratory pilot study on the interplay between aging, renal function, and complement system.
Patients with MCTD present subclinical retinal microvascular abnormalities detectable by OCT-A, with retinal vascular changes linked to disease duration, renal function, and complement levels.
LncRNA GAS6-AS2 regulates vascular smooth muscle cell senescence through the miR-138-5p/AKT1 axis and serves as a diagnostic and prognostic marker for atherosclerosis.
GAS6-AS2 is a potential diagnostic and prognostic biomarker for atherosclerosis that regulates ox-LDL-induced vascular smooth muscle cell senescence and inflammatory response through sponging of miR-138-5p to upregulate AKT1.
Peripheral blood mononuclear cell mitochondrial bioenergetics are related to vascular endothelial function in young and older adults.
Age-related changes in PBMC mitochondrial bioenergetics (oxygen consumption rates and membrane potential) and antioxidant buffering capacity are associated with vascular endothelial dysfunction as measured by flow-mediated dilation.
Bridging patient-reported outcomes and performance assessments in older adults: linking the Short Physical Performance Battery to the standardised PROMIS Physical Function scale.
The Short Physical Performance Battery (SPPB) can be meaningfully linked to the PROMIS Physical Function T-score metric in older adults, enabling standardised interpretation, comparison, and aggregation of performance-based and self-reported physical function.
Gender-based differences in telomere attrition and long-term respiratory dysfunction in COVID-19 ICU survivors one year post-infection: implications for aging-associated pulmonary decline.
Telomere attrition serves as a sex-specific biomarker of aging-associated pulmonary vulnerability in critical COVID-19 survivors, with shorter RTL associated with persistent respiratory symptoms in women who underwent pronation and with diffuse parenchymal lung disease in men.
Association of Urinary Equol Concentration with Frailty in Community-Dwelling Older Adults: The Itabashi Longitudinal Study on Aging.
Equol production was inversely associated with the prevalence of frailty or prefrailty in community-dwelling older adults, particularly with respect to maintaining physical activity, suggesting a potential protective role of equol-producing capacity in healthy aging.
Tuned to walk: cue type, beat perception, and gait dynamics during rhythmic stimulation in aging.
The optimal parameters of rhythmic auditory cueing depend on age, beat perception, and the target gait parameter, with fractal cues increasing long-range correlations in gait while isochronous cues decreased long-range correlations particularly for those with better beat perception.
Tissue-Specific Expansion of Age-Associated B Cells via IFN-γ and IL-21 Within Salivary Glands in Sjögren Disease.
Age-associated B cells (ABCs) accumulate in salivary glands of Sjögren disease patients and model mice through IL-21 signaling from CD4+ T cells and autocrine IFN-γ activity, suggesting a tissue-specific mechanism linking aging-associated immune changes to SjD development and progression.
Development and validation of the Physical Capacity Score (PiC) to overcome the lack of correlation among traditional physical tests in detecting age-related decline.
The Physical Capacity Score platform demonstrated good repeatability and revealed that all physical capacities declined with age but captured distinct aspects of physical function, highlighting the necessity of employing a comprehensive battery of tests to gain a holistic understanding of an individual's physical health and detect age-related decline effectively.
Multi-Omics Analysis of Human Blood Cells Reveals Unique Features of Age-Associated Type 2 CD8 Memory T Cells.
Multi-omics analysis of human PBMCs revealed an age-associated population of CXCR3-negative central memory CD8 T cells with Th2-like cytokine production driven by epigenetic drift, linked to asthma, chronic liver conditions, and type 2 diabetes.
Single-item versus scale: Comparing respondent demographic, social, and health characteristics by measure of loneliness using the Canadian Longitudinal Study on Aging (CLSA) data.
The direct single-item question and the indirect multi-item scale provided comparable overall classifications of loneliness, but respondent characteristics varied across more granular response categories, highlighting the importance of measure selection depending on study aims.
G-ALPS: An index for evaluating cognitive decline and aging using diffusion tensor imaging.
The G-ALPS index, an optimized version of the ALPS index derived using Genetic Programming, shows stronger correlation with cognitive measures and enhanced sensitivity in identifying aging effects and sleep-related disorders compared to the original ALPS index.
Associations between life-course cognitive reserve and cognitive domains over 8 years in a large cohort of middle-aged and older adults: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
Participants with higher cognitive reserve exhibited significantly slower age-related cognitive decline across multiple domains over 8 years, and in a middle-income country with strong socioeconomic inequalities, early-life socioeconomic conditions were key determinants of cognitive reserve development.
