Gut Microbiome
417 peer-reviewed studies indexed
Brucea javanica oil emulsion ameliorates ulcerative colitis by upregulating Deoxyribonuclease 2 to suppress cytosolic DNA-sensing signaling.
BJOE alleviates ulcerative colitis by targeting the DNase2-mediated cytosolic DNA-sensing pathway, stabilizing DNase2 to clear inflammatory DNA triggers, resolve sterile inflammation, and restore epithelial barrier integrity.
Fermented Black Soybean and Dehulled Adlay Improve Metabolic Syndrome via AMPK-SIRT1 Activation and Gut Microbiota Modulation.
Fermentation significantly potentiates the bioactivity of black soybean and dehulled adlay, with FBA supplementation attenuating metabolic syndrome features via AMPK-SIRT1 and PI3K-Akt signaling pathways and gut microbiota modulation in HFFD-fed mice.
Intratumoral microbiome signatures in a North Central Indian colorectal cancer cohort: identification of novel prognostic biomarkers and functional pathways.
Intratumoral microbiome analysis of North Central Indian colorectal cancer patients revealed distinct enrichment of oral pathobionts including Leptotrichia buccalis and Filifactor alocis associated with mortality risk, first detection of Caldilinea aerophila in human tumor tissue associated with advanced TNM stages, and depletion of Lactobacillus plantarum suggesting microbial modulation by lifestyle.
Socioeconomic and nutritional determinants outweigh gut microbiota influence on neurodevelopment in young children from Antananarivo, Madagascar.
Stunting and low socioeconomic status are consistently linked to poorer neurodevelopmental outcomes in young Malagasy children, with nutritional and social factors playing a primary role and gut microbiota diversity playing a more limited role in neurodevelopment.
Melatonin Biosynthesis, Receptors, and the Microbiota-Tryptophan-Melatonin Axis: A Shared Dysbiosis Signature Across Cardiac Arrhythmias, Epilepsy, Malignant Proliferation, and Cognitive Trajectories.
A unifying microbiota-tryptophan-melatonin axis plausibly integrates circadian, electrophysiologic, and immune-oncologic phenotypes across cardiac arrhythmias, epilepsy, malignant proliferation, and cognitive trajectories, with moderate-to-severe dysbiosis observed across all three disease cohorts.
Human umbilical cord MSC-derived exosomes attenuate radiation-induced pulmonary fibrosis via remodeling the gut-lung axis in mice.
hUC-MSC-Exos attenuate radiation-induced pulmonary fibrosis through comprehensive remodeling of the gut-lung axis, in which L-Glutamic acid and its associated microbiota serve as potential mediators.
Polyphenol-Rich Coffee Leaf Extract Alleviates High-Fat Diet-Induced Intestinal Barrier Dysfunction through Modulation of Barrier Integrity, Enterohepatic Axis, and Gut Microbiota.
WEAC, a polyphenol-rich coffee leaf extract, mitigated HFD-induced intestinal barrier damage and enterohepatic function, reduced systemic inflammation, and stabilized the gut microbiome in C57BL/6 mice.
Temporal dynamics of gut microbiota and virome in preterm infants: insights from longitudinal metagenomic analysis.
Longitudinal metagenomic analysis of preterm neonates revealed that Staphylococcus epidermidis declined significantly over time while Enterococcus faecalis and its associated bacteriophages showed progressive enrichment becoming predominant by day 28, suggesting dynamic microbial colonization patterns during the first month of life.
Antibiotic exposure exacerbates acute-on-chronic liver failure via gut microbiota imbalance and secondary liver lesion.
Antibiotic exposure aggravated hepatitis and had no survival benefit for ACLF, with the underlying mechanism potentially related to dysbiosis in the gut microbiota.
2',4'-dihydroxychalcone alleviates inflammatory bowel disease by inhibiting NLRP3 inflammasome and modulating gut microbiota.
