Gut Microbiome
417 peer-reviewed studies indexed
Metagenomic Analysis Reveals Alterations in the Gut Microbiome of Preterm Infants with Extrauterine Growth Restriction.
Metagenomic sequencing of fecal samples from preterm infants revealed significant differences in gut microbial community composition between EUGR and normal growth (AGA) infants, with increased Klebsiella pneumoniae and Enterococcus faecalis and decreased beneficial bacteria in the EUGR group, along with higher antibiotic resistance gene abundance.
Alterations in cardiovascular biomarkers and gut microbiome associated with night shift work: Insights from the Chinese platform workers study.
Night shift work in ride-hailing drivers was significantly associated with adverse cardiovascular biomarker profiles and distinct gut microbiome alterations, with gut microbial changes linked to the observed cardiovascular risk.
Maternal and infant microbiota in early infancy: Longitudinal findings from a randomised controlled trial.
Microbial composition in breast milk and infant gut shifted over the first 8 weeks postpartum while maternal gut remained stable, and findings suggest maternal stress-reduction interventions may influence breast milk microbiota.
Gut Microbiota and Nutritional Profiles of Colon Cancer Patients Undergoing Chemotherapy: A Longitudinal Pilot Study.
Chemotherapy was associated with declines in diet quality and gut microbial alpha diversity, and higher diet quality appeared protective against microbial disruption, supporting a bidirectional relationship between diet and the gut microbiome during chemotherapy.
Adenosine signaling driven by the gut microbiota underlies chronic alcohol-induced anesthetic resistance.
Long-term alcohol exposure reduces anesthetic efficacy via a gut microbiota-adenosine pathway that downregulates GABA receptors, mediating alcohol-induced anesthetic resistance.
Plasmacytoid dendritic cell-mediated L-glutamate catabolism links gut microbiota to male infertility.
This study provides suggestive genetic evidence that pDC-mediated glutamate catabolism may connect gut microbial metabolic activity to male infertility.
Gut Microbial Composition and Short-Chain Fatty Acid Metabolism in Cognitively Unimpaired Adults Stratified by Amyloid-β Status.
Distinct SCFA-microbial interaction patterns in Aβ High individuals suggest subtle early gut microbial alterations linked to amyloid burden, highlighting the potential role of SCFA-related microbial pathways in preclinical AD.
Epigenetic Role of Gastrointestinal Microbiota in Individuals Receiving Hemodialysis.
Statistically significant correlations were found between a subset of GI microbiota and miRNA that were different in groups with varying levels of fiber intake and physical activity, suggesting diet and exercise as potential modifiable factors to modulate the epigenetic role of GI microbiota in individuals receiving hemodialysis.
Gut-liver axis dysregulation in colitis underlies structure-dependent pharmacokinetics of a traditional Chinese medicine.
UC-induced alterations in liver metabolism and gut microbiota cause structure-dependent pharmacokinetic shifts in a multi-component herbal formula, with iridoids and flavonoids showing reduced systemic exposure, alkaloids showing delayed elimination, and dysregulation of hepatic enzymes and microbial glycoside hydrolases identified as key determinants.
Altered abundance in cancer patients gut of diadenylate cyclase-encoding bacteria.
c-di-AMP-producing bacteria are depleted in cancer-associated microbiota, with DAC-encoding species showing significantly higher abundance in healthy subjects compared to cancer patients across melanoma, NSCLC, and renal carcinoma.
Associations Between Gut Microbiome Enterotypes and Body Weight Change During Whole Milk Consumption.
Gut microbial enterotypes modulate body weight and metabolite responses to whole milk consumption, with Bacteroides1 enterotype individuals showing decreases in body weight while Ruminococcaceae enterotype individuals do not, identifying enterotype as 'a strong predictor of body weight change.'
Differences in gut microbiota and faecal metabolomics characteristics in preterm infants with feeding intolerance.
Bacterial genera Staphylococcus, Clostridium_P, Bifidobacterium, and Escherichia in gut microbiota, along with metabolites Arg-Pro, Glu-Arg, and lactaldehyde, can serve as diagnostic criteria for feeding tolerance in preterm infants.
Integrated Microbiome and Metabolomic Profiling to Identify Potential Biomarkers of Major Depressive Disorder.
