Dietary Supplements
470 peer-reviewed studies indexed
Evaluating the Efficacy of Probiotics on Inflammatory Cytokines in Alcoholic Liver Disease: A Focus on IL-6 and IL-10.
Probiotics led to a significant reduction in IL-6 levels (SMD = -0.68, p = 0.005) and a significant increase in IL-10 levels (SMD = 0.93, p = 0.05) in patients with alcoholic liver disease, with limited impact on IL-1β and TNF-α.
Cost-Effectiveness of Oral Immunotherapy Treatments vs No Treatment for Peanut Allergy in Children.
Both PPOIT and OIT were cost-effective and good value compared with no treatment for peanut allergy in children, with OIT associated with a larger effect size for remission but no clinically meaningful difference, and PPOIT offering the best value when QALYs are prioritized.
Gut Microbiota Diversity and Composition Across Shift Types and the Effects of Walnut Supplementation-An Observational and Interventional Study.
Overall GM composition did not differ between the beginning and end of shifts, by shift type, or following walnut supplementation, though a significant decrease in bacterial diversity at the end of the night shift during observation was not observed during walnut supplementation.
Enhancing Perioperative Oral Nutritional Supplements in Elderly Hip Fracture Patients: A Pilot Project on Evidence-Based Practice.
Implementing an evidence-based protocol for perioperative oral nutritional supplementation in elderly hip fracture patients significantly improved healthcare staff knowledge, enhanced adherence to care standards, and reduced patients' nutritional risk.
Calcium and vitamin D reduce hypoparathyroidism and hospital stay after thyroidectomy: A randomized controlled trial.
Routine calcium and vitamin D supplementation after total thyroidectomy significantly reduces transient hypoparathyroidism and shortens hospitalization, supporting its use as a standard postoperative strategy to enhance recovery and reduce health care resource utilization.
The effect of short-term consumption of Bifidobacterium bifidum on the gut microbiome of obese individuals.
Short-term consumption of a Bifidobacterium bifidum probiotic supplement demonstrated a positive effect on bacterial species including Bacteroides uniformis, Alistipes putredinis, Alistipes shahii, Dysosmobacter welbionis, and Gemmiger formicilis in the gut microbiome of obese individuals.
Effect of antioxidant and statin supplementation on endothelial function and cardiovascular markers among people with HIV in Nigeria: A protocol for a randomised controlled trial.
This protocol describes a randomised, double-blind, placebo-controlled trial designed to assess the individual and combined effects of antioxidant and statin supplementation on endothelial function and cardiovascular markers among people living with HIV in Nigeria.
Effects of a Red-Ginger-Based Multi-Nutrient Supplement on Optic Nerve Head Blood Flow in Open-Angle Glaucoma.
Oral supplementation with a red ginger extract-based multi-nutrient supplement was associated with acute and short-term increases in optic nerve head blood flow in glaucomatous eyes, with relative mean blur rate increasing to 106.9% at 1 hour and 115.4% after 1 month of continuous intake.
Maternal 12-HETE is associated with childhood asthma and the responses to prenatal omega-3 supplementation.
Maternal plasma 12-HETE during pregnancy associates with increased risk of childhood asthma and respiratory infections, and maternal 12-HETE status may determine responsiveness to prenatal n-3 LCPUFA supplementation.
Analysis of Oral and Gut Microbiota Composition in Children with Dental Caries by NGS Approaches.
Dental caries in children cause modifications in oral microbiota composition at the family and species levels, and Streptococcus salivarius M18 DSM 14685 administration shifts oral microbiota toward a healthier state, while gut microbiota showed increased Bifidobacterium adolescentis and Ruminococcus torques in caries-active children.
Improved HDL, LDL and total cholesterol levels following a 3-month administration of Mentha spicata leaf extract and Amaranthus caudatus seed flour extracts, flavonoids and B vitamins. A placebo-controlled, double-blind, randomized clinical trial.
Treatment B (highest dose food supplement containing Mentha spicata leaf extract, Amaranthus caudatus seed flour, flavonoids, and B vitamins) was associated with a significant reduction in LDL-C (~31.5 mg/dL; -22%) and TC (~19.5 mg/dL; -9%), along with an increase in HDL-C, in subjects with borderline high cholesterol levels over 90 days.
Micronutrient Testing, Supplement Use, and Knowledge Gaps in a National Adult Population: Evidence from Saudi Arabia.
