Dietary Supplements
470 peer-reviewed studies indexed
The beneficial effect of a multispecies probiotic intervention on quality of sleep - a randomized, double-blinded, placebo-controlled study.
A randomized, double-blind, placebo-controlled trial found that 28-day multispecies probiotic intervention improved quality of sleep beyond the effect of a placebo intervention, with improved sleep efficiency and latency, suggesting microbiome modulation may be of clinical benefit in alleviating sleep disturbances.
l-Malic Acid Potentiates Bifidobacterium breve Bb18 Tolerance and Synergistically Ameliorates Colitis via Gut Microbiota-Metabolite Modulation.
l-Malic acid (l-MA) enhanced Bifidobacterium breve Bb18 bile tolerance by 52.3% in vitro and synergistically alleviated DSS-induced colitis in mice, potentiating Bb18 colonization by 217.6% under inflammatory stress via gut microbiota-metabolite modulation.
Selenium-Enriched Yeast Supplementation and Its Influence on Nerve Function Parameters and Oxidative Stress Markers in Diabetic Peripheral Neuropathy: A Randomized Placebo-Controlled Study.
Selenium-enriched yeast supplementation over 8 weeks significantly improved sexual satisfaction and reduced pro-oxidant-antioxidant balance in diabetic peripheral neuropathy patients, but did not produce significant between-group differences in neuropathy symptoms or severity compared to placebo.
Maternal red blood cell folate and periconceptional folic acid supplementation are associated with neonatal brain maturation: a retrospective EEG-MRI study with term-equivalent imaging.
Higher maternal RBC folate at delivery is associated with more advanced structural and functional neonatal brain maturation at term-equivalent age, and periconceptional folic acid supplementation was more common among mothers with RBC folate sufficiency.
Effects of Structured Lipid Supplementation for Eight Weeks on Substrate Utilization During Moderate Intensity Exercise in Healthy Untrained Men.
Eight weeks of structured lipid supplementation increased erythrocyte membrane EPA and DHA and enhanced fat oxidation during moderate-intensity exercise in untrained men, though the endurance performance improvement was within natural variability and showed substantial interindividual differences.
The impact of Symprove™ multi-strain probiotic on enterotoxigenic Escherichia coli- or antibiotic-induced gut microbiome dysbiosis using high-throughput in vitro screening.
Symprove™ supplementation significantly affected microbial metabolism, with many of the observed changes being considered positive for human health, including in fecal microbiomes with in vitro antibiotic-induced dysbiosis, showing therapeutic potential.
Effect of Perioperative Supplementation with Arginine and Omega-3 on Postoperative Complications in Patients Undergoing Gastrointestinal Cancer Surgery: A Pilot Open-Label Randomized Controlled Trial.
Perioperative immunonutrition with arginine and omega-3 fatty acids did not improve postoperative clinical outcomes or inflammatory markers in patients undergoing gastrointestinal cancer surgery compared to standard care.
A multimodal lifestyle intervention program targeting the muscle and gut to improve metabolic health among Indian adults with (pre)diabetes: Design of the GUT-DM randomized trial.
This paper describes the design of the GUT-DM randomized trial, which aims to explore the effect of a lifestyle intervention (exercise and dietary modification) with/without synbiotics on metabolic, physical, mental and gut health of (pre)diabetic Indian adults compared to standard of care.
Synbiotic supplementation reduces intestinal permeability and inflammation in overweight or obese kidney transplant recipients: a randomized controlled trial.
Synbiotic supplementation for 12 weeks reduces LBP (a marker of intestinal permeability), as well as hs-CRP, IL-6, and sICAM-1, which are risk factors for CVD and graft failure, in overweight or obese kidney transplant recipients.
A Randomized Controlled Trial to Determine the Effects of Curcumin and Epigallocatechin-3-Gallate Supplementation on Serum Brain-Derived Neurotrophic Factor and Mood Disturbance in Adults.
