Gut Microbiome
417 peer-reviewed studies indexed
Identification of an Anti-inflammatory Peptide from Walnut (Juglans sigillata) Protein and the Effect on DSS-Induced Colitis in Mice.
A novel anti-inflammatory peptide VLRWPR (VR6) from walnut protein markedly reduced disease activity in DSS-induced colitis mice by suppressing the TLR4-NF-κB axis, maintaining intestinal barrier function, and reversing gut microbiota imbalance.
Gynostemma pentaphyllum polysaccharides alleviate ulcerative colitis in mice via the Nrf2/ROS/NLRP3 axis and modulation of the gut microbiota.
GPP alleviates UC symptoms by activating the Nrf2/HO-1 pathway, reducing ROS levels, subsequently inhibiting NLRP3 inflammasome activation, mitigating oxidative stress, and improving intestinal barrier dysfunction, while modulating gut microbiota homeostasis.
Rosa chinensis cv. 'JinBian' flowers alleviates brain damage and cognitive deficit by inhibiting ferroptosis via the Keap1/Nrf2/GPX4 pathway and regulating gut microbiota.
The ethyl acetate fraction of Rosa chinensis cv. 'JinBian' flowers (RE) alleviates cognitive deficit and brain damage in D-galactose-induced aging mice by inhibiting ferroptosis via the Keap1/Nrf2/GPX4 pathway, suppressing apoptosis and modulating autophagy, while also improving gut microbiota diversity.
The roles of helicobacter pylori infection on the pathogenesis of Alzheimer's disease: Gut-brain axis dysfunction and blood-brain barrier disruption.
HP infection exacerbates gut dysbiosis, promotes BBB disruption, intensifies neuroinflammation, accelerates AD pathology, and aggravates cognitive decline in Alzheimer's disease patients.
Effect of combined continuity care guided by Orem's self-care model and low FODMAP diet on gut microbiota composition and symptoms in patients with irritable bowel syndrome.
The integration of a low FODMAP diet with continuity care guided by Orem's Self-Care Model significantly alleviates IBS symptoms and improves gut microbiota composition and quality of life.
Multi-omics reveals that 4'-O-β-D-glucosyl-5-O-methylvisamminol ameliorates acute liver injury by modulating the miR-30e-3p/Tfrc axis and a multi-dimensional network of ferroptosis, inflammation, metabolism, and gut microbiota.
5-O ameliorates APAP-induced acute liver injury through a multi-dimensional network involving ferroptosis inhibition, inflammation suppression, lipid metabolism activation, and gut microbiota reshaping, with whole transcriptome analysis revealing a potential miR-30e-3p/Tfrc axis in modulating iron metabolism.
A study on the correlation between intestinal flora characteristics and serum zinc and iron levels in paediatric patients with mycoplasma pneumoniae pneumonia.
Paediatric patients with MPP exhibit disrupted intestinal flora composition alongside reduced serum zinc and iron levels, with specific bacterial genera correlating with alterations in serum zinc and iron concentrations.
Discovery of a Highly Potent and Selective Small-Molecule Inhibitor of In Vivo Anaerobic Choline Metabolism by Human Gut Bacteria.
Discovery of compound 7, a highly potent and selective covalent inhibitor of TMA Lyase that significantly reduces circulating TMAO levels in rats and inhibits TMAO generated from a human microbiome in a fecal mouse transplant model.
Investigation into the Allergenicity and Functional Properties of Soybean 7S Protein upon Ultrasound-Assisted Punicalagin Binding.
Ultrasound-assisted punicalagin binding effectively reduced soy 7S protein allergenicity through multiple pathways including reducing allergen-specific antibody binding, inhibiting mast cell degranulation, adjusting Th1/Th2 immune homeostasis, improving intestinal barrier integrity, and reshaping gut microbiota, while also enhancing functional properties.
Erucic acid attenuates post-influenza secondary Staphylococcus aureus infection by modulating VCAM-1 and CEACAM-1 expression and gut dysbiosis.
Erucic acid attenuated S. aureus adhesion by suppressing PR8-mediated upregulation of VCAM-1 and CEACAM-1, and mitigated pulmonary injury and gut dysbiosis induced by post-influenza secondary S. aureus infection.
From dysbiosis to prediction: a novel gut microbiota-derived index for spontaneous bacterial peritonitis in HBV-related cirrhosis.
Distinct dysbiosis characterizes SBP in HBV-related cirrhosis, and a novel microbiota-derived index (SBP-MI) combined with clinical factors (INR and previous SBP history) in a risk prediction model yielded an AUC of 0.91 for early risk stratification.
Propionate attenuates osteoarthritis progression by regulating the gut-joint axis.
