Aging & Longevity
500 peer-reviewed studies indexed
The influence of social support on active aging in chronic disease patients among older adults: mediating role of coping strategies.
Social support contributes to higher levels of active aging among older adults with chronic diseases through both direct and indirect pathways, with medical coping styles partially mediating the relationship and confrontation coping style exerting a significant positive influence on active aging.
Characterizing mitochondrial phenotypes and MERCS in aged human skeletal muscle myoblasts.
Aged human skeletal muscle myoblasts exhibit senescence features, mitochondrial hyperfusion, increased mitochondrial DNA content, and elevated mitochondria-endoplasmic reticulum contact sites (MERCS) associated with oxidative stress, yet mitochondrial oxygen consumption rate and membrane potential per mitochondrial area remain comparable to young cells.
The role of frailty in the association between testosterone levels and mortality risk in older men.
Frailty substantially mediates the association between testosterone levels and mortality in older men, accounting for 35.9% of the total effect for all-cause mortality and 21.7% for cardiovascular disease mortality.
Education shapes the link between EEG aperiodic components and cognitive aging.
Education moderates the relationship between EEG aperiodic components (exponent and offset) and cognitive performance, such that among older adults the direction of the association between aperiodic components and MMSE scores reverses depending on educational level.
Composition of the Gut Microbiota in Older Adults Residing in a Nursing Home and Its Association with Dementia.
Age-related remodeling of the gut microbiota was observed in nursing home residents, with dementia associated with a distinct microbial signature including enrichment of Actinobacteriota, Euryarchaeota, and Proteobacteria alongside depletion of Bacteroidota and Firmicutes, suggesting increased inflammatory species correlate with dementia-related microbiota changes.
Associations of Lifetime Cognitive Enrichment With Incident Alzheimer Disease Dementia, Cognitive Aging, and Cognitive Resilience.
Lifetime exposure to cognitive enrichment was related to lower risk of AD dementia and a slower rate of cognitive decline, including after adjustment for common ADRD pathologies, indicating higher resilience provided by lifetime enrichment.
LS-MAT: Lifespan structural magnetic resonance imaging synthesis for microstructural covariance profile analysis toolbox.
LS-MAT, a generative framework integrating a variational autoencoder with GAN, latent diffusion model, and ControlNet, achieves strong performance in synthesizing personalized multimodal age-conditioned structural MRIs across ages 5-100 years, outperforming previous approaches in both modality conversion and age-conditioned synthesis tasks.
The transcriptomic signature of age and sex is not conserved in human primary myotubes.
A comparison of the transcriptomic signature of 30 human muscle biopsies and their corresponding differentiated HPMCs indicated a near-complete lack of retention of the genes and pathways differentially regulated in vivo when compared to their in vitro equivalent, with the exception of several genes encoded on the Y-chromosome.
Religiosity, spiritual practices, and epigenetic aging: Insights from a population-based sample of middle-aged US adults.
Several dimensions of religiosity and spirituality were associated with slower epigenetic age acceleration, but after accounting for health behaviors (smoking, alcohol, BMI), only religious/spiritual coping remained significantly associated with a slower pace of aging as measured by DunedinPACE.
Association of biological age markers with stroke prevalence: Insights from a cross-sectional study.
Biological age markers, particularly PhenoAge and its acceleration, were significantly associated with stroke prevalence and all-cause mortality, suggesting they may enhance stroke risk stratification and management.
Physical frailty, self-rated health, and all-cause mortality: implications for understanding resilience in aging.
Physical frailty and self-rated health, while related, capture distinct aspects of health, each independently and jointly predicting all-cause mortality, with SRH retaining prognostic value even among frail individuals.
From behavior to belonging: reframing exercise participation as a psychosocial pathway to active aging.
Exercise participation enhanced life satisfaction both directly and indirectly via psychological wellbeing and social connectedness among older adults, with these psychosocial mediators accounting for 43% of the total effect.
Latent Toxoplasma gondii Infection Does Not Modulate Immune Aging in a Cross-Sectional Working-Age Population Study.
