Dietary Supplements
470 peer-reviewed studies indexed
"Hot spring"-mimetic microneedle patches delivering probiotics to accelerate infected wound healing via antibacterial, anti-inflammatory, and angiogenesis.
A hot spring-inspired microneedle patch co-delivering inactivated Akkermansia muciniphila, copper sulfide nanoparticles, and arginine accelerated infected wound healing via synergistic photothermal antibacterial, anti-inflammatory, and pro-angiogenic effects in a mouse model.
Konjac mannan oligosaccharides as a sustainer of fasting-associated gut microbiome signature after discontinuation of intermittent fasting in overweight individuals: A protocol for an open-label randomized clinical trial.
This protocol describes a prospective randomized controlled trial to test whether konjac mannan oligosaccharides (KMOS) supplementation (1.5 g/d) can maintain intermittent fasting-provoked levels of SCFA-producing bacteria after discontinuation of intermittent fasting in overweight individuals.
Factors associated with adherence to allocated treatment in the ASCEND trial: a mail-based randomised trial of aspirin and of omega-3 fatty acid supplementation in people with diabetes.
In the ASCEND mail-based randomised trial, women and those with higher levels of frailty, smoking, and vascular risk score had poorer adherence to trial medication, while overall adherence was comparable to less streamlined trials in similar populations.
The effect of exogenous ketone monoester supplementation on cerebral blood flow and functional brain characteristics in adults with subjective cognitive decline: study protocol for a randomized crossover trial.
This paper describes a protocol for a randomized placebo-controlled crossover double-blind trial investigating whether 14-day ketone monoester (KME) supplementation increases cerebral blood flow, brain functional connectivity, and cognitive performance in middle-to-older adults with subjective cognitive decline.
The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial.
12 weeks of combined interval resistance-aerobic training and fisetin supplementation significantly reduced pro-inflammatory adipokines (asprosin -60.71%, MCP-1 -46.50%) and improved lipid profiles in obese men, with the combined training plus fisetin group achieving the most substantial effects.
Randomized, placebo-controlled trial reveals the impact of dose and timing of Bifidobacterium infantis probiotic supplementation on breastfed infants' gut microbiome.
Supplementing exclusively breastfed infants aged 2-4 months with B. infantis EVC001 at any tested dose successfully restored beneficial gut bacteria, with colonization persisting at least 1 month post-supplementation.
Inclusion of stabilised rice bran in ready-to-use therapeutic food supports growth in Indonesian children with severe and moderate acute malnutrition: solutions to enhance health with alternative treatments (SEHAT), a double-blinded, randomised clinical trial.
A double-blinded RCT found that RUTF containing stabilised rice bran produced significantly greater weight gain velocity and MUAC velocity at week 4 compared to RUTF without rice bran in Indonesian children with acute malnutrition, showing 'promising impact of stabilised rice bran as a prebiotic and nutrient-dense ingredient for inclusion into RUTFs.'
Caffeine Supplementation Increases Muscle Strength, but Not Endurance, While Both Caffeine and Its Expectation Elevate Blood Lactate: A Balanced-Placebo Design Study.
Caffeine supplementation significantly increased muscle strength but not muscle endurance, while both caffeine and its expectation elevated blood lactate levels in resistance-trained men using a balanced-placebo design.
Could taurine supplementation improve graft functions after liver transplantation? A randomized clinical trial among liver transplant recipients.
Supplementation with 2 g/day taurine for 30 days after liver transplantation was associated with improved graft function markers (AST, total bilirubin, INR) and better clinical recovery outcomes, suggesting taurine may be a beneficial adjunct therapy to support early post-transplant recovery.
Effect of Supplementation with Lactobacillus reuteri SGL 01 in Lactating Women on Breast Milk and Neonatal Gut Microbiota: An Exploratory, Randomized, Open-Label Clinical Trial.