Combined EGCG and curcumin supplementation did not show additional benefits beyond placebo for mood disturbance or serum BDNF over eight weeks, with significant improvements observed across all participants suggesting behavioral or lifestyle factors may play a larger role in short-term mood improvements than supplementation alone.
Beneficial Effect of Xanthohumol Supplementation on the Clinical Course of IgA Nephropathy Refractory to Conventional Treatment-A Prospective, Open-Label Case Series.
Xanthohumol supplementation at 2 mg/kg/day induced decreases in proteinuria and albumin-creatinine ratio in all five IgA nephropathy patients refractory to conventional treatment, with no adverse effects observed over 52 weeks.
Omega-3 fatty acids as host-directed immunomodulatory therapeutics in sepsis: real-world evidence supporting drug development potential for systemic inflammatory diseases.
Omega-3 fatty acid supplementation was associated with significantly reduced adjusted ICU mortality in sepsis (HR=0.60, 95% CI: 0.43-0.83, p=0.003), underscoring its host-directed immunomodulatory properties.
Oleoylethanolamide supplementation improves mood and reduces fatigue in veterans with GWI in a 15-week randomized, double-blind, placebo-controlled exploratory clinical trial.
OEA was safe and improved fatigue and mood in Veterans with GWI, with a main effect of OEA for reducing fatigue (MFI-20, p≤0.05) and improving total mood disturbances score (POMS, p≤0.05) in a 15-week randomized, double-blind, placebo-controlled exploratory clinical trial.
Effects of an 8-week liquid protein supplementation on resistance training adaptations in untrained healthy college students.
Post-exercise liquid protein supplementation enhanced resistance training adaptations in chest circumference and maximal strength (bench press and squat) compared to resistance training alone in untrained college students over 8 weeks.
Short-Term Effects of Broccoli-Derived Glucoraphanin on Recovery from Eccentric Muscle Damage: A Double-Blind Randomized Crossover Study.
Short-term high-dose broccoli-derived glucoraphanin supplementation reconstituted with hot water does not modulate recovery following eccentric muscle damage under the conditions tested.
Six Weeks of Baker's Yeast β-Glucan Supplementation Reveals Unique Immune Maturation mRNA Signature: Implications for Immunity?
Six weeks of baker's yeast beta-glucan supplementation significantly affected 42 mRNAs across 21 annotated immune maturation pathways at rest, which may underlie previously reported improvements in immune function.
Impact of Oral Nutritional Supplementation at Hospital Discharge on Healthcare Costs in Older Adults: A Retrospective Analysis of Japanese Claims Data.
Healthcare costs over 360 days were higher in the ONS-at-discharge group compared with the no-ONS-at-discharge group, however, among patients who continued ONS use after discharge, costs were lower in the ONS-at-discharge group.
A Randomized, Placebo-Controlled Trial Evaluating Multi-Species Synbiotic Supplementation for Bloating, Gas, and Abdominal Discomfort.
Daily supplementation with a multi-species synbiotic (DS-01) significantly improved GI quality-of-life, bloating, gas, abdominal discomfort, and bowel habits compared to placebo in a generally healthy, diverse, real-world population.
Modulation of sepsis by Lacticaseibacillus rhamnosus and the potential role of short-chain fatty acid levels in feces and blood.
Both Lacticaseibacillus rhamnosus strains fa1 and fg2 attenuated sepsis severity partly through increased levels of short-chain fatty acids, supporting the potential of probiotics in preventing sepsis and the use of SCFAs for sepsis disease monitoring.
A new perspective on the association between maternal folic acid supplementation across the perinatal period and cognitive and behavioral outcomes in children at age 4: findings from the MABC birth cohort study.
Maternal folic acid supplementation during the second trimester was associated with a higher risk of externalizing behavioral problems and poorer cognitive development in 4-year-old children, particularly boys, while preconception supplementation was also linked to lower cognitive function.