2',4'-dihydroxychalcone (2',4'-DHC) from Abrus cantoniensis Hance alleviates inflammatory bowel disease by inhibiting NLRP3 inflammasome activation and modulating gut microbiota in both macrophage models and DSS-induced colitis mice.
Integrating bioinformatic prediction and the "gut microbiota-inflammation-skin axis" to decipher the mechanisms of quercetin (from Evodia rutaecarpa) in diabetic wound healing.
Quercetin from Evodia rutaecarpa promoted diabetic wound healing by modulating the 'gut microbiota-inflammation-skin axis', thereby reducing systemic inflammation and enhancing local angiogenesis via direct binding and stabilization of HIF1α and upregulation of the HIF1α/VEGF pathway.
Xia Ku Cao Paste restores intestinal microbiota homeostasis and improves hepatic metabolism disturbances to alleviate hyperlipidemia.
Xia Ku Cao Paste effectively mitigated HFD-induced hyperlipidemia through improvement of gut microbiota balance, regulation of free fatty acids and SCFAs levels, and modulation of the SCAP/SREBP-2 pathway, with rosmarinic acid and chrysoeriol identified as the potential active components responsible for the anti-hyperlipidemic effects.
Preterm birth alters the gut microbiota, metabolome and health outcomes of twins at 12 months of age.
Preterm birth is linked to gut microbiota dysbiosis and metabolic perturbations which may affect twin development, and notably preterm birth exerts a stronger effect than genetic factors in shaping the gut microbiota of 12-month-old twins.
Unveiling the causal relationships between gut microbiota, circulating metabolic biomarkers, and benign prostate hyperplasia: A Mendelian randomization study.
Two-sample and mediation Mendelian randomization analysis revealed 18 gut microbiota taxa and 2 circulating metabolites significantly linked to benign prostatic hyperplasia, but no mediation effects of circulating metabolites on BPH were detected.
Influence of the origin of dietary proteins (plant vs. animal) on the faecal microbiota of older adults.
A diet rich in plant-based protein was linked to a lower BMI and significantly higher relative abundance of Verrucomicrobiota, while increasing plant-based protein and fibre intake may promote a more favourable gut microbiota composition and enhance resilience against dysbiosis in older adults.
The Degree of Mucosa-Associated Microecological Imbalance in Ulcerative Colitis Patients with Different Mayo Score and Its Relationship with Mucosal Mechanical Barrier Damage.
The progression of mucosa-associated microecological imbalance is associated with increasing inflammation in UC, potentially contributing to disruptions in the intestinal mucosal mechanical barrier.
Kynurenine mediates the chemotherapy-induced intestinal toxicity through modulation of gut microbiota.
Serum L-kynurenine, elevated via IFN-γ-mediated IDO1 induction in myeloid cells, drives chemotherapy-induced intestinal toxicity through gut dysbiosis characterized by loss of Lactobacillus johnsonii and subsequent TNFα/JNK pathway activation leading to intestinal epithelial apoptosis.
[Mechanism of total flavonoids from Astragali Complanati Semen in treating chronic liver injury based on intestinal flora].
TFACS can improve intestinal flora composition, SCFAs formation, and intestinal barrier integrity in CLI mice, providing a research basis for TFACS' anti-CLI mechanism.
Agarotriose Alleviates Colitis by Promoting Akkermansia muciniphila-Derived Spermidine Production to Suppress PI3K/AKT/NF-κB Signaling.
Agarotriose alleviates colitis through a gut microbiota-dependent 'A3-A. muciniphila-spermidine-host signaling' axis, whereby A3 enriches Akkermansia muciniphila, promotes spermidine production, and suppresses PI3K/AKT/NF-κB signaling.
Relationship Between Diet Quality, Intestinal Permeability, and Gut Microbiota Features in Individuals with Obesity.
Higher dietary pattern adherence scores correlated with lower intestinal permeability measures and favorable gut microbiota features in a diverse, obese sample, suggesting a potential role for diet quality in promoting intestinal health.
