Cardiovascular
497 peer-reviewed studies indexed
Utility of three-dimensional echocardiography for evaluating right ventricular size and function and ventricular myocardial deformation in repaired tetralogy of fallot.
Three-dimensional echocardiography demonstrates a consistent association with CMR for assessment of right ventricular volumes but modest underestimation of volumetric and functional parameters, and may serve as a feasible complementary tool for longitudinal right ventricular assessment in patients with repaired tetralogy of Fallot.
Hypochloremia, non-medication related associated factors, and impact on clinical outcomes in patients with acute heart failure: Insights from resource limited setups.
Hypochloremia at admission was common (33.1%) among acute heart failure patients in a resource-limited setting and was associated with higher in-hospital mortality and longer hospital stays, occurring more frequently in patients with severe heart failure, COPD, hypokalemia, and hyponatremia.
Co-Designing a Community-Based Health Literacy Programme for Individuals With Prehypertension: An Application of Ophelia (Optimise Health Literacy and Access) Process.
Co-design approaches underpinned by the Ophelia framework enable the development of tailored, culturally appropriate health literacy interventions that improve health outcomes and access to services by addressing the diverse, real-world needs of rural communities.
Microsurgical management of vein of Galen aneurysmal malformations.
Modern microsurgical VGAM management achieved safe and durable outcomes, challenging the perception of surgery as solely a salvage option and suggesting microsurgery may still have a role in selected patients.
Effect of Normothermic Machine Perfusion on Glycocalyx Shedding During Liver Transplantation - A Prospective Pilot Study.
Glycocalyx injury, reflected by elevated syndecan-1 levels, develops during normothermic machine perfusion particularly in DCD livers, with a syndecan-1 cut-off of 4,796.13 ng/mL after 6 hours of NMP showing predictive potential for early allograft dysfunction.
Influencing factors of physical activity among young and middle-aged patients with coronary heart disease: a multicenter cross-sectional study.
Young and middle-aged patients with CHD exhibit low levels of physical activity (compliance rate 34.36%), influenced by hemoglobin, glycated hemoglobin, fear of movement, exercise self-efficacy, family care, and fatigue.
[Clinical Study on the Transition of First-Line Bortezomib Intole- rance to Carfilzomib in the Treatment of Multiple Myeloma].
Transition of first-line bortezomib intolerance to carfilzomib can significantly improve symptoms such as peripheral neuropathy and deepen remission in multiple myeloma patients.
Health care cost trajectories among patients with cancer and cardiometabolic comorbidities over a decade including the pandemic period.
Health care costs for patients with cancer and preexisting cardiometabolic comorbidities increased significantly from 2012 to 2018, followed by a temporary decline after 2019 potentially due to the COVID-19 pandemic, with comorbid patients incurring 1% to 21% higher annual costs than those without these conditions.
An interpretable machine learning model for detecting vision-threatening diabetic retinopathy among patients with diabetic retinopathy: a web-based cross-sectional study.
An interpretable Support Vector Machine model effectively detected vision-threatening diabetic retinopathy among patients with diabetic retinopathy using routine clinical data, achieving an AUC of 0.879 and a total score of 57/64 in the testing cohort.
Effects of temperature and humidity on hospitalizations for metabolic syndrome with cerebral infarction among older adults in Panzhihua: a distributed lag non-linear model analysis.
High temperature and high humidity may reduce the overall risk of hospital admission for metabolic syndrome with cerebral infarction among older adults in Panzhihua's dry-hot valley climate, though these protective effects vary across sex and age subgroups.
Circulating Factors Induce Cardiomyopathy after Burn Injury.
Circulating factors in post-burn serum cause mitochondrial damage and cardiomyopathy in human cardiomyocytes in vitro, and PDE5A inhibitor sildenafil reverses these effects to near sham levels.
Tirofiban with sequential dual antiplatelet therapy in mild acute ischemic stroke (TiMIS): protocol for a multicenter, randomized controlled trial.
The TiMIS trial is a prospective, multicenter, open-label, blinded-endpoint randomized controlled study designed to determine whether intravenous tirofiban for 48 hours followed by DAPT improves the proportion of patients with excellent functional outcomes (mRS score 0-1) at 90 days compared with DAPT alone in patients with mild noncardioembolic AIS within 48 hours of onset.
Inhibition of sortilin reduces neuronal and vascular damage after ischemia/reperfusion through reduced inflammatory and autophagy actions in retinal Müller cells.
Inhibition of sortilin using AF38469 eye drops reduced I/R-induced retinal neuronal and vascular damage, and sortilin regulates inflammatory, autophagic, and apoptotic pathways in Müller cells grown in high glucose.