Latent T. gondii infection exhibited significant bivariate associations with immune aging markers, but associations with immunosenescence biomarkers disappeared when adjusting for sex and age, suggesting latent T. gondii infection is unlikely to modulate immune aging concerning cellular senescence in otherwise healthy working-age adults.
Aging-related CD8+ T cell alterations and calcium/calmodulin dependent protein kinase 1D activation in the pathogenesis of diabetic kidney disease.
CD8+ T cells decline progressively from young individuals to elderly subjects to DKD patients, and CAMK1D exhibited the strongest causal relationship with DKD, potentially serving as a shared molecular risk factor linking aging and diabetic renal injury.
Replicated evidence for an accelerated rate of whole-body aging in schizophrenia.
Consistent evidence of faster DunedinPACNI was found in schizophrenia compared with controls across four neuroimaging datasets, supporting the hypothesis that schizophrenia is accompanied by accelerated whole-body aging that is not explained by familial risk, tobacco smoking, or antipsychotic medication use.
Advancing global precision in dementia research: Examining Normative Heterogeneity of Aging and Neurodegeneration in Chinese Elders (ENHANCE).
The ENHANCE project uses a transadaptation approach to develop culturally and linguistically appropriate cognitive assessments for Cantonese and Mandarin-speaking Chinese American elders, combining data from UCSF, ISMMS, and NACC to explore cross-cultural differences in AD/ADRD risk and progression.
Amyloid burden, brain metabolism, and gray matter volume in SuperAgers.
SuperAgers exhibited similar amyloid burden to age-matched healthy controls, yet amyloid deposition specifically impaired their memory, while increased rBGM and GMV in the salience network and striatum suggest these regions support successful cognitive aging.
Pupil dilation as a marker of attention/effort in aging and mild cognitive impairment.
Pupil dilation is a useful marker for investigating attention and cognitive effort in MCI, as suggested by elevated PD to salient stimuli in particular of individuals with better attentional control in MCI patients, as well as younger and older adults.
Aging affordances: Navigating expectations of dementia prevention for aging adults in Canada.
Drawing from interviews with dementia experts and middle-aged adults in Canada, the authors propose 'aging affordances' as the particular ways mid-life adults construct, make sense of, and act toward their aging process as they navigate expectations of dementia prevention amidst competing tensions.
How do autistic adults experience ageing? A qualitative interview study.
Autistic adults aged 46-72 reported that current ageing support is generally felt to be incompatible with autistic adults' characteristics, highlighting a need for increasing societal knowledge about ageing with autism and for improved, autism-informed services.
Age-Related Olfactory and Cognitive Decline: Potential Effects of Rosmarinus officinalis and Carum carvi Essential Oils.
Olfactory function could be a potential early indicator of attentional, memory, language, and visuospatial/executive dysfunctions, and rosemary and caraway essential oils were perceived without any significant decrease in odor pleasantness, intensity, and familiarity ratings in relation to aging.
Event-Related Potentials as Markers of Age-Related Changes of Spatial Hearing in Normal-Hearing Adults.
ERPs, specifically N100 amplitudes, showed strong correlation with age and unmasking function, underscoring 'the validity of ERP components as markers of spatial hearing performance and aging' in normal-hearing adults.
Zinc Supplementation Partially Reconstitutes Impaired Interferon-γ Production in the Elderly.
Zinc supplementation in zinc-deficient elderly hospitalized patients for approximately 7 days resulted in increased serum zinc levels, increased IFN-γ production, and a trend toward increased ZIP8 expression, partially reconstituting impaired interferon-γ production.
Precision estimates of longitudinal brain aging capture unexpected individual differences in one year.
Cluster scanning, an approach that reduces measurement error by densely repeating rapid structural scans, substantially improves precision of individualized brain aging estimates, revealing previously undetectable individual differences in brain change across three timepoints in one year.
Single-cell transcriptional and epigenomic landscape of human blood immune cells across the lifespan.
