Cardiovascular
497 peer-reviewed studies indexed
Beyond body mass index: visceral adiposity and metabolic alterations as early markers of atrial dysfunction and atrial fibrillation in midlife.
Visceral adiposity and metabolic alterations are independently associated with atrial dysfunction and atrial fibrillation in middle-aged individuals with cardiometabolic risk, with epicardial adipose tissue being the highest discriminatory marker for new-onset AF and left atrial reservoir strain showing good discriminatory performance for recurrent AF.
Different response to vitamin D supplementation in children with RVOT morphology PVCs vs LV fascicular PVCs.
Vitamin D supplementation may be effective in reducing PVC burden in children with vitamin D deficiency and RVOT PVCs, but showed no significant effect in children with left ventricular fascicular morphology PVCs.
PRKAG2 Cardiomyopathy: A Case-Control Study on the Diagnostic Yield Of Histopathology and Ultrastructural Analysis from Endomyocardial Biopsy.
Histological and ultrastructural examination of right ventricular endomyocardial biopsy samples reveals a distinct set of features that strongly suggest PRKAG2 cardiomyopathy.
Application of VVI layered strain technology to analyze changes in left ventricular myocardial motion in patients with uremia.
VVI layered strain technology is a precise and sensitive tool for evaluating left ventricular myocardial motion in uremic patients, detecting impaired circumferential strain across myocardial layers even when LVEF remains preserved.
GLP-1 receptor agonists or SGLT2-inhibitors? Evaluation of a personalized treatment algorithm for individuals with type 2 diabetes: a registry-based cohort study.
A personalized treatment algorithm for GLP-1 receptor agonists versus SGLT2-inhibitors did not result in clear individual ASCVD benefits on either drug, 'a finding consistent with the clinical equipoise reflected in current T2D treatment guidelines.'
Comparison of early and late surgical ligation of patent ductus arteriosus in preterm infants.
Late PDA ligation in preterm infants is associated with a higher risk of severe bronchopulmonary dysplasia and prolonged ventilator support, supporting consideration of earlier surgical ligation in selected preterm infants with hemodynamically significant PDA when medical therapy fails.
Multiparametric OCTA Biomarkers for Classifying Mild Diabetic Retinopathy: A Cross-Sectional Evaluation.
Multiparametric combinations of OCTA features improved discrimination between mild diabetic retinopathy and healthy controls, with the most stable contributors to high-performing models being features that were weakly correlated with the broader parameter set rather than the strongest individual discriminators.
DOACs reduce risk for new-onset portal hypertension in patients with cirrhosis and atrial fibrillation: A retrospective cohort study.
In cirrhotic patients with AF, anticoagulation, particularly direct oral anticoagulants, may lower the risk of portal hypertension and gastrointestinal bleeding without increasing mortality.
Assessment of subclinical myocardial dysfunction and osteogenic biomarkers in normoglycemic individuals with familial predisposition to type 2 diabetes mellitus.
Normoglycemic first-degree relatives of type 2 diabetes mellitus patients exhibit early myocardial impairment detectable by LV-STE and reduced osteocalcin levels, suggesting subclinical cardiometabolic dysfunction before overt disease onset.
Mendelian randomization study of lithocholate sulfate mediating the effect of MMP-1 on ischemic stroke.
This Mendelian randomization study provides genetic evidence that elevated MMP-1 is causally associated with an increased risk of ischemic stroke, with lithocholate sulfate identified as a protective mediator accounting for a small proportion (0.0071) of this pathway.
Risk of atrial fibrillation in patients with differentiated thyroid cancer: a nationwide population-based analysis.
Patients with differentiated thyroid cancer had a two-fold higher risk of incident atrial fibrillation than controls, with the risk being higher in those who underwent total thyroidectomy than those who underwent lobectomy alone.
Feasibility of Free-breathing Deep Learning-reconstructed Single-Shot Cine MRI in Participants with Arrhythmia: Comparison with Conventional Segmented Cine MRI.
AI-CS single-shot cine demonstrated greater image quality and clinical feasibility compared with bSSFP cine in healthy participants and participants with suspected arrhythmias, with significantly reduced scan time.
Intravitreal Ranibizumab versus Vitreous Lavage for Postoperative Vitreous Hemorrhage in Proliferative Diabetic Retinopathy: A Randomized Controlled Trial.
VL and IVR were both associated with improved visual outcomes in patients with POVH throughout the 24-week follow-up period, with VL achieving immediate BCVA improvement and IVR showing a progressive improvement pattern, while final outcomes and complication rates did not significantly differ.
