Cardiovascular
497 peer-reviewed studies indexed
Diagnostic Value of Serum sCD40L, CCL3, and NT-ProBNP Levels in Detection of Lower Limb Venous Thrombosis among Elderly Patients with Heart Failure.
Elevated serum sCD40L, CCL3, and NT-proBNP levels were associated with lower limb venous thrombosis in elderly patients with heart failure, and the combination of these markers provides high diagnostic value for detection of LLVT in this population.
Therapeutic Plasma Exchange for Uncontrollable Bleeding After Platelet Inhibition with Ticagrelor: A Report of 2 Cases.
TPE may be an effective novel option for emergency removal of circulating ticagrelor in refractory bleeding cases.
Effects of a Hypertension Management Mobile App on Urinary Sodium Excretion in Patients With Chronic Kidney Disease: Randomized Controlled Trial.
A hypertension management smartphone app did not reduce urinary sodium excretion in patients with CKD despite a substantial improvement in self-reported salt intake behaviors, suggesting an intention-behavior gap.
The Mediating Effect of Inflammatory Biomarkers in the Associations Between Sarcoidosis and Incident Ischemic Stroke: A Prospective Cohort Study.
Sarcoidosis independently increases the risk of ischemic stroke (HR = 1.335), with inflammatory biomarkers SII, lymphocyte percentage, and CRP serving as significant mediators, and shared molecular pathways involving ANKRD22, FCGR1A, and NOG genes identified through transcriptomic analysis.
Diagnostic value of 3D arterial spin labeling plus diffusion-weighted imaging for transient ischemic attack and short-term stroke prognosis: A retrospective cohort study.
Combining 3D-ASL with DWI significantly improves cerebrovascular pathology detection and 90-day stroke risk prediction beyond clinical scoring, identifying high-risk TIA patients for intensified secondary prevention.
Automated Multi-Modal MRI Segmentation of Stroke Lesions and Corticospinal Tract Integrity for Functional Outcome Prediction.
This exploratory study demonstrates the feasibility of combining automated lesion segmentation with anatomically informed biomarkers using routine clinical MRI, supporting interpretable stroke outcome modelling and motivating future large-scale validation.
Heart failure readmissions in urban and rural hospital settings: An analysis of 30-day readmissions using the 2021 Nationwide Readmissions Database.
Rural hospitals had lower overall odds of 30-day heart failure readmission, but structural inequities persisted for rural patients with self-pay or no-charge status, who had the highest readmission risk.
Cost-effectiveness of percutaneous patent foramen ovale closure versus medical therapy for cryptogenic stroke prevention: A Chinese healthcare perspective.
PFO closure demonstrated economic dominance over medical therapy in Chinese cryptogenic stroke patients, yielding 1.41 additional QALYs while reducing lifetime costs by $4,045 per patient, resulting in a negative ICER of -$2,868 per QALY.
Revealing causal associations of 91 inflammatory protein factors with endocarditis: Insights from genome-wide association study.
Two-sample Mendelian randomization identified significant causal relationships between CD40L receptor levels (risk factor) and fibroblast growth factor 21 levels (protective factor) with endocarditis, suggesting they may serve as potential biomarkers and offer directions for targeted interventions.
Inverse Association Between Triglyceride-Glucose Index and Ischemic Stroke in Hospitalized Patients with Chronic Obstructive Pulmonary Disease and Atrial Fibrillation: A Retrospective Analysis.
Contrary to observations in the general population, in hospitalized COPD and AF patients, a higher TyG index was associated with lower short-term ischemic stroke risk, suggesting a potential metabolic paradox that may reflect reverse causality whereby low TyG marks disease severity.
The effects of cold application on blood pressure in patients with hypertension: A randomized placebo-controlled trial.
Cold application to the back of the neck reduced blood pressure in patients with hypertension, with significant decreases in systolic blood pressure during the first 27 minutes and diastolic blood pressure during the first 17 minutes following application compared to placebo and control groups.
Clinical outcomes of endovascular aortic repair in blunt traumatic aortic injury: A retrospective case series and a CARE-compliant case report.
EVAR is effective for BTAI, especially in reducing early mortality and complications, though careful evaluation of comorbidities and associated injuries is crucial, particularly in older patients.
Echocardiographic Markers of Cardiac Response to Therapy in Patients with Light Chain Amyloidosis.