The effects of beta-hydroxy-beta-methylbutyrate on sarcopenia in stable decompensated cirrhosis: A pilot randomized controlled trial.
In patients with stable decompensated cirrhosis and sarcopenia, 12-week HMB-containing ONS was well-tolerated and showed promise for improving phase angle, mid-arm muscle circumference, and chair stand test performance compared to baseline, but did not significantly increase muscle mass or handgrip strength compared to the control group.
Management of IBD through improving intestinal barrier function by a novel Lactiplantibacillus plantarum C4 strain.
A novel Lactiplantibacillus plantarum C4 strain significantly decreased inflammatory markers and oxidative stress while strengthening intestinal barrier function in DSS-induced colitis mice, with effects comparable to sulfasalazine and superior to commercial probiotic preparation.
Postbiotic effects elicited by heat-inactivated Lacticaseibacillus rhamnosus GG against cow's milk allergy in human cells.
Heat-inactivated Lacticaseibacillus rhamnosus GG postbiotic (LGGp) elicited Tregs activation, beneficial modulation of cytokines production, and improved gut barrier integrity in human cell models of cow's milk allergy, suggesting it 'could be a promising therapeutic strategy against CMA.'
The synergistic effects of Lactobacillus casei HDS-01-konjac glucomannan synbiotic: probiotic potential and in vitro fecal fermentation.
The L. casei HDS-01-KGM synbiotic demonstrated synergistic effects by selectively stimulating probiotic growth, surviving gastrointestinal conditions, enhancing colonization, and promoting SCFAs-producing bacteria and beneficial gut microbiota during in vitro fecal fermentation.
L-fucose supplementation in a patient with global hypofucosylation and a mono-allelic variant in SLC35C1: Clinical improvement and assessment of biomarkers.
L-fucose supplementation in a patient with global hypofucosylation and a mono-allelic SLC35C1 variant led to improvements in weight, head circumference, IgG normalization, and remarkable developmental catch-up, with biochemical evidence of increased fucosylated glycan species.
Understanding consumer perceptions to guide the design of functional yogurts: Evidence from a Brazilian online survey.
Consumer-driven research using projective techniques identified eight distinct consumer profiles for functional yogurt in Brazil, revealing that health benefits (especially probiotics and intestinal health) are the primary motivation while price and taste are the main barriers to consumption.
Hitchhiking novel nanozymes on Bacillus licheniformis as an interactive reinforced bioactive platform for multifaceted therapy of ulcerative colitis.
BL@APPCs, a novel interactive reinforced bioactive platform consisting of Bacillus licheniformis integrated with hybrid nanozymes, demonstrated significant therapeutic efficacy in preventing and treating ulcerative colitis in murine models by combining nano-catalytic therapy, bacteriotherapy, and flavonoid therapy.
The effects of marine fatty acid omega-3 supplements on incident fractures and bone mineral density in generally healthy adults.
Supplementation with marine omega-3 fatty acids did not reduce incident fracture risk or benefit bone density in community-dwelling midlife to older adults.
Muno-IgY Supplementation Improves Respiratory Health, Immune Response, and Exercise-Induced Physiological Stress in Healthy Adults: A Randomized Controlled Pilot Study.
Muno-IgY supplementation was safe and associated with significant improvements in selected markers of exercise-induced immune response and muscle damage, with numerical trends in URTI incidence and gut microbiome composition that were not statistically significant.
Long-Term Outcomes of Multimodal Prehabilitation with High Protein Oral and HMB Supplementation in Sarcopenic Surgical Patients: The HEROS Study.
Multimodal prehabilitation with high-protein oral nutritional supplementation and HMB in sarcopenic surgical patients showed improvements in anthropometric and functional outcomes that persisted to six months post-operatively.
Overall Survival of Glioblastoma Patients Treated With a Combination of 7 Micronutrients: A Nutraceutical Trial.
