Aging & Longevity
500 peer-reviewed studies indexed
Modifying Role of Sustainable Diets on the Association Between Particulate Matter and Biological Aging: The Guangzhou Biobank Cohort Study.
Sustainable dietary patterns rich in plant-based foods may attenuate the associations between air pollution and biological aging in older adults, with stronger associations found in those with lower polygenic risk scores for longevity.
Sensitivity to horizontal and vertical spatial relations in younger and older adults' face perception.
Older adults showed much stronger age-related decline in sensitivity to vertical than horizontal 2nd order spatial relations in faces, with impaired internal feature coding and loss of spatial cue integration, though intact inversion effects suggest elderly still process faces using category-specific modules.
Harmonization of late-life participation in cognitively stimulating activities across four cohort studies of cognitive aging.
Harmonized self-reported cognitive activity data across four cohort studies using an item-banking approach demonstrated that the harmonized factor score was associated with incident AD dementia, cognitive decline, and cognitive resilience, supporting the utility of combining psychosocial survey data across studies to evaluate modifiable risk factors for ADRD.
The impact of Internet use on older adults' attitudes toward positive aging: evidence from China.
Internet use has a significant positive impact on the rejuvenation of age identity in older adults, partially mediated by life satisfaction and health comparisons with peers, with online life services and social interaction functions exerting greater influence than entertainment and information functions.
Transitioning from Anti-aging to Skin Activation: Limiting Cellular Fatigue and Senescence for Skin Longevity.
A skin activation program targeting ECM remodeling, barrier restoration, and senescent cell reduction demonstrated significant improvements in skin structure and function, representing a shift from broad anti-aging to targeted skin activation for skin longevity.
The processing of ambiguous words without context: Semantic activation, inhibition, selection and controlled retrieval in younger and older adults.
Aging selectively affects semantic selection, whereas activation, early inhibition, and controlled retrieval remain largely intact, challenging global decline models of cognitive aging.
Age-related diversity of the oral and gut microbiome and its correlation with systemic fatty acids and cytokine profiles in healthy subjects.
This study characterized oral and gut microbiome composition across age groups in healthy adults and correlated them with systemic fatty acid and cytokine profiles, finding that age critically shapes microbiome composition and associated metabolites.
A versatile platform for sequential glyco-, phospho-, and proteomics with multi-PTMs integration.
MuPPE (Multi-level PTMs-Proteomic Enrichment platform) enables sequential glycoproteome, phosphoproteome, and proteome analysis from single biological samples with superior reproducibility (CV 12.3% vs 17.6%) and 87.5% reduction in processing time compared to conventional methods.
Subjective well-being and allostatic load in multimorbidity transitions: A multi-state survival analysis of three international longitudinal cohorts.
Low SWB functions as a generalized driver of multimorbidity, whereas high AL specifically accelerates cognitive pathways, and their combined presence triples the risk of complex physical-psychological-cognitive multimorbidity.
Genetic insights into number of long-term conditions and their relationship with lifespan.
This study identifies significant genetic factors associated with LTC burden and their association with lifespan, finding that individuals in the highest 10% polygenic risk score for LTC burden had, on average, a 0.9-year shorter lifespan and 0.73 more long-term conditions than those in the lowest 10%.
Preserved perception-action dissociation but altered visuomotor behaviours in healthy aging.
The perception-action dissociation is preserved in healthy aging, but older adults rely more on contextual cues during action, potentially reflecting compensatory mechanisms to maintain visuomotor performance.
Growth arrest-specific 6 rejuvenates senescent HUCMSCs through upregulating Nrf2 for diabetic wound therapy.
GAS6 rejuvenates senescent HUCMSCs by promoting Nrf2 nuclear accumulation through PI3K/Akt-mediated p62 upregulation and p62-dependent Keap1 degradation, thereby improving the angiogenic capacity of aging MSC-conditioned medium for diabetic wound healing.
Entropy of Muscle Fiber Histology Predicts Mobility in Older Adults: The Study of Muscle, Mobility, and Aging.
