Gut Microbiome
417 peer-reviewed studies indexed
Gut Commensal Klebsiella pneumoniae Extracellular Vesicles Shape a Liver Microenvironment Conducive to Gut-Liver Bacterial Translocation and Pro-Tumorigenic Processes.
Gut commensal Klebsiella pneumoniae-derived extracellular vesicles carrying two bacterial tsRNAs shape a liver microenvironment that suppresses macrophage antimicrobial functions, promotes gut-liver bacterial translocation, and may influence hepatocellular carcinoma progression.
The Gut Metabolite Phenylacetylglutamine Inhibits the Angiogenic Potential of Human Umbilical Vein Endothelial Cells Via the β-Adrenergic Receptor-LDHA Axis.
The gut metabolite phenylacetylglutamine (PAGln) suppresses angiogenesis of HUVEC by targeting β-receptors and subsequently inhibiting LDHA expression, impairing blood flow recovery in a murine hindlimb ischemia model.
Gut-Lung Axis in COPD: Investigating the Impact of Dietary Fiber Intake on Systemic Inflammation and Lung Function Decline.
Low dietary fiber intake is significantly associated with COPD and correlates with increased systemic inflammation and reduced lung function, supporting the potential role of the gut-lung axis in COPD pathophysiology.
Exploring the causal link between microbiota and tic disorders: a gene sequencing and Mendelian randomization approach.
Two-sample Mendelian randomization integrated with 16S rRNA sequencing identified specific gut bacterial genera—Anaerotruncus, Butyrivibrio, and Ruminococcaceae UCG-002 as potentially protective and Dialister and Ruminiclostridium 6 as candidate risk taxa—that may be causally associated with tic disorder/Tourette syndrome susceptibility.
Longitudinal multi-omics pilot study: Small sample size human model of gut microbiota-mitochondrial metabolic dysregulation in primary biliary cholangitis.
UDCA nonresponders exhibit persistent gut dysbiosis and mitochondrial TCA cycle dysfunction, while responders show gut microbiota remodeling and serum itaconate enrichment, suggesting UDCA nonresponse may represent a distinct pathological state centered on persistent mitochondrial metabolic dysfunction.
Early oral anti-inflammatory diet in patients with mild acute pancreatitis: study protocol for a randomized controlled trial.
This paper describes a protocol for a single-center randomized controlled trial to evaluate the efficacy and safety of an early oral anti-inflammatory diet (initiated within 48 hours, with a Dietary Inflammatory Index score less than 0) compared to conventional management in patients with mild acute pancreatitis.
Green Tea Catechin Plus Inulin Improves Insulin Resistance Without Reducing Visceral Fat and Shows Exploratory Gut Microbiota Signals in Adults with Visceral Obesity: A Double-Blind Randomized Controlled Trial.
Catechin plus inulin for 12 weeks did not reduce visceral fat but was associated with improved insulin resistance, with exploratory analyses suggesting a potential association between increased Coprococcus and improved HOMA-IR.
Association between the dietary index for gut microbiota (DI-GM) and all-cause mortality in older adults with COPD: Evidence from the NHANES.
Higher dietary index for gut microbiota (DI-GM) scores were independently associated with lower all-cause mortality among older adults with COPD, with individuals in the highest quartile having a 35% lower mortality risk after full adjustment.
Mucosal fungal dysbiosis is associated with early postoperative endoscopic recurrence after bowel resection for Crohn's disease.
Early postoperative endoscopic recurrence in Crohn's disease is significantly associated with mucosal fungal dysbiosis during bowel resection, and integrating mycobial factors can more effectively predict early postoperative endoscopic recurrence.
Gut mycobiota dysbiosis and an emergent state of "co-dysbiosis" are associated with IgE sensitization in children with comorbid allergic rhinitis and constipation.
Gut mycobiota dysbiosis—marked by depletion of immunoregulatory fungi and an ecological shift toward cooperative interkingdom interactions ('co-dysbiosis')—is associated with IgE sensitization in children with comorbid allergic rhinitis and functional constipation.