Age-related changes in visual performance: A defocus curve study in healthy phakic eyes.
Defocus curve analysis reveals a functional inflection point in visual performance beginning at 45 years of age, reflecting early presbyopic changes marked by reduced tolerance to defocus and diminished depth of focus.
The Level of Ischemia-Modified Albumin in Healthy Individuals of Different Age Groups.
Oxidative modification of serum albumin increases with age, as demonstrated by elevated ischemia-modified albumin (IMA) and IMA/albumin ratio (IMAR) in elderly individuals compared to younger age groups.
Generation of an Age-Dependent and Harmonized 18F-FDG Brain PET Atlas Using a High-Sensitivity Short-Axial FOV PET/CT System.
A set of age-dependent, harmonized FDG-PET brain atlases was developed using a high-sensitivity short-axial FOV PET/CT system, with quantitative metrics across age characterized for two effective image resolution ranges (5.0–6.0 mm and 8.0–10.0 mm).
Everyday discrimination among middle-aged and older adults in India: a multilevel cross-sectional analysis from the Longitudinal Ageing Study in India.
Everyday discrimination among Indian adults aged 45 and above showed significant state/union territory and community-level geographic variation, with men, non-married adults, migrant residents, rural dwellers, and those with functional disability or physical/mental impairment having higher discrimination rates.
Cortical activity during supported and unsupported choice-stepping reaction time tasks in young and older people: a functional near-infrared spectroscopy study.
Supporting balance control during cognitively demanding stepping tasks reduced cortical activity in the PFC, SMA, and PMC in young but not older people, with both groups showing slower response times in unsupported compared to supported conditions, supporting the involvement of these cortical regions in balance control.
Incidence of altered proteins in the aging brain: Implications for biological diagnostic markers.
Common ADNC and frequent concomitant pathologies in older individuals will influence the interpretation of diagnostic biological tests, and current tests can confirm that a subject displays ADNC but a definite diagnosis can only be achieved through postmortem neuropathological assessment.
Exploring the impact of age, sex and life experiences on plasma inflammatory profiles through comparative proteomics.
Proteomic analysis of plasma from 229 subjects revealed a chronic inflammatory state, complement activation, impaired coagulation regulation, and immunosenescence in elderly individuals, with a 25-protein upregulated signature whose expression varied with life-experience and correlated inversely with physical and cognitive condition.
Symptoms provide predictive information on daily functioning beyond signs and diseases in middle-aged and older adults, particularly those with multimorbidity.
In people with multimorbidity, symptoms and signs explain more variability in functional limitations than diseases alone, supporting the need for a symptom-oriented approach in clinical care and research.
Association of mitochondrial oxidative capacity with physical fitness in ageing: the Baltimore longitudinal study of ageing.
Muscle mitochondrial oxidative phosphorylation contributes to interindividual variability in cardiorespiratory fitness, especially in young and middle adulthood, with differences between OxPhos groups attenuating after age 70.
Unveiling tumor senescence-driven prognostic heterogeneity via MALISS in stage II/III colorectal cancer.
A machine learning-based immunosenescence signature (MALISS) using a 30-gene CoxBoost-Lasso model effectively stratifies stage II/III colorectal cancer patients into high- and low-risk groups with distinct progression-free survival and provides insights into tumor biology including mutational landscape, tumor microenvironment, and drug sensitivity.
What stole Chinese older adults' life satisfaction? Integrating medical statistics and machine learning with a life-course perspective using CHARLS data.
Using an integrated framework combining Generalized Ordered Logit Regression and XGBoost machine learning with CHARLS data, this study found that determinants of life satisfaction among older Chinese adults are heterogeneous across satisfaction levels, with present-day psychosocial and material conditions dominating at lower levels while early-life factors become increasingly important at higher satisfaction levels.
"It's part of getting old": ageing perceptions and cultural beliefs underpin hip recovery and refracture prevention experiences: a qualitative study.
Recovery and refracture prevention after hip fracture are strongly shaped by age-related beliefs, cultural context and care structures, highlighting the need for person-centred, culturally responsive and better-coordinated models to optimise engagement and outcomes in diverse ageing populations.
Adverse childhood experiences and sarcopenia: a prospective study embedded in the Canadian Longitudinal Study on Aging.
