Gut Microbiome
417 peer-reviewed studies indexed
Distinct gut microbiome signatures associated with sedentary behavior improvement following rehabilitation in chronic obstructive pulmonary disease patients with higher functional exercise capacity.
In COPD patients with higher functional exercise capacity, distinct changes in the gut microbiota were observed among participants whose sedentary time decreased following a 12-week home-based rehabilitation program.
Fermented and non-fermented pickles modulate gut microbiota in older adults with dysphagia: A pilot crossover study.
Texture-modified pickles and fermented pickles can be safely provided and feasibly consumed by older adults with dysphagia risk, inducing modest, taxon-specific shifts in gut microbial composition without altering global diversity.
New hypothesis: a gut-lipid-kidney axis in constipated CKD patients-insights from multi-omics triangulation.
Constipation is a key and independent predictor of mortality in patients with CKD, mediated through a gut-lipid-kidney axis whereby constipation reduces Herbidospora, depleting protective phosphatidylcholine (14:0_18:2) that mediates 12.5% of the protective pathway from Herbidospora to CKD.
Oxidative Balance Score, Genetic Predictors of the Gut Microbiome, and the Risk of Metabolic-Associated Fatty Liver Disease: A Cohort Study.
Higher oxidative balance score (OBS) was associated with lower MASLD risk independent of genetic and microbial GRS, with adjusted HRs of 0.82, 0.71, and 0.68 for the second, third, and fourth OBS quartiles compared to the lowest quartile.
3'-Hydroxypterostilbene Alleviates Obesity and Lipoprotein Metabolism Dysregulation by Reshaping Gut Microbiota in High-Fat Diet-Induced Obese Mice.
3'-Hydroxypterostilbene (OHPt) significantly reduced body weight gain, adiposity, and lipid dysregulation in high-fat diet-induced obese mice by reshaping gut microbiota and enhancing cholesterol homeostasis.
Engineering carboxymethyl chitosan/dialdehyde starch hydrogel as a therapeutic platform for immuno-microbial modulation in ulcerative colitis.
An injectable, self-healing CMCS/DAS hydrogel loaded with dexamethasone achieved localized anti-inflammatory delivery, macrophage polarization modulation, epithelial barrier repair, and gut microbiota rebalancing in a TNBS-induced rat model of ulcerative colitis.
Enhancing diagnosis of mild cognitive impairment through brain-heart-gut metabolic networks in whole-body PET imaging.
A framework integrating brain-heart-gut interactions using whole-body PET achieves diagnostic performance for MCI comparable to whole-body PET while showing promising generalizability across datasets, identifying a multi-organ metabolic network involving specific brain regions, myocardium, and distal colon.
Gut microbiome-driven modulation of the tumor immune microenvironment optimizes dual checkpoint blockade in advanced non-small-cell lung cancer.
Gut microbiota diversity and SCFA-producing bacteria are associated with improved efficacy of ipilimumab plus nivolumab in advanced NSCLC, and baseline gut microbiota diversity may help identify patients more likely to benefit from dual checkpoint blockade with or without chemotherapy.
Fecal carbohydrate-degrading bacteria are associated with reduced incidence of lower gastrointestinal GVHD.
Fecal carbohydrate-degrading bacteria, specifically Parabacteroides and Bacteroides species and their associated CAZymes including xylosidase, are associated with reduced incidence of lower gastrointestinal graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.
Gut microbiome-metabolomics integration explores the adjunctive effect of Naoxintong capsule on atorvastatin in ameliorating hyperlipidemia: A randomized controlled pilot study.
The addition of Naoxintong Capsule to atorvastatin could enhance the therapeutic effect against hyperlipidemia, which might be related to the composition alterations of gut microbiota and changes in plasma metabolite abundances.
Gut microbiome compositional clusters in association with cardiovascular risk: An observational cohort study.
Distinct gut microbiome profiles identified through unsupervised hierarchical clustering are associated with varying cardiovascular risk, with one cluster showing a significantly lower incidence of Major Adverse Cardiac Events (HR=0.48) over a median follow-up of 7.4 years.
Lycopene Regulates Gut Fungi through Bacterial Vitamin B6-Mediated Trichocladium Suppression.
Lycopene regulates gut fungi by promoting Lactobacillus johnsonii growth and altering vitamin B6 metabolism, which in turn suppresses the fungal genus Trichocladium, rather than acting directly on fungi itself.
Colorectal adenoma presence is associated with decreased menaquinone pathway functions in the gut microbiome of patients undergoing routine colonoscopy.