Elaidic acid suppresses hepatocellular carcinoma growth through modulating the production of intestinal Ligilactobacillus murinus-derived spermidine.
Dietary elaidic acid suppresses hepatocellular carcinoma growth by increasing intestinal Ligilactobacillus murinus abundance, which drives spermidine production that attenuates HCC growth via phosphorylation of p38 MAPK and upregulation of apoptosis biomarkers.
Simiao Decoction alleviates hyperuricemia-induced renal injury through regulating gut dysbiosis and decreasing gut-derived uremic toxins.
Simiao decoction alleviates hyperuricemia-induced renal injury by modulating gut microbiota and bacterial metabolism of tryptophan and tyrosine, thereby reducing gut-derived uremic toxins indoxyl sulfate and p-Cresol, which promote epithelial-mesenchymal transition and cellular senescence in tubular cells respectively.
Preventive effects of sea cucumber-derived fucoidan on Helicobacter pylori-induced gastritis: a mechanistic investigation based on regulation of the gut microbiota and metabolic products.
Fucoidan extracted from sea cucumber cooking liquid (Fuc-SC) exerts multifaceted protective effects on the gastric mucosa against H. pylori-induced gastritis by reducing colonization, modulating oxidative stress and inflammation, and regulating gut microbiota and metabolic products.
Different types of sweetened coffee consumption, genetic predictor of gut microbe, and the risk of metabolic dysfunction-associated steatotic liver disease.
Higher intake of unsweetened coffee, particularly the caffeinated variety, was significantly associated with a reduced risk of MASLD, irrespective of genetic predisposition related to the abundance of intestinal microbiota or MASLD itself.
[Anti-depressant mechanism of Bupleuri Radix in regulating hippocampal FGFR1-5-HT_(1A)R heterodimer formation via intestinal flora-short-chain fatty acids].
The antidepressant effect of Bupleuri Radix is mediated by intestinal bacteria such as B. acidifaciens, which regulate the synthesis and metabolism of SCFAs, thereby modulating hippocampal FGF21 expression and activating FGFR1-5-HT1AR heterodimers.
Gut Microbiota May Predict the Short-Term Recurrence of Symptomatic Uncomplicated Diverticular Disease.
This study suggests an association between recurrent SUDD and pro-inflammatory taxa that have previously been implicated in severe SUDD and other gut disturbances, with specific taxa enriched in relapsers versus non-relapsers.
Identification of monomethylsulochrin as a novel agent to ameliorate DSS-induced ulcerative colitis through dual modulation of the IL-17/TNF pathway and gut microbiota.
Monomethylsulochrin (MMSC) alleviates DSS-induced ulcerative colitis through a dual mechanism integrating suppression of IL-17/TNF signaling and restoration of gut microbiota homeostasis, highlighting it as a promising candidate for developing novel therapies against UC.
Long-Term Use of Proton Pump Inhibitors Affects Blood Levels of Indoxyl Sulfate in Japanese Patients with Chronic Kidney Disease.
Long-term PPI use was significantly associated with higher serum indoxyl sulfate concentrations in Japanese CKD patients, with multiple regression analysis linking PPI prescription and lower eGFR to elevated serum IS levels.
High-Molecular-Weight Pectin Alleviates Fiber-Free High-Fat Diet-Induced Obesity by Regulating the Colonic Microenvironment and Spatial Microbiota Distribution.
High-molecular-weight apple pectin (HAP) more strongly improved body weight gain, glucose homeostasis, lipid abnormalities, barrier markers, systemic inflammation, and gut microbiota distribution than low-molecular-weight pectin (LAP) in a fiber-free high-fat diet mouse model, highlighting molecular weight as a practical lever to optimize pectin-based interventions.
Integrated multi-omics analysis unveils microbiota-metabolite-host interactions and novel biomarkers for early diabetic kidney disease diagnosis.
Multi-omics integration combined with machine learning identified microbiota-metabolite interactions and achieved over 90% accuracy in distinguishing T2DM from DKD in an East Asian cohort, suggesting candidate biomarkers for early DKD detection.
