Cardiovascular
497 peer-reviewed studies indexed
Burden of atherosclerosis, cardiovascular risk factors and atrial fibrillation in individuals with covert brain infarcts in late midlife: the Akershus Cardiac Examination 1950 Study.
In this community-based cohort of individuals in late midlife, individuals with CBI did not have an increased cardiovascular risk compared with those without, as indicated by SCORE2, CHA₂DS₂-VA score, age-appropriate carotid plaque burden and a low prevalence of AF.
Stage-specific utility of obesity indices across the chronic kidney disease continuum.
TyG-ABSI is superior for identifying prevalent CKD risk while ABSI is a stronger predictor of mortality in established CKD patients, suggesting a shift in the primary driver of adverse outcomes as CKD progresses.
Association of plasma ceramide with stroke-associated pneumonia in acute ischemic stroke.
Plasma C16:0-Cer served as an independent predictor for stroke-associated pneumonia in acute ischemic stroke patients, demonstrating moderate predictive accuracy with an AUC of 0.725, suggesting its potential as a novel biomarker for early SAP risk stratification.
Cerebral vasospasm following arteriovenous malformation rupture: a population-based longitudinal study.
In a population-based cohort of 10,375 adult patients with ruptured AVMs, vasospasm occurred in approximately 3% and was associated with a more than twofold increase in mortality at both 30 days and one year, with subarachnoid hemorrhage, male sex, hydrocephalus, and leukocytosis identified as the greatest risk factors for vasospasm.
Impact of Metabolic Syndrome on Cataracts: A Systematic Review and Meta-Analysis.
MetS, obesity, DM, HT, and DLP are associated with cataracts, suggesting that prevention or treatment of MetS or its components likely represent a modifiable risk factor in cataract development.
Association of Serum Lipids with 10-Year CVD and All-Cause Mortality in Iranian Adults: A Prospective Cohort Study.
Abnormal levels of serum lipids, specifically low HDL-C concentration, are associated with an elevated risk of both non-CVD and CVD mortality, with these relationships more pronounced in older participants and in persons with hypertension or diabetes.
Gender Differences in Major Risk Factors for Cardiovascular Disease in Mexican Adults.
Women exhibited greater prevalence of obesity, diabetes, dyslipidemia, and personal history of myocardial infarction than men, with obesity, dyslipidemia, and hypertension in women associated with increased likelihood of CVD diagnosis (aOR=2.6), while pharmacological treatment alone has not been sufficient to achieve therapeutic goals.
Risk factors associated with cardiac dysfunction in men with erectile dysfunction.
Cardiometabolic risk factors are associated with echocardiographic signs of cardiac dysfunction in men with erectile dysfunction, with elevated BMI, diastolic blood pressure, and HbA1c linked to LV systolic dysfunction, while BMI and dyslipidemia are associated with LV diastolic dysfunction.
Association between high-risk drinking and cardiovascular health based on Life's Essential 8: analysis using 2016-2021 Korean National Health and Nutrition Examination Survey data.
High-risk drinking was negatively associated with ideal cardiovascular health in Korean adults, with total CVH scores up to 14% higher in those who rarely or never engaged in high-risk drinking compared to nearly daily high-risk drinkers, and this association showed sex differences.
Machine-Learning-Based Prediction of Hypertension and Its Risk Factors Among Adults in the Northern Region of Bangladesh.
A machine-learning-based study in rural Bangladesh found a hypertension prevalence of 36.5% among adults aged ≥30 years, with the random forest model achieving the highest predictive performance (AUC 0.80), and age, body weight, sweets consumption, vigorous activity, education, family size, height, and family income emerging as the most influential determinants.
Association between statin use and major adverse cardiovascular events in patients with chronic kidney disease and cardiomyopathy: A retrospective case-control study.
Regular statin therapy significantly reduces the incidence of major adverse cardiovascular events in a dose-dependent manner in patients with chronic kidney disease and cardiomyopathy, with consistent cardioprotective effects across different CKD stages and cardiomyopathy etiologies.