PTEN/PI3K/AKT Axis Mediates Aflatoxin B1-Induced Intestinal Injury via Dual Regulation of Apoptosis and Necroptosis in Jejunal Epithelial Cells.
AFB1 induces intestinal damage through disrupting gut microbiota structure and the 'PTEN/PI3K/AKT-epithelial barrier' axis by promoting apoptosis and necroptosis in jejunal epithelial cells, effects which can be alleviated by the PTEN-specific inhibitor VO-Ohpic.
Comparative metagenomics reveals the differential gut microbiota involved in bile acid metabolism in patients with crohn's disease.
Comparative metagenomics of CD patients and healthy controls identified differential gut microbiota involved in bile acid metabolism, including significantly lower abundance of bile salt hydrolase-associated species and higher abundance of hydroxysteroid dehydrogenase-associated species in CD patients.
Study on the Mechanism of Ganoderma lucidum Polysaccharides for Ameliorating Dyslipidemia via Regulating Gut Microbiota and Fecal Metabolites.
G. lucidum polysaccharides (GLP) ameliorate dyslipidemia through modification of gut microbiota composition and regulation of fecal metabolite profiles, particularly affecting amino acid metabolism and lipid metabolism pathways.
Chaihu-Shugan-San ameliorates chronic atrophic gastritis by inhibiting nuclear factor-kappa B-mediated inflammation and apoptosis.
Chaihu-Shugan-San alleviated chronic atrophic gastritis by inhibiting NF-κB-mediated inflammation and apoptosis, with core targets including TNF, IL-1β, IL-6, BAX, BCL2, caspase-3/caspase-9, and NFKBIA.
Understanding the bacteriome, phageome and phage-associated bacteriome in healthy Vietnamese children under two years of age.
Pooled metagenomics of healthy Vietnamese infants aged 6-24 months revealed a gut microbiota dominated by Bifidobacterium (>80%) and Podoviridae phages (65.5-70.2%), with 41% of healthy infants being asymptomatic carriers of diarrheal pathogens, and age-related shifts in bacterial and phage community composition between 6-11 and 12-24 month age groups.
Microbial profile along the maternal-infant axis: Early characterization and relationships in breastfeeding women and their newborns in a Colombian population.
This cross-sectional study offers the first comprehensive characterization of the maternal-infant microbial axis in a Colombian population, highlighting distinct microbial profiles in maternal gut, human milk, and infant gut, and identifying 644 shared ASVs indicating potential microbial interactions important for early-life colonization.
Gut microbial signatures expose the westernized lifestyle of urban Ethiopian children.
Urban Ethiopian children display a gut microbiota resembling European rather than rural Ethiopian children, characterized by absence of rural African signature genera, high Firmicutes/Bacteroidota ratio, and enrichment of metabolic pathways linked to a westernized diet, which may be partially offset by consumption of traditional fermented foods.
Functional Training Mitigates Reduced Circulating Indole-3-Lactate Levels in Persons With Relapsing-Remitting Multiple Sclerosis.
Multimodal functional training over 10 weeks led to an improved ILA/IAA index suggesting a neuroprotective shift in gut microbiota composition, and a single bout acutely increases the circulating level of ILA in persons with relapsing-remitting multiple sclerosis.
The therapeutic mechanism of bornyl acetate in alleviating ulcerative colitis by regulating the intestinal flora.
Bornyl acetate alleviates ulcerative colitis through a synergistic mechanism encompassing NF-κB pathway inhibition, microbiota homeostasis restoration, and intestinal barrier repair.
Colon-targeted microbiota-modulating nanoparticles amplify azathioprine efficacy via gut microbiota axis remodeling in inflammatory bowel disease.