Entropy of muscle fiber histology, quantified as a homeostatic dysregulation index of muscle (HDIM), was associated with slower 400-m walk speed, lower peak VO2, muscle power, and decreased maximum rate of oxidative phosphorylation, suggesting muscle fibers accumulate entropy with aging that contributes to physical performance decline.
Prognostic value of senescence, lymphatic proliferation, and histology in post-COVID-19 interstitial lung disease.
Cellular senescence and lymphatic proliferation in lung tissue are associated with impaired gas exchange in mid-term follow-up, suggesting their potential as prognostic markers in post-COVID-19 ILD.
Associations of adiposity, atherogenic lipid phenotypes, systemic immune-inflammatory indices, and vascular aging markers with depression in US adults: NHANES 2005-2020.
Adiposity, dyslipidemia, systemic immune-inflammatory activation, and vascular aging were independently associated with moderate-to-severe depression in US adults, with associations generally stronger in women than in men.
The effect of base-rate priors on decision-making and confidence in healthy aging.
Older and younger adults can incorporate base-rate priors in perceptual decision-making, with older adults particularly benefiting from implicit learning of the prior, while explicit prior knowledge negatively impacted older adults' performance relative to younger adults.
Longitudinal changes in epigenetic clocks predict survival in the InCHIANTI cohort.
Faster increases in several epigenetic clocks over time were linked robustly to higher risk of death, independent of baseline epigenetic age and other confounders, in a longitudinal study of 699 adults followed for up to 24 years.
The Immune-Autonomic Interface in Aging: Baseline Immune Profile Shapes Cardiac Autonomic Response to Exercise.
Baseline levels of specific immune cell subsets (B-cells, T-cells, CD4+/CD8+ ratio, and NK cells) were significantly associated with the pattern and magnitude of exercise-induced HRV changes, indicating that the pre-existing immune state modulates the dynamic cardiac autonomic response to stress in older adults.
Cognitive and motor inhibition in balance-related tasks: task-specific associations with executive and physical functions in young and older adults.
Cognitive and motor inhibition in balance-related tasks showed task-specific associations with general inhibition tests in young adults but not older adults, supporting the notion that the balance-related tasks comprise different aspects of inhibitory control.
Age- and Genotype-Associated Specific Expression of IL-1 and TNF Receptors on Immunocompetent Cells.
This study reveals significant, cell-specific alterations in the IL-1 and TNF receptor landscapes with age, with monocytes being particularly affected, and demonstrates that genetic polymorphisms exert age-dependent effects on receptor expression, highlighting the dynamic interplay between genetics and immunosenescence.
The Mediating Role of Biological Age Advance in the Association Between Periodontitis and Mortality: Biological Aging Links Periodontitis to Mortality.
Biological aging (assessed by PhenoAge and KDM advances) plays a significant, though partial, mediating role in the link between periodontitis and elevated mortality.
'Aging without growing old': Identity reconstruction and individualization among rural older adults in China.
Rural older adults in China navigate the erosion of filial obligation and inadequate socialized care by employing dual instrumental and moral agency to reconstruct dignity, identity, and meaning in later life.
Exploring the dynamic biopsychosocial health needs of middle-aged adults living alone: a qualitative study.
Semi-structured interviews with 12 middle-aged adults living alone in South Korea revealed five themes around health needs, with participants valuing independence but experiencing disconnection from traditional support systems and emphasizing the need for tailored multilevel strategies including strengthening social connections, addressing caregiving gaps, and improving community and residential support.
Typology of ageing and its associations with the end of life and death among older adults in China: a longitudinal person-centred study.
Four qualitatively distinctive ageing profiles emerged among deceased older adults in China, with heterogeneity revolving around functional and cognitive capacities and economic/financial characteristics, and distinct end-of-life patterns emphasizing the need for targeted care strategies.
A Conceptual Digital Health Framework for Longevity Optimization: Inflammation-Centered Approach Integrating Microbiome and Lifestyle Data-A Review and Proposed Platform.
This paper proposes a conceptual digital health framework integrating quarterly inflammation and microbiome monitoring with continuous lifestyle tracking, introducing the Longevity-Inflammation Index (L-II), and synthesizes published evidence showing Mediterranean dietary interventions reduce hs-CRP by 18-32% and increase microbiome diversity by 6-28%, while noting validation studies are needed to confirm the integrated platform's efficacy.