Single-cell RNA sequencing and ATAC sequencing of peripheral blood mononuclear cells from healthy donors spanning mid-fetal to late adulthood revealed age-associated reprogramming across lymphoid and myeloid lineages, with T cells undergoing the most significant transcriptional remodeling and various age-related immune cell signatures identified across the lifespan.
Association of adverse and positive childhood experiences with subjective age: findings from 5759 Chinese young adults.
ACEs significantly increased the risk of subjective aging, while PCEs significantly buffered ACEs' impact, revealing their protective role in aging perceptions.
Determinants of oral functions and oral frailty in older community-dwelling individuals: a comprehensive analysis.
Oral function determinants show age-related changes and have the potential to estimate the prevalence of poor oral functions in older community-dwelling individuals, with chewing strokes, natural teeth, and tongue pressure identified as significant predictors of age.
Largely Distinct Post-Translational Modifications Differentiate Skeletal Muscle Wasting Caused by Cancer, Dexamethasone and Aging.
Most post-translational modifications associated with muscle wasting are stimulus-specific, but P27 dihydroxylation of Lrpprc declines during muscle wasting induced by cancer, dexamethasone, and aging, and experimental expression of the dihydroxylation-resistant variant LrpprcP27A reduces muscle force in young and old mice, suggesting this modification contributes to disease-associated muscle weakness.
Ventromedial prefrontal cortex supports prototype representations in healthy older adults.
Both young and older adults recruited the ventromedial prefrontal cortex to support prototype-based generalization, and engagement of the VMPFC prototype-learning system may help maintain concept generalization in older adults despite age-related memory declines.
Aging-associated GSK3β overexpression exacerbates hepatic ischemia-reperfusion injury through Nrf2 deficiency-induced hepatocyte ferroptosis.
Aging-induced GSK3β overexpression drives Nrf2 deficiency-mediated ferroptosis in hepatocytes, thereby exacerbating hepatic ischemia-reperfusion injury, and pharmacological targeting of this pathway via microdose lithium or ferrostatin-1 alleviates HIRI in aged mice.
Eugenol Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Senescence via Downregulation of Milk Fat Globule-EGF Factor 8.
Eugenol prevents Ang II-induced aging in VSMCs and vascular tissues by downregulating MFG-E8 expression, underscoring its potential as an antiaging drug.
Creatine plus β-Hydroxy-β-Methylbutyrate supplementation is associated with preserved glutathione redox-balance and redox-function associations in older adults: a secondary analysis of a randomized crossover trial.
Creatine plus HMB supplementation was associated with nominal modulation of glutathione-centered redox balance during training in active older adults, though effects did not remain significant after FDR adjustment, and exploratory redox-function associations support further investigation in larger, adequately powered trials.
Community threat, positive parenting, and accelerated epigenetic aging: Longitudinal links from childhood to adolescence.
Positive parenting reduced the pace of epigenetic aging in contexts of low, but not high, community threat, suggesting that multilevel interventions across multiple socioecological systems may be necessary to prevent the biological embedding of early life adversity.
"Everything We Do in Life Is a Teaching Tool": The Role of Indigenous Cultural Generativity in Promoting "Aging in a Good Way" and Cultural Endurance.
Indigenous cultural generativity is not solely a component of Alaska Native successful aging, but the primary pathway to achieving successful aging.
Short telomeres in mitochondrial DNA depletion disorders.
Telomere length was shorter overall in patients with mitochondrial DNA depletion disorders compared to healthy controls, with the most significant differences observed in granulocytes, suggesting telomere length may have potential as a biomarker in mitochondrial disease.
Concurrent associations between visit-to-visit changes in actigraphy-based physical activity and cognitive aging in older adults.
Within-person increases in daily step count were most strongly associated with within-person increases in executive functioning and decreases in depressive symptoms, suggesting that changes in PA may reduce real-time risk of cognitive decline in older adults.
Multidimensional approach of theory of mind in healthy aging.
A multidimensional assessment of Theory of Mind showed a progressive age-related decline across all ToM dimensions, although the direction and magnitude of effects varied depending on the contextual demands involved.
State but not trait measures of vividness relate to memory accuracy.