Propionate, a gut-derived short-chain fatty acid, alleviated pain, protected cartilage, reduced inflammation, restored gut barrier integrity, and rebalanced microbiota in OA rats, and in human OA chondrocytes it upregulated ECM-related genes, downregulated inflammatory mediators, and enhanced autophagy, suggesting it may serve as a promising disease-modifying therapy for OA.
Sinensetin Ameliorates Metabolic Syndrome via Regulating Gut Microbiota and Bile Acid Metabolism.
Sinensetin alleviated metabolic syndrome by reshaping the gut microbiota to enhance non-12-hydroxy bile acid synthesis, with therapeutic efficacy that was microbiota-dependent as demonstrated by antibiotic depletion and fecal microbiota transplantation experiments.
Naringenin Alleviates 5-Fluorouracil-Induced Intestinal Mucositis via Modulating the Gut Microbiota, Bile Acid Metabolism, and PPAR Signaling Pathway.
Naringenin mitigated 5-fluorouracil-induced intestinal mucositis in mice via a gut microecology-dependent mechanism involving regulation of gut microbiota, bile acid metabolism, and activation of the PPAR signaling pathway.
Daidzein Confers Prophylactic Protection against Food Allergy by Restoring Immune Regulation, Intestinal Barrier Integrity, and Microbiota-Metabolite Homeostasis.
Daidzein pretreatment attenuated allergic manifestations in an OVA-induced murine food allergy model by coordinating Th-cell-mediated immunity, epithelial barrier function, and microbiota-metabolite profiles, supporting its potential as a dietary candidate for preventive management of food allergy.
Impacts of an antioxidant-rich diet and lifestyle factors on gut microbiota diversity and brain health: An exploratory analysis from the NutBrain study.
Higher dietary antioxidant capacity (ORAC) was associated with greater gut microbiota diversity, enrichment of specific beneficial taxa, and greater brain volumes, with these associations being stronger in individuals with a healthy lifestyle profile (regular physical activity, non-smokers).
Machine learning and causal inference applied to the gut metagenome-metabolome axis reveals a link between neonatal jaundice and autism spectrum disorder.
Both neonatal jaundice and autism spectrum disorder are associated with altered gut bile acid metabolism and elevated bile acid metabolism gene diversity, with gut DNA virome dysbiosis (human betaherpesviruses and human mastadenoviruses, respectively) mediating these effects through bile acid-metabolizing bacteria, suggesting a shared mechanistic link between NJ and ASD.
Microplastic-associated gut microbial profile and antibiotic resistance in preschool children: a multicentre cross-sectional study in China.
MP exposure may be associated with the composition of the host gut microbiota and total plastic concentration was significantly related to the relative abundance of species and ARGs in preschool children, raising concerns regarding potential adverse effects on the human gut and drug resistance risks in younger populations.
Extracellular Polysaccharides of Eurotium cristatum from Fu Brick Tea Ameliorated Type 2 Diabetes in Mice by Remodeling of Gut Microbiota-Dependent Tryptophan Metabolism to Activate the Hepatic AhR/TSC2/mTORC1 Axis.
Extracellular polysaccharides of Eurotium cristatum (ECP) from Fu brick tea ameliorated type 2 diabetes in mice by promoting gut microbiota-derived beneficial metabolites (acetate and IPA) to activate the hepatic AhR/TSC2/mTORC1 axis.
Serum and Urinary Metabolomics Reflect the Early Stages of De Novo Metabolic Syndrome After Liver Transplant: A 2-Center Longitudinal Study.
Elevated urinary TMAO, together with reduced serum phosphocholine and lipid-CH3 responses, characterize patients who develop post-LT MetS and may serve as early biomarkers of cardiometabolic risk in LT recipients.
Profiling of the mycobiome and metabolome: a comparative study of benign pulmonary nodules and lung adenocarcinoma.
A significant difference in gut fungal communities was observed between benign pulmonary nodules and lung adenocarcinoma, and an integrated model combining gut fungi and metabolites demonstrated excellent performance in distinguishing the two conditions.
Increased Gut Microbiota Diversity in Patients With Retinitis Pigmentosa and Implications for Disease Phenotypes and Progression.
Patients with retinitis pigmentosa exhibited distinct gut microbiota characteristics with higher diversity compared to healthy individuals, and antibiotic treatment attenuated disease progression in the rd10 mouse model by suppressing the NLRP3 inflammasome pathway.
Machine learning reveals targets of Gnaphalium hypoleucum DC. flavonoids against rheumatoid arthritis through gut microbiota and anti-inflammation.
GHTFs are identified as a promising therapeutic candidate for RA, ameliorating disease progression through modulation of inflammatory responses and microbiota-mediated immune regulation.
The antimicrobial gut resistome of the Wayampi reveals a shared background of antibiotic and metal resistance genes with industrialized populations, underscoring the "robust-yet-fragile" architecture of human gut microbiomes.