Maternal supplementation with L. reuteri SGL 01 did not modify breast milk microbiota but was associated with a modulation of neonatal gut colonization, including an increased abundance of beneficial taxa such as Bifidobacterium, suggesting potential indirect maternal-to-infant microbial effects.
Weizmannia coagulans BC99 alleviates alcohol-induced oxidative stress and gut barrier dysfunction via modulation of butyrate metabolism: A randomized, double-blind, placebo-controlled trial.
BC99 supplementation improved alcohol metabolism, reduced oxidative stress, and supported intestinal barrier function in chronic alcohol consumers, with modulation of butyrate-related metabolic pathways as a potential contributing mechanism.
Remission of impaired glucose tolerance by anthocyanin supplementation: a randomized, double-blind, and placebo-controlled trial.
Anthocyanin supplementation (160 mg/d for 12 weeks) significantly reversed impaired glucose tolerance by improving insulin sensitivity, with IGT reversion rates of 55.9% versus 29.4% in the placebo group, though no significant between-group difference was found in the primary outcome of β-cell disposition index.
High-dose vitamin C supplementation in patients undergoing allogeneic hematopoietic stem cell transplantation: A pilot randomized, triple-blind, placebo-controlled trial.
High-dose vitamin C supplementation effectively corrected plasma vitamin C levels in allo-HSCT patients, and while trends toward reduced complications were observed, larger trials are needed to confirm these findings.
Effect Modification by Serum Vitamin A Levels on the Association between Vitamin D and Relapse or Death in Patients with Digestive Tract Cancer.
Serum vitamin A levels modify the effect of vitamin D supplementation on relapse or death among patients with digestive tract cancer, with benefit observed only in patients with middle-to-upper range serum vitamin A levels (deciles 6-8).
Therapeutic Impact of Systemic Probiotics Combined with Mechanical Debridement in Peri-Implant Disease: A Clinical and Microbiological Evaluation.
Systemic probiotics, when used as an adjunct to mechanical debridement, significantly improve clinical and microbiological outcomes in peri-implantitis management, offering a synergistic approach for enhanced therapeutic efficacy.
Comprehensive nursing care for advanced digestive malignancy patients during chemotherapy based on probiotic intervention: a randomized controlled study on improvement of gastrointestinal function and prevention of complications.
A comprehensive nursing protocol combined with probiotic intervention significantly improves gastrointestinal function, enhances nutritional status, reduces non-infectious complications, and boosts quality of life in chemotherapy patients with advanced digestive malignancy.
Effect of Flaxseed Supplementation on Headache Characteristics and Quality of Life in Patients with Migraine: A Randomized Controlled Trial.
Daily consumption of 20 g flaxseed powder for 8 weeks significantly improved headache severity, sleep quality, and quality of life in patients with migraine compared to a control group.
Using Dose-Response Correlation Re-Analyzing to Distinguish Placebo from Standardized Rose-Hip Powder (Lito) in a Clinical Trial on Osteoarthritis Where Data Initially Looked Identical.
Dose-response correlation analysis uncovered positive effects of Rosa-canina powder on osteoarthritis symptoms that were not detectable through standard between-group comparisons, by exploiting body-weight-driven variability in mg/kg exposure.
The effect of Cornus mas L. fruit extract supplementation on glycemic control, insulin resistance, and adiponectin levels in patients with metabolic dysfunction-associated steatotic liver disease: a double-blind randomized controlled clinical trial.
CMFE consumption may have a beneficial impact on adiponectin levels especially in women, but had no significant effect on glycemic control and insulin resistance indices in MASLD patients.
Impact of Subgingival Lactobacillus reuteri Probiotic Therapy on Clinical Outcomes and Porphyromonas gingivalis Quantification in Peri-Implant Disease: A Prospective RT-PCR-Based Clinical Study.
Adjunctive subgingival Lactobacillus reuteri probiotic therapy significantly improves clinical outcomes and reduces microbial load in peri-implantitis patients, offering a beneficial addition to mechanical debridement.