Interleukin-10 expressing B lineage cells in visceral adipose tissue protect against aging-related insulin resistance and extend lifespan.
IL-10 expressing B lineage (B-10) cells expand in aged visceral adipose tissue and protect against aging-related inflammation and insulin resistance, with their expansion mediated by BAFF, such that VAT-specific BAFF overexpression prolonged lifespan.
Neurofilament light chain may serve as a cross-species blood biomarker to assess aging and predict mortality.
Blood neurofilament light chain (NfL) shows age-related increases and mortality prediction conserved across species, suggesting NfL 'may serve as a cross-species blood biomarker for assessing aging interventions and predicting mortality.'
The Universal Model of Growth: Dependence of Brain and Body Mass on Age.
A two-stage DS model with a transition at ~1.5 years post-conception accurately described both brain and body mass trajectories from conception to old age, reproducing the complex 'hook-shaped' allometric relationship between brain and body mass.
Identification of fecal microbiome signatures associated with longevity through 16S rRNA sequencing in different age groups in China.
Long-lived individuals (≥90 years) had more diverse gut microbiota than typical older individuals, with marked increases in Bacteroidota and Akkermansia and enrichment in unsaturated fatty acid metabolism, ketone body synthesis and degradation, and tryptophan metabolism.
Telomere Shortening Drives Atrial Fibrillation Through VCAM-1 Mediated Atrial Electrical and Structural Remodeling.
Telomere shortening drives atrial fibrillation through a telomere-VCAM-1 axis that promotes atrial electrical and structural remodeling, with VCAM-1 inhibition reducing AF susceptibility by 30%.
Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age-Related Studies in Thai Adults and Cross-Population Comparisons.
Aging significantly increased simvastatin Cmax but did not alter simvastatin acid exposure, while Thai subjects showed significantly higher simvastatin acid levels than Caucasians, Chinese, and Japanese, with SLCO1B1 and PON gene variants potentially contributing to these interethnic pharmacokinetic differences.
Longitudinal Analysis of Mitochondrial D-Loop Methylation and Copy Number in Peripheral Blood: Epigenetic Signatures of Alzheimer's Disease Progression and Aging.
Healthy controls showed a progressive increase in D-loop methylation over time, whereas individuals converting to Alzheimer's disease exhibited a marked decrease, with an opposite trend observed for mtDNA copy number, suggesting these epigenetic alterations are associated with mitochondrial dysfunction and disease progression.
Association of the essential metal mixture with biological aging in Chinese older adults: Investigating superoxide dismutase as a potential mediator.
A biological profile characterized by higher levels of Mg, Rb, and Mn and lower Cu is associated with decelerated biological aging in older adults, and this relationship is partly statistically explained by the antioxidant activity of SOD.
Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity.
Total sleep deprivation significantly increases gBOLD signal amplitude and its coupling with CSF flow in a compensatory mechanism, but these enhancements exhibit robust age dependency with markedly attenuated responses in midlife adults (40 to 50 y).
High vulnerability of medial prefrontal pyramidal neurons in post-stroke, vascular, Alzheimer's disease, and aging-related dementias.
The medial prefrontal cortex shows high neuronal vulnerability in dementia, with pyramidal neuron densities lowered by approximately 45% and volumes by approximately 37% across all dementia groups relative to controls, suggesting a vascular-metabolic mechanism.
Migration Effects on Cognition: Protocol for the Aging in Kerala Americans Research Study.
The AKKARE study protocol describes a longitudinal cohort study designed to examine migration effects on cognitive aging in 400 first-generation Kerala American older adults, assessing immigrant, cultural, biological, and vascular factors over up to 5 years.
Single-nucleus multiome analysis in the human prefrontal cortex identifies gene expression and cis-regulatory elements associated with aging.
Single-nucleus multiome ATAC plus gene expression profiling of over 1.5 million cells from 357 human prefrontal cortex samples identified cell-type-specific gene expression and cis-regulatory elements associated with aging across European and African admixed ancestry individuals aged 15 to 100 years.
Physical Fitness Dynamics Shape Immune Remodeling in Healthy Aging: A 3-Year Longitudinal Study.