Mitral Regurgitation Caused by Concomitant Pseudoaneurysms of the Sinus of Valsalva and Ascending Aorta.
A rare case of concomitant pseudoaneurysms of the left and right sinuses of Valsalva and ascending aorta causing severe mitral regurgitation via extrinsic annular distortion was successfully treated with surgical closure, excision, and mitral valve annuloplasty.
Laparoscopic application of intraoperative fascial traction (fasciotensⓇHernia) during loss of domain scrotal hernia repair: A European multicenter case series with technical details and preliminary results.
Laparoscopic intraoperative fascial traction (IFT) is a safe and useful adjunct in the surgical repair of loss of domain scrotal hernias, potentially reducing the need for preoperative pneumoperitoneum and possibly preventing postoperative abdominal compartment syndrome.
Incremental Value of NT-proBNP Over HCM-AF Score in Risk Stratification for Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy.
NT-proBNP demonstrated incremental value over HCM-AF score in the prediction of new-onset AF in patients with HCM, with C-index increasing from 0.709 to 0.768 when NT-proBNP was added to the model.
Adherence and barriers to early discharge for patients with low-risk pulmonary embolism at a Latin American tertiary center: A retrospective cohort study.
Adherence to early discharge for low-risk pulmonary embolism was limited (20.9%) despite excellent short-term safety outcomes, with system- and process-level barriers including echocardiography utilization, warfarin/INR requirements, direct oral anticoagulants access, and pain management identified as key obstacles.
Clinical outcome following best medical management in acute stroke with a proximal isolated occlusion of the anterior cerebral artery: an international multicentre study.
Nearly half of AIS patients with isolated proximal ACA occlusion treated with medical management alone had poor 3-month functional outcomes, with older age, high NIHSS at admission, and lack of recanalisation at 24h independently associated with poor outcome.
Association between TyG-related indices and in-hospital acute heart failure in patients with acute myocardial infarction after emergency percutaneous coronary intervention.
Poor control of TyG-related indices is associated with an increased in-hospital risk of acute heart failure in AMI patients after emergency PCI, with TyG-WHtR serving as a relatively important and independent predictor (OR: 2.29, 95% CI: 1.35-3.91).
Impact of Tacrolimus Intra-Patient Variability on Toxicity Development Among Lung Transplant Recipients.
An observational retrospective study involving 195 lung transplant recipients suggests that tacrolimus intra-patient variability (Tac-IPV) may serve as a biomarker for post-transplantation complications, with several measures of Tac-IPV statistically associated with de novo arterial hypertension and high Tac-IPV as measured by MAD associated with higher risk for renal impairment.
Naples prognostic score shows potential complementary value to agatston scoring in patients with very high coronary calcium burden: A single-center hypothesis-generating study.
NPS provides complementary value in extensive calcification (Agatston ≥1000), capturing distinct pathophysiologic domains, while metabolic markers (HDL, glucose, HbA1c) are more discriminative than inflammatory markers for obstructive CAD.
Successful single-center experiences of laser crossectomy in zone zero in Endovenous Laser Ablation (EVLA) for chronic venous insufficiency - a case series.
Zone-zero laser crossectomy using a 1470 nm radial double-ring swift laser demonstrated complete GSV obliteration with no recanalization at 3-month follow-up and low complication rates in 57 consecutive patients with chronic venous insufficiency.
Telephone Outreach Is Associated With Improved Blood Pressure in Patients at an Urban Community Health Center.
Telephone outreach combined with skill-based in-person education showed a reduction in SBP and DBP among engaged patients and improved hypertension knowledge in a historically underserved Black American population at a Federally Qualified Health Center.
[A case of hereditary transthyretin amyloidosis cardiomyopathy complicated with monoclonal gammopathy of undetermined significance].
A 69-year-old male heart failure patient was ultimately diagnosed with hereditary transthyretin amyloidosis cardiomyopathy complicated with monoclonal gammopathy of undetermined significance (MGUS) through immunofixation electrophoresis, 99Tcm-pyrophosphate myocardial scintigraphy, myocardial biopsy, and genetic testing.
Effect of intravitreal bevacizumab on kidney function and proteinuria among diabetic patients: a prospective observational study in Asian population.
Patients with diabetic retinopathy who received intravitreal bevacizumab injections showed significant worsening of kidney function and proteinuria at six months but not at one month, with higher baseline UACR being an indicator of poor kidney outcomes.