ACEs predicted incident sarcopenia only among depressed participants, with depression emerging as a key pathway linking early adversity to later-life sarcopenia.
TMEM106C, BSG, COPE, CDCA8, KPNA2, LIG1, UQCRH, and CCT5: Predictive of Survival and Immunotherapy Resistance in Hepatocellular Carcinoma.
An eight-gene senescence-related risk model (TMEM106C, BSG, COPE, CDCA8, KPNA2, LIG1, UQCRH, and CCT5) robustly predicts survival and immunotherapy response in hepatocellular carcinoma, with CDCA8 knockdown repressing malignant phenotypes in HCC cell lines.
The role of age in the relationship between brain structure and cognition: moderator or confound?
There is an asymmetry in generalisability such that models trained on younger subjects successfully predicted cognition in older subjects, but models trained on older subjects failed to generalize to younger individuals, revealing a trade-off between model specificity and generalisability.
Older persons' lived experiences of being playful in nursing home settings - a phenomenological reflective lifeworld research study.
The essential meaning of being playful in nursing home settings emerges as 'getting in touch with an inner dynamic life force that enables and enhances well-being,' though ageing, bodily changes, and institutional constraints shape how playfulness is expressed and manifested in the lifeworld.
PTPN2 alleviates Silicotic pulmonary fibrosis by inhibiting senescence of type II alveolar epithelial cells via retinol metabolism regulated by ALDH1A2.
PTPN2 alleviates silicotic pulmonary fibrosis by inhibiting senescence of type II alveolar epithelial cells via influencing retinol metabolism regulated by ALDH1A2.
Novel height estimation formula that accounts for the effects of aging based on lumbar length measurements in postmortem CT images.
Height estimation formulas based on lumbar spine length measurements (PLV2, SPLV, and LVTL) from postmortem CT images are not affected by aging, unlike sternal length-based formulas which overestimate height in elderly persons.
[Liver function and distribution of liver fibrosis in older adults aged 65 years and above in 18 longevity areas in China].
The risk for advanced liver fibrosis was relatively high in older adults in China, showing an upward trend with age and being higher in men than in women, with liver function abnormalities characterized by lower levels than reference range.
Longitudinal associations of chronic pain severity trajectories and number of pain site trajectories with risk of limitations in ability in daily activities: Evidence from two 10-year prospective cohort studies.
Persistent high-level pain and worsening pain trajectory groups exhibited the highest increased risk of ADL limitations, with the increasing number of pain sites trajectory showing the strongest association (HR = 2.738, 95% CI: 2.147–3.492), and depression mediated these associations.
The impact of age on muscle and kinematic responses following an unpredictable forward slip while walking.
Older adults had inferior muscle and kinematic responses to an unpredictable forward slip compared to young, with delayed contralateral limb activation, greater slip severity, and worse recovery kinematics.
On exploring muscle aging of the biceps brachii in the middle-aged population using HD-sEMG signal analysis.
Midlife in women may be characterized by subtle, task-dependent neuromuscular reorganization rather than a generalized decline, as evidenced by lower RMS amplitudes, higher RMS CoV, and lower modified entropy in middle-aged women compared to younger women during isometric contractions of the biceps brachii.
Tongue Pressure: A Critical Bridge Between Oral Frailty and Systemic Longevity in Older Adults.
Incorporating tongue pressure as an indicator of oral frailty allows for a comprehensive approach to frailty management in older adults.
Methodological approaches to estimate physical resilience in older adults: a comparison across two clinical settings.
Various physical resilience approaches identified different patient groups as resilient and demonstrated limited prognostic value, suggesting current approaches may inadequately capture the dynamic construct of physical resilience.
Regional and Socioeconomic Disparities in Frailty Across Tasmania: Evidence From Island Study Linking Ageing and Neurodegenerative Disease.
The distribution of frailty across Tasmania varied by geographic remoteness and socioeconomic disadvantage, with frailty index scores significantly higher in rural towns, remote communities, and areas of middle or low socioeconomic advantage after adjustment for confounders.
Cancer and Ageing Reflections for Elders (CARE): Australian Adaptation of a Psychotherapy for Older Adults With Cancer.
Cultural adaptation of the USA-developed CARE psychotherapy intervention was required even between English-speaking countries to ensure cultural appropriateness and acceptability for older Australians with cancer and depression.