An AZA-loaded colon-targeted nanoparticle (APZE) constructed from pectin, Zein, and Eudragit S100 significantly reduced inflammation, repaired the intestinal barrier, and modulated gut microbiota in DSS-induced IBD mice, with effects that are largely microbiota-dependent and further enhanced by co-administration with Bifidobacterium.
Human Fecal Transplantation Modifies the Gut Microbiota but Not Metabolites in Colon Cancer Patient-Derived Xenografts.
FMT induced robust microbiota remodeling but did not modify selected stool metabolites or intrinsic tumor growth, though FMT enhanced FOLFOX responsiveness in selected CRC PDX models, supporting a microbiota-mediated modulation of chemotherapy outcomes.
Clinical impact of altered gut microbiota and metabolite profiles on mortality in patients with candidemia: a prospective observational pilot cohort study.
Low gut bacterial diversity is independently associated with mortality in patients with candidemia, with Shannon diversity index, septic shock, and underlying malignancy identified as significant predictors of in-hospital mortality.
Distinct oral and fecal microbiota composition in preschool children with overweight/obesity: a cross-sectional study.
Preschool children with overweight/obesity exhibit distinct microbial signatures in the oral cavity and intestine compared to normal-weight children, with reduced fecal microbiota richness and diversity, altered abundances of specific genera across oral and fecal niches, and attenuated negative correlations between oral and fecal bacteria.
Harnessing gut microbiota for brain health: protective role of Hungatella hathewayi for post-mTBI cognitive impairment.
Hungatella hathewayi may mitigate post-mTBI cognitive impairment by boosting butyrate production, which alleviates intestinal inflammation, shifts microglia toward the protective M2 phenotype, reduces neuroinflammation, and supports neuroprotection.
Effects of repeated freeze and thaw cycles on the stability of faecal microbiome composition.
Inter-individual sample differences consistently outweighed any effects introduced by freeze-thaw cycles, supporting the reuse of stored faecal samples that have undergone a single thaw with minimal risk of compromising microbiome integrity.
[Mechanism of Jingangteng Capsules in ameliorating chronic nonbacterial prostatitis based on gut microbiota and metabolomics].
Jingangteng Capsules can significantly alleviate inflammatory injury in the prostate tissue of EAP rats, with mechanisms involving regulating intestinal microbiota dysbiosis and metabolic disorders and inhibiting the activation of the SPHK1/S1P1/PI3K/Akt signaling pathway.
Multi-omics chemical and biochemical profiling reveals ellagic acid enhances insulin sensitivity via gut microbiota-tryptophan-indole signaling mechanism.
Ellagic acid alleviates insulin resistance through a gut microbiota-indole metabolite-multi-tissue axis, enriching beneficial bacteria, elevating tryptophan-derived indole metabolites, and modulating lipid profiles and gene expression across liver, skeletal muscle, and adipose tissues.
Oral Health and Its Association With Gut Microbiota Diversity in Older Post-Stroke Inpatients.
Poorer oral health (higher ROAG score) was associated with lower gut microbiota α-diversity (Shannon index) in older post-stroke inpatients, though findings are exploratory and require confirmation.
An integrated drug repositioning analysis identifies rosiglitazone as a treatment for sarcopenia.
Integration of network-based drug repurposing and Mendelian randomization identifies rosiglitazone as a potential therapeutic candidate for sarcopenia, with aged murine models showing improved muscle strength, mass, and endurance via a 'gut-muscle-metabolism' axis.
Dietary index for gut microbiota and its protective role against osteoporosis: Evidence from NHANES 2007 to 2018.
A higher dietary index for gut microbiota (DI-GM) was associated with a reduced risk of osteoporosis, with each unit increase in DI-GM reducing osteoporosis risk by 10% (adjusted OR = 0.90, 95% CI: 0.83–0.99) among U.S. adults.
Improving glucose tolerance in obese rats: the role of Jinlida granules ( ) in gut microbiota modulation.