Polystyrene Microplastics Disrupt the Gut-Brain Axis via Activating Brain TLR4 and Impair Hippocampal Synapses through the TLR4/MyD88/NF-κB Pathway.
PS-MPs exhibit size-dependent bioaccumulation and induce gut dysbiosis-mediated barrier disruption that elevates circulatory LPS, triggering excessive activation of the TLR4/MyD88/NF-κB pathway and ultimately leading to synaptic lesions in the hippocampal region.
Species-Level Comparative Metagenomic Analysis of the Bacterial Abundance of the Gut Microbiome in Psoriasis, Hidradenitis Suppurativa, and Pemphigus Foliaceous Patients Using Shotgun Next-Generation Sequencing.
Species-level comparative metagenomic analysis of gut microbiome in psoriasis, hidradenitis suppurativa, and pemphigus foliaceus patients revealed disease-specific bacterial abundance patterns, with immunosuppression significantly influencing intestinal parasitosis prevalence and virulence functional markers.
Gut microbiota-based prediction of clinical response to sublingual immunotherapy in Artemisia pollen-induced allergic rhinitis: A prospective cohort study.
Baseline gut microbiota characteristics, particularly butyrate-producing bacterial abundance, microbial diversity, and Prevotella/Bacteroides community structure, significantly predict SLIT response in Artemisia pollen-induced AR and provide substantial incremental value over conventional clinical parameters.
Gut Microbiota-Derived Metabolite and Heart Failure with Reduced Ejection Fraction (HFrEF): Elevated Trimethylamine N-Oxide (TMAO) as a Potential Biomarker.
TMAO levels were significantly elevated in HFrEF patients compared to healthy controls and demonstrated good discriminative ability as a biomarker (AUC = 0.853), which improved further when combined with clinical covariates (AUC = 0.967), supporting its integration into HFrEF risk stratification frameworks.
Catch-Up Weight Gain and Gut Microbiota Development in Full-Term Small for Gestational Age Children During the First Year of Life-A Prospective Cohort Study.
SGA infants exhibited higher alpha diversity than AGA children at most time points, and in SGA infants more mature microbiota was linked to faster weight gain and increased abundance of short-chain fatty acid-producing and obesity-associated bacteria, suggesting early microbial development may affect the risk of overweight and obesity later in life.
Severity of Depressive Symptoms by Perceived Stress and Gut Microbiota Composition: A Sex-Stratified Bayesian Approach in a Non-Clinical Sample.
Perceived stress predicted depressive symptoms in both sexes, and in women specifically, the genus Eubacterium moderated this relationship such that higher perceived stress combined with lower Eubacterium abundance predicted more severe depressive symptoms.
Gut Microbiota of Sarawak's "Orang Ulu" Indigenous Community in East Malaysia Reveals Vanish Microbes: A Comparison With Urban Communities.
The Sarawak Indigenous community exhibited the highest gut microbial diversity and were dominated by VANISH microbes (Prevotella, Faecalibacterium, and Succinivibrio), contrasting with BIoSSUM microbes (Bacteroidaceae) found in the urbanized Kuala Lumpur cohort, highlighting the impact of urbanization on gut microbiota composition.
Gut microbiota-derived isoxanthohumol metabolite, 8-prenylnaringenin, mitigates endothelial dysfunction in Angiotensin II-induced hypertension through G protein-coupled estrogen receptor-mediated eNOS activation.
8-prenylnaringenin (8-PN), a gut microbiota-derived metabolite of isoxanthohumol, mitigates endothelial dysfunction in Angiotensin II-induced hypertension through GPER-mediated eNOS activation via dual Ca2+-dependent and EGFR/c-Src/PI3K/Akt signaling pathways.
Tracing the early bacterial settlers in preterm and very-low birth-weight infants: first report of microbiota dynamics in South American neonates.
The gut microbiota of very-low birth-weight infants in Uruguay is dominated by Klebsiella pneumoniae and Escherichia coli, diversity increases over time, and postnatal antibiotic exposure is a major factor orchestrating microbial community composition.