An integrated multi-omics approach in a Korean cohort identified a functional 'gut-lipid axis' in MDD, where enrichment of Eubacterium eligens group and Veillonella was associated with alterations in acylcarnitine and fatty acid metabolism, and plasma metabolic profiling yielded superior diagnostic accuracy (AUC = 0.862) compared to gut microbiota profiling (AUC = 0.654).
Mass azithromycin distribution and antibiotic resistance in the gut and nasopharynx: a cluster-randomized trial.
Mass azithromycin distribution to children 1-59 months significantly increased gut macrolide AMR burden compared to placebo, while targeting only infants (1-11 months) did not, and no statistically significant differences in nasopharyngeal macrolide AMR were detected between arms.
Early-life herbicides exposure with gut microbiota and neurobehavioral development of hospitalized infants in China.
Herbicides exposure was inversely associated with neurobehavioral development of hospitalized infants, with potential mechanisms involving translation, ribosome function, and amino acid and derivative metabolism, and herbicides exposure also significantly altered infant gut microbiome.
Oral Microbiota Alterations and Potential Salivary Biomarkers in Colorectal Cancer: A Next-Generation Sequencing Study.
Oral microbiota analysis via next-generation sequencing revealed significant differences in microbial community composition between CRC patients and healthy controls, with specific taxa including Metamycoplasma salivarium, Bacteroides intestinalis, and Pseudoprevotella muciniphila identified as potential salivary biomarkers for colorectal cancer.
Portal Vein Tryptophan Pathway Analysis Reveals Gut-Mediated Inflammatory Pathway Predominance in HCV Infection.
Elevated kynurenine in portal blood suggests upregulation of gut-mediated pro-inflammatory pathways during HCV infection, with integration of multi-omics data from the gut-liver axis highlighting the contribution of the tryptophan pathway to inflammatory responses in HCV.
Host factors dictate gut microbiome alterations in chronic kidney disease more strongly than kidney function.
Intestinal transit time and medications significantly explained microbiome variation in CKD more than eGFR-related effects, and only three covariate-independent microbial markers for eGFR were identified, none of which replicated convincingly across 11 studies.
Modulating Bacteroides to boost anti-PD-1 immunotherapy in HCC.
Bacteroides thetaiotaomicron was identified as a key immunomodulatory species that enhances anti-PD-1 efficacy in HCC by reprogramming dendritic cells through the KLF2/TLR9 signaling pathway.
Meta-analysis of the effectiveness of fecal microbiota transplantation in the treatment of metabolic-associated fatty liver disease: A systematic review based on liver inflammation indicators and fat content.
FMT effectively improves hepatic inflammation and steatosis in MASLD, with age modulating ALT response, while lack of BMI improvement suggests localized liver effects rather than systemic metabolic impact, supporting FMT as a targeted adjunctive therapy.
Polyphenols Nonmonotonically Modulate the Inulin-Driven Gut Microbial Network In Vivo.
In a high-fiber context, polyphenols act as subtle modulators rather than primary drivers, whose structure and dose critically shape microbiome function through nonmonotonic dose-response changes in short-chain fatty acid production.
Sinomenine regulated gut-joint axis for alleviating rheumatoid arthritis.
Sinomenine exerts anti-arthritis effects, at least in part, by regulating the gut microbiota, as demonstrated by loss of efficacy in pseudo-sterile CIA rats treated with broad-spectrum antimicrobials.
Discriminative Gut Microbial Signatures in Hyperuricemia and Overweight Populations Revealed by Metagenomic Sequencing.
Gut microbial compositional alterations, reduced alpha-diversity, and discriminatory species identified by LEfSe represent potential biomarkers for chronic metabolic disease progression in hyperuricemia and overweight individuals.
Dysbiosis of intestinal microbiota in patients with neuromyelitis optica spectrum disorders.
Gut microbiome dysbiosis and metabolic abnormalities were found in NMOSD patients compared to healthy controls, and these differences were markedly alleviated after six months of immunosuppressive treatment.
Loss of eating control and cognitive flexibility: Involvement of gut microbiota.
Gut microbiota transplanted from human subjects with high or low cognitive flexibility modified short-term and long-term memory performance in mice depending on diet exposure, showing that gut microbiota is a major contributor to cognitive flexibility.
Gut microbiota and metabolic pathway profiles in infected and non-infected heart transplant patients before and after surgery.
Dynamic preoperative shifts in the Bacteroides-Enterococcus-Limosilactobacillus axis and postoperative shifts toward Blautia-Enterococcus dominance were found in heart transplant patients and were associated with infection status and antibiotic exposure.