Fatal Cardiomyopathy Secondary to Seronegative Immune-Mediated Necrotizing Myopathy: A Case Report.
A case of fatal, treatment-refractory cardiomyopathy secondary to seronegative immune-mediated necrotizing myopathy in a previously healthy 35-year-old man, suggesting that clinical cardiac involvement in seronegative IMNM likely conveys a poor prognosis.
Effect of Modular Training on Self-Management, Disease, and Treatment Adaptation in Individuals With Hypertension: A Randomized Controlled Trial.
Nurse-led modular education significantly improved key hypertension self-management outcomes, including self-efficacy, medication knowledge, and physical and social adaptation to chronic illness.
Clinical outcomes after catheter-directed therapies for pulmonary embolism in a regional hub-and-spoke system: lessons learned from a real-world experience.
Initial experience with pharmacomechanical interventions for intermediate-high/high-risk PE in a regional hub-and-spoke system shows favorable hemodynamic improvements with a nonnegligible complication rate, and optimization of technical aspects and patient selection is necessary.
Exploring the multifactorial reasons for treatment-seeking delays among young and middle-aged stroke patients: a qualitative study.
Treatment-seeking delay among young and middle-aged stroke patients arises through dynamic interactions across socioecological strata rather than isolated factors, characterized as a sequential cascade mediated by cognitive misattribution, emotional paralysis, relational dependency, institutional constraints and cross-level feedback loops.
[A preliminary study on the role of platelet mitochondria in the proliferation and metabolism of multiple myeloma cells].
In vitro experiments suggest that platelets and their mitochondrial respiratory function may be involved in regulating MM cell proliferation, metabolic reprogramming, and mitochondrial dynamics.
Thorough QT Study on the Effect of Therapeutic and Supratherapeutic Dosing of Givinostat in Healthy Volunteers.
Givinostat at the maximum labeled dose (up to 53.2 mg twice daily for DMD) is not expected to pose a QT prolongation risk, though a supratherapeutic dose of 300 mg produced clinically relevant QTc prolongation of 13.6 ms.
Reliability and validity of EuroQol-5 Dimensions-5 Levels in patients with haematologic malignancies: a cross-sectional study in China.
EQ-5D performed well in patients with multiple myeloma but showed moderate validity in acute leukaemia and poor validity in lymphoma, with EQ-5D utility values consistently higher than TTO-elicited utility scores across all three haematologic malignancy groups.
Double-barrel STA-MCA bypass with endovascular parent artery occlusion for complex anterior circulation aneurysms: indications and outcomes.
A hybrid approach combining double-barrel STA-MCA bypass with endovascular parent artery occlusion offers a safe and effective treatment option for complex intracranial aneurysms, providing reliable flow restoration and durable aneurysm exclusion.
Liver resection versus transarterial chemoembolization plus PD-1 inhibitors and lenvatinib for hepatocellular carcinoma with portal vein tumour thrombus.
The LRPL strategy (liver resection plus PD-1 inhibitors and lenvatinib) was associated with superior survival compared with TPL (transarterial chemoembolization plus PD-1 inhibitors and lenvatinib), especially in patients with secondary branch PVTT, indicating its potential as the preferred therapeutic option for this patient population.
Clinical Values of Serum Extracellular Vesicle MicroRNA Profiles as Molecular Biomarkers for Ischemic Stroke and Transient Ischemic Attack.
A serum EV miRNA signature (downregulated let-7f-5p, upregulated miR-486-5p and let-7b-5p) may serve as a non-invasive biomarker panel for assessing IS severity and TIA stroke risk, with dysregulation of these miRNAs and their targets potentially contributing to ischemic injury pathology.
Deep learning-based identification of chronic pulmonary embolism on CTPA: a regional lung analysis using multiplanar MIP images.
A convolutional neural network can identify chronic pulmonary embolism and chronic thromboembolic pulmonary hypertension from CTPA-derived MIP images, with performance improving as more vessels were included and proximal vessels being most relevant for CTEPH detection.
Registry of Percutaneous Coronary Interventions in Very Small-Caliber Vessels: Analysis of a Sirolimus-Eluting Stent and Other Contemporary Drug-Eluting Stents.
The Inspiron® sirolimus-eluting stent demonstrated acceptable safety and efficacy and provided comparable 12-month clinical outcomes to other contemporary drug-eluting stents in very small-caliber coronary vessels (≤2.25 mm).
