Gut Microbiome
417 peer-reviewed studies indexed
Dietary Quality and Microbiome Profiles among Rectal Cancer Patients: A Cross-Sectional Pilot Study.
Findings suggest important associations between the taxa abundances of gut bacteria and the abundances of predicted B-vitamin biosynthesis pathways and dietary quality at the end of neoadjuvant chemoradiotherapy for rectal cancer.
Fucoidan attenuates age-related skeletal muscle atrophy via gut microbiota-dependent tryptophan metabolic Remodeling.
Fucoidan alleviates age-related muscle atrophy by remodeling gut microbiota and promoting tryptophan metabolism, highlighting its potential as a dietary intervention for age-related skeletal muscle atrophy.
Dietary Protein Modulation, Gut Microbiota, and Metabolic Control in Methylmalonic Acidemia: A Prospective Longitudinal Study.
A phased dietary regimen emphasizing intact protein, combined with intermittent metronidazole therapy, favorably modulated biochemical and microbial parameters in MMA, supporting microbiome-informed dietary strategies and selective gut-targeted interventions to optimize metabolic control in organic acidemias.
Disentangling Gut Microbiome Alterations in Children with Cow's Milk Allergy: Impact of Sex, Milk Elimination, and Family History of Allergies.
Gut microbiome alterations associated with cow's milk allergy are sex-dependent, with effects more pronounced in girls, suggesting that sex-specific strategies may be more effective at modulating them toward healthier states.
Low Serum sRAGE and MASLD Are Associated and Share a Similar Gut Microbiota Profile: A Prospective and Cross-Sectional Analysis.
Low sRAGE levels are associated with higher odds of MASLD, and MASLD and low sRAGE levels share a similar gut microbiota signature, suggesting a potential biological link that warrants further investigation.
Gut bacterial O-demethylation modulates systemic exposure to oral etoposide.
Gut microbial O-demethylation is a significant determinant of etoposide metabolism and disposition, increasing systemic etoposide exposure 1.9-fold and decreasing its O-demethylated metabolite M1 exposure 3.7-fold when gut bacteria are depleted with antibiotics.
Development of an untargeted metabolomics analytical protocol for fecal samples by liquid chromatography-mass spectrometry.
A single extraction of 50 mg lyophilized feces with 1 mL methanol combined with data-dependent acquisition (DDA) for LC-MS provides comprehensive and reproducible untargeted fecal metabolomics analysis.
Gut microbiota and parasite dynamics in an Amazonian community undergoing urbanization in Colombia.
Urbanization in the Colombian Amazon is associated with reduced gut bacterial diversity and shifts in microbiota composition, with STH infections primarily in rural areas and both parasite types linked to higher bacterial richness and diversity.
EEG and gut microbiota response patterns in high-altitude indigenous populations.
Indigenous high-altitude populations show coordinated gut-brain adaptations to chronic hypoxia, including enhanced delta power, increased frontal-occipital functional connectivity, elevated P3 amplitude, and higher abundance of short-chain fatty acid-producing gut microbiota genera.
Re-evaluating gut microbiome signatures of post-antibiotic dietary fiber intake in a large adult cohort.
Post-antibiotic microbiome signatures associated with fiber intake are distinct and specific, with Bifidobacterium and Lachnospira identified as robust genus-level biomarkers enriched in high-fiber intake rather than a uniform enrichment of commensal Clostridia as previously suggested.
Multi-kingdom gut microbiota characterization in Chinese patients with idiopathic inflammatory myopathies.
Shotgun metagenomic sequencing revealed significant alterations in gut bacteriome, mycobiome, and virome in IIM patients, with the virome demonstrating the strongest discriminatory power and a combined multi-kingdom classifier achieving AUC = 0.997.
Association of yoga with cognitive and gut microbiome changes in Alzheimer's disease: An exploratory case-control study.
A 12-week yoga intervention was associated with cognitive and mood improvements and partial normalization of gut microbial function in mild Alzheimer's disease.
Concomitant COX-1 and COX-2 suppression is not sufficient to induce enteropathy associated with chronic NSAID use.
Concomitant postnatal deletion of Cox-1 and Cox-2 failed to cause intestinal injury in mice unless treated with naproxen or its non-COX-inhibiting structural analog, showing that prostaglandin suppression played a trivial role in NSAID-induced enteropathy, while Cox deletion-induced dysbiosis amplified the enteropathic response to NSAIDs.
Fucoidan alleviates chemotherapy-induced steatohepatitis by regulating the gut-liver axis.