Subchronic arsenic exposure induced intestinal microbiota dysbiosis and intestinal inflammation via activating the NF-κB signaling pathway.
Arsenic exposure compromises the integrity of the intestinal mucosa and disrupts the homeostasis of the intestinal microbiota, mediating intestinal inflammation through the NF-κB signaling pathway.
MIND Pattern Nutritional Intervention Modulates Mediterranean Diet Adherence and Gut Microbiota in Alzheimer's Disease: An Observational Case-Control Study.
A structured, non-restrictive MIND intervention was feasible, improved dietary adherence, and accompanied higher diversity and compositional remodeling of the gut microbiota in Alzheimer's disease.
Structure-function relationship of Konjac glucomannan with varying acetylation degrees in modulating gut microbiota and alleviating prediabetes.
Higher acetylation degree enhances KGM's efficacy in modulating gut microbiota and alleviating prediabetes, with effects associated with DS-dependent enrichment of Bacteroides uniformis and upregulation of beneficial faecal metabolites including D-pantothenic acid.
Effect of evolocumab on the gut microbiota in patients with acute myocardial infarction.
Evolocumab can regulate the gut microbiota of patients with AMI to promote a healthier state, with increased beneficial bacteria such as Odoribacter and Parabacteroides following treatment.
VERU-111 Promotes an Anti-Tumor Response Through Restoration of Gut Microbial Homeostasis and Associated Metabolic Dysregulation.
VERU-111 administration in a murine CRC model led to a restructured microbial community characterized by increased alpha and beta diversity, with shifts in gut microbiota associated with suppression of several metabolic and cancer-related pathways that might facilitate suppression of CRC.
Ginsenoside CK regulates non-alcoholic fatty liver disease by regulating liver fat metabolism and gut microbiota.
Ginsenoside compound K (CK) attenuates NAFLD in a high-fat-high-cholesterol diet mouse model by activating the PPAR signaling pathway to regulate lipid metabolism and reversing gut microbiota dysbiosis via the gut-liver axis.
Whole-component soymilk prepared based on high-energy fluidic microfluidization alleviates ulcerative colitis by modulating gut microbiota and regulating metabolic pathways.
Whole-component soymilk prepared by high-energy fluidic microfluidization alleviated ulcerative colitis by modulating gut microbiota and regulating colonic metabolic pathways, with greater efficacy than traditionally processed soymilk.
Baicalin Restores the Hypoglycemic Effect of Metformin by Regulating the Microbial Imidazole Propionate and Short-Chain Fatty Acids.
Baicalin restores metformin sensitivity by enriching SCFAs, suppressing ImP-producing bacteria (Staphylococcus epidermidis and Streptococcus mutans), and lowering serum imidazole propionate, thereby reinstating metformin's hypoglycemic action.
Pear peel polyphenols protect against ulcerative colitis via coordinated modulation of gut microbiota and mucosal immunity.
Pear peel polyphenols (PPP) exert a protective effect against colitis through the coordinated regulation of gut microbiota and mucosal immunity, highlighting their potential as a functional food ingredient for intestinal health.
In vitro utilization of barley husk by human gut microbiota depends on husk composition and particle size.
Starch content, rather than particle size, is the main driver of phenolic acid bioaccessibility, microbial composition and SCFA production during in vitro fermentation of barley husk by human gut microbiota.
Detection of Fungal Translocation in Patients With Alcohol Use Disorder Using a Real-Time PCR Assay.
Fungal DNA was found in the blood of AUD patients, showing that fungal elements can translocate across the intestinal barrier, and absence of correlation between intestinal integrity markers and fungal translocation indicates that fungal elements may be able to translocate independently of the integrity of gut barrier.
Fusobacterium nucleatum drives CD40-mediated dendritic cell activation and Th17/Treg imbalance to exacerbate intestinal inflammation in Crohn's disease.
Fusobacterium nucleatum exacerbates intestinal inflammation in Crohn's disease through CD40-mediated dendritic cell activation and subsequent Th17/Treg imbalance, identifying CD40 as a promising target for microbiota-directed immunotherapy.