The presence of colorectal adenomas was associated with reduced microbial metabolic functions linked to vitamin K₂ biosynthesis, amino acid fermentation, and propionate production, alongside compositional shifts toward a less functionally robust gut microbiome.
Exploring the gut microbiota alterations with obesity in older adults: a case-control study in the context of Bushehr Elderly Health (BEH) program.
The abundance of Bacteroides, Blautia, and Faecalibacterium were negatively associated with obesity in older adults after adjusting for confounders, highlighting associations between specific gut microbiota and obesity in this population.
Time-restricted eating in patients with metabolic syndrome: A protocol paper for a feasibility clinical trial.
This paper describes a protocol for a pilot feasibility study evaluating a 12-week time-restricted eating intervention (10-hour eating window, 14-hour fasting) in 40 adult patients with metabolic syndrome, with primary outcomes of feasibility and acceptability.
Types and characteristics of shared microbiota within families of ethnic minorities in Inner Mongolia.
Cohabitation within the same family was a more significant determinant of variation in both macrodiversity and microdiversity of gut microbiota than other factors including family role, ethnicity, sex, age, and geographical region among ethnic minority families in Inner Mongolia.
Gut unclassified Ruminococcaceae reweights cortical functional gradients and small-world topology with links to mood and diet.
Increased abundance of unclassified Ruminococcaceae was associated with a functional shift in the brain from unimodal to transmodal hubs, accompanied by a drift of the small-world network toward randomization, with functional gradient values significantly negatively correlated with depression and anxiety scores.
Informed Therapeutic Microbiome Modulation for Post-Infectious Irritable Bowel Syndrome: Pilot Experience of a Microbiome Clinic.
Based on preliminary results, targeted therapeutic microbiome modulation informed by microbiome profiling might be a promising strategy for post-infectious irritable bowel syndrome, with 100% of cases achieving treatment response compared to 55% of controls.
Gut Microbiome Dysbiosis Promotes Gallstone Formation via Bile Acid Metabolic Disorder: A Multiomics Study.
Gallstone patients exhibit intestinal dysbiosis characterized by increased BSH-producing bacteria, leading to bile acid dysregulation with accumulation of hydrophobic bile acids as a key factor in gallbladder stone formation.
Characterizing the gut virome in ulcerative colitis and crohn's disease: signatures of disease severity.
IBD is associated with reduced virome diversity, loss of core protective phages, and selective enrichment of bacteriophages and eukaryotic viruses, with virome features achieving an AUC of 0.89 for distinguishing IBD from controls and 0.83 for classifying mild versus severe disease.
Sugarcane bagasse arabinoxylan alleviates dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota.
Sugarcane bagasse arabinoxylan (BGAX) significantly improved colitis outcomes in DSS-induced mice by modulating gut microbiota composition, reducing inflammatory cytokines, and restoring colonic architecture.
Elevated fecal silver, lithium, and platinum in cognitive impairment: A pilot exploration of microbiota-metal interactions.
This pilot study revealed elevated fecal excretion of silver, lithium, and platinum in participants with cognitive impairment compared to healthy controls, while no significant differences in gut microbial diversity were observed between groups.
Association analysis of the differences in intestinal flora and clinical tumor indicators among colorectal cancer patients.
Intestinal flora of CRC patients is characterized by decreased diversity, enrichment of pathogenic bacteria, and reduction in protective flora, with microbial alterations associated with tumor progression, and flora health and dysbiosis indices showing potential as adjunctive diagnostic tools.
Effects of tacrolimus treatment on the gut microbiota and metabolites in liver transplant recipients.
Tacrolimus treatment is associated with distinct alterations in gut microbiota and metabolites among liver transplant recipients, with duration, whole-blood concentration, and concentration-to-dose ratio each linked to specific changes in microbiota diversity, bacterial and viral abundance, and fecal metabolite profiles.
Protective Effect of Luteolin Isolated from Taraxacum coreanum Against Neuroinflammatory Responses Induced by Lipopolysaccharide: Involvement of Gut-Brain Axis.
Luteolin isolated from Taraxacum coreanum attenuates neuroinflammation and maintains blood-brain barrier integrity by suppressing inflammatory responses, protecting the gut barrier, and modulating the gut microbiome in LPS-injected mice.
Gut microbiota profiles by LDL-C target achievement in statin-treated patients: A cross-sectional study.
The LDL-C target-achieved group (LDL-C < 70 mg/dL) in statin-treated chronic disease patients showed no significant differences in alpha or beta diversity or microbial dysbiosis index, but was associated with significant reductions in short-chain fatty acid-producing bacteria including Barnesiella, Coprococcus 1, Flavonifractor, and Odoribacter.