Improvement in GLS correlated with improvement in RV and left atrial strain measurements in AL-CA patients receiving treatment, with changes in RV strain seen early within 1 year of treatment.
Clinical outcomes of drug-coated balloon angioplasty for venous in-stent restenosis: A prospective clinical study.
Drug-coated balloon angioplasty resulted in lower restenosis rates, better pain scores, and improved mobility compared to standard balloon angioplasty in patients with recurrent venous in-stent restenosis over a 24-month follow-up period.
Right Atrial Functional Reserve is Associated With Right Ventricular Diastolic Reserve and Liver Stiffness in Repaired Tetralogy of Fallot.
RA functional reserve during exercise stress is impaired and is associated with RV diastolic reserve and liver stiffness in adolescents and young adults after repair of TOF.
COMPARISON OF FOVEA-SPARING (BUTTON-HOLE) AND CONVENTIONAL INTERNAL LIMITING MEMBRANE PEELING IN RETINAL ARTERIAL MACROANEURYSM RUPTURE: Visual and Anatomical Outcomes.
Foveal-sparing ILM peeling (button-hole) has superior visual and anatomical outcomes than conventional ILM peeling, reducing postoperative macular hole incidence in patients with retinal arterial macroaneurysm rupture.
Clinical and Histopathological Findings of Six Cases of Intravascular Large B-cell Lymphoma Diagnosed from 161 Random Skin Biopsy Cases.
Patients diagnosed with intravascular large B-cell lymphoma had a tendency to have B symptoms (p=0.046), senile/cherry angioma(s) at biopsy sites (p=0.040), and thrombocytopenia (p=0.009), and random skin biopsy is recommended in cases with these manifestations.
Outcomes of multiple myeloma in patients with access to novel drugs.
Basic clinical and laboratory data (age and hemoglobin level) predict overall survival in modern patients with multiple myeloma with access to novel therapies, similar to the International Staging System, and a less toxic treatment approach should be considered for high-risk patients.
Cost-effectiveness of three screening strategies for atrial fibrillation in Sri Lanka: a decision-tree modelling analysis using community-based prevalence data.
Targeted screening with AliveCor was the most cost-effective strategy for atrial fibrillation detection in Sri Lanka, as systematic screening detected only one additional AF case compared to targeted screening at a substantially higher incremental cost.
Transmission of F12-related hereditary angioedema through a sperm donor.
This study provides the first direct evidence of transmission of HAE-FXII through assisted reproductive technologies, highlighting how autosomal dominant disorders with incomplete and sex-dependent penetrance can remain clinically silent in donors and be unknowingly transmitted to multiple offspring.
Functional Outcome Following Blood Pressure Drops Within 24 Hours After Successful Mechanical Thrombectomy.
BP drops within 24 hours after successful mechanical thrombectomy are associated with worse functional outcome, and targeted measures to prevent or mitigate BP drops should be explored in future studies.
Analysis of Biomarkers in Diabetic Foot Ulcer Patients With Dampness-Heat Syndrome Based on 4D-DIA Proteomics Technology.
4D-DIA proteomics identified four serum biomarkers (APOA1, LCAT, PLTP, and CETP) linked to dysregulated cholesterol metabolism in DFU-DHS patients, which show diagnostic potential with an AUC of 0.9672 and provide insights for integrating TCM syndrome differentiation with precision medicine.
Prognostic Value of HALP Score in Rheumatic Mitral Stenosis: A Long-Term Follow-up Study.
The HALP score demonstrated a modest but statistically significant ability to predict MACCE in rheumatic mitral stenosis patients, but was not identified as an independent predictor in multivariable analysis, suggesting it may serve as a complementary rather than standalone prognostic tool.
Measurement of blood pressure in European Society of Hypertension Excellence Centres: a survey by the Young Investigators Group of the European Society of Hypertension.
A survey of ESH Excellence Centres reveals considerable discrepancies in blood pressure measurement practices, with substantial non-adherence to recommended guidelines even within highly specialised settings.
Effects of ACE inhibitor and afterload reduction in single ventricles following bidirectional Glenn.
BDG patients treated with ACEI did not demonstrate decreased SPC, showed a suggestion of no improvement of ventricular performance, and had decreased cerebral blood flow, suggesting that routine ACEI use in single ventricle patients post BDG should be considered with caution.