Micronutrient deficiencies remain common and under-recognised among adults in Saudi Arabia, with laboratory-confirmed deficiency prevalence of 7.6% for vitamin D, 5.5% for vitamin B12, and 7.0% for iron, alongside critical knowledge gaps and limited routine testing.
Hypolipidemic activity of Limosilactobacillus fermentum SHY0004 from Miao sour soup.
Limosilactobacillus fermentum SHY0004 isolated from Miao sour soup demonstrates hypolipidemic activity across multiple experimental models including HepG2 cells, zebrafish, and high-fat diet mice, effectively regulating total cholesterol and triglyceride levels in serum and liver.
Healthcare professionals' experience with oral oligomeric supplements in malnourished patients in Spain: S-QUEST Study.
Healthcare providers in Spain, particularly endocrinologists and gastroenterologists, reported frequent use of oligomeric formulas in malnutrition management with high self-reported patient adherence (85%) and 95% perceiving clinical benefits.
Vitamin D-Related Information Exposure, Attitudes, and Practices Among Prostate and Breast Cancer Survivors in Poland: Implications for Patient-Physician Communication.
Among breast and prostate cancer survivors in Poland, vitamin D supplementation was common but physician-directed testing and supplementation were rare, and patient-physician communication about supplement use was poor, with most patients not informing their physicians about supplement intake.
Acute effects of dietary whey protein supplementation after endurance exercise on serum osteokine and inflammatory cytokine concentrations in endurance runners.
Acute whey protein supplementation (0.5 g/kg) did not induce a different bone or inflammatory response following exhaustive running exercise in young endurance runners compared to a water control.
Sex-dependent locus coeruleus vulnerability in Alzheimer's disease: gut dysbiosis as a driver and probiotic intervention as rescue.
Gut dysbiosis destabilizes locus coeruleus integrity through parallel immune-vascular, metabolite, endocrine, and vagal neural pathways, with sex-dependent differences in immune reactivity, autonomic regulation, and hormonal transitions rendering female LC neurons uniquely vulnerable to microbial and inflammatory perturbation in Alzheimer's disease.
Leuconostoc citreum enhances the colonization ability of Lactiplantibacillus plantarum in the gut by synergistically modifying the intestinal niche.
Coadministration of Leuconostoc citreum more than doubled Lp082 abundance by reducing competing bacterial species and increasing beneficial fecal metabolite levels, providing a viable strategy for enhancing the colonization capability of L. plantarum in the gut.
Rash decisions: diagnosing zinc deficiency in unexplained dermatitis .
Acquired zinc deficiency can mimic acrodermatitis enteropathica in high-risk individuals, and clinicians should consider serum zinc testing in patients with severe unexplained dermatitis and predisposing risk factors such as alcohol-related liver disease and ulcerative colitis.
Inhibitory Effect of Fucoidan Combined with Bifidobacteria on Helicobacter pylori.
The combination of fucoidan (FUC) and B. animalis BD7 significantly inhibited H. pylori adhesion, decreased urease activity, alleviated gastric mucosal inflammation in infected mice, and reversed flora disruption via inhibition of the TLR2/MyD88/NF-κB pathway.
The effect of antacid and mineral supplements on bictegravir pharmacokinetics: results from a Phase 1, open-label, drug-drug interaction study.
Co-administration of BIC with aluminum/magnesium-containing antacid, calcium carbonate, or ferrous fumarate under fasted conditions reduced BIC exposure by 79%, 33%, and 63%, respectively, while co-administration with a meal or administration 2 hours before the antacid effectively mitigated these chelation-type drug-drug interactions.
Prolonged zinc use for dysgeusia causing copper deficiency.
Prolonged zinc supplementation for dysgeusia in a cancer patient caused copper deficiency presenting as fatigue, anemia, and myelopathy, which gradually improved over 5-6 weeks following inpatient treatment with IV cupric chloride.
Use of Weight Loss Supplements According to the Purported Mechanisms of Action Among Polish Adults Living in an Obesogenic Environment: The Role of Sociodemographic and Health-Related Factors.
Nearly 70% of Polish adults in an obesogenic environment used weight loss supplements, with thermogenesis-enhancing supplements being most popular, and sociodemographic factors being strong determinants of specific supplement type use, including among individuals without overweightness/obesity or cardiometabolic risk.