A study on the role of Tai Chi training in improving type 2 diabetes mellitus.
Tai Chi training can improve blood glucose homeostasis, gut microbiota richness and diversity, intestinal mucosal barrier function, and systemic inflammatory status in T2DM patients.
Exogenous myrosinase from mustard seed increases bioavailability of sulforaphane from a glucoraphanin-rich broccoli seed extract in a randomized clinical study.
Exogenous myrosinase from mustard seed powder doubled the bioavailability of sulforaphane (39.8% vs 18.6%) compared to gut microbial conversion alone from a glucoraphanin-rich broccoli seed extract in a randomized crossover study.
Roudoukou-Suanzaoren Ameliorates Chronic Restraint-Induced Anxiety- and Depression-Like Behaviors in Mice via the Gut-Brain Axis.
Roudoukou-Suanzaoren (RS) exerts antianxiety and antidepression effects by modulating the gut microbiota, controlling inflammatory responses, and increasing BDNF levels through the 'gut-brain axis' pathway in a chronic restraint stress mouse model.
Distinct Gut Microbiome Signatures of Complete Responders to Omalizumab in Chronic Spontaneous Urticaria.
Complete responders to omalizumab in chronic spontaneous urticaria had distinct gut microbiome signatures at baseline, with higher alpha-diversity and greater abundance of specific bacterial genera, suggesting that 'the CR patients' distinct and characteristic gut bacterial microbiota profile before treatment may contribute to their better responses to omalizumab.'
Gut microbiome dysregulation is associated with segmental glomerulosclerosis in IgA nephropathy: insights from Oxford classification-based microbiome profiling.
Gut microbiota dysregulation is closely associated with IgAN segmental sclerosis, with S1 showing pro-inflammatory microbial profiles and S0 retaining protective functions, providing new insights into gut-kidney axis mechanisms and potential microbiome-targeted therapies for IgAN.
GLP-1RA Liraglutide Attenuates Sepsis by Modulating Gut Microbiota and Associated Metabolites.
Liraglutide mitigates sepsis by modulating the gut microbiota and regulating associated metabolic pathways, with citrulline representing a potential microbial mediator or exploratory biomarker within this axis.
Investigating the Role of Diet-Manipulated Gut Bacteria in Pathogenesis of Type 2 Diabetes Mellitus-An In Vitro Approach.
Metabolites derived from high-carbohydrate/high-fat diets exacerbate metabolic dysfunction, whereas those generated under high-fibre conditions significantly enhance insulin secretion and glucose-dependent ERK1/2 activation in co-culture compared to monocultures.
Fecal fermentation of human ileal fluid after mango intake impacts on colonic microbiota and microbial (poly)phenol catabolism.
Ileal fluid enriched with mango (poly)phenols undergoes substantial microbial catabolism during ex vivo fecal fermentation, with the IF matrix rather than mango (poly)phenols per se significantly influencing gut bacterial diversity and SCFA production, while characteristic catabolites positively correlate with commensal and healthy-related bacteria.
Comparison of Stool Microbiome in Children with Cystic Fibrosis Treated with and Without Elexacaftor-Tezacaftor-Ivacaftor-A Pilot Study.
In this pilot study, there were no significant differences in stool microbiome alpha diversity between children with CF treated with ETI, children with CF not treated with ETI, and healthy sibling controls, though alpha diversity showed a negative trend with duration of ETI therapy for both bacteriome and mycobiome.
Association Between Hemodynamic Parameters and Gut Microbiota in Fontan Circulation: A Cross-Sectional Study.
Fontan patients exhibit characteristic gut dysbiosis that parallels their hemodynamic and hepatic burden, supporting a hemodynamic-gut-liver axis in Fontan physiology.
The characteristics of gut microbiome changes in tuberculosis patients and latent tuberculosis infection in Xinjiang.
Gut microbiota in Han tuberculosis patients showed significantly lower alpha diversity, enrichment of pro-inflammatory and opportunistic pathogenic genera, and distinct metabolic pathway profiles compared to latent tuberculosis infection and healthy controls in Xinjiang, China.
Fecal metaproteomics reveals alterations in gut microbiota and intestinal proteins in adolescents with bipolar depression.
Fecal metaproteomics revealed increased abundance of Bifidobacteriaceae, Megasphaera, and Alistipes in adolescents with bipolar depression, and identified host proteins CELA2A, DEFA3, and KLK1 as potential diagnostic biomarkers with high ROC-AUC values (0.905, 0.897, and 0.897).