Operative Experience and Clinical Outcomes in Cardiac Myxoma Patients: A Retrospective Single-Center Study.
Cardiac myxomas are associated with significant thromboembolic and hemodynamic risks, and early surgical resection provides excellent long-term outcomes and should be considered even in asymptomatic patients.
Systolic Blood Pressure Trajectory and Outcomes in Acute Intracerebral Hemorrhage: Pooled Analysis of the 4 INTERACT and ATACH-II Clinical Trials.
Distinct SBP trajectories over 24 hours defined prognosis after ICH, with a severe hypertensive group having the highest odds of death or disability, regardless of the BP-lowering strategy used.
Effect of genetically proxied plasma sclerostin levels on the risk of ischemic stroke: A drug-target Mendelian randomization study.
Reduced plasma sclerostin levels causally increase the risk of ischemic stroke, particularly large artery stroke, suggesting the importance of monitoring cerebrovascular risk in patients receiving sclerostin-reducing therapies.
COVID-19 associated CKM syndrome progression in diabetic patients is linked to pancreatic beta cell dysfunction, rather than RASi use: a retrospective cohort study.
COVID-19 exacerbates CKM progression in diabetic patients, but this is not driven by RASi therapy itself; rather, viral infection causes failure of compensatory mechanisms in pancreatic β-cell function manifested as low C-peptide and spurious low HOMA-IR.
Practical adaptability of a pre-hospital prognostic prediction model for patients following out-of-hospital cardiac arrest during the COVID-19 pandemic.
A pre-hospital prognostic prediction model for out-of-hospital cardiac arrest patients developed using machine learning on pre-pandemic data demonstrated practical adaptability during the COVID-19 pandemic, yielding 'substantially high performance with precise calibration' with AUROCs of 0.94 and 0.95 before and during the pandemic, respectively.
Diabetic Foot Infection: Exploratory Analysis of Its Clinical Profile, Microbiology, and Outcomes.
DFI in Chile exhibits high morbidity, recurrent hospitalizations and progressive antibiotic resistance, with mortality not significantly associated to infection but to other factors linked to DM.
[Evaluation of myocardial work in patients with mitral valve prolapse and severe regurgitation: predictive value for prolonged postoperative ICU stay].
GWE is negatively correlated with postoperative ICU length of stay and has certain predictive value for prolonged ICU stay after surgery in patients with mitral valve prolapse and severe regurgitation with normal LVEF.
Prediction of adherence to treatment with statins and anti-platelet drugs in first-year post-stroke patients: Validation of beta-regression models.
Beta regression models using first 90-day adherence data as a single predictor performed well in predicting 1-year statin and antiplatelet adherence in post-stroke patients, enabling early identification of patients at high risk for low adherence.
[Role and mechanism of Wnt9a in human and mouse chronic wound healing].
Wnt9a expression is downregulated in chronic wound tissue of human and mice, and overexpression of Wnt9a may promote migration of fibroblasts and collagen remodeling through non-classical Wnt signaling pathway, thereby accelerating chronic wound healing.
Outbreak of toxoplasmosis with pulmonary involvement in immunocompetent military population.
Four immunocompetent military personnel developed toxoplasmosis with pulmonary involvement, one with hypoxemic ventilatory failure and myocarditis, following exposure to common sources in the Colombian Amazon during a military training exercise.
Self-Assembling Hydrogel for Controlled Release of bFGF and Ang-1 Mimetic Peptide Promotes Neurovascular Repair in Ischemic Stroke Rats.
A self-assembling hydrogel (FGFP/TIMP-AMP) comprising bFGF-mimetic peptide, angiopoietin-1-mimetic peptide, and MMP-2-responsive TIMP sequence promoted neurovascular repair, BBB integrity, and motor function recovery in ischemic stroke rats.
Efficacy of goal-directed rehabilitation on functional recovery in patients with cerebral infarction.
Goal-directed rehabilitation achieved larger gains in activities of daily living and motor function compared with conventional rehabilitation in cerebral infarction patients, suggesting that integrating individualized, explicitly defined rehabilitation goals into multidisciplinary stroke rehabilitation may enhance short-term functional recovery.
Efficacy comparison of dapagliflozin combined with liraglutide versus monotherapy in obese patients with heart failure.
Dapagliflozin combined with liraglutide has a synergistic effect in improving cardiac function and metabolic disorders in obese patients with HFpEF, with good safety, providing a more effective therapeutic strategy for clinical practice.