Bifidobacterium Mediates the Associations Between the Dietary Approaches to Stop Hypertension (DASH) Diet and Blood Pressure and Blood Lipids in Chinese Adults.
Greater DASH diet adherence was correlated with lower diastolic blood pressure and LDL-C, with Bifidobacterium (specifically B. kashiwanohense and B. longum) partially mediating these relationships in Chinese adults.
The triglyceride-glucose index and neutrophil-to-lymphocyte ratio jointly predict the no-reflow phenomenon in T2DM patients with STEMI after primary PCI.
The combination of TyG index and NLR effectively stratifies the risk of no-reflow in T2DM-STEMI patients undergoing PPCI, with a combined model demonstrating superior predictive performance (AUC 0.785) over either marker alone.
BP-METROLOGY: non-invasive continuous blood pressure monitoring to predict haemorrhagic transformation after endovascular thrombectomy.
Short-timescale BP variability captured by continuous monitoring in the first 8 hours post-EVT is associated with increased HT risk, whereas intermittent monitoring fails to detect this signal and may miss opportunities for early risk stratification.
An echo from the past: open access repository of over 10,000 annotated Doppler audio recordings of venous gas emboli.
A landmark open-access repository of 10,099 annotated Doppler audio recordings of venous gas emboli has been compiled and released under a public domain license, enabling development of a deep learning algorithm that can grade bubble loads without a human operator.
Changes in rehabilitation service utilisation during COVID-19 bed surges in Japan: a seasonal autoregressive integrated moving average (SARIMA) analysis of care utilisation with 10-year claims data.
Rehabilitation services in Japan showed substantial changes associated with the COVID-19 pandemic, with inpatient services for cerebrovascular and musculoskeletal conditions being particularly vulnerable to disruptions during high COVID-19 bed utilisation periods, and differential recovery patterns persisting beyond the acute pandemic phase.
Analysis of treatment for improving cognitive dysfunction in elderly patients with hypertension.
Elderly hypertensive patients in Huacao community have high MCI prevalence closely tied to lifestyle, and a cognitive intervention course combined with conventional antihypertensive treatment can effectively boost cognition and fit into community management systems.
Association of systolic blood pressure time in target range and all-cause mortality in patients with atherosclerotic cardiovascular disease: an analysis of a prospective cohort study.
This study demonstrated a significant inverse association between SBP-TTR and all-cause mortality among patients with ASCVD, with the association between maintaining SBP within the 120–140 mm Hg target range and reduced mortality more evident in younger individuals.
Hematologic adverse events following COVID-19 vaccination and revaccination in persons aged 12 and above: A Canadian Immunization Research Network study.
There were no recurrences of the same hematologic adverse event following immunization reported after revaccination with an mRNA vaccine, suggesting that hematologic AEFI recurrences following COVID-19 vaccines are likely uncommon.
Determinants of the Uptake and Frequency of Use of a Web Portal Digital Health Intervention in Patients With Type 2 Diabetes and/or Coronary Heart Disease: Secondary Analysis of a Randomized Controlled Trial.
Factors driving uptake of a web portal digital health intervention do not necessarily increase frequency of use, demonstrating that distinct strategies are required to promote adoption versus sustained engagement.
A Novel Intracardiac Echocardiography-Guided Approach for Vein of Marshall Ethanol Infusion in Persistent Atrial Fibrillation Ablation.
ICE-guided VOM ethanol infusion enhances procedural precision, reduces radiation exposure, and achieves more extensive substrate modification compared with venography, though clinical recurrence rates at 12 months were similar between groups.
Carotid intima-media thickness in relation to primary open-angle glaucoma: epidemiological and structural evidence from a cross-sectional study.
Greater carotid intima-media thickness was associated with a 10% increased risk of primary open-angle glaucoma, with the association more pronounced in women and individuals with high genetic predisposition, suggesting CIMT may be a useful biomarker with potential clinical relevance.
Comparing TA-TAVR and SAVR in severe aortic regurgitation: outcomes and valve haemodynamics.
In patients with severe aortic regurgitation, TA-TAVR using the J-Valve system showed comparable outcomes to SAVR regarding mortality and other clinical events, while TAVR provided superior valve haemodynamics and significantly improved LV function, especially in high-risk patients.
Plasma ceramide Cer24:0 and insulin resistance: associations with TyG and TG/HDL-C in a multicenter study of coronary artery disease cohorts.
Across complementary analytic frameworks, Cer24:0 consistently exhibited positive associations with lipid-centric IR metrics among adults with established CAD, suggesting that circulating ceramide profiling may refine metabolic risk stratification beyond conventional indices in cardiology practice.