Subtle functional decline in clinically healthy older adults is paralleled by immune changes characteristic of early immunosenescence, occurring largely in the absence of overt systemic inflammation, with physical fitness identified as a potentially modifiable determinant of immune trajectories.
The impact of adverse childhood experiences on DNA methylation age: a systematic review and meta-analysis.
Current evidence does not support a robust or consistent association between cumulative adverse childhood experiences and epigenetic age acceleration, with meta-analyses of six studies revealing no significant associations across first- or second-generation epigenetic clocks.
The impact of volunteering on cognition and cognitive decline in older diverse cohorts: KHANDLE and STAR.
Volunteering was associated with better baseline cognition but not slower decline, suggesting immediate cognitive benefits for racially and ethnically diverse older adults.
Obstructive Sleep Apnea Risk and Mental Health Conditions Among Older Canadian Adults in the Canadian Longitudinal Study on Aging.
Middle-aged and older adults at high risk of OSA had consistently worse mental health outcomes, with approximately 40% higher odds of a composite poor mental health outcome both concurrently and prospectively.
Insights into Healthy Ageing in Malaysia: A Qualitative Study.
Inductive thematic analysis of Malaysian Healthy Agers revealed four main themes attributed to sustained health: having a life's role and purpose, developing and maintaining independence, drive to maintain health, and coping strategies and resilience.
"Comprehensive multi-omics of age-respective plasma and matrix-bound extracellular vesicles identifies anti-fibrotic miRNAs validated on a heart-on-a-chip".
Direct comparison of young and aged extracellular vesicles from heart tissue matrix and plasma identified differential miRNA cargo with aging, with young-enriched miRNAs validated as anti-fibrotic and cardioprotective agents in a microfluidic heart-on-a-chip model.
A structure-motivated constitutive model of human cerebral arteries with age-dependent collagen fiber engagement.
A structurally motivated, age-dependent constitutive model incorporating collagen fiber recruitment as a continuous function of age successfully captured cerebral arterial stiffening in human anterior cerebral arteries, revealing that collagen increasingly dominates load bearing with age, particularly at physiological pressures.
The Association Between Foot-Ankle Mechanical Leverage and Instability During Walking in Older and Younger Adults.
Older adults exhibited smaller peak ankle moments and larger whole-body angular momentum ranges than younger adults, and better foot-ankle leverage during habitual walking correlated with larger margins of stability and smaller ranges of whole-body angular momentum.
Atlas of human cerebellar aging: nonlinear molecular trajectories reveal multidimensional mechanisms underlying cognitive and motor function regulation.
Cerebellar aging comprises complex, stage-dependent molecular alterations including nonlinear expression trajectories of synaptic plasticity, metabolic regulation, and protein homeostasis genes, accompanied by accelerated gray matter reductions after age 70, highlighting the 'synaptic plasticity-stress homeostasis' module as a key molecular axis.
A gut microbiota-stem cell axis mediates the anti-intestinal aging effect of fucoidan from Apostichopus japonicus.
Aj-FUC mitigates intestinal aging primarily by modulating the gut microbiota and subsequently promoting ISC-mediated epithelial renewal via the Wnt/β-catenin pathway.
The effect of attribute framing and polarization levels on evaluations among older and younger adults.
Older adults sampled from community centers were more susceptible to attribute framing and less sensitive to polarization levels than younger adults, but these age-related differences were not replicated when older adults were recruited from an online working panel, suggesting that chronological age is not the sole predictor of changes in evaluations and decision making among older adults.
Dectin-1 epigenetic reprogramming rescues senescent-like Treg function in allergic asthma.
KQS-1 treatment rescues senescent-like regulatory T-cell dysfunction in allergic asthma through Dectin-1/Raf-1/ROS-mediated epigenetic reprogramming at FOXP3 and IL10 loci, attenuating airway hyperresponsiveness and inflammation.
Sex Differences in Associations Between Adversity and Biological Ageing.
In 153,557 UK Biobank participants, the timing of adversity distinguished sex-specific associations with biological ageing, with childhood adversity more strongly associated with ageing markers in females and adulthood adversity more strongly associated with certain ageing markers in males.