Trial-by-trial state measures of vividness were significantly related to subsequent memory performance, while trait-level and averaged measures of vividness did not predict memory accuracy.
Distinct roles of chronotype, daytime napping, and sleep duration in biological and functional aging: a univariable and multivariable Mendelian randomization study.
Sleep traits show distinct, partly independent causal links with aging: excessive napping adversely influences GrimAge and frailty; longer sleep duration independently protects against frailty; and chronotype benefits facial ageing and cognition after accounting for other sleep behaviors.
The cardiac neurovascular unit: sympathetic control of the capillary network in aging and transplantation.
This study identifies a previously unrecognized cardiac neurovascular unit in which sympathetic fibers lie in close anatomical apposition to capillary endothelial cells, and shows that disruption of this interface during aging, pharmacological sympathectomy, or heart transplantation is associated with capillary remodeling and cardiomyocyte atrophy.
Accelerated brain aging in prolonged grief disorder of later life: Influence of comorbid depression.
Adults with PGD exhibit structural brain patterns consistent with accelerated and AD-like aging, but these findings were largely driven by comorbid depressive symptoms.
LEAP2 acts in hepatocytes and at central level, alleviates steatosis and inflammation but resistance in obese and aging.
LEAP2 inhibits lipid accumulation in hepatocytes and reduces hepatic lipid deposition in standard diet-fed mice, but fails to prevent high-fat diet-induced steatosis in young mice and age-associated steatosis and inflammation in aged animals, suggesting resistance to LEAP2 in obese and aging conditions.
Associations Between Cardiovascular Risk Factors and Neurofilament Light Levels Among US Mexican American Adults.
NfL levels differed between Mexican American and non-Latino White participants based on diabetes and CVD diagnosis, with more pronounced differences in the MA group, and the association between white matter hyperintensity volume and NfL was steeper in the MA group.
Exposure to benzene, toluene and xylenes (BTX) and biological aging: epidemiological evidence from Chinese industrial workers and mechanistic insights.
Higher urinary BTX metabolites, particularly benzene biomarkers SPMA and TTMA, were associated with higher biological age acceleration in Chinese industrial workers, with network toxicology implicating oxidative stress, inflammatory signaling, and cell-cycle regulation pathways.
The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus.
The Smarcal1-Usp37 locus modulates hippocampal polyglucosan body burden in aged mice through trans-regulation of glycogen-mobilizing factors, and cognition remains intact despite age-related polyglucosan body accumulation.
Nourishing longevity: sustainable healthy eating behaviors and successful aging in community-dwelling older adults, Abha, Saudi Arabia.
Sustainable healthy eating behaviors emerged as a significant predictor of successful aging among community-dwelling older adults in Saudi Arabia, alongside sociodemographic factors, physical activity, and sleep quality.
Gender-related facilitators and barriers to participation in research on aging using fuzzy cognitive mapping.
Fuzzy cognitive mapping identified both shared and gender-dissociable barriers and facilitators to participation in cognitive neuroscience aging research, with prior personal/professional experiences facilitating women's engagement and willingness to return benefits to the general population encouraging men's participation.
Effects of age and mild cognitive impairment on postural control during lifting a load.
Aging and MCI differentially affect the ability to regulate APAs and CPAs during lifting, with young adults demonstrating efficient scaling and rapid adaptation, older adults showing reduced anticipatory efficiency and slower adjustment, and individuals with MCI exhibiting exaggerated yet less targeted APA patterns suggesting impaired strategy selection.
The growing burden of Alzheimer's Disease and other dementias in China: Lessons for an aging society.
Using Global Burden of Disease 2021 data, substantial increases in incidence and prevalence of Alzheimer's disease and other dementias were observed in China over the past three decades, particularly among women and the oldest age groups, underscoring growing strain on family-based care systems.
Developing strategies and quality control in the Ageing and Brain Working Study in ELSA-Brasil.
The adoption of systematic stages of development and quality control was fundamental to ensure the production and reliability of information from brain neuroimaging studies in the Ageing and Brain Working Study linked to ELSA-Brasil.