Novel immune-modulating formula versus standard formula for gastrointestinal cancer patients at risk of malnutrition undergoing surgery: A pilot randomized controlled trial.
Preoperative supplementation with a curcumin-containing immunonutrient formula for 10-14 days reduced preoperative inflammatory response and produced greater weight gain compared to a standard formula in gastrointestinal cancer patients at nutritional risk.
Effects of Heat-Killed Lactobacillus acidophilus IDCC 3302 on Skin Aging Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial in Healthy Adults.
12-week supplementation with heat-killed Lactobacillus acidophilus IDCC 3302 was safe and well tolerated, but no placebo-adjusted benefit was observed for prespecified primary wrinkle endpoints, with an exploratory between-group difference observed only for the Cutometer overall elasticity index (R2).
Effect of probiotic supplementation on the progression of non-cavitated carious lesions in children: A 12-month randomized controlled trial.
Daily consumption of milk supplemented with L. rhamnosus SP1 for 10 months reduced the number of preschool children who developed cavitated carious lesions over a 12-month period and may represent a safe and feasible adjunct for community-based prevention of early childhood caries.
Efficacy of Oral Vitamin B-12 at 1000 μg Compared with 2000 μg on Neuropathic Outcomes in Patients with Diabetic Peripheral Neuropathy and Low Serum Vitamin B-12: a Randomized Clinical Trial.
In patients with DPN and low serum vitamin B-12 levels, 16 weeks of daily supplementation with either 1000 μg or 2000 μg of vitamin B-12 similarly improves neuropathic symptoms, and apart from higher serum B-12 levels, the 2000 μg dose did not offer additional neuropathic or metabolic benefits.
IMPACT OF GINGER SUPPLEMENTATION ON BLOOD PRESSURE AND GLUCOSE LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND CARDIOVASCULAR DISEASE.
Ginger supplementation significantly reduced inflammatory markers, lipid levels, and fasting glucose in patients with T2DM and CVD, suggesting it 'can be used as an adjunctive treatment to control cardiometabolic risk.'
Impact of Mango Puree Supplementation on Inflammatory, Muscle Damage, and Selected T-Cell Biomarkers in Elite Beach Volleyball Players During Regular Training.
Mango puree supplementation during regular training was associated with lower inflammatory and muscle damage biomarkers and alterations in selected T-cell subsets compared with the placebo in elite beach volleyball players.
Vitamin D supplementation and selected metabolic parameters in patients with type 2 diabetes and obesity: a prospective observational study.
High-dose vitamin D3 supplementation (4,000 IU/day for 12 weeks) significantly improved vitamin D status and was associated with modest improvements in glycemic control in obese patients with T2DM, without affecting blood pressure, calcium, or body weight.
Impact of High Doses of Vitamin D on Specific Metabolic Parameters in Type 2 Diabetes Patients: A Prospective Biomedical Study.
High-dose vitamin D supplementation (10,000 IU/day for 12 weeks) effectively corrected vitamin D deficiency and reduced PTH levels in type 2 diabetes patients, while other metabolic markers (HbA1c, FBG, calcium, and phosphorus) remained stable.
Lactiplantibacillus plantarum GUANKE ameliorates influenza a virus-induced inflammation and lung barrier dysfunction through enhancing mitophagy and improving oxidative phosphorylation.
Lactiplantibacillus plantarum GUANKE and its metabolite linoleic acid ameliorate influenza A virus-induced pulmonary damage by enhancing Parkin-dependent mitophagy and restoring mitochondrial oxidative phosphorylation capacity.
Endothelial sensitivity to exercise-induced shear rate in older adults: effect of biological sex and acute folic acid consumption.
Endothelial sensitivity to exercise-induced shear rate does not differ between healthy postmenopausal females and age-matched males, and acute folic acid consumption does not improve endothelial sensitivity to exercise-induced shear rate in healthy older females or males.
