Dietary Supplements
470 peer-reviewed studies indexed
Chronic magnesium supplementation in a patient with relapsing severe hypomagnesaemia due to a novel TRPM6 variant diagnosed in adulthood.
Adult-onset familial hypomagnesaemia with secondary hypocalcaemia (HOMG1) due to a novel TRPM6 variant was managed long-term with parenteral magnesium supplementation, with intravenous administration effective for over 3 years before device infections and venous occlusions necessitated transition to subcutaneous infusion.
Effects of couscous supplementation on breast milk production and infant weight gain: a crossover clinical trial.
Couscous supplementation proved to be a viable strategy for enhancing both milk production and infant weight gain in exclusively breastfed infants.
[Effects of probiotics combined with breastfeeding on intestinal colonization and the risk of allergic diseases in newborns delivered by cesarean section: a 5-year follow-up study].
Among cesarean-delivered newborns, the combination of probiotics and breastfeeding positively modulates the gut microbiota, promotes the growth of beneficial bacteria, enhances immunity, and reduces the risk of allergic diseases.
The Effects of Vitamin K2 on Recovery from Muscle-Damaging Resistance Exercise in Young and Older Adults: The TAKEOVER Randomized Controlled Trial.
Vitamin K2 supplementation had no effect on muscle strength, physical function, muscle soreness, or inflammatory responses in the recovery period after a bout of resistance exercise, though effects on electromechanical delay, EMG root mean square, IL-6, and creatine kinase were observed specifically in older adults.
Secondary prevention of leg cramps using compression stockings or magnesium supplements: a three-arm randomized clinical trial.
Daily use of compression stockings was effective in reducing the frequency and pain intensity of leg cramps, as well as the number of nocturnal awakenings caused by them, while magnesium showed no significant benefit over placebo.
Effectiveness of a soccer injury prevention program based on creatine supplementation and internal load monitoring: a randomized controlled pilot study.
Creatine supplementation (3 g/day for 14 weeks) improved strength and jump performance and showed a trend toward lower injury incidence in amateur soccer players, supporting its potential as an adjunct in soccer injury-prevention programs.
Effect of probiotic lozenges on improvement in tympanometric classification within 12 weeks in children aged 3-6 years with adenoid hypertrophy and otitis media with effusion undergoing non-surgical management: a randomized controlled trial.
Daily SSK12 lozenges for 12 weeks significantly improved tympanogram classification and auditory function, mediated by enhanced probiotic colonization and pathogen suppression, with excellent safety and adherence.
Efficacy of Sertraline Combined With Intestinal Microecological Therapy in Adolescents With Moderate Depression and Suicidal Ideation and Its Effects on Serum Inflammatory Factors.
Sertraline combined with Bacillus subtilis probiotic preparation enhanced antidepressant efficacy in adolescents with moderate depression and suicidal ideation by reducing neuroinflammation, as evidenced by significantly improved clinical symptoms and reduced serum inflammatory markers compared to sertraline monotherapy.
Orally Administered Bacillus licheniformis F0726 Attenuates MPTP/P-Induced Neurodegeneration by Modulating Gut Microbiota and Suppressing Inflammatory Responses.
Orally administered Bacillus licheniformis F0726 may alleviate neurodegenerative lesions in PD mice by modulating the gut microbiota and suppressing inflammatory responses.
A randomised, placebo-controlled trial in healthy humans of modified cellulose or psyllium evaluating the role of gelation in altering colonic gas production during inulin co-administration.
While psyllium significantly reduced initial breath hydrogen production compared to placebo when co-administered with inulin, a non-inferior effect with methylcellulose was not demonstrated, despite similar physicochemical properties in vitro.
Effects of an amino acid mixture on alcohol metabolism and alcohol-related symptoms in healthy adults.
AL supplementation was associated with more rapid reduction in blood alcohol and acetaldehyde concentrations and lower severity of alcohol-related symptoms, particularly fatigue and cognitive difficulty, compared with placebo in healthy adults.
Administering Bifidobacterium pseudolongum With Arsenic Trioxide Attenuates Acute Promyelocytic Leukemia in Mice by Restoring Immune Microenvironment and Intestinal Homeostasis.
Bifidobacterium pseudolongum supplementation adjunctive to arsenic trioxide counteracts gut dysbiosis, intestinal damage, and immune microenvironment disruption while synergistically improving antileukemic efficacy in a murine APL model.
Bifidobacterium Breve SHMB 8001 Alleviates DSS-Induced Colitis in Mice Via Modulating the Intestinal Barrier and Gut Microbiota.