A Contemporaneous and Longitudinal Network Analysis of Fear of Disease Progression and Dyadic Self-Care in Stroke Patients and Their Spouses.
Fear of disease progression and dyadic self-care among stroke patients and their spouses are dyadic phenomena that can predict each other, with bidirectional predictions confirmed between patients' fear of disease progression and their self-care, and between spouses' fear of disease progression and their contribution to self-care.
Excess cardiovascular morbidity in psoriatic arthritis and cardioprotective effects of biologic dmards: a propensity-matched analysis.
PsA confers substantial excess cardiovascular risk comparable to other inflammatory arthropathies, and biologic DMARDs modestly reduce cardiovascular events, supporting their role in comprehensive PsA management.
GRACE score for risk stratification and completeness of revascularization in older patients with myocardial infarction.
The GRACE score was confirmed to be predictive of adverse outcomes even in older MI patients, and physiology-guided complete revascularization was associated with benefit across the GRACE spectrum, suggesting that the GRACE score alone should not preclude this strategy in older patients with MI.
Helicobacter pylori, Inflammation, and Long-Term Outcome in Patients With Acute Myocardial Infarction: A Prospective Cohort Study.
Hp may contribute to an inflammatory response in patients with MI, indicated by higher CRP and inflammatory/immune-modulatory biomarkers emerging as its top predictors, but although Hp was not associated with adverse outcomes after MI, its predictive inflammatory biomarkers were associated with MACE and mortality.
Effect of a clinical decision support system on stroke care quality and outcomes in patients with acute ischaemic stroke (GOLDEN BRIDGE II): cluster randomised clinical trial.
Use of the stroke CDSS in patients with acute ischaemic stroke in China led to a significant decrease in new vascular events at three months, and was also effective in improving stroke care quality and decreasing long term vascular events.
Genetic predisposition to coffee consumption and the association with the early risk of atherosclerosis.
Genetically influenced coffee consumption may be associated with coronary atherosclerosis risk in frequent coffee drinkers, although the underlying biological basis remains to be clarified.
Associations of cardiovascular risk factors with handgrip strength and gait speed among older males and females: A systematic review protocol.
This article describes a protocol for a systematic review to identify which cardiovascular risk factors are associated with measures of physical function (handgrip strength and gait speed) and whether this association varies by sex among older adults.
Comorbidity indices in observational studies on cardiovascular risk.
Simple indicators measuring a few well-established cardiovascular risk factors outperformed a complex index such as the Nordic Multimorbidity Index in predicting cardiovascular disease outcomes.
Exploring the association between 5 different alternative indicators of insulin resistance and the risk of multiple cardiovascular and metabolic diseases: A cross-sectional NHANES study from 2005 to 2018.
Increased levels of all five insulin resistance surrogates (TyG index, TyG-BMI, METS-IR, TG/HDL-C ratio, and HOMA-IR) were significantly associated with higher cardiometabolic multimorbidity risk, with HOMA-IR demonstrating the best predictive performance (AUC 0.699) and a J-shaped nonlinear relationship with CMM risk.
Efficacy of stem cell boost (SCB) for chimeric antigen receptor-T cell therapy (CAR-T)-related hematologic toxicity in patients with relapsed/refractory multiple myeloma (RRMM)-real world experience from the US multiple myeloma immunotherapy consortium.
Stem cell boost led to rapid and successful hematologic recovery in nearly all patients with prolonged cytopenias after CAR-T therapy, with significantly improved hemoglobin and platelet counts by day 90 compared to matched controls who received supportive care alone.
Effect of antidiabetic medication adherence on risk of all-cause mortality and cardiovascular diseases in type 2 diabetes patients: Impact of antidiabetic adherence on cardiovascular disease.
TZD therapy, especially with high adherence, reduced CV risk and mortality compared with SUs and DPP-4 inhibitors, highlighting the importance of sustained TZD adherence for optimal long-term outcomes in routine clinical practice.
Diabetic Foot Infections: A Toolkit for Wound Care Clinicians.
This case-based review applies the 2024 International Working Group on the Diabetic Foot guidelines to real-world scenarios, providing frontline wound clinicians with a pragmatic, equity-informed approach to diagnosing and managing diabetic foot infections in community and resource-limited settings.