Maternal supplementation of vitamin B12 in predominantly vegetarian pregnant women improves their vitamin B12 status and the neurodevelopment of their infants: the MATCOBIND multicentric double-blind randomised control trial.
Daily supplementation with 250 µg of vitamin B12 during pregnancy in vegetarian mothers significantly improved infant mental developmental quotient and maternal B12 status compared with a 50 µg dose.
Pharmacological and metabolic effects of Bifidobacterium triple viable capsules and Five-animal Play in patients with impaired glucose tolerance.
Huatuo Five-animal Play exercise may offer a safe, mechanism-based non-pharmacological approach for early metabolic intervention in pre-diabetes, with outcomes comparable to Bifidobacterium triple viable capsules and superior to low-intensity aerobic exercise in reducing FBG, 2hFBG, HOMA-IR, and Wnt5a.
Preliminary clinical study on the synergistic effects of prebiotics and β-hydroxy-β-methylbutyrate in improving muscle function and intestinal barrier function in elderly patients with sarcopenia.
HMB improves muscle function in sarcopenic elderly, and prebiotics combined with HMB further enhance intestinal barrier repair and reduce inflammation, offering a promising gut-muscle-targeted nutritional strategy.
Case Report: Resolution of complete heart block following vitamin D supplementation in a child with Graves disease.
This case report describes resolution of complete heart block to first-degree AV block following vitamin D3 supplementation in an 11-year-old male with Graves disease, highlighting a potential association warranting further investigation.
Phytotherapeutic Supplementation with Momordica charantia: Beneficial Effects in Patients with Suboptimal Glycemic Control on Double Antidiabetic Therapy-A Real-World Evidence Observational Study.
Adjunctive Momordica charantia supplementation was associated with additional improvements in glycemic control compared with continuation of dual antidiabetic therapy alone, with the most pronounced effects observed for HbA1c and fasting plasma glucose in patients with suboptimal glycemic control on metformin plus dapagliflozin.
Effects of Astragalus membranaceus and Panax notoginseng Saponins Extract on the Pharmacokinetics of Whey Protein Absorption, Intestinal Permeability, and Muscle Function: A Pilot Study.
APS supplementation enhances amino acid absorption from whey proteins, muscle function and gut barrier integrity, especially in older adults, highlighting its synergistic role in improving protein supplementation efficacy for those with age-related muscle loss.
Long-Term Efficacy of Limosilactobacillus reuteri DSM17938 in the Prevention of Functional Abdominal Pain Disorders.
Early supplementation with L. reuteri DSM 17938 was associated with a markedly lower prevalence of functional abdominal pain at age 10, with FAP diagnosed in 13.1% of the probiotic group versus 80.2% of the placebo group.
Interpheron type II signature in mucosal swabs of patient with infantile colic treated with Limosilactobacillus reuteri (L. reuteri) LMG P-27481.
L. reuteri LMG P-27481 administration significantly upregulated CXCL9, IDO1, and HLA-DRA in the oral mucosa of colicky infants, suggesting it modulates mucosal immunity beyond the gastrointestinal tract and promotes immune homeostasis.
Acute exogenous ketone monoester supplementation decreases indices of cardiac vagal modulation in a dose-dependent manner in healthy adults.
Acute exogenous ketone monoester supplementation decreases HR variability measures associated with cardiac vagal modulation in a dose-dependent manner in healthy adults.
Daily mango (Mangifera indica L.) consumption supplemented with probiotics differentially modulates inflammation and cognitive function in individuals with overweight or obesity: a placebo-controlled, double-blind, and randomized trial.
Mango plus probiotics supplementation for 8 weeks differentially modulated inflammation and cognitive function based on BMI status, with probiotics enhancing cognitive performance in lean participants while attenuating inflammation and improving cognitive function in overweight/obese participants, likely due to increased systemic exposure to gallotannin-metabolites.
Effectiveness of the national vitamin D supplementation program: evaluation of children aged 0-3 years in Karabük province.