[A case of left ventricular apical hypoplasia].
Left ventricular apical hypoplasia is a rare congenital anomaly confirmed by echocardiography and cardiac MRI, and the patient and family members (with hypertrophic cardiomyopathy) both carried MYBPC3 gene mutations, suggesting MYBPC3 mutations may have broader phenotypic associations with myocardial developmental abnormalities.
Machine Learning Models Reveal New Risk Factors for Sub-/Supra-Therapeutic Concentrations of Sirolimus in Children with Vascular Anomalies.
Machine learning models (MLP and XGB) can predict sub-therapeutic and supra-therapeutic sirolimus concentration risks in children with vascular anomalies, with the supra-therapeutic XGB model achieving AUROC of 0.825, enabling personalized exposure risk prediction to optimize dosing accuracy.
Association of systemic immune-inflammation index (SII) with 28-day all-cause mortality in acute heart failure: A retrospective cohort study.
Elevated SII is an independent predictor of increased 28-day all-cause mortality in AHF patients, and as a readily available and cost-effective marker, SII could be integrated into early risk stratification protocols to guide personalized therapeutic strategies in acute care settings.
Effects of PDCA Cycle-Guided Individualized Evidence-Based Nursing on Functional Recovery and Quality of Life After Intracerebral Hemorrhage Surgery.
PDCA cycle-guided individualized evidence-based nursing significantly promotes neurological and motor recovery, improves psychological well-being, enhances self-management abilities, and optimizes overall quality of life in patients following intracerebral hemorrhage surgery.
Development and validation of a prediction model for long-term cognitive frailty risk in stroke patients based on CHARLS data.
The XGBoost algorithm demonstrated superior performance (AUC = 0.810) for predicting cognitive frailty risk in community-dwelling elderly stroke survivors, with age and education level identified as the most significant predictive factors.
Association between oxidative balance score and kidney function among Chinese adults: impact of gender, diabetes and hypertension.
OBS was inversely associated with low eGFR in hypertensive women without diabetes and in normotensive and prehypertensive men, with NHR and PHR partially mediating the effects on albuminuria and low eGFR.
Older adults and major cardiovascular events requiring emergency department consultation during the 1st wave of the COVID-19 pandemic: results from the EDEN-4 Study.
During the 1st wave of the COVID-19 pandemic, the rate of ED visits for major acute cardiovascular events decreased by 39.1% among older adults, with patients who presented having fewer comorbidities, fewer ICU admissions, and more ED revisits, with no significant changes in 30-day mortality.
A patient with a history of syncope experiencing cardiac arrest after brachial plexus block.
A 65-year-old male with hypertension and diabetes experienced syncope and cardiac arrest during shoulder arthroscopy after brachial plexus block, attributed to possible vasovagal reflex, dexmedetomidine effects, and Bezold-Jarisch reflex.
Applying the Behavior Change Wheel to develop strategies to integrate hypertension and HIV care in South African urban primary care clinics.
Using the Behavior Change Wheel framework with community engagement, this formative study developed locally relevant implementation strategies—including structured patient education, clinician training, care champions, audit and feedback, and workflow revisions—to integrate hypertension and HIV care in South African urban primary care clinics.
A hemorheological perspective on coronary microvascular dysfunction: Association of erythrocyte parameters with angiography-derived coronary microcirculatory resistance.
Elevated RBC parameters (RBC count, hematocrit, and hemoglobin) are independently associated with increased angiography-derived microcirculatory resistance, particularly in non-LAD vessels, suggesting RBC parameters may serve as clinically relevant markers of microvascular dysfunction.
Development, Characterization, and Clinical Evaluation of a 6% Nitroglycerin-Aloe Vera Transdermal Gel for Stable Angina Management.
A 6% NTG-Aloe vera transdermal gel demonstrated sustained drug release, superior SAQ scores (p<0.001), and improved tolerability compared to sublingual NTG tablets in patients with stable angina, indicating it offers a stable, effective, and patient-friendly transdermal delivery system for angina management.
Moyamoya syndrome associated with hereditary spherocytosis: pathogenesis, management, and an illustrative case with rapid radiological progression.
This review and case report of a 13-year-old boy with hereditary spherocytosis and moyamoya syndrome — the ninth such reported case — suggests that chronic hemolysis and anemia in HS may potentiate rapid progression of MMS, indicating necessity of vigilant neurological monitoring and a multidisciplinary treatment strategy.