High diffuse bone marrow uptake in 18F-FDG PET/CT may reflect the diverse mutational characteristics of multiple myeloma.
Patients with high diffuse FDG uptake in bone marrow on 18F-FDG PET/CT showed higher tumor burden, inferior overall survival, and diverse mutational characteristics associated with various oncogenic pathways including epigenetic regulators, potentially reflecting the heterogeneous nature of multiple myeloma.
Metabolic syndrome and the risk of perioperative ischemic stroke in non-cardiac surgery: a case-control retrospective study.
Metabolic syndrome is an independent predictor of perioperative ischemic stroke among non-cardiac surgical patients, with participants with MetS having a 2.18-fold increased risk of PIS, driven principally by elevated blood pressure and glucose.
Determinants of quality of life in older adults with atrial fibrillation: a structural equation modeling analysis.
Quality of life among older adults with atrial fibrillation was influenced by multiple interrelated factors, with social support, psychological status, and economic circumstances exerting significant combined effects through both direct and indirect pathways.
Elevated Driving Pressure in Pressure-Controlled Ventilation: An Independent Risk Factor for Adverse Outcomes in Mechanically Ventilated Neonates.
Elevated driving pressure (≥10 cmH2O) is an independent, modifiable risk factor for adverse outcomes—particularly bronchopulmonary dysplasia—in mechanically ventilated neonates, with the effect most pronounced in very preterm infants.
Lemierre's Syndrome in a Commercial Airline Pilot.
This case report highlights the importance of an individualized approach to prevent unjustified grounding of pilots on anticoagulation, as there is currently no consensus in the medical literature on the timing, duration, dosing, or type of anticoagulant for Lemierre's syndrome.
Orthostatic blood pressure trajectories characterize heterogeneous disease progression in Parkinson's disease.
An increasing orthostatic systolic blood pressure change trajectory was associated with a more pronounced progression across multiple clinical domains in PD, suggesting that longitudinal orthostatic blood pressure patterns may represent a clinically relevant dimension of disease heterogeneity.
Impact of Stroke History and Interval on Outcomes of Total Hip Arthroplasty: A Retrospective Cohort Study.
A history of stroke increases postoperative complications after THA, particularly PJI, and the authors recommend patients defer THA for at least 18 months following a stroke to minimize risks.
Whole-body vibration training on functional capacity, vascular function, and glycemic control in individuals with type 2 diabetes and peripheral arterial disease: protocol for a randomized controlled trial.
This paper describes a protocol for a randomized controlled trial investigating whether whole-body vibration is non-inferior to supervised treadmill walking for improving functional capacity, vascular function, and glycemic control in individuals with type 2 diabetes and peripheral arterial disease.
Biomarkers of iron deficiency and prognosis in patients hospitalised with new-onset heart failure and a reduced left ventricular ejection fraction.
Lower TSAT is associated with a greater risk of clinical events in patients with new-onset HFrEF, as were the ratios of iron/STFR and TSAT/STFR, but neither ratio appeared to offer a substantial advantage compared with TSAT alone.
Integrated Assessment of Wall Shear Stress-Related Hemodynamic Parameters in Abdominal Aortic Aneurysms: A Retrospective Cross-Sectional Study on Ruptured Cases.
Analyzing the spatial distribution of WSS-related hemodynamic parameters (TAWSS, OSI, ECAP, RRT) can be a powerful approach for predicting the site of rupture in AAAs, with low TAWSS and high OSI/ECAP/RRT regions identified as high-risk locations.
PCSK9 inhibitoRs for Early Passivation of coRonary athEroSclerotic plaqueS in acute coronary syndromes (REPRESS): study protocol for a multicentre randomised controlled trial.
The REPRESS trial protocol describes a prospective, multicentre, open-label randomised controlled trial designed to assess the impact of early intensive LDL-C lowering with PCSK9 inhibitors added to moderate-intensity statin therapy on OCT-derived plaque characteristics in non-culprit coronary lesions in patients with acute coronary syndrome.
Paediatric Snakebite Toxicity up to Compartment Syndrome: A Ten-Year Retrospective Study in Iasi, Romania.
Viper bites in children remain a public health problem in Romania, and appropriate multidisciplinary treatment including antivenom and selective fasciotomy considerably improves functional prognosis.