Effect of modified air-pulse stimulation on tracheotomised patients with dysphagia after stroke: A randomized clinical trial.
Modified air-pulse stimulation delivered via flexible endoscopy is an effective therapy for improving swallowing function in tracheotomized stroke patients with dysphagia, producing significantly better outcomes than conventional air-pulse stimulation across all measured indicators.
Prognostic Value of In-Hospital Nutritional Status Improvement in Heart Failure: Insights From JROADHF-NEXT Registry.
In hospitalized patients with acute HF and moderate to severe malnutrition, improvement in CONUT score during hospitalization was associated with lower post-discharge mortality and rehospitalization.
Cardiometabolic index is associated with hypertension among US older adults: An analysis of NHANES 2011-2018.
CMI exhibited a positive correlation with hypertension among older adults, indicating that CMI is expected to become a simple and cost-effective biomarker.
Real-world healthcare resource utilization and clinical outcomes among patients with relapsed/refractory multiple myeloma receiving ciltacabtagene autoleucel after four or more prior lines of therapy in inpatient versus outpatient settings.
Outpatient administration of ciltacabtagene autoleucel yielded similar effectiveness and safety outcomes relative to inpatient administration, while significantly reducing inpatient resource use in patients with relapsed/refractory multiple myeloma after ≥4 prior lines of therapy.
Synergistic Impact of Fasting Plasma Glucose and Serum Uric Acid on Peripheral Diabetic Retinopathy Severity in T2DM Patients.
Concurrent elevations of FPG and SUA are strongly associated with an increased likelihood of S-NPDR, with a strong synergistic interaction confirmed (adjusted OR for high FPG/high SUA = 17.56; RERI = 12.58), and a validated nomogram demonstrated excellent discrimination (AUC = 0.925) for personalized risk stratification.
Evaluating Arrhythmia Risk in Patients with Chronic Obstructive Pulmonary Disease Treated with Aclidinium/Formoterol Fumarate and Other Inhaled Bronchodilators: A Post-Authorization Safety Study.
CA and AF risks were increased for most study medications compared with LABA, and increased risks of CA and AF for several medications relative to LABA, LAMA, or LAMA/LABA may be driven by differences in baseline characteristics such as COPD severity.
Antithrombotic Therapy Discontinuation, Bleeding, and Thromboembolic Events in Patients With Cancer During the Last Phase of Life: Insights From Primary Care Records.
One-third of patients with cancer used antithrombotic therapy at the initiation of GP palliative care, with most continuing until death or discontinuing shortly before death, and bleeding events largely outnumbered thromboembolic events among both ATT users and non-users.
RNA sequencing-derived gene co-expression and drug-gene interaction analysis reveal STAT1 as a potential therapeutic target in thrombotic antiphospholipid syndrome.
STAT1 is identified as a central regulator of gene expression networks in thrombotic primary antiphospholipid syndrome, integrating both immune-related and regulatory processes, and assessment of pharmacological target availability revealed STAT1 as a promising treatment target.
Baseline Cerebral Small Vessel Disease Predicting Long-Term Cognitive Decline in Transient Ischemic Attack Patients.
Higher CSVD-score was independently associated with greater cognitive decline over 3 years in TIA patients, with CMB burden being the strongest predictive component and memory being the most affected cognitive domain.
[Application of transcatheter edge-to-edge repair in the treatment of papillary muscle rupture of mitral valve after acute myocardial infarction].
TEER is technically feasible for treating acute severe mitral regurgitation caused by papillary muscle rupture following AMI, and can effectively reduce mitral regurgitation and improve hemodynamic status in selected high-risk patients in the short term.
The Fatty Acid Transporter CD36 Mediates Uptake, Biodistribution, and Cardioprotection by Small Extracellular Vesicles From HEK293 Cells.
CD36 mediates uptake and cardioprotection of HEK293-derived small extracellular vesicles, which significantly reduced infarct size following cardiac ischaemia and reperfusion injury, suggesting therapeutic potential in myocardial infarction.
Prolonged Systemic Inflammatory Response Syndrome Predicts Atrial Fibrillation After Cardiac Surgery.
A subset of cardiac surgery patients demonstrates impaired adaptation to the perioperative inflammatory response, placing them at increased risk for AF both early after surgery and following discharge.
Evolution of Right Ventricular Function and Pulmonary Artery Coupling After Transapical Transcatheter Mitral Valve Replacement.
RV dysfunction and impaired RV-PA coupling are frequent among TMVR candidates, may inform risk stratification, and carry prognostic significance, while TMVR is associated with haemodynamic improvements that could benefit RV-PA coupling.