Blackcurrant Anthocyanin Supplementation Alters Exercise-Induced Substrate Utilization - A Systematic Review and Meta-Analysis.
Blackcurrant anthocyanin supplementation increases fat oxidation (0.042 g·min-1) and decreases carbohydrate oxidation (-0.099 g·min-1) during exercise, though responses are not consistent for all individuals.
Assessing head injury risk and neuroprotective effect of ketone monoester supplementation in military airborne training.
ISLT training resulted in approximately 35% head strike incidence and KME supplementation showed limited protection of cognitive and balance performance without corresponding biomarker changes.
Oral nutritional supplement compliance among hospitalized cancer patients: a cross-sectional study based on the KAP model.
Compliance with oral nutritional supplements in hospitalized cancer patients was significantly associated with social support, adverse effects, and knowledge, suggesting nursing staff should offer personalized health education plans that enhance nutritional knowledge, strengthen social support, and improve self-efficacy.
Usual Nutrient Intake Adequacy and Nutritional Status of United States Children and Adolescents: National Health and Nutrition Examination Survey 2001-March 2020.
This secondary analysis of NHANES 2001-March 2020 found that US children and adolescents aged 1-18 years reported inadequate intake of key nutrients including dietary fiber, EPA, DHA, vitamin D, and vitamin E, with inadequacies becoming increasingly common with age, particularly among adolescent girls.
The Ergogenic Potential of Succinic Acid in Exercise Performance and Post-Exercise Recovery: A Systematic Review.
Current evidence does not provide reliable support for performance-enhancing benefits of succinate supplementation, as the majority of included studies were at high risk of bias and the only low-risk study reported no ergogenic effects.
Effect of multicomponent exercise and nutrition intervention on frailty status in older adults: a network meta-analysis.
Combined interventions were most effective in improving frailty scores, demonstrating potential synergistic effects between physical exercise and nutrition, while nutritional supplementation showed the most significant benefit for gait speed, with different interventions exhibiting outcome-specific variations in their impacts on frailty in older adults.
Exploring Dietary Supplement Utilization Patterns Among African American Survivors of Prostate and Breast Cancer: A Cross-Sectional Analysis.
DS use is common among African American PC and BC survivors participating in lifestyle interventions, with 63.80% reporting at least one DS, and total comorbidities significantly predicting increased DS use among both BC and PC survivors.
Consumer Perception, Sensory Acceptance, and Microbial Characterization of Artisanal Milk Kefir During Shelf Life.
Artisanal milk kefir remains safe, microbiologically stable, and acceptable to consumers for at least 30 days, maintaining probiotic potential while showing significant differences mainly in texture during storage.
The Effects of Vitamin D Replacement with a High-Dose Treat-to-Goal Strategy.
A high-dose treat-to-target vitamin D supplementation protocol achieved and maintained vitamin D adequacy (≥30 ng/mL) in 91.6% of patients over 5 years with no increase in renal adverse events or hypervitaminosis compared to unsupplemented controls.
Vitamin D Deficiency and Replacement Challenges in Type 1 Gastric Neuroendocrine Tumors: A Comparative Study.
Type 1 gastric neuroendocrine tumors show a higher burden of vitamin D deficiency, increased vitamin D supplementation requirements, and a higher prevalence of bone impairment compared with entero-pancreatic NETs, irrespective of dietary habits.
Recovery with vistula tart cherries following a marathon.
Vistula tart cherry supplementation reduced hs-CRP inflammation levels following a marathon but had no effect on functional recovery measures or muscle soreness compared to placebo.
The role of intestinal microflora in prehabilitation for colorectal cancer surgery - systematic review.
This systematic review assessed the role of probiotics in prehabilitation of patients scheduled for colorectal cancer surgery, finding that probiotics administered perioperatively may improve surgical outcomes by modulating intestinal microflora, though the evidence is not yet definitive.
Oral nutritional supplements in clinical nutrition: Insights into healthcare professionals' knowledge and practices.
Substantial knowledge deficits exist among healthcare professionals regarding optimal oral nutritional supplement use, with 8 of 22 survey items answered incorrectly by more than half of participants, especially in geriatrics, neurology, dysphagia, chronic kidney disease, and diabetes.
Use of herbal and supplement products for weight loss among Jordanians: A cross-sectional study.
Many Jordanians use herbal products/supplements for weight loss—most commonly green tea, ginger, and cinnamon—often due to low cost and longstanding beliefs about safety, though many use them incorrectly and without awareness of health risks.