B. breve SHMB 8001 represents a potential probiotic strain for alleviating colitis by normalizing intestinal homeostasis via modulating intestinal barrier proteins, short-chain fatty acids, regulatory T cells, inflammatory cytokines, and gut microbiota composition.
Pharmacokinetic effects of a single dose nutritional ketone ester supplement on brain glucose and ketone metabolism in alcohol use disorder.
A single dose of ketone ester supplement (395 mg/kg) rapidly shifted brain energy use from glucose to ketones, producing a 17% reduction in brain glucose metabolism and significantly reducing alcohol craving in individuals with alcohol use disorder.
Effect of carotenoids supplementation on visual function in Chinese adults free of retinal disease: protocol for the CSV double-blind, randomised, placebo-controlled trial.
The CSV trial is a double-blind, randomised, placebo-controlled trial designed to investigate whether carotenoid supplementation (10 mg lutein, 10 mg meso-zeaxanthin, and 2 mg zeaxanthin daily for 1 year) can improve visual function, particularly contrast sensitivity, in Chinese adults free of retinal disease.
O08 The elemental clue: a case series of Acrodermatitis enteropathica in a tertiary centre.
Six cases of Acrodermatitis enteropathica in a tertiary centre highlight that prematurity and exclusive breastfeeding are key risk factors for acquired disease, with diagnosis primarily based upon the dermatological presentation.
A QSP Model of Valproic Acid Toxicity in Pediatric and Adult Populations: Implications for Formulation Selection and L-Carnitine Supplementation.
A QSP model incorporating age, sex, and formulation covariates predicted VPA-induced toxicity incidences across pediatric and adult populations, revealing age-dependent toxicity patterns and demonstrating that extended-release formulations and L-carnitine supplementation at twice the VPA dose (in mg) may reduce adverse effects.
Sprayable dynamic Schiff-base hydrogel engineers an oxygen-limited microenvironment for viable Bifidobacterium bifidum delivery and accelerated oral ulcer healing.
A sprayable dynamic Schiff-base gelatin/cellulose hydrogel engineers an oxygen-limited microenvironment for viable Bifidobacterium bifidum delivery, synergistically accelerating oral ulcer healing through enhanced fibroblast migration, macrophage M2 polarization, and improved collagen deposition without systemic toxicity.
Fish oil supplementation and clinical outcomes in patients with sepsis-associated acute kidney injury: A retrospective cohort study from the MIMIC-IV database.
Fish oil supplementation in critically ill patients with SA-AKI was associated with reduced 21-day mortality (HR = 0.74) and improved renal function recovery (OR = 1.76), supporting the need for prospective randomized controlled trials to confirm the therapeutic potential of ω-3 PUFA in sepsis-related organ dysfunction.
Efficacy of inulin supplementation in metabolic control and Akkermansia muciniphila levels in subjects with type 1 diabetes: a pilot study.
Inulin supplementation in type 1 diabetes was associated with a slight body weight decrease and insulin need reduction, but not with an increase in Akkermansia muciniphila levels.
Case Report: Lifestyle changes and probiotic supplementation for improving longstanding type 2 diabetes in a male undergoing testosterone replacement therapy.
A 52-year-old male with type 2 diabetes and hypertension undergoing testosterone replacement therapy demonstrated improved glycemic control (HbA1c from 7.2% to 5.9%) and favorable body composition changes at 6 months through combined lifestyle interventions and targeted probiotic supplementation.
Early Protein Supplementation Enhances Wound Healing and Reduces Complications Following Abdominoplasty: A Controlled Study in Non-bariatric Patients.
Postoperative protein supplementation significantly improves wound healing and reduces complications in patients undergoing abdominoplasty, even outside the bariatric population, supporting incorporation of targeted nutritional protocols into routine perioperative care pathways.
A multi-strain probiotic modulates gut microbiome composition, intestinal barrier integrity and inflammation in a multi-compartmental in vitro gut model of decompensated advanced chronic liver disease.
A multi-strain probiotic (Symprove™) modulated gut microbiome composition, improved intestinal barrier integrity, increased short chain fatty acids and anti-inflammatory cytokine production, and decreased pro-inflammatory chemokines in an advanced in vitro gut model using faecal material from people with alcohol-related decompensated advanced chronic liver disease.
Spirulina Supplementation Can Reduce Serum Levels of C-Reactive Protein: A Systematic Review and Meta-Analysis on Randomized Clinical Trials.
Spirulina supplementation significantly reduced serum CRP levels (WMD: -0.09 mg/L; 95% CI: -0.16 to -0.02), whereas its effects on IL-6 and TNF-α were not statistically significant, though significant heterogeneity warrants further high-quality RCTs.