Intestinal barrier dysfunction-activated NETs formation drives CPT-11-induced steatohepatitis, and fucoidan alleviates this by restoring tight junction proteins, improving gut microbiota composition, reducing LPS translocation, and suppressing hepatic NETs accumulation.
Integrated Metabolomics and Microbial Profiling in Patients with Irritable Bowel Syndrome.
Integrating plasma metabolites, urinary metabolites, and gut microbial communities demonstrates that functional interactions between discriminative gut microbial features and systemic metabolic alterations, particularly within fatty acid metabolism, may represent a mechanistic link between gut dysbiosis and the metabolic manifestations of IBS.
Prenatal exposure to persistent organic pollutants modulates the metabolism and gut microbiota of the offspring.
Prenatal exposure to persistent organic pollutants, particularly PCBs, was strongly associated with alterations in the infant metabolome affecting lipid metabolism and microbiota-derived metabolites, and with disruptions in gut microbial composition at three months of age.
Impact of medium- and long-chain triacylglycerols and sn-2 palmitate on temperament development in term infants: potential role of gut Bifidobacterium.
Supplementation with MLCTs and sn-2 palmitate improves infant temperament, potentially mediated via increased Bifidobacterium, highlighting the potential of nutrition to alter infant temperament by modulating the gut microbiome.
Influences of transcutaneous neuromodulation on fecal microbiota and short chain fatty acids in patients with functional constipation.
TN treatment significantly improved the symptoms of FC patients and increased their plasma 5-HT expression levels, with the correlation between 5-HT and Blautia-serotonin disappearing after treatment, indicating potential interaction between 5-HT changes and dynamic changes of intestinal microbiota.
Altered Duodenal Mucosa-Associated Microbiota and Immune Profiles in Functional Dyspepsia: A Study of Host-Microbiome Homeostasis.
FD patients exhibit distinct alterations in duodenal mucosa-associated microbiota and immune profiles compared to controls, with immune-microbiome associations present in controls being absent in FD patients, suggesting a loss of host-microbiome homeostasis that may contribute to FD pathophysiology.
Mechanistic study of Dendrobium huoshanense polysaccharides improving ulcerative colitis by promoting Lachnoclostridium edouardi metabolism of short-chain fatty acids.
DHP alleviates ulcerative colitis by modulating gut microbiota (specifically promoting Lachnoclostridium edouardi), increasing short-chain fatty acid production, and activating the PPAR γ/NF-κB pathway.
The analysis of gut microbiota characteristics in children with global developmental delay.
Children with Global Developmental Delay (GDD) have significant differences in gut microbiota composition and diversity compared to healthy children, with abundance changes and abnormal metabolic pathways that may be closely related to the neuroinflammatory process, suggesting that intestinal microecological regulation may become a new intervention target for GDD.
Different Cadmium Bioavailability from Wheat and Rice Dictates Toxicity via Distinct Intestinal Pathways in Mice.
Cd-containing wheat may pose remarkably lower health risk to humans compared to rice, due to over 2-fold lower Cd accumulation in liver and kidneys of wheat-fed mice driven by transporter downregulation and gut microbiota-mediated improvements in intestinal integrity.
Impact of proton pump inhibitors on immunotherapy is modulated by prior chemotherapy and linked to gut microbiome-immune cell signatures.
PPI use was associated with shorter overall survival in patients with advanced cancers treated with ICIs, with the strongest effects seen in melanoma, and prospective studies implicate its effect on the microbiome.
Bacterial Metabolites in the Plasma of Type 1 Diabetes Patients: Acetate Levels Are Elevated and Correlate with Glycated Haemoglobin and Para-Cresol Is Associated with Liver Disturbances and Hypertension.
T1D is associated with a marked alteration in circulating gut-derived metabolites, characterized by increased acetate levels, particularly in women, and an imbalance in SCFA ratios that correlates with glycemic control, with p-cresol associated with liver dysfunction and hypertension.
Citrus-Derived Exosome-like Nanoparticles Attenuate High-Fat Diet-Aggravated Colitis by Gut Microbiota-Metabolites Modulation.
Citrus-derived exosome-like nanoparticles (CELNs) ameliorated high-fat diet-aggravated colitis by restoring gut barrier integrity, suppressing oxidative stress and pro-inflammatory signaling, and rebuilding microbial dysbiosis with subsequent normalization of critical metabolic pathways.
Ganoderic Acid A Modulates Enteric Neurons and Intestinal Homeostasis in Irritable Bowel Syndrome by Microbiota Sensing.