Multi-omics insights into gut microbial dysbiosis and metabolic alterations in immune checkpoint inhibitor-induced thrombocytopenia.
Multi-omics analysis revealed that patients with immune checkpoint inhibitor-induced thrombocytopenia exhibited distinct gut microbiota profiles and systemic arginine depletion, suggesting that disruptions in arginine and associated metabolic pathways are associated with ICIs-TCP pathogenesis.
Gut microbial signatures in schizophrenia: exploring archaea, fungi, and bacteria.
Gut microbial signatures in schizophrenia include significantly lower archaeal α-diversity and distinct β-diversity differences across archaea, fungi, and bacteria, with functional differences concentrated in glucose, lipid and amino acid metabolic pathways, and potential diagnostic biomarker panels achieving AUCs of 0.73, 0.69, and 0.74 for archaea, fungi, and bacteria respectively.
Revolutionizing hepatic fibrosis staging: A machine learning approach combining clinical, biochemical, and microbiome insights.
Machine learning models integrating clinical, biochemical, and microbiome data demonstrated excellent classification accuracy for non-invasive hepatic fibrosis staging in NASH patients, with balanced accuracy of 99.1% for Random Forest and AUC of 1.0 for XGBoost, outperforming traditional scoring systems.
Cohort profile: Infant Gut Bacterial Study in Nigeria (INBUGS-NG).
The Infant Gut Bacterial Study in Nigeria (INBUGS-NG) is a prospective longitudinal cohort of 90 mother-infant dyads enrolled at a tertiary hospital in Kano city, Nigeria, investigating how delivery mode, antibiotic exposure, feeding practices and environmental factors shape gut microbiome development and acquisition of antibiotic resistance genes during the first year of life.
Machine Learning-based Diagnostic Potential of Bipolar Disorder Using Gut Microbiota Signatures.
Machine learning models using gut microbiota signatures demonstrated excellent diagnostic performance for bipolar disorder, with a combined compositional and functional random forest model achieving AUC=0.9499 and AUPR=0.9586.
Gut microbiota alterations and microbial translocation in HIV/SARS-CoV-2 co-infected patients.
HIV/SARS-CoV-2 co-infection is characterized by heightened microbial translocation and species-specific microbiota alterations rather than global dysbiosis, with Blautia depletion potentially correlating with COVID-19 severity.
The Role of Changes in the Proportion of Fecal Short-Chain Fatty Acids on the Severity of Hepatic Encephalopathy in Cirrhosis Patients.
Changes in SCFA composition may be associated with the presence of hepatic encephalopathy in cirrhosis patients, although no statistically significant relationships were found in multivariable analysis.
Fecal microbiome predicts treatment response after the initiation of semaglutide or empagliflozin uptake.
Semaglutide and empagliflozin use is associated with changes in the gut microbiome after treatment initiation, and the baseline gut microbiome predicted changes in glycohemoglobin for both semaglutide and empagliflozin users.
Alterations in gut microbiota and their association with nutrition and disease progression in advanced schistosomiasis.
Advanced schistosomiasis exhibited significantly lower β-diversity and reduced relative abundance of Bacteroidetes, with gut microbiota alterations closely associated with disease progression and nutritional status, and Veillonella identified as the most discriminative genus separating advanced from chronic schistosomiasis.
Gut virome and metabolic associations in patients with acute pancreatitis.
AP is characterized by profound gut virome remodeling reflecting disease severity and etiology, with diagnostic and mechanistic relevance, and a minimal seven-virus panel achieved an AUC of 97.5% for AP classification.
The gut-heart axis in coronary artery disease: a scoping and narrative review of sex-based microbial and metabolic disparities.
Preliminary studies suggest sex-related differences in gut microbiota composition and metabolite profiles in CAD patients, with men showing increased pro-inflammatory taxa and elevated TMAO and indoxyl sulfate levels, while women show enrichment in potentially beneficial taxa and higher secondary bile acids.
Interplay between colorectal cancer-related lifestyles and the gut microbiome: an exploratory analysis of metagenomic data.
Higher-risk lifestyles for colorectal cancer were associated with lower microbial diversity and differences in gut microbiome composition, with higher relative abundance of Lachnospiraceae-related species and lower relative abundance of Bifidobacterium species.
Liraglutide alters gut microbiota and improves endothelium-dependent relaxation in db/db mice.