Jinlida granules effectively improve glucose tolerance and ameliorate obesity-related intestinal dysfunctions in HFD-induced obese rats, likely mediated through modulation of the gut microbiota, suppression of intestinal inflammation, enhancement of barrier function, and attenuation of proinflammatory pathways.
Lycium barbarum Polysaccharides-enriched extract Ameliorate Rheumatoid Arthritis via Gut microbiota-mediated regulation of the Tfh/B cell axis.
Lycium barbarum polysaccharide-enriched extract (LBP) ameliorates rheumatoid arthritis by counteracting gut microbiota dysbiosis—specifically modulating Ligilactobacillus, Limosilactobacillus, and Blautia—and suppressing excessive Tfh cell proliferation and subsequent abnormal B cell differentiation.
Astragaloside IV alleviates ulcerative colitis via gut microbiota - butyrate metabolism axis to reshape Th17/Treg balance.
AS-IV inhibits chronic colitis by regulating gut microbiota composition, butyric acid metabolism, and Th17/Treg cell differentiation balance, whose protective effects are dependent on the regulatory mechanism of Th17/Treg cell differentiation balance mediated by gut microbiota-derived butyrate metabolism.
Scytosiphon lomentaria Fucoidan Ameliorates Glucose and Lipid Abnormalities via Modulation of the Microbiota-Gut-Liver/Pancreas Axis: Insights from Multiomics Analysis.
Fucoidan (FUC2) purified from Scytosiphon lomentaria improved glucose and lipid metabolism in mice by modulating the gut-liver/pancreas axis through structural remodeling of the gut microbiota, acting via the bile acid-FXR-FGF15 axis and AMPK/Nrf2 signaling pathways.
Antibiotic-Mediated Modulation of the Gut Microbiome Identifies Taurine as a Modulator of Adipocyte Function Through TGR5 Signaling.
Antibiotic treatment in high-fat diet-fed rats reduced adiposity and enhanced adaptive thermogenesis, with metabolomics revealing elevated taurine levels correlating with increased UCP1 and TGR5 expression in brown adipose tissue, uncovering a gut-adipose axis whereby taurine activates adipose thermogenesis and lipolysis through TGR5 signaling.
Combined acupuncture and herb treatment improves intestinal flora inabdominally obese subjects based on 16s rRNA sequencing: a randomized controlled trial.
Combined acupuncture (press needle) and herbal medicine (Huatan Lishi Fang) treatment modulated 25 key gut flora across multiple taxonomic levels in abdominal obesity, significantly reduced waist circumference, and altered gut microbiota diversity and composition compared to single or placebo treatments.
Effects of fermented versus unfermented red cabbage on symptoms, immune response, inflammatory markers and the gut microbiome in young adults with allergic rhinoconjunctivitis: a randomised controlled trial protocol.
This paper describes the protocol for a single-centre randomised controlled trial investigating the effects of daily consumption of fermented versus unfermented red cabbage for 8 weeks on symptoms, immune response, inflammatory markers, and gut microbiome in young adults (18-35 years) with allergic rhinoconjunctivitis.
Gut Microbiome Mediates the Causal Link Between Autism Spectrum Disorder and Dietary Preferences: A Mendelian Randomization Study.
ASD is associated with specific dietary preferences, likely mediated via gut microbiota, highlighting the future potential of gut microbiome-based therapeutics to modify eating disorders for ASD.
Disease-specific crosstalk of Alistipes with lipoprotein profiles in overweight individuals at high cardiometabolic risk.
Alistipes abundance showed a significant association with small LDL particle concentrations modulated by disease type, highlighting condition-specific host-microbiota-lipid relationships in overweight individuals with metabolic syndrome versus systemic lupus erythematosus.
Colonic biopsy-associated microbial signatures are predictive of response to anti-TNFα biological therapy in Crohn's disease.
The colonic mucosal microbiome prior to anti-TNF α treatment can distinguish responders from non-responders in Crohn's disease, with an AUC of 0.90, supporting its potential as a predictive biomarker.