Impact of Protein Intake on Training Response in Chronic Lung Disease.
Low-effort interventions combining targeted resistance training with increased protein intake led to measurable improvements in strength and body composition in patients with chronic lung disease, even when training intensity was less than once weekly and protein consumption remained below recommended levels.
Knowledge and perceptions of probiotics among medical and dietetics students: a cross-sectional study.
The overall level of knowledge was low, with dietetics students outperforming medical students in key areas, suggesting a potential need for enhanced evidence-based education on probiotics at the Medical University of Bialystok.
Docosahexaenoic acid supplementation aggravates myasthenia gravis through immune dysregulation.
Dysregulated lipid metabolism, particularly elevated DHA levels, is a significant risk factor for MG, and dietary DHA supplementation exacerbates EAMG severity by enhancing B cell immune responses and impairing Treg inhibitory function partially through the PI3K-Akt signaling pathway.
Synergistic Effects of High-Intensity Interval Training and Asparagus officinalis L. Root Extract Supplementation on Metabolic Regulation, Oxidative Stress, and Inflammation in Overweight and Obese Adults.
Combining HIIT with asparagus root extract supplementation produces synergistic improvements in oxidative and inflammatory status, whereas HIIT alone primarily enhances metabolic regulation in overweight and obese individuals.
Awareness, attitude and practice of Indian population regarding probiotic foods in everyday life.
Indian participants showed mean knowledge, attitude and practice scores of 16, 23 and 8 respectively regarding probiotic foods, with significant variation by age, gender, state, field of specialization, and occupation, suggesting household-level training could improve awareness and consumption.
Systematic Review and Meta-Analysis of Milk Fat Globule Membrane Supplementation for Mental Well-Being.
Bovine MFGM supplementation produced small but statistically significant reductions in stress and anxiety in adults, though effects on depression were non-significant, suggesting MFGM 'may confer modest benefits for stress and anxiety in adults and could be part of a nutritional strategy to support overall mental well-being.'
Low calcium intake from diet and supplements in a group of Polish patients with SLE - an additional risk for osteoporotic fractures?
Median dietary calcium intake in Polish SLE patients was 540 mg/day, well below recommendations, with only 25% meeting guidelines, indicating that greater attention to osteoporosis prevention is needed among SLE patients from both healthcare professionals and the patients themselves.
Patterns, motivations, and determinants of dietary supplement use among physically active adults in Eastern Saudi Arabia: a cross-sectional survey.
Dietary supplement use is common among physically active adults in Eastern Saudi Arabia (66.9%) and is largely unaffected by basic anthropometric or demographic factors, but is shaped by sex-specific exercise patterns and educational and occupational contexts.
The effect of resveratrol supplementation on anthropometric indices, adiponectin and leptin levels in individuals with overweight and obesity: a graded, systematic review and meta-analysis of randomized controlled trials.
Resveratrol supplementation did not significantly impact most anthropometric measures and serum leptin and adiponectin in individuals with overweight and obesity, but led to a significant reduction in waist circumference.
ExoBDNF Probiotic Supplementation Enhances Cognition in Subjective Cognitive Decline.
ExoBDNF probiotic supplementation over 9 weeks significantly enhanced cognitive performance, sleep quality, and emotional well-being in adults with Subjective Cognitive Decline, with improvements in subjective cognition closely tied to alleviated emotional distress.
Development of a synbiotic snack for gut-brain axis health.
A synbiotic snack incorporating chickpea and red lentil flour with dark chocolate enriched with SLAB51® probiotic formulation demonstrated better nutritional composition, high prebiotic potential, low glycaemic index, and high probiotic viability after six months of storage, with positive consumer response among the senior population.
Probiotic characterization and spore production optimization of Lysinibacillus sp. MK212927.
Lysinibacillus sp. MK212927 demonstrated strong antagonistic activity against human enteropathogens, tolerated physiologically relevant stress conditions, showed favorable safety profiles, and achieved a 3.1-fold increase in biomass and 5.4-fold increase in spore yield through RSM optimization, supporting its potential as a probiotic candidate for animal and human nutrition.
Differential Effects of Vitamin C from Fruit and Vegetables Versus Supplements on the Risk of Frailty.
A higher intake of fruit and vegetables and dietary vitamin C, but not supplemental vitamin C, was associated with a lower risk of frailty, particularly among women.