Dietary Supplements
470 peer-reviewed studies indexed
Effects of combined nutritional supplementation and exercise on proxy measures of muscle mass, strength, and function in older adults with sarcopenia: a 12-week multicentre RCT.
A 12-week combined intervention of multi-ingredient nutritional supplementation and exercise led to modest improvements in proxy measures of muscle mass, strength, function, and quality of life in older adults with sarcopenia.
Nutritional and Pharmacological Interventions for Sarcopenia in Older Adults: A Systematic Review and Network Meta-Analysis.
Moderate evidence indicates that the combination of protein and vitamin D supplements, along with multiple nutritional intervention measures, probably enhance the quality of life, muscle strength, and muscle mass in older individuals with sarcopenia, while pharmacological therapy may increase muscle mass but does not yield significant improvements in handgrip strength, knee extension strength, or timed up and go tests.
Limosilactobacillus mucosae attenuates hyperlipidemic periodontitis via the gut-oral axis.
Gut dysbiosis causally exacerbates periodontitis severity in hyperlipidemia via a protective 'L. mucosae–α-GPC–CLDN1' axis, wherein oral administration of live Limosilactobacillus mucosae ameliorates hyperlipidemic periodontitis by restoring intestinal glycerophosphocholine levels that upregulate the tight junction protein Claudin-1 in periodontal tissue.
Short-term creatine supplementation enhances strength, reduces fatigue, and accelerates recovery in resistance-trained athletes: a double-blind, randomized, crossover trial.
Three days of creatine monohydrate supplementation (0.3 g·kg-1·d-1) significantly enhanced strength performance, reduced physiological stress, and accelerated recovery compared to placebo in resistance-trained males, demonstrating potential ergogenic benefits even from short-term acute ingestion.
Gut-brain cholinergic signaling mediates the antiseizure effects of Bacteroides fragilis.
B. fragilis activates a colonic ChAT+-nodose ganglion gut-brain cholinergic circuit to suppress seizures in mouse models and in a randomized clinical trial of pediatric refractory epilepsy.
Effects of Coenzyme Q10 Supplementation on Physical Function Adaptations to High-Intensity Interval Training in Older Adults.
CoQ10 supplementation enhanced improvements in lower-body strength and power (5XSST and 30CST) compared to placebo during an 8-week HIIT program in older adults, but no between-group differences were observed in grip strength, balance, mobility, or aerobic endurance outcomes.
Manganese-engineered Lactobacillus Reuteri with enhanced antitumor and immunomodulatory activities for colorectal cancer prevention and treatment.
Manganese-engineered Lactobacillus reuteri (MnLR) administered orally with glycerol achieves 95.6% inhibition of orthotopic tumor growth and provides durable protection as a standalone probiotic therapy for colorectal cancer prevention and treatment.
Magnesium Supplementation and Tachyarrhythmias: A Nonrandomized Clinical Trial.
Routine supplementation of magnesium with currently used doses and treatment thresholds was not associated with beneficial effects for individuals with serum magnesium values close to those cutoffs.
Targeting the microbiome in pediatric migraine: gastrointestinal manifestations and the therapeutic role of Bifidobacterium longum.
Pediatric migraine patients exhibit distinct gut microbial signatures including reduced Bifidobacterium longum, and B. longum supplementation attenuated trigeminal activation in animal models and showed reductions in headache days, intensity, and frequency in an exploratory pilot study.
Maternal Folic Acid Supplement Use, Folate Intake, and Preterm Birth Among Infants With Spina Bifida.
Among infants with spina bifida, the combination of no folic acid supplementation and low dietary folate intake was associated with a modestly elevated risk of preterm birth (RR 1.73, 95% CI: 1.01-2.96), though neither factor alone reached statistical significance.
Selenium supplementation and male fertility: Mechanistic insights and therapeutic potential.
Selenium plays a crucial role in male reproductive health through its dose-dependent antioxidant and endocrine function, with organic selenium demonstrating superior bioavailability and human trials showing that 100 µg/day improved sperm motility and resulted in an 11% increase in paternity.
Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database.
Serum vitamin D and folic acid were inversely associated with cognitive impairment risk in elderly NHANES participants, FA contributed the largest protective effect (56.0%) in mixture analyses, and vitamin B12 showed a U-shaped association with cognitive disorder risk with interactions between B12 and FA.
Supplementation with short-chain fatty acids and a prebiotic improves clinical outcome in Parkinson's disease: a randomized double-blind prospective study.
Short-chain fatty acids (propionic and butyric acid) and/or the prebiotic 2'-fucosyllactose supplementation ameliorate clinical symptoms in Parkinson's disease patients and modulate intestinal and peripheral immunity in a randomized double-blind prospective study.
Calcium tartrate tetrahydrate bladder stone.
A bladder stone of 100% calcium tartrate tetrahydrate composition was identified in a man in his early 60s, a finding reported predominantly in animal models and only rarely in humans, with likely contributing factors including excessive consumption of L-carnitine L-tartrate-containing energy drinks and supplements, occupational pesticide exposure, and neurogenic bladder.
Nano-functionalized probiotic treats atherosclerosis via inhibiting intestinal microbiota-TMA-TMAO axis.
Orally administered nano-functionalized probiotics (PDMF@LGG) inhibit the gut microbiota-TMA-TMAO axis to reduce plasma TMAO levels, alleviate atherosclerotic plaque formation, and regulate gut microbial composition in male ApoE-/- mice.
Dietary habits, nutritional supplement use, and adherence to national dietary guidelines in patients with psoriasis.
Patients with moderate-to-severe psoriasis have less healthy dietary patterns compared to those with mild disease, but no difference in adherence to dietary guidelines was found when comparing all patients with psoriasis to healthy controls.
Periodontitis salivary microbiota exacerbates colitis by CXCL3 derived from gut microbiota-induced macrophages.
Periodontitis salivary microbiota exacerbates colitis by enriching gut pathogens such as Escherichia coli and LPS, which activate macrophages to secrete CXCL3, promoting neutrophil chemotaxis and M2b-like macrophage polarization, an effect reversible by Lactobacillus rhamnosus GG.
ω-3 Fatty Acids in Pediatric Major Depressive Disorder: A Randomized Clinical Trial.
Adjunctive ω-3 fatty acid administration, 1.5 g/d (EPA:DHA, 2:1), did not outperform placebo in youths with moderate-to-severe major depressive disorder.
Dietary Supplement Interventions and Sleep Quality Improvement: A Systematic Review and Meta-Analysis.
Dietary supplement interventions significantly improved sleep outcomes including reduced PSQI scores, increased sleep efficiency, prolonged total sleep time, and shortened sleep latency and wake after sleep onset across 28 randomized controlled trials.
Akkermansia muciniphila outer membrane protein Amuc_0904 modulates intestinal homeostasis by promoting goblet cell differentiation.
Amuc_0904, a previously uncharacterized A. muciniphila outer membrane protein, induces goblet cell differentiation by interacting with MET and decreasing its phosphorylation, leading to decreased Wnt/β-catenin signaling and enhanced oxidative phosphorylation, thereby protecting mice from colitis and colitis-associated colorectal cancer.