Prevalence of Hypertension in Venezuela: A Systematic Review and Meta-Analysis.
The pooled prevalence of hypertension in Venezuela was 42% (95% CI: 39%-46%), meaning 4 out of 10 Venezuelan adults suffer from hypertension, a rate exceeding that reported in most regional and global studies.
Angiography-derived fractional flow reserve versus coronary angiography to guide coronary artery bypass grafting in patients undergoing surgical valve procedures with concomitant coronary artery disease in China (FAVOR IV-QVAS): a multicentre, triple-blind, randomised trial.
Physiologically guided CABG using angiography-derived FFR reduced the incidence of the composite perioperative outcome compared with anatomically guided CABG in patients undergoing valve surgery with concomitant coronary artery disease.
Assessment of Ten Insulin Resistance Surrogate Indexes Predicts New-Onset Cardiovascular Disease Incidence in Patients with Prediabetes or Diabetes: Insights from CHARLS Data with Machine Learning Analysis.
eGDR and CVAI outperformed other IR indexes in predicting CVD in Chinese patients with prediabetes or diabetes, and their integration into K-Nearest Neighbors machine learning models significantly improved risk stratification (AUC = 0.936).
Cardiovascular risk and cognitive performance: A population-based cross-sectional study (NEDICES2-RISK).
Higher cardiovascular risk was associated with worse cognitive performance in the Spanish population aged 55-75 years, with the most affected cognitive domains being memory, attention, and psychomotor speed.
Medication adherence after myocardial infarction: Predictors, mortality and cardiovascular outcomes.
Just over half of MI survivors adhered to prescribed secondary prevention medications based on dispensation data from 2 to 14 months post-MI, with adherence influenced by sociodemographic and clinical factors and associated with improved outcomes.
Frailty and Recurrent Cardiovascular Events in Patients With Obstructive Sleep Apnoea: The SAVE Study.
In adults with co-occurring OSA and CVD, a higher frailty index was associated with significantly higher risk of recurrent cardiovascular events, but frailty did not modify CPAP treatment adherence or the effect of CPAP on recurrent cardiovascular events.
Determinants and Health Outcomes of Digital Health Literacy in Patients With Cardiovascular Disease: Systematic Review and Meta-Analysis.
Digital health literacy in cardiovascular disease patients showed a pooled mean eHEALS score of 24.26, with lower DHL consistently associated with older age, lower educational attainment, female sex, limited social support, and less digital experience, while higher DHL was associated with more favorable health-related outcomes.
Congenital heart diseases: population-based cross-sectional study and spatial analysis, São Paulo, 2012-2022.
Individual maternal characteristics and territorial factors were associated with the occurrence of congenital heart diseases, revealing population profiles and priority areas for health actions in the municipality of São Paulo between 2012 and 2022.
Remote monitoring and outcomes in heart failure: 5-year study.
Despite the proven effectiveness of remote monitoring, the clinical impact of heart failure in patients with CIEDs remains substantial, with ischemic disease, age ≥75 years, atrial fibrillation, CRT-D implantation, and severe CKD all independently associated with higher risk of cardiovascular events and mortality over 5 years.
Risk factors and surrogate indicators for cardiovascular disease are prevalent in Common Variable Immunodeficiency and associate with inflammatory phenotype.
CVID is associated with a substantial burden of cardiovascular risk factors and subclinical atherosclerosis, especially in the inflammatory phenotype.
Association between cardiovascular disease and non-melanoma skin cancer: The mediation effect of obesity and inflammation.
CVD increases the risk of developing NMSC, and obesity and inflammation partially mediate the relationship, suggesting that weight loss and control of inflammation may be beneficial in reducing the prevalence of CVD and NMSC.
Albuminuria and masked hypertension in overweight and obese children and adolescents: A cross-sectional study.
A significant prevalence of masked hypertension (9.5%) was identified in overweight and obese pediatric populations, with albuminuria being the only predictor of masked hypertension in obese individuals (OR 3.6, p <0.01).