Liraglutide improves endothelium-dependent relaxation and eNOS/NO signaling in diabetic db/db mice and high-glucose-exposed HUVECs, associated with restoration of gut microbial diversity and enrichment of SCFA-producing taxa, supporting the concept of a GLP-1RA-microbiome-vascular axis.
N-Acetylglucosamine and Immunoglobulin Strengthen Gut Barrier Integrity via Complementary Microbiome Modulation.
SBI and NAG exert complementary, metabolically balanced effects on the gut microbiota, with combined use producing the strongest improvement in gut barrier integrity (+36% TEER) via distinct and additive shifts in microbial composition and metabolite output.
Integrated analysis of gut microbiome and fecal metabolome reveals potential non-invasive biomarkers for early-stage silicosis.
Integrated gut microbiome and fecal metabolome analysis identified stage I silicosis as a critical turning point of microbial dysbiosis, with microbe-metabolite signatures such as Lactobacillus with N-succinyl-2-amino-6-ketopimelate achieving an AUC of 0.84 for distinguishing early-stage silicosis patients from healthy controls.
Gut microbiota and metabolomic changes across preterm stages: potential associations with bronchopulmonary dysplasia.
Integrated multiomics analysis of preterm infant fecal samples identified altered Bacteroidota succession and Streptococcus-associated oxidative imbalance as early microbial-metabolic perturbations potentially associated with bronchopulmonary dysplasia development.
The perioperative microbiome of patients undergoing rectal cancer surgery: A pilot study.
This pilot study reveals significant perioperative shifts in the gut microbiome of rectal cancer patients, including postoperative decreases in alpha diversity and increases in Enterococcus and Streptococcus, underscoring the importance of considering microbiome dynamics perioperatively when designing and interpreting studies that correlate the microbiome with clinical outcomes.
Paired Duodenal and Salivary Microbiome Analysis in Pancreatic Cancer Without Duct Obstruction.
PDAC is associated with reduced duodenal phylogenetic diversity and subtle disease-related shifts in duodenal microbiota, independent of major confounders and in the absence of duct obstruction, with salivary α-diversity and selected genera holding prognostic relevance.
Modulation of gut microbiota and its metabolite Equol by Huaier granule suppresses hepatocellular carcinoma via the gut-liver axis.
Huaier granule suppresses hepatocellular carcinoma in a gut microbiota-dependent manner by modulating gut microbiota composition and increasing Equol production via Adlercreutzia, which inhibits HCC through the MAPK signaling pathway and Cyclin E1-CDK2/Rb-mediated G0/G1 phase blockade.
Primate gut microbiota induce evolutionarily salient changes in mouse neurodevelopment.
Inoculation of germ-free mice with primate gut microbiota induces evolutionarily salient changes in brain gene expression, with larger-brained primate GMs upregulating energy production genes and human GMs specifically increasing oxidative phosphorylation gene expression correlated with glucose metabolism pathways.
Variation in microbiome and metabolites is associated with advantageous effects of cholestyramine on primary biliary cholangitis with pruritus.
Cholestyramine mitigates pruritus in primary biliary cholangitis by modulating the microbiome-metabolite-host axis, specifically through the Romboutsia-norharman-ATX/ALP axis, with Enterobacteriaceae/long-chain fatty acids identified as significant markers for predicting cholestyramine response.
The Effects of Soy Protein-Rich Meals on Muscle Health of Older Adults Are Linked to Gut Microbiome Modifications.
A soy protein-rich dietary intervention improved muscle health in older adults through beneficial gut microbiota modifications, supporting the gut-muscle axis hypothesis and suggesting dietary soy protein may alleviate sarcopenia by promoting a healthier gut microbiome.
Elucidation of mechanisms underlying the therapeutic effects of cordycepin on pulmonary hypertension, with a focus on cell senescence and gut microbiota.
Cordycepin exerts multi-target therapeutic effects in PH by inhibiting PASMC proliferation via the p53-CDK1/pTERT axis, modulating gut microbiota-linked immunometabolism, and inducing proinflammatory macrophage senescence.
Microbiome-Metabolome Crosstalk as a Driver of COVID-19 Severity.
Severe COVID-19 was associated with reduced microbial diversity and enrichment of pro-inflammatory taxa alongside alterations in bile acids, unsaturated fatty acids, tryptophan, and inositol phosphate pathways, highlighting associations between gut microbiota composition, microbial metabolism, and circulating metabolites in COVID-19 severity.