High-Dose Zinc Supplementation Therapy Does Not Improve Survival Rates in Severe Trauma Patients: A Single-Center Retrospective Observational Study.
High-dose zinc supplementation did not improve 30-day survival or other clinical outcomes compared with standard doses in patients with severe trauma requiring mechanical ventilation.
Disolución exitosa de un bezoar gigante tras tratamiento con complejo enzimático.
A conservative approach using an oral enzyme complex (Digeston Plus®) containing digestive enzymes and probiotic bacteria led to symptom resolution and near-complete dissolution of a giant gastric phytobezoar without invasive intervention after a three-month treatment course.
Effects of L-Tyrosine Ingestion on Endurance Performance in Mentally Fatigued Cyclists.
L-tyrosine ingestion increased endurance performance by approximately 16% in mentally fatigued cyclists, accompanied by a reduction in RPE slope during cycling to exhaustion.
Limosilactobacillus fermentum LF61: A multidimensional study on safety and functionality from genomics to clinical application.
Limosilactobacillus fermentum LF61 demonstrated genomic safety (no virulence factors, resistance genes, or toxin clusters), strong in vitro and in vivo safety profiles, and in a randomized double-blind clinical trial increased serum antimicrobial peptide LL-37 and immunoglobulins while promoting short-chain fatty acid-producing bacteria, indicating beneficial effects via a gut-immune axis bidirectional regulatory mechanism.
Combined intravenous bolus amino acid supplementation and mobilization on early muscle loss in critically ill adults: A randomized controlled trial.
A short-duration combined intervention of intravenous bolus amino acids and cycle ergometry, limited to the acute phase of critical illness, did not reduce muscle loss or improve muscle quality, strength, or physical capability.
Renal effects of short-term ketone monoester supplementation in healthy adults: A randomized, placebo-controlled study.
Short-term ketone monoester supplementation was associated with acute increases in measured GFR and urinary sodium excretion, while reducing urinary potassium excretion in healthy adults, but no changes in electrolyte excretion were detectable in 24-h urine, indicating that renal effects are not sustained over the full collection period.
Supplementary parenteral arginine corrects hypoargininaemia and rebalances plasma amino acid profiles in very preterm infants receiving parenteral nutrition: A prospective study.
PN arginine supplementation of 18 g/100 g AA increases arginine concentrations and reduces provision of EAA as demonstrated in the plasma AA profile in very preterm infants.
Lacto-N-Triose II Alleviates DSS-Induced Colitis via Gut Microbiota and Metabolites Associated with the PI3K-Akt Pathway.
Lacto-N-triose II (LNT II) alleviates DSS-induced colitis by remodeling gut microbiota, regulating key metabolites (D-xylulosonic acid, Sakacin P, and taurocholic acid), and inhibiting the PI3K-Akt signaling pathway.
Does Vitamin D Concentration Matter? The Consequential Effects of Serum Vitamin D Concentration and Supplementation on Paediatric Fracture Risk.
Higher serum 25(OH)D concentrations were associated with lower fracture risk, suggesting that optimisation of vitamin D status may represent a modifiable factor in paediatric bone health, though causality cannot be inferred from this retrospective dataset.
Aronia melanocarpa extract supplementation affects brain vascular function and cognitive performance: A randomized, double-blind, placebo-controlled, cross-over study in older adults with overweight or obesity.
Six weeks of AME supplementation improved executive functioning in older adults with overweight or obesity, though CBF in predefined brain regions and other potential underlying mechanisms were not affected.
Microenvironment Self-Adaptive Nanoarmor to Address Adhesion- and Colonization-Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease.
A microenvironment self-adaptive nanoarmor using partially acetylated chitosan oligosaccharides enables probiotic colonization in inflamed intestine by leveraging CHI3L1 as a colonization niche, demonstrating improved intestinal and extraintestinal therapeutic outcomes including treatment of Parkinson's disease.
Improvements in quality-of-life dimensions through medium-chain triglyceride (MCT) supplementation in rheumatoid arthritis: updated findings from a randomised clinical trial.
Patients with RA supplemented with MCTs obtained significant improvements in several health-related QOL components compared to control, and fibre inclusion did not interfere with MCT efficacy.
Effect of processing methods on the phytochemicals, digestion behaviors, and nutraceutical potential of Yunnan large-leaf tea: A combined in vitro and in vivo study.
Fermented teas (ripePT and BT) exhibited unique effects on gut health including enhancing gut microbiota diversity and promoting the production of short-chain fatty acids especially butyrate, associated with selective enrichment of beneficial microbial taxa, while low-fermentation teas showed highly similar phytochemical profiles before and after digestion.