The Wayampi gut resistome reveals a shared background of 'core' and 'shell' acquired ARGs and MRGs with industrialized populations, consistent with the 'robust-yet-fragile' architecture of scale-free networks, while showing significant differences in composition and higher metal/biocide resistance gene richness compared to Europeans.
Microbially produced bile acids are associated with increased IgG autoantibodies and poorer mental wellbeing in fibromyalgia.
Fibromyalgia subjects had significantly higher levels of non-conjugated microbially produced (secondary) bile acids compared to healthy controls, with strong associations between bile acids, anti-SGC IgG levels, and mental well-being.
Mechanistic insights into fecal microbiota transplantation for the treatment of ulcerative colitis: analysis of the STOP-Colitis trial.
Colonic FMT is a more effective delivery route than nasogastric administration, with clinical response driven by the engraftment of immunomodulatory bacteria that restore a healthy host-microbe dialogue.
A validation for sex differences in gut microbiome of essential hypertension based on cohort analysis.
GM dysbiosis is more significantly associated with HTN in females, with sex constituting a critical factor in evaluating the role of intestinal flora in the pathogenesis of hypertension.
An in vitro model of the small intestinal microbiota provides key insights into interindividual variability in structure and function.
Despite high interindividual variability in taxonomic structure, the small intestinal microbiota shares a core set of genes that correlates with a relatively consistent metabolomic signature, as demonstrated using an in vitro model of the terminal ileum representing four unique donors.
An Exploratory Study on the Pathogenic Role of Faecal Extracellular Vesicles in Metabolic Dysfunction-Associated Steatotic Liver Disease Progression and in Drug-Induced Liver Injury.
Bacterial extracellular vesicles from faeces enter the bloodstream and modulate immune responses, with DILI and MASLD F≥3 fEVs driving pro-inflammatory responses and hepatocyte steatosis, and DILI fEVs exhibiting a distinct bacterial profile that enhances the hepatotoxic potential of diclofenac.
Theaflavins ameliorate obesity through enhanced antioxidant capacity, a suppressed hepatic BCAA degradation pathway, and gut microbiota modulation.
Theaflavins ameliorate HFD-induced obesity through enhanced antioxidant capacity, suppression of the hepatic BCAA degradation pathway, and gut microbiota modulation, highlighting their potential as a dietary intervention for metabolic diseases.
A cross-sectional study of salivary and gut microbiomes in hemodialysis patients with heart failure with preserved ejection fraction.
HFpEF in MHD patients may be associated with structural alterations in the oral microbiome, which appear more pronounced than those in the gut, with salivary Anaerocolumna enrichment as a candidate feature associated with the HFpEF group.
Associations of epidemiologic risk factors with Fusobacterium nucleatum and bacterial alpha diversity in the colorectal tumor-associated microbiota.
Normalized counts of F. nucleatum were consistently higher in tumor tissue than in patient-matched normal tissue across all risk factors, while alpha diversity was lower, with female sex associated with high presence and enrichment of F. nucleatum in tumor tissue and younger age associated with lower alpha diversity.
Gut bacterial and fungal signatures in relation to human leukocyte antigen-DQ2/DQ8 in children with celiac disease and siblings.
While HLA-DQ2.5 plays a central role in celiac disease pathogenesis, it appears to have less direct influence on microbial composition, and distinct fungal signatures observed in siblings may serve as early indicators of risk.
Exploring the molecular mechanism of Shenling baizhu formula in the treatment of ulcerative colitis via the cGMP-PKG signaling pathway.
SLBZ alleviates UC by activating the sGC-cGMP-PKG pathway to restore intestinal barrier function through tight junction upregulation and microbiota modulation.
Polysaccharide from Ribes nigrum L. Ameliorates Diabetic Kidney Injury in Mice by Modulating the GUDCA/GPBAR1 Axis through the Remodeling of the Gut Microbiota.
Blackcurrant polysaccharides (BCP) ameliorate diabetic nephropathy in mice by enriching Akkermansia muciniphila in the gut microbiota, which elevates serum GUDCA levels that activate the bile acid receptor GPBAR1 in the kidney to suppress NF-κB/NLRP3 inflammasome and TGF-β-mediated fibrosis.
Circulatory dietary and gut-derived metabolites predict early cognitive decline.
A panel of six microbial-derived metabolites (indoxyl sulfate, choline, 5-hydroxyindole acetic acid, indole propionic acid, kynurenic acid, and kynurenine) classified early cognitive decline with an AUC of 0.79, suggesting these metabolites may serve as putative composite biomarkers for metabolic risk stratification.
β-Glucan-rich Hericium erinaceus hot-water extract ameliorates acute colitis by suppressing inflammation, preserving the epithelial barrier, and modulating gut microbiota ecosystem.