Plasma Metabolites Mediate the Associations of Gut Microbial Diversity with Ambulatory Blood Pressure and Its Variability.
Gut microbial richness (Chao1) correlates with lower blood pressure and blood pressure variability, and four key metabolites (imidazole propionate, 2-hydroxy-3-methylbutyric acid, homovanillic acid, and hydrocinnamic acid) mediate these associations, providing novel insights into the pathogenesis and prevention of hypertension.
Gut microbiota dysbiosis and bone mineral density in hemodialysis patients: The mediating role of immune-metabolic pathways and clinical implications for nursing care.
Gut microbiota dysbiosis is independently associated with lower bone mineral density in hemodialysis patients, partially mediated through immune-inflammatory pathways and gut-derived metabolites, with nursing-modifiable factors significantly modifying this association.
The gut microbiota composition is shaped by disease activity and individual treatment responses in patients with multiple sclerosis.
Treatment influences gut microbiota composition, and patients with active disease (CIS and treatment non-responders) share a similar gut microbiota profile and higher levels of molecules associated with microbial translocation, suggesting higher permeability of their gut barrier leading to pro-inflammatory tuning of their immune system.
Serum PCBs, OCPs, PBDEs and PCAs: Associations with metabolic syndrome risk factors in the Flemish Gut Flora Project cohort.
Multi-pollutant models revealed significant associations between POPs and several MetS indicators stratified by sex, with females exhibiting significantly increased odds of elevated blood pressure (OR: 2.29, FDR <0.05), providing evidence of ongoing exposure to POPs in Belgium linked to cardiometabolic alterations.
Extraction-Dependent Structural Diversity of White Kidney Bean Cotyledon Polysaccharides Determines Their Effects on Ex Vivo Fermentation of the Elderly Gut Microbiota.
Acidic and alkaline extractions of white kidney bean cotyledon polysaccharides yield fractions that most effectively support beneficial microbial growth and SCFAs generation in aging microbiota, suggesting these polysaccharides represent promising prebiotic candidates for maintaining gut homeostasis and metabolic health in elderly populations.
Chronic Exposure to Thermally Processed Food-Derived Carbon Polymers Accelerated Neuroinflammation in Alzheimer Disease Mice through Microbe-Gut-Brain Axis.
Chronic exposure to carbon-based polymers (CPs) isolated from processed foods (roasted lamb) accelerated neuroinflammation and synaptic dysfunction in Alzheimer disease transgenic mice via gut microbiota dysbiosis, elevated LPS production, increased blood-brain barrier permeability, and activation of the LPS-TLR4-NF-κB signaling pathway.
Synergistic Effects of Fu Brick Tea Extract and Millet on Antiobesity in High-Fat Diet-Fed Mice through Gut Microbiota Modulation and Activation of the Ffar2-Gcg/Pyy Molecular Pathway.
The Fu brick tea extract-millet complex (FTE-M) exhibited antiobesity effects in high-fat diet-fed mice through gut microbiota modulation, increased SCFAs production, and activation of the Ffar2-Gcg/Pyy molecular pathway contributing to enhanced satiety.
Longitudinal Interaction Between Individualized Gut Microbial Dynamics and Diet Is Associated with Metabolic Health in School-Aged Children.
Fecal microbiota dynamics exhibit inter-individual variation among school-aged children, with low-stability microbiota associated with adverse blood lipid profiles and linked to dietary fiber and amino acid consumption, suggesting gut microbial dynamics as a possible complementary biomarker for individualized dietary interventions aimed at improving metabolic health in childhood.
Integrative analysis across metagenomic taxonomic classifiers: A case study of the gut microbiome in aging and longevity in the Integrative Longevity Omics Study.
Integrative analysis using both MetaPhlAn4 and Kraken2 classifiers with a correlated meta-analysis approach (AdjMaxP) captures more age-associated taxa than either classifier alone, identifying 17 taxa robustly age-associated across cohorts.