Preoperative symbiotic supplementation modulates the intestinal microbiota of patients with colorectal cancer: Evidence from a randomized clinical trial.
Preoperative symbiotic supplementation in patients with CRC undergoing tumor resection positively altered intestinal microbiota diversity, and increased short-chain fatty acid and mucus production.
Multi-Strain Probiotic and Common Infections in Early Childhood Education Settings: A Randomised Controlled Trial.
Multi-strain probiotic supplementation led to a 62% reduction in gastrointestinal tract infections in early childhood education settings during the last 16 weeks of a 24-week trial, though no beneficial effect was observed on respiratory tract infections.
Impact of an Oral Nutrition Supplement on the Nutritional Status of Stunted and At-Risk of Stunting Children: A Community-Based Intervention Trial.
A daily intake of 510 mL of oral nutrition supplement for 180 days significantly improved linear growth (height-for-age Z-score) and nutrient intake among stunted and at-risk of stunting children aged 12-36 months in Malaysia.
Nutraceutical Effects of Gastrodiae elata and Coenzyme Q10 on Oxidative Stress and Inflammatory Pathways in an In Vitro Gut-Prostate Axis Model.
A combination of Gastrodiae elata extract and coenzyme Q10 reduced oxidative stress, pro-inflammatory mediators, and 5-α-reductase activity in an in vitro gut-prostate axis model, suggesting potential for supporting prostate health through antioxidant, anti-inflammatory, and hormonal control mechanisms.
Energy dense nutritional supplements improve weight gain among malnourished adults with drug-sensitive pulmonary tuberculosis: An open-label randomized controlled trial in Faridabad, India.
Energy-dense nutritional supplements significantly improved weight gain among undernourished adults with drug-sensitive pulmonary tuberculosis, with high acceptability and adherence, and may represent a practical, scalable approach to complement existing food basket and cash transfer strategies.
Feasibility of a randomized clinical trial comparing 5-methyltetrahydrofolate and folic acid prenatal multivitamins in couples with recurrent pregnancy loss.
A fully online RCT comparing 5-MTHF and FA is feasible, with high acceptability and adherence rates, though formulation instability of 5-MTHF in retained samples was identified as a critical confounder.
Probiotics Outperform Antioxidants in Improving Semen Parameters of Men with Idiopathic Oligoasthenoteratozoospermia: A Randomized Controlled Trial.
Probiotics showed superior performance in sperm motility and morphology compared to antioxidants in treating idiopathic oligoasthenoteratozoospermia, although drawing a strong conclusion requires further robust studies.
Effect of 21-Day Omega-3 Polyunsaturated Fatty Acid Supplementation on Exercise-Induced Secretory Factors and Inflammation Status in Young Men: A Randomized Double-Blind Trial.
21 days of n-3 fatty acid supplementation (3250 mg/day) modified PUFA content and influenced inflammation status, but did not affect maximal anaerobic performance in physically active young men.
Efficacy and safety of a nutritional supplement based on vitamins, minerals, amino acids and plant extracts on a large population of older adults experiencing fatigue.
Daily intake of a specially formulated nutritional supplement (ApportAL®) resulted in a progressive improvement of both fatigue and quality of life in older adults, with significant improvements observed as early as after the first week of supplementation.
Akkermansia muciniphila enhances the antitumour efficacy of αPD-1 therapy in gastric cancer by remodelling the tumour immune microenvironment.
A. muciniphila augmented the efficacy of αPD-1 therapy against gastric tumours by driving CD8+ T-cell infiltration and activation and reshaping the intestinal microbiota.
Evaluation of iron supplementation effects of whey protein peptide-ferrous chelate: enhancing bioavailability and antioxidant capacity, promoting gut microbiota balance.
Medium-dose whey protein peptide-ferrous chelate (WPP-Fe) exhibited superior efficacy compared with ferrous chloride and ferrous gluconate in IDA mice, significantly increasing hemoglobin levels and iron bioavailability while alleviating oxidative stress and promoting gut microbiota balance.
The Effects of Nitrate on Brown Fat Fraction and Activation in Older Adults With Type 2 Diabetes: A Randomised, Double-Blind and Placebo-Controlled Crossover Trial.
14-day of nitrate supplementation did not increase BAT fat fraction or activation in older adults with T2DM.
Anemia Mukt Bharat Index: Methodology and State Rankings of Iron and Folic Acid Supplementation Coverage in India, 2018-2019 to 2022-2023.
The AMB index confirmed that between 2018-2019 and 2022-2023 IFA supplementation coverage increased overall in India by 22.1 percentage points, from 35.5% to 57.6%, with supply chain management and reporting identified as key factors substantially impacting coverage.