Ganoderic acid A alleviates IBS-like symptoms in mice by reshaping gut microbiota, promoting indole-3-aldehyde production, and activating aryl hydrocarbon receptor signaling to modulate enteric neurons and intestinal homeostasis.
[Shenzao Jiannao Oral Liquid treats Alzheimer's disease by regulating gut microbiota].
High-dose Shenzao Jiannao Oral Liquid improves learning and memory abilities, mitigates intestinal pathological damage, and protects the intestinal tissue of AD mice by regulating the gut microbiota.
Blastocystis hominis infection inducing gut microbiome dysbiosis and aggravating Parkinson's disease symptoms: a case report.
A case report describing an 86-year-old male with Parkinson's disease whose Blastocystis hominis infection and associated diarrhea resolved within 4 days of intravenous ciprofloxacin and metronidazole, with the patient also reporting mild improvement in Parkinson's disease symptoms by end of hospitalization.
Alterations in Gut Microbiota and Metabolic Profiles in Relapsed or Refractory Lymphoma.
Patients with relapsed or refractory lymphoma exhibited distinct gut microbiota compositions and metabolic profiles compared to treatment-naïve lymphoma patients, with alterations suggesting enhanced central carbon metabolism and amino acid metabolism in cancer.
The gut-prostate axis in benign prostatic hyperplasia: systematic review of microbial dysbiosis and pathogenic mechanisms.
Changes in specific gut microbiota abundances and metabolites, including an increased Firmicutes/Bacteroidetes ratio and decreased Lactobacillus abundance, as well as inflammatory indicators and markers of intestinal barrier dysfunction, may play a crucial role in the pathogenesis of BPH and may become effective diagnostic means and potential therapeutic targets.
Banxia Xiexin decoction alleviates N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric precancerous lesions by modulating the gastric microbiota.
Banxia Xiexin Decoction alleviates gastric precancerous lesions by restoring gastric microbiota dysbiosis, promoting Lactobacillus growth, suppressing Streptococcus, modulating inflammatory responses, and alleviating mucosal damage via PI3K-Akt and MAPK signaling pathways.
Analysis of biomarkers in the Human Phenotype Project using disease models from UK Biobank.
By modeling disease outcomes from the UK Biobank to predict pseudo-outcomes in the Human Phenotype Project cohort, the authors identified individual biomarkers across gut microbiome, liver ultrasound, and other modalities, recapitulating known biomarkers and revealing less-attested ones, while also identifying systemic and sex-specific biomarkers correlated with many diseases.
Pre-existing β-lactamase gene diversity is associated with lower risk of ESBL-producing Enterobacterales colonization in patients exposed to ceftriaxone.
Pre-existing β-lactamase gene diversity (β-lactamasome diversity) was independently associated with protection against ESBL-producing Enterobacterales colonization in patients receiving ceftriaxone, providing the first real-world evidence that functional resistome diversity may confer ecological protection against antibiotic-driven colonization.
Gut Associated Metabolites Enhance PD-L1 Blockade Efficacy in Prostate Cancer.
Targeting the 'gut-tumor metabolic axis' via gut-associated metabolites 16(R)-HETE and 6-Keto-PGE1 is a promising strategy to improve the efficacy of immune checkpoint inhibitors in prostate cancer by enhancing PD-L1 expression and anti-PD-L1 treatment efficacy.
Xin-Jia-Tong-Xie-Yao-Fang restores the intestinal barrier to alleviate irritable bowel syndrome via microbial butyrate mediated PI3K/Akt pathway suppression.
XJTXYF restores intestinal barrier function through microbial butyrate-mediated PI3K/Akt inhibition to improve diarrhea-predominant irritable bowel syndrome symptoms.
Altered gut microbiota, SCFAs, and barrier integrity markers in Alzheimer's and Parkinson's disease patients.
Significant reductions in beneficial gut microbiota, elevated inflammatory markers (calprotectin and zonulin), and altered short-chain fatty acid levels were observed in Parkinson's disease and Alzheimer's disease patients compared to healthy controls, suggesting microbial dysbiosis may contribute to gut barrier dysfunction and systemic inflammation.
Distinct Gut Microbiome Profiles Underlying Cardiometabolic Risk Phenotypes in Individuals with Obesity.
Selected taxon-specific gut microbiome signatures are associated with cardiometabolic risk phenotypes in obesity, with reduced Lachnospiraceae associated with metabolic syndrome, lower Faecalibacterium with arterial hypertension, and increased Prevotella with dyslipidemia.
Characterization of gut microbiota in patients with diabetic kidney disease.