Remote monitoring of heart failure exacerbations using a smartwatch.
Wearable-derived daily pVO2 from an Apple Watch provides earlier and improved risk discrimination compared with existing wearable fitness estimates and established clinical markers, offering a scalable and generalizable approach for longitudinal HF research and monitoring.
Efficacy and Safety of Sodium-Glucose Cotransporter 2 Inhibitors (SGLT2i) in Cardiac Amyloidosis: A Systematic Review.
SGLT2 inhibitors were associated with significant reductions in all-cause mortality and stroke risk in cardiac amyloidosis patients, though evidence is limited by observational study designs and heterogeneity.
The prevalence, prevention, and treatment of cardiovascular diseases in Twelve African Countries (2014-2019): An analysis of the World Health Organisation STEPwise approach to chronic disease risk factor surveillance.
The prevalence of CVD was relatively low (5%) and CVD treatment uptake was sub-optimal across twelve African countries, with only 22% of persons with CVDs receiving treatment and counselling.
M6A-modified circArhgap26 attenuates cardiac ischemia‒reperfusion injury by suppressing plakophilin-1 palmitoylation.
circArhgap26, regulated by m6A modification, attenuates cardiac ischemia-reperfusion injury by binding PKP1 to inhibit its palmitoylation by ZDHHC1, thereby reducing APAF1 synthesis and suppressing Caspase-9/Caspase-3-mediated cardiomyocyte apoptosis.
Gender and Age Differences in Hypertension Screening and Cardiovascular Risk Factors in Rural Kazakhstan.
Males exhibited higher cardiovascular risk behaviors and blood pressure, while females showed greater healthcare engagement and abdominal obesity, highlighting the need for gender-specific strategies in cardiovascular disease prevention and management in rural Kazakhstan.
Adherence to Healthy Lifestyle and Risk of Cardiometabolic Diseases in Individuals With Hypertension.
In this cohort study of individuals living with hypertension, maintaining a healthy lifestyle was associated with lower risk of major cardiometabolic diseases independent of antihypertensive medication use, underscoring the value of adopting multiple healthy lifestyle behaviors.
Hydralazine Use and Risk of Vasculitis.
In this cohort study of adults newly prescribed hydralazine, vasculitis was rare and hydralazine use is unlikely to be associated with a clinically meaningful increased risk of vasculitis.
Atopic Dermatitis and Markers of Early Cardiovascular Risk in Children and Adolescents.
In a population-based UK cohort of children and adolescents followed up into early adulthood, AD, including more active and severe disease over time, was not associated with increases in markers of cardiovascular risk, suggesting that systematic screening of all children with AD is unlikely to improve identification of early cardiovascular risk.
Sex Differences in Cancer-Associated Thrombosis.
Current evidence supports sex as a clinically relevant modifier of cancer-associated thrombosis risk, with men generally exhibiting higher overall VTE incidence while women may experience earlier, treatment-associated thrombotic events, underscoring the need for systematic sex- and gender-informed research to advance precision medicine in thrombosis and oncology.
A Placebo-Controlled Trial of the Oral PCSK9 Inhibitor Enlicitide.
Among participants who had a history of or were at risk for a first atherosclerotic cardiovascular disease event, treatment with the oral PCSK9 inhibitor enlicitide resulted in significantly lower LDL cholesterol levels than placebo at 24 weeks.
Associations of cumulative exposure and dynamic trajectories of cholesterol-HDL-glucose (CHG) index with cardiovascular disease in middle-aged and older Chinese adults: a longitudinal analysis.
Both cumulative CHG exposure and dynamic CHG trajectories are associated with CVD risk in middle-aged and older Chinese adults, particularly for those with consistently high-risk CHG levels, which are linked to a significantly increased CVD risk.
Effusive-Constrictive Pericarditis.
Multimodality imaging demonstrated effusive-constrictive physiology characterized by pericardial thickening with effusion, pericardial enhancement consistent with active inflammation, and ventricular interdependence, highlighting the complementary role of cardiac magnetic resonance in the diagnosis and management of inflammatory constrictive pericardial disease.