Cardiovascular
497 peer-reviewed studies indexed
Effectiveness of rosemary extract on the cardiovascular risk of emergency nursing professionals - an intervention study.
Dry rosemary extract (1g/day for 8 weeks) was effective in reducing the estimated cardiovascular risk of emergency nursing professionals, with significant differences found in blood pressure, total cholesterol, and Framingham Global Risk Score.
Incidence and risk factors of calcium channel blocker-related edema in hypertensive patients: A Multicenter retrospective cohort study.
Calcium channel blocker-related peripheral edema developed in 38.7% of hypertensive Ethiopian patients, with longer daily standing duration as the only independent risk factor and higher amlodipine doses associated with greater and earlier edema onset.
Blood Types May Be Involved in the Occurrence of Coronary Heart Disease Through Serum Lipids.
Type A blood group is an independent risk factor for coronary heart disease, increasing risk by 24% compared with non-A blood types, and CHD patients with Type A exhibit higher blood lipid levels, suggesting that blood type antigens may be involved in the occurrence of CHD through the lipid pathway.
Multidomain Biomarkers as Predictors of Cardiovascular Risk in Acute Coronary Syndrome: A Prospective Evaluation.
Beyond traditional risk factors, markers of coagulation (D-dimer) and autoimmunity (IgG anti-β2-glycoprotein I) are independent predictors of short-term adverse events in ACS patients.
Association Between Health Literacy and Prehypertension in South Korean Adults: Cross-Sectional Study Using the 2023 Korea National Health and Nutrition Examination Survey.
Low health literacy was significantly associated with a 43% higher likelihood of prehypertension in South Korean adults, with variations across subgroups suggesting context-dependent mechanisms.
Association Between Increased Central and Peripheral Arterial 2 Stiffness and Vitamin Intake in Healthy Adults: EVA Follow-Up 3 Study.
The progression of central and peripheral arterial stiffness over five years was greater in individuals with lower dietary intakes of vitamin B9 and vitamin C, providing novel evidence supporting the possible role of dietary vitamin intake in the progression of arterial stiffness with aging.
Behavioural withdrawal during an acute stress test as a marker of psychobiological vulnerability in hereditary angioedema.
Early withdrawal during the Socially Evaluated Cold Pressor Test identifies a vulnerable HAE-C1INH subgroup with distinct psychological, cardiovascular, and inflammatory patterns.
ST-segment elevation in acute pericarditis and myocardial involvement: electrocardiographic and clinical profiling.
ST-segment elevation in acute pericarditis was associated with myocardial involvement, supporting the concept that the pericardium is electrically inert, and myopericarditis was associated with lower remission rates and slightly higher hospitalisation needs compared to isolated pericarditis.
Balloon-expandable valve vs. self-expandable valve for small aortic annuli: a GRADE-assessed systematic review and updated meta-analysis.
In patients with small aortic annuli undergoing TAVR, balloon-expandable valves and self-expandable valves yield comparable rates of prosthesis-patient mismatch and permanent pacemaker implantation, though BEV may be associated with a higher risk of moderate or greater paravalvular leak.
Age-related associations between the CALLY index and advanced cardiovascular-kidney-metabolic (CKM) syndrome: Insights from NHANES population data.
The CALLY index is inversely associated with advanced CKM syndrome, with age-dependent associations suggesting opportunities for early detection and targeted interventions, especially in younger adults.
Circulating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study.
A multi-stage metabolomics study identified and validated circulating gut microbial metabolites associated with incident coronary heart disease across diverse populations, with five metabolites (imidazole propionate, 3-hydroxy-2-ethylpropionate, 4-hydroxyphenylacetate, trans-4-hydroxyproline, and 3-hydroxybutyrate) and four additional metabolites (TMAO, phenylacetyl-L-glutamine, 4-hydroxyhippuric acid, and indolepropionate) significantly associated with incident CHD.
Comprehensive evaluation of cardiovascular risk control in a large national cohort: insights from over 1 million participants in a cardiovascular prevention program.
In a large cross-sectional cohort of over 1.1 million adults without cardiovascular disease, alarmingly high levels of modifiable cardiovascular risk factors were identified, with significant age and sex disparities, highlighting the urgent need for targeted, sex- and age-specific prevention strategies.