Gut microbial shifts along the DM-DKD axis correlate with adverse glycemic and renal phenotypes, as well as functional characteristics associated with inflammation and barrier injury, suggesting that microbially driven metabolic and structural pathways represent potential targets for mitigating the progression of DKD.
ATOMIC: a graph attention network for atopic dermatitis prediction using human gut microbiome.
ATOMIC, an interpretable graph attention network incorporating microbial co-expression networks, outperformed baseline models in predicting atopic dermatitis from gut microbiome data, achieving an AUROC of 0.810 and AUPRC of 0.927, while identifying candidate microbial biomarkers for potential therapeutic strategies.
Establishment of threshold of human gut microbes and risk assessment system for colorectal cancer.
We established, for the first time, quantitative thresholds for CRC-associated bacteria and have driven advances in microbial risk prediction for CRC, developing a CRC evaluation intelligent system software with accuracy ranging from 89.14% to 91.50%.
Metataxonomic Analysis and Fatty Acid Profiling of Feces from Children Undergoing Hematopoietic Stem Cell Transplantation.
Children experiencing GvHD after HSCT have distinct gut microbiota and SCFA profiles, with fecal samples at engraftment characterized by loss of bacterial diversity, depletion of Blautia, and significantly lower concentrations of butyrate and acetate.
Gut Microbiota and Metabolome Dynamics Along Gastric Cancer Progression: An Exploratory Multi-Omics Analysis.
By integrating gut microbiota and metabolomic data across the Correa sequence, this study delineates stage-specific microbial and metabolic alterations in gastric cancer progression, with atrophy representing a pivotal inflection point in the transition from homeostasis to carcinogenesis.
Characteristics of gut microbiota and metabolites in patients with ulcerative colitis with fatigue.
Patients with UC with fatigue exhibit a distinct gut microbial structure and metabolomic profile, with the pro-inflammatory metabolite thromboxane and the genus Anaerococcus uniquely enriched in this group, suggesting their potential roles in the development of UC-associated fatigue.
[Differences in Oral and Gut Microbiome Composition Among Preschool Children in Urumqi During the Deciduous and Mixed Dentition Periods].
The composition of oral and gut microbiota varies among children at different dentition stages, and as dentition changes, the structural diversity and metabolic functions of both oral and gut microbiota also change.
Profound taxonomic and functional gut microbiota alterations associated with trichuriasis: cross-country and country-specific patterns.
T. trichiura infection was associated with consistent depletion of key short-chain fatty acid producers and enrichment of mucin-degrading genera across three endemic regions, suggesting compromised gut barrier function and immune modulation that may promote parasite persistence.
Long-term capsaicin intake and gut inflammation: microbial alterations, metabolic mechanisms, and intervention effects.
Long-term capsaicin intake induced gut dysbiosis characterized by increased Klebsiella and decreased Lactobacillus, which correlated with gut inflammation and dysregulation of key metabolites, while Lactobacillus plantarum and Enterococcus faecalis significantly alleviated capsaicin-induced gut inflammation by directly degrading capsaicin.
Identification of bacterial key genes and therapeutic targets in hypertensive patients with type 2 diabetes through bioinformatics analysis.
This study identified 10 bacterial hub genes associated with hypertension coexisting with type 2 diabetes and identified Bromocriptine, Naringin, and Neohesperidin as top drug candidates based on molecular docking, dynamics simulations, and ADMET evaluations.
Study on the characteristics and correlation of fecal microbiota and metabolites in patients with acute lung injury after cardiopulmonary bypass based on 16S rRNA sequencing and non-targeted metabolomics analysis.
Patients with postoperative ALI following CPB exhibit marked gut microbiota structural disruption and metabolic dysfunction, both closely associated with adverse clinical outcomes, with genera such as Bacteroides and their associated metabolites potentially serving as early predictive biomarkers.
Metabolic profiling of Gegen-Qinlian Decoction and its modified formula in gut microbiota from healthy individuals and ulcerative colitis patients with different syndromes using UHPLC-QTOF-MS/MS and an in vitro incubation model.
GQD and MGQD remained stable in artificial gastrointestinal fluids but were extensively metabolized by gut microbiota, with healthy individuals showing the highest metabolic capability followed by UC-SDS and UC-DHS patients, and metabolic rates depending on glycoside structural features.
Household Food Insecurity Alters Gut Microbiome Composition and Enriches Sutterella in Ethiopian Schoolchildren.
Food insecurity is associated with alterations in gut microbial composition in Ethiopian schoolchildren, with Sutterella consistently enriched among food-insecure participants and a microbial feature-based machine learning model accurately predicting food security status (AUC = 0.81).