[Regulatory effect of electroacupuncture at "Neiguan" (PC6) and "Zusanli" (ST36) with different intensities on autonomic nerves and cardiac function after myocardial ischemia].
The optimal intensity of electroacupuncture at PC6 for improving cardiac function is 1.5 mA, while that at ST36 is 3 mA, and these regulatory effects depend on the integrity of the autonomic nervous system.
Risk assessment for cardiovascular adverse drug events in the ICU: Case study on COVID-19 patients.
Simulated hypothetical drug substitutions using MedUTI software in COVID-19 ICU patients resulted in a 53% decrease in high-risk patients (from 96.0% to 43.0%) based on Tisdale score assessment of cardiovascular adverse drug events.
Identifying clinico-radiological determinants of post-stroke fatigue 3 months post-stroke in a French hospital-based cohort of non-severe stroke patients without psychiatric comorbidities.
Post-stroke fatigue in non-severe stroke patients without psychiatric comorbidities arises from an interplay of socio-demographic, emotional, and cerebral risk factors, with lesions in the right corona radiata and external capsule associated with total fatigue scores, and cerebro-cerebellar tract involvement linked to mental fatigue and reduced activity subdimensions.
Temporal Assessment of Pressure and Stiffness in Compression Therapy for Venous Leg Ulcers: Implications for Clinical Optimization.
Initial sub-bandage pressures in compression therapy for venous leg ulcers were higher than guideline recommendations but showed notable reduction within the first 24 hours, stabilising within therapeutic ranges for the remainder of the 96-hour study period.
[Risk factors of unfavorable clinical outcome in orbital granulomatosis with polyangiitis].
In a cohort of 107 patients with orbital granulomatosis with polyangiitis, a favorable outcome of orbital inflammation was observed in 62.6% of cases, while an unfavorable outcome occurred in 27.4%, with positive ANCA, systemic disease form, diffuse orbital inflammation, optic neuropathy, and peripheral ulcerative keratitis identified as risk factors for unfavorable outcomes.
Recurrent intracranial hemorrhage secondary to congenital factor XIII deficiency: A case report and literature review.
Clinicians should consider FXIII deficiency when recurrent ICH occurs with normal routine coagulation tests, to enable early diagnosis and life-saving replacement therapy.
Home based, tailored intervention to reduce rate of falls after stroke (FAST): randomised trial.
A tailored multidisciplinary home-based intervention resulted in a 33% reduction in the rate of falls over 12 months in community-dwelling ambulatory people with stroke (incidence rate ratio 0.67, 95% CI 0.48 to 0.94; P=0.02).
Diagnostic value of 24-h urinary aldosterone and related biomarkers for screening primary aldosteronism in medication-exposed populations.
Under conditions of ongoing antihypertensive medication use, UARR exhibits excellent diagnostic accuracy (AUC = 0.862) for primary aldosteronism screening, whereas 24h-Uald alone demonstrates only modest diagnostic performance (AUC = 0.657).
[Effects of electroacupuncture with different waveforms on NLRP3 inflammasome and pyroptosis in the cerebral cortex of rats with cerebral ischemia-reperfusion injury].
Different electroacupuncture waveforms could all alleviate neurological deficits and reduce cerebral infarct volume in CIRI rats, and the mechanism may be related to inhibition of NLRP3 inflammasome-mediated pyroptosis.
Multiview deep learning improves detection of major cardiac conditions from echocardiography.
Multiview deep neural networks integrating multiple echocardiographic video views simultaneously improved discrimination by 0.06-0.09 AUC compared to single-view DNNs for detecting ventricular abnormalities, diastolic dysfunction, and substantial valvular regurgitation.
Qualitative Study of Breast Cancer and Lymphoma Patients Participating in a Physical Activity Intervention: The Case for Tailored Physical Activity.
Qualitative interviews with breast cancer and lymphoma patients receiving cardiotoxic chemotherapy revealed that altruism and provider recommendation drove enrollment, while intrinsic motivation, ease of participation, and positive study experiences supported completion, and symptom burden and lack of motivation were the main barriers to adherence.
PRECISION study: impact of personalised cardiac anaesthesia and cerebral autoregulation on neurological outcomes in patients undergoing cardiac surgery - protocol for an international, multicentre, prospective cohort study.
The PRECISION study is a multicentre prospective cohort study protocol designed to assess whether perioperative duration and magnitude of mean arterial pressure deviation from an individual's cerebral autoregulation limits are associated with adverse neurological complications in patients aged 65 or older undergoing cardiac surgery with cardiopulmonary bypass.