Serum osteopontin is associated with coronary plaque vulnerability and short-term cardiovascular events: a prospective cohort study.
Elevated serum osteopontin (SPP1) levels are independently associated with imaging-defined plaque vulnerability and short-term cardiovascular events in patients with coronary artery disease, with MMP-9 partially mediating the association between SPP1 and plaque vulnerability.
[Association between triglyceride glucose index combined with obesity index and cardiovascular disease risk in middle-aged and old adults in China].
The TyG index combined with obesity index is significantly associated with the risk for CVD in middle-aged and old adults in China, with TyG-BMI showing the strongest association (HR 1.74, 95%CI: 1.51-2.01) comparing Q4 to Q1.
GHC-net: A gramian angular field based hybrid CNN for cuffless blood pressure classification using PPG signals.
GHC-Net, a hybrid CNN leveraging Gramian Angular Field encoding of PPG signals, achieves BP triple-classification accuracy of 76.39% on a public dataset and 92.66% on a private dataset, providing an efficient automated method for cuffless blood pressure classification.
The Reorganization of Cerebellar Functional Network Topology in Post-stroke Aphasia: A Resting-State fMRI Study.
PSA patients showed significant reductions in small-world index, clustering coefficient, and local efficiency in cerebellar functional networks, with these topological changes associated with poorer auditory comprehension, memory, and reasoning.
Evaluation of Prothrombin Time and Activated Partial Thromboplastin Time in Antithrombotic-Treated Cardiac Patients: A Cross-Sectional Study from Sana'a City, Yemen.
Coagulation profiles in cardiovascular patients vary significantly according to both the underlying cardiac diagnosis and the type of antithrombotic therapy, with MVR and RHD patients displaying notably elevated parameters, underscoring the need for diagnosis-specific monitoring strategies in a Yemeni population.
Association of a Comprehensive Healthy Lifestyle Score with Risk of All-Cause, Cancer, and Cardiovascular Mortality: Evidence from an 18-Year Cohort Study.
Greater adherence to a comprehensive healthy lifestyle score was strongly associated with reduced risks of all-cause, cancer, and cardiovascular mortality in a Korean cohort, with smoking cessation identified as a particularly important component.
TRIM47 Promotes Atherosclerosis by Activating NF-κB Signaling via IκBα Ubiquitination.
TRIM47 promotes atherosclerosis progression through IκBα ubiquitination and NF-κB activation, and TRIM47 knockdown attenuates vascular inflammation and atherosclerotic plaque formation.
The Relationship Between Triglycerides and Coronary Artery Disease Stratified by Sex and High-Density Lipoprotein Cholesterol in Men and Women.
Triglyceride levels were associated with an increased risk of CAD in both men and women, particularly in patients with HDL-C < 1.8 mmol/L, among primary prevention participants not on lipid-lowering drugs.
Factors Associated With the Selection of Anti-Hypertensive Medications: A Retrospective Cross-Sectional Analysis.
This study demonstrates significant deviations from existing clinical guidelines, notably the overprescription of beta blockers in the management of hypertension within a Saudi Arabian cohort.
Triglyceride-glucose index and mortality in critically ill patients with cardiovascular-kidney-metabolic syndrome stage 4.
Higher TyG index levels are independently associated with increased short- and long-term all-cause mortality in critically ill patients with CKM stage 4, with each 1-standard deviation increase associated with a 23% higher risk of 1-year mortality.
Distinct Genetic Profiles Associated With Subretinal Drusenoid Deposits and Cardiovascular Risk in Age-Related Macular Degeneration.
AMD patients with SDDs show distinct genetic signatures potentially relevant to cardiovascular health, suggesting that SDDs may represent a genetically and systemically unique AMD phenotype.
Low Toe-Brachial Indices are Associated with Saccular Intracranial Aneurysms.
Low TBI was associated with a fourfold higher prevalence of unruptured IAs compared with normal TBI, with the strongest association remaining between low TBI and unruptured IAs after adjustment for established IA risk factors.
Higher HbA1c-Hemoglobin Ratio Was Associated With Poor Outcome in Endovascular Thrombectomy Patients.