A randomized double-blind Phase II trial of a 7-micronutrient combination in glioblastoma patients showed overall survival of 14 months (active) versus 13 months (placebo), a difference that was not statistically significant (p=0.752).
Effects of protein sources at sahur on anaerobic power and strength during Ramadan in combat sport athletes: A single blind, randomized, placebo-controlled, counterbalanced crossover study design.
MC supplementation at sahur provides partial protection against fasting-induced declines in anaerobic power and upper body endurance, but does not fully restore performance to non-fasting levels.
Novel Therapeutic Approaches for Treating Moderate-to-Severe Atopic Dermatitis in Infants with Polyvalent Allergic Sensitisation.
Combined therapy comprising pseudoceramides, a calcineurin inhibitor, and an oral synbiotic demonstrated significant superiority over standard therapy, providing clinical improvement, suppression of the Th2 response, and normalisation of gut microbiota in infants with atopic dermatitis and multiple allergic sensitisation.
Almond Supplementation Improves Acne Lesions and Skin Microbial Diversity in Adults with Mild to Moderate Acne Vulgaris.
Daily almond consumption (60 g/day for 20 weeks) reduced acne lesion counts and improved skin microbial diversity and acne-specific quality of life in adults with mild to moderate acne vulgaris.
Combined high-intensity interval training and spirulina supplementation synergistically improve inflammatory and lipid-associated biomarkers in men with obesity.
Combining 12-week HIIT and Spirulina supplementation demonstrates superior efficacy than either intervention alone for targeting lipid- and inflammation-associated markers in men with obesity.
Assessing Parental Understanding and Perspectives on Vitamin A Supplementation for Children: A Quantitative Study using the Health Belief Model.
Perceived susceptibility, perceived benefits, fewer perceived barriers, and higher self-efficacy significantly predicted adherence to Vitamin A supplementation, while perceived severity was not a significant predictor.
Effectiveness and Safety of a Supplement Containing a Pharmacologically Active Basidiomycete Mushroom for Chronic Fatigue and Post-COVID-19 Fatigue Syndrome: Protocol for a Randomized Controlled Trial.
This paper describes the protocol for a randomized, waitlist-controlled trial evaluating whether a 6-week intake of CP003, a lingzhi-containing supplement, can reduce physical and mental fatigue in patients with chronic fatigue syndrome or post-COVID-19 fatigue syndrome, while exploring associations with inflammatory, immune, and oxidative stress biomarkers.
Impact of vitamin D non-reimbursement policy on therapy discontinuation in the general and rheumatic population in the Netherlands: a cross-sectional study.
The implementation of the non-reimbursement policy resulted in a small proportion of patients (6.4%) discontinuing their vitamin D therapy, with elevated discontinuation rates associated with younger age, financial constraints, and limited health literacy.
Lacto-N-triose II alleviates metabolic dysfunction-associated Steatotic liver disease via microbiota-dependent citrulline biosynthesis.
LNT II supplementation significantly ameliorates HFD-induced MASLD in mice via microbiota-dependent glutamine-citrulline synthesis pathway, and serum citrulline levels correlate with MASLD progression in human patients, reinforcing its candidacy as a noninvasive diagnostic biomarker.
A probiotic from longevity populations: Lactiplantibacillus plantarum FLPL05 as a functional food adjuvant for melanoma via immunomodulation and tumor suppression.
Lactiplantibacillus plantarum FLPL05, a probiotic derived from a Chinese longevity individual, dose-dependently inhibited melanoma tumor growth by 55.7-77.7% via immunomodulation, apoptosis activation, EMT suppression, and angiogenesis inhibition, while synergizing with 5-fluorouracil.
Acute ketone monoester ingestion increases monocyte lysine β-hydroxybutyrylation and plasma β-hydroxybutyrate amino acid conjugates in humans.