β-glucan-rich Hericium erinaceus hot-water extract (HE-HW) protects against colitis by modulating inflammation, reinforcing epithelial integrity, and rebalancing gut microbiota in cell and mouse models.
Unique gut microbiota and metabolomic profiling as biomarker of post-transplant recovery in acute-on-chronic liver failure after liver transplantation.
ACLF patients exhibit unique gut microbiota and metabolomic profiles after liver transplantation, with g__Anaerostipes as a prominent multi-omics biomarker and g__Lachnoclostridium as a promising indicator of post-LT recovery.
A montmorillonite-based oral fermentation system enables long-lasting in-situ biosynthesis to restore intestinal homeostasis.
A montmorillonite-based oral fermentation system (MOFS) achieves long-lasting in-situ preparation of beneficial bioproducts through continuous substrate release and bacterial biofilm formation, demonstrating superior efficacy in restoring intestinal homeostasis in murine models compared to clinical therapeutics.
Long-Term Associations of Early-Life Human Milk Oligosaccharide Intake with Allergic Disease Development and Gut Microbiota Profiles in 5-Year-Old Children.
Early-life HMO intake is associated with long-term differences in allergic outcomes in 5-year-old children, potentially through modulation of gut microbiota composition, particularly the enrichment of Bifidobacterium adolescentis.
Temporal dynamics & determinants of antibiotic resistance gene profiles in the infant gut during the first year of life.
Infants carry a diverse range of ARGs with peak prevalence observed at 6 and 14 wk, and delivery mode and maternal antibiotic exposure significantly impact ARG carriage during the first year of life.
[Mechanism of Quzhou Aurantii Fructus in treating rats with functional dyspepsia based on gut microbiota and metabolomics].
QAFA and AFA may improve FD symptoms in rats by modulating specific gut microbiota to restore gastrointestinal hormones and phospholipid metabolism, though there are differences in the specific microbiotas they regulate.
SSTDhunter: a curated gene database for investigating androgen producing potential in microbiota species.
SSTDhunter, a curated gene database of SSTD-coding genes for investigating androgen-producing potential in microbiota, was constructed using large-scale genomic analysis with homologous genes as background to enable rapid identification of SSTD-coding genes in massive metagenomic data.
Parasutterella excrementihominis is associated with attenuated metabolic improvements during obesity therapy in humans.
P. excrementihominis abundance attenuates metabolic and inflammatory improvements in obese human subjects under therapy and plays a potential role in metabolic adaptation during weight loss interventions.
Hepatoprotective potential of anthocyanins from purple highland barley bran against non-alcoholic fatty liver disease through gut-liver axis.
Purified anthocyanin-rich extract (PAE) from purple highland barley bran mitigated NAFLD via the gut-liver axis by reducing hepatic lipid accumulation, activating the Nrf2 pathway, inhibiting p38 MAPK signaling, improving intestinal barrier function, and alleviating gut dysbacteriosis.
Multimodal brain-gut-sleep phenotypes predict delirium, long-term cognitive decline, and survival after colorectal cancer surgery.
Multimodal brain-gut-sleep phenotypes strongly predict delirium, long-term cognition, and survival after colorectal cancer surgery, supporting a systems-based model in which perioperative resilience reflects coordinated regulation of circadian, microbial, autonomic, inflammatory, and psychological pathways.
Gut microbiota dysbiosis promotes chronic kidney disease-associated atrial fibrillation through activation of the NLRP3 inflammasome.
Gut dysbiosis-driven elevation of indoxyl sulphate and subsequent activation of the atrial NLRP3 inflammasome are key mechanisms in CKD-associated AF, and modulating the gut microbiota could provide a new therapeutic strategy for CKD-associated AF.
Bile acids are associated with baseline and longitudinal amyloid and tau pathology in patients with Alzheimer's disease.
Lithocholic acid (LCA)-family and deoxycholic acid (DCA)-family bile acids are associated with baseline and longitudinal amyloid-β and tau pathology in Alzheimer's disease, representing potential biomarkers and therapeutic targets through the gut-brain axis.
A Comprehensive Analysis of Serum and Urine Bile Acid Profiles in Chronic Kidney Disease: An Exploratory Study of Clinical Associations.
Patients with advanced CKD exhibited lower serum unconjugated bile acids and higher sulfate-conjugated bile acids compared to those with normal renal function, while urinary bile acid levels were significantly lower, with specific bile acids associated with eGFR decline even after adjusting for demographic factors and diabetes status.
Danggui-Baishao herb pair protects against dextran sulfate sodium-induced colitis by modulating the Wnt/β-catenin pathway.
The Danggui-Baishao herb pair effectively reduces colonic inflammation and maintains the integrity of the intestinal barrier, with anti-colitis efficacy closely associated with activation of the Wnt/β-catenin pathway.