Increased HHR levels demonstrate an independent correlation with poorer 90-day recovery rates among ischemic stroke patients undergoing endovascular thrombectomy, positioning HHR as a potentially valuable indicator for clinical prognosis assessment.
State-Dependent DNA Methylation Signatures Distinguish Acute from Stable Coronary Syndromes.
Acute and stable coronary syndromes are characterized by distinct DNA methylation landscapes and pathway signatures, with ACS showing the most pronounced methylation alterations and enrichment of stress response, apoptotic signaling, and cell adhesion pathways.
Cerebrovascular CTA radiomics for objective collateral grading in acute ischemic stroke.
A fully automated CTA cerebrovascular radiomics pipeline combining vessel-tree and circle of Willis features objectively assesses collateral status in acute large vessel occlusion, achieving AUROC of 0.88 on internal and 0.83 on external test sets, outperforming atlas-based MCA mask models.
Prehypertension and hypertension among older adults: prevalence, awareness, treatment, control and associated factors - findings from Iranian STEPS survey (2016 and 2021).
Despite improvements in treatment and control of hypertension among older adults in Iran between 2016 and 2021, hypertension prevalence remains high and on the rise, with obesity strongly associated and higher education inversely associated with hypertension.
Hidden morphological clues in deceptive bone marrow pathologies.
A five-case series demonstrates that morphological assessment extending beyond isolated cytologic features to include spatial distribution of cells, functional behavior, and bone marrow microenvironmental context remains central to the accurate diagnosis of aggressive malignancies.
Deficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscular Connectivity in Barth Syndrome.
Whole-body deficiency of tafazzin enzymatic activity is sufficient to result in widespread neuromuscular remodelling, including fibre size/type shifts, motor unit loss, NMJ dysregulation and stress pathway activation, without overt energetic failure at rest.
Macrophage-derived CCL20 promotes abdominal aortic aneurysm progression via lymphocytes CCR6.
Macrophage-derived CCL20 aggravates lymphocyte recruitment via CCR6, promoting AAA progression, and targeting the CCL20-CCR6 axis could inhibit immune recruitment and AAA progression.
Micronutrient Profiles and Anxiety in Adolescents with Non-Structural Palpitations: A Case-Control Study.
Adolescents with non-structural palpitations had significantly lower serum magnesium, selenium, and ferritin levels and higher anxiety scores than controls, with lower magnesium and selenium independently associated with palpitations in age- and sex-adjusted analyses.
Socioeconomic Disadvantage, John Henryism, and Incident Heart Failure in the Jackson Heart Study.
The association between income disadvantage and incident heart failure differed by John Henryism level, such that for every 1-unit increase in income disadvantage score, the risk of HF increased 2-fold among Black adults with high John Henryism after full adjustment.
3-D Evaluation of Abnormal Upper Extremity Joint Coupling Post-Stroke.
In 18 individuals post-stroke, joint coupling was abnormal in- and out-of-plane for seven upper extremity degrees of freedom, and a regression model using both in- and out-of-plane joint coupling explained significantly higher variance (up to 33.8%) in stroke-induced functional task deficits compared to models using either measure alone.
Nitazoxanide reduced inflammatory markers and mitochondrial changes in human retinal endothelial cells grown in high glucose.
Nitazoxanide increased MNRR1 levels in retinal endothelial cells, reduced inflammatory markers, and increased oxygen consumption rate and mitochondrial mass in cells grown in high glucose, suggesting NZT may offer a new therapeutic option for diabetic retinopathy.
Plasma metabolomic profiling reveals lipid biomarkers for early detection of exercise-induced myocardial ischemia.
LC-MS-based metabolomic profiling identified distinct lipid metabolic signatures associated with early myocardial ischemia, with 13Z-docosenamide, PC (16:0/22:5), and PC (18:1/20:4) demonstrating strong diagnostic potential (AUC = 0.941; sensitivity 92%; specificity 93%) as early biomarkers for noninvasive detection.
Synchronous arch arterial occlusion - A clinical impasse?
A case of synchronous athero-thrombotic obliteration of the right brachio-cephalic and left subclavian arteries is presented in a hypertensive male who had been symptomatic for only 6 hours.