Acute high-dose KME ingestion increases monocyte lysine Kbhb and plasma BHB amino acid conjugates in healthy humans, highlighting the possible immunomodulatory and systemic signaling effects of raising BHB through exogenous ketone supplementation.
Exploring the impact of auricular acupressure and nutritional assistance, enhanced with ferulic acid supplementation, on pediatric cough variant asthma: An observational study.
In a retrospective observational study, the combination of auricular acupressure with ferulic acid supplementation was associated with enhanced symptom relief, lung function, and quality of life in children with cough variant asthma compared to standard care only.
Effects and mechanism of Bifidobacterium on intestinal inflammation resulting from deoxycholic acid-induced M1 polarization of macrophages.
Bifidobacterium can inhibit HFD-induced intestinal inflammation or that resulting from DCA-induced M1 polarization of macrophages, and may regulate bile acid levels and target cholesterol metabolism pathways as potential therapeutic strategies for HFD-associated colitis.
Effects of Acute Caffeine Supplementation on Integrated Biathlon Performance in Elite Male Athletes.
Caffeine (3 mg/kg) enhanced early-lap skiing distance and increased physiological stress markers but impaired standing shooting accuracy and postexercise prone shooting precision, resulting in no net improvement in integrated biathlon race times across individual, mass start, or pursuit formats.
Kinetics and concentrations of circulating 25-hydroxyvitamin D using different vitamin D repletion regimens.
All three vitamin D repletion regimens (low dose-high frequency, medium dose-medium frequency, high dose-low frequency) achieved similar circulating 25(OH)D levels at steady state by weeks 12 and 36, supporting provider flexibility in selecting replacement strategy based on individual patient variables.
Protective Effect of Bifidobacterium longum subsp. infantis E4 Exopolysaccharide on Intestinal Barrier, Regulation of Gut Microbiota and Metabolite In Vitro, and Immunosuppressed Mice.
Exopolysaccharides EPS-1 and EPS-2 from Bifidobacterium longum subsp. infantis E4 demonstrated protective effects on the intestinal barrier through promotion of tight junction proteins, regulation of gut microbiota and metabolites, and enhancement of immune cell levels in both IEC-6 cells and immunosuppressed mice.
Effect of a Nutraceutical Combination on Oxidative Stress Biomarkers in Healthy Subjects and Patients with Alzheimer's Disease.
A screening-guided anti-glycation blend (quercetin, rutin, genistein) supplementation was associated with decreases in serum MDA across cohorts and selective decreases in urinary CML in Alzheimer's disease patients in a randomized, double-blind, placebo-controlled 3-month trial.
Serum 25-Hydroxyvitamin D3 Status in Adolescents With Anxiety Disorders: A Case-Control and Vitamin D Supplementation Substudy.
Serum 25-(OH)D3 levels were significantly lower in adolescents with anxiety disorders than healthy controls, anxiety scores were negatively correlated with 25-(OH)D3 levels, and vitamin D supplementation reduced anxiety scores in deficient/insufficient adolescents with anxiety disorders.
Sequentially responsive nanogels enhance probiotic delivery and reprogram M2 macrophage polarization for synergistic alleviation of colitis.
Multifunctional sequentially responsive nanogels (Se-MHA/BG NGs) coating probiotic EcN improved colonization efficiency by 560%, promoted M2 macrophage uptake, and exerted both therapeutic and prophylactic effects in DSS-induced murine colitis by alleviating epithelial barrier damage, oxidative stress, and inflammation.
Exclusive Breastfeeding Is Not Ensuring an Adequate Vitamin B Status in Premature Infants with Very Low Birth Weight.
Exclusive breastfeeding with inadequate multivitamin supplementation does not provide an adequate B vitamin status in infants born prematurely with very low birth weight, with 80% of exclusively breastfed infants showing plasma tHcy concentrations indicative of cobalamin deficiency during the first 6 months of corrected age.