Gut Microbiota Composition in Adolescents From Mexico City, Associations With Nutritional and Socioeconomic Factors: Results From a Pilot Study.
Diet and socioeconomic status influenced the adolescent gut microbiome by shaping diversity, potentially pathogenic taxa, and their associations with metabolic health indicators in a pilot study of 95 Mexican adolescents aged 11-15 years.
Investigating the Interplay between the Gut Microbiota and Host Immunity in Gastroenteric Disorders: The Potential of Combined Drug Therapies to Restore Microbial-immune Homeostasis.
Combination drug therapy demonstrated superior efficacy over monotherapy and control in enhancing gut microbial diversity, reducing inflammatory indices, shifting immune phenotype, and improving symptom severity in patients with moderate to severe gastrointestinal disorders over 12 weeks.
Gut DNA virome enterotype dictates inflammation heterogeneity through tuning the phage-bacteria-sphingosine-intestine axis in Crohn's disease.
Two mucosal DNA virome enterotypes (E1 and E2) exist in humans, with E2 being causally more proinflammatory through a phage-bacteria-sphingosine-intestine axis in which a novel Wulfhauvirus phage lysogenically infects Bacteroides thetaiotaomicron to increase sphingosine production, which suppresses Blautia obeum and worsens intestinal inflammation.
The impact of autism awareness of mothers of preschool children on the level of microbiota awareness.
Autism awareness level has a positive and significant impact on microbiota awareness level, with increased autism awareness of individuals found to increase microbiota awareness.
[Asthma-alleviating effects of Poria cocos based on network pharmacology and gut microbiota].
Poria cocos reduced cough frequency, improved lung function, maintained immune homeostasis, and restored intestinal microecological homeostasis by reducing levels of Muribaculum intestinale and Alistipes inops, thereby exerting asthma-alleviating effects in OVA-sensitized mice.
Dynamic Gastrointestinal Simulation Reveals that Short-Term Mango Purée Feeding Modulates (Poly)phenol Metabolism, Gut Microbiota and Metabolic Activity.
Short-term mango purée feeding in a dynamic gastrointestinal simulator promoted extensive microbial metabolism of (poly)phenols, increased beneficial taxa such as Bifidobacterium spp., enhanced butyric acid production, and reduced ammonium concentration, confirming that mango (poly)phenols promoted bioactive metabolites and supported a healthier gut environment.
Correlation study between gut microbiota and intestinal permeability in cerebral small vessel disease.
Patients with CSVD-associated cognitive impairment have gut microbiota imbalance and increased intestinal permeability associated with cognitive decline, and FMT from these patients can cause intestinal leakage and production of harmful metabolites in mice.
Functional shotgun metagenomic insights into gut microbial pathway and enzyme disruptions linking metabolism, affect, cognition, and suicidal ideation in major depressive disorder.
Shotgun metagenomics in MDD reveals gut dysbiosis characterized by loss of barrier protection, antioxidants, and short-chain fatty acids alongside activation of neuro-immune, metabolic, and oxidative stress (NIMETOX) pathways, with gene and pathway scores explaining significant variance in suicidal ideation, recurrence of illness, neurocognitive impairments, immune functions, and atherogenicity.
Discovery and functional validation of a gut microbiota-metabolite-miRNA axis in diabetic encephalopathy.
This study identified a novel gut-brain axis pathway in diabetic encephalopathy whereby gut microbiota dysbiosis and metabolic alterations promote neuronal damage via the miR-493-3p/RAF1 signaling axis.
The Norwegian Microbiota Study in Anorexia Nervosa (NORMA): Integrating a clinical trial with preclinical experiments-A study protocol.
NORMA is a comprehensive study protocol integrating a clinical observational trial, in vitro fermentation experiments, and animal experiments to investigate gut microbiota and its interaction with the gut-brain axis in anorexia nervosa.
Polysaccharide Engineered Nanozymes Target Inflammation for Alleviating Colitis-Associated Mental Disorders via Microbiome-Gut-Brain Axis.
Fucoidan-cerium nanocomplexes (FucCeNCs) alleviate colitis-associated mental disorders by targeting inflammation, restoring gut microbial homeostasis, and regulating amino acid metabolism via the microbiome-gut-brain axis.
[Study on the characteristics and differences of intestinal microbiota in children with allergic diseases].
There are significant differences in the composition of intestinal flora among children with different allergic diseases, and the lack of Bifidobacterium may be related to the occurrence and development of allergic diseases.