Endothelial C-type natriuretic peptide/guanylyl cyclase-B signaling prevents pulmonary arterial hypertension.
Endothelial CNP/GC-B signaling exerts pivotal preventative effects against development of pulmonary hypertension, suggesting the therapeutic potential of CNP for PAH.
Prevalence and Incidence of Diabetes-Related Peripheral Neuropathy, Peripheral Artery Disease, Foot Ulcers and Lower Extremity Amputations in Ireland; A Systematic Review.
There is a paucity of information on prevalence and incidence of diabetes-related foot disease in Ireland, but findings suggest prevalence is similar to, if not lower than, global rates of peripheral neuropathy, peripheral artery disease, and amputation incidence outcomes.
The beneficial effects of clazosentan on the perioperative management of patients with subarachnoid hemorrhage.
Clazosentan-based management was associated with reduced angiographic vasospasm, earlier rehabilitation, and shorter hospitalization compared with fasudil-based management in patients with aneurysmal subarachnoid hemorrhage.
Vitreous from patients with proliferative diabetic retinopathy induced changes in neutrophil activation markers.
Vitreous from patients with proliferative diabetic retinopathy showed twofold increases in CCL2, CXCL5, and angiogenin and significantly downregulated neutrophil activation markers CD11b and CD15, suggesting the presence of immunosuppressive or exhaustion-inducing factors that may alter neutrophil function in diabetic retinopathy.
Mortality risk in relation to diet quality assessed by the 2023 nutri-score nutrient profiling model: a prospective analysis.
Lower dietary quality assessed with the updated 2023 Nutri-Score nutrient profiling model dietary index was prospectively associated with higher risks of all-cause, cardiovascular, and other-cause mortality in older adults at high cardiovascular risk.
Prediction Model for Frailty in Middle-Aged and Older Adults with Cardiovascular Disease.
A nomogram incorporating sleep duration, ADL, waist circumference, cognitive function, handgrip strength, age, and depression demonstrated good discrimination for predicting frailty risk in middle-aged and older adults with cardiovascular disease, with AUC values of 0.851 and 0.861 in training and validation cohorts respectively.
Changes in Cerebral Hemodynamics in Patients with Hypertension and Post-Covid.
Patients with controlled hypertension and history of Covid-19 infection were shown to have impaired cerebral blood flow, manifested by a decrease in the vasomotor reactivity index compared to hypertensive patients without Covid-19 history.
FTO-CHRM3 axis regulates multiple myeloma progression: a machine learning-based identification.
The FTO-CHRM3 axis contributes to multiple myeloma progression via calcium signaling pathway dysregulation, identified through machine learning-based analysis.
Sex-Specific Fifteen-Year Alcohol Consumption Trajectories and Their Association with Cardiovascular Events and Mortality: The Framingham Heart Study.
Sustained low to moderate drinking was associated with lower risks of mortality and CHD compared to high-level or fluctuating patterns in both sexes, though these findings do not confirm causality or the protective effects of alcohol use.
Willingness to Share Internet Use Data for Research on Early Disease Detection: Cross-Sectional Survey.
Willingness to share internet use data for early disease detection research was high across conditions (74%-77%), with perceived benefits and concerns being the factors most consistently associated with willingness to share, though sociodemographic differences suggest risk of bias and inequality in datasets.
A Link Between the Triglyceride-Glucose Index and the Risk of Hypertension Among Employees in the Titanium Dioxide Industry.
A high TyG index increases the risk of hypertension among workers in titanium dioxide production enterprises, with the highest TyG quartile showing 11.12 times higher hypertension risk than the lowest quartile.
[Effects of acupuncture on ferroptosis and ferritinophagy in cerebral ischemia-reperfusion rats based on KAT3B/ACSL4 pathway].
Acupuncture can improve cerebral injury in CIRI rats and reduce ferroptosis and ferritinophagy, potentially through inactivation of the KAT3B/ACSL4 pathway.
Poor glycemic control impairs recovery from central retinal vein occlusion.
Poor glycemic control in patients with central retinal vein occlusion is associated with greater central macular thickness at both 3 months and 1 year, emphasizing the importance of optimal glycemic control to improve retinal outcomes.