The majority of children in Karabük province fail to attain desired vitamin D levels, with only one-fourth achieving adequate levels in the first 12 months, declining to one-tenth by 36 months, indicating the need for reforms in Turkey's national vitamin D supplementation program.
Effectiveness of Streptococcus salivarius probiotics on alleviating radiation-induced oral mucositis via inflammatory and microecological modulation: a prospective pragmatic interventional study in nasopharyngeal carcinoma.
SsM18 supplementation significantly delayed OM onset, reduced severe OM duration, and shortened total OM duration compared with no probiotic, while elevated IL-6 and high BOAS score were independent predictors of a 'Rapid-Onset, Severe' OM trajectory in NPC patients receiving chemoradiotherapy.
Effects of Greek Yogurt Versus Whey Protein Supplementation on Markers of Bone Turnover and Inflammation in University Athletes: A 24-Week Intervention Study.
Although protein supplementation, independent of source (wholefood or isolates), showed potential bone and inflammatory benefits during athletic training, it remains unclear whether these effects were solely attributable to the supplements.
Association of fish oil supplementation with risk of incident severe non-alcoholic fatty liver disease: a prospective study of 488 888 individuals.
Fish oil supplementation was associated with a 7% lower risk of severe NAFLD (HR 0.93, 95% CI 0.87-0.99) over 12.3 years of follow-up in 488,888 UK Biobank participants, with CRP, HDL-C, and cystatin C partially mediating this association.
Effects of the micronutrient Sanopal® (5-hydroxymethyl-2-furfural and α-ketoglutaric acid) on oxygen affinity of hemoglobin, oxygen saturation and exercise responses at altitude.
Sanopal® did not alter hemoglobin-oxygen affinity or SpO2 under resting conditions in normoxia or acute hypoxia, but after exercise at altitude it slightly increased Hb-O2 affinity without significantly affecting SpO2 or other measured blood parameters.
Omega-3 polyunsaturated fatty acid supplementation for muscle health in community-dwelling older adults at high risk of sarcopenia: protocol for a multicentre, randomised, double-blind, placebo-controlled trial.
This paper describes a protocol for a multicentre, randomised, double-blind, placebo-controlled trial investigating the efficacy of three different n-3 PUFA supplementation regimens compared with corn oil placebo on muscle health in community-dwelling older adults at high risk of sarcopenia.
Therapeutic potential of Lactobacillus kefiranofaciens ZW18 postbiotic in alleviating hepatocellular carcinoma.
Post18 (Lactobacillus kefiranofaciens ZW18 postbiotic) supplementation inhibited tumor growth, improved the tumor microenvironment, and modulated gut microbiota in hepatocellular carcinoma models, representing a potential strategy for alleviating HCC.
The impact of vitamin D supplementation on sudden sensorineural hearing loss in vitamin D deficient patients: A double-blind, placebo-controlled trial: A pilot study.
Vitamin D supplementation added to routine corticosteroid treatment may enhance auditory recovery at key speech-related frequencies (2000 Hz and 4000 Hz) in SSNHL patients with vitamin D deficiency.
Factors associated with enrollment in a randomized clinical trial of docosahexaenoic supplementation in toddlers born preterm.
Maternal, child, and socioeconomic characteristics were different for families who enrolled relative to families who did not enroll, with factors associated with enrollment differing between families who were non-responsive to recruitment attempts and those who declined enrollment.
Impact of osteoporosis pharmacotherapy and vitamin d supplementation on fracture morphology and treatment of pelvic fragility fractures: a retrospective cohort study of 1493 patients from the German Pelvic Trauma Registry.
Two-thirds of elderly pelvic fragility fracture patients received neither specific osteoporosis medication nor vitamin D supplementation before fracture, and patients with prefracture specific osteoporosis medication treatment sustained more unstable fractures requiring surgical intervention, possibly reflecting advanced disease severity or altered bone biomechanics.