Dietary Supplements
470 peer-reviewed studies indexed
Exploring probiotic awareness, perceptions, and practices in the Saudi population: a cross-sectional study.
Probiotic awareness was moderate (65%) and use was reported by 54.5% of Saudi residents, with positive perceptions but barriers including limited knowledge (56.2%) and high cost, and usage significantly associated with age, education, marital status, and monthly income.
Advances in the management of osteopenia: a case series.
Combined supplementation with calcium, cholecalciferol, vitamin K2, D-chiro-inositol, and α-lactalbumin for 2 months improved serum levels of vitamin D and osteocalcin in osteopenia patients, suggesting enhanced bone formation, though no significant changes in T-score values were observed.
Effect of Luteolin Supplementation on Kidney Damage and Long-Term Prognosis in Diabetic Patients: A Cohort Study.
High Luteolin intake is associated with low kidney damage prevalence and high survival probability among diabetic patients, with a 14.2% decrease in mortality for every 1 mg/d increase in Luteolin intake.
Optimizing Clinical Nutrition Management for Elderly Hospitalized Patients: Current Practices and Insights.
Effective clinical nutrition management for elderly hospitalized patients requires enhanced dietary supply practices, standardized consultation implementation, and active family involvement, with adherence to nutritional advice associated with significantly shorter hospital stays.
The Effectiveness of Nutritional Interventions on Maternal and Childhood Anaemia in Sindh, Pakistan.
Lady Health Workers can effectively reduce maternal anaemia when iron-folic acid supplementation is complemented with wheat soya blend and targeted behaviour change communication, with a 10.7-percentage-point greater decline in maternal anaemia in intervention areas, though no overall significant reduction in childhood anaemia was observed.
An open-label interventional study on efficacy and safety of 25 µg of daily calcifediol capsule versus 100 µg of cholecalciferol sachets in apparently healthy volunteers.
This study establishes the efficacy and safety of correcting vitamin D deficiency with daily 25 µg calcifediol capsules as an alternative to 4000 IU (100 µg) cholecalciferol sachets.
Dietary advice alone or with oral nutritional supplements after hospital discharge in colorectal cancer surgery patients: Five year follow-up of a randomized controlled trial.
Patients with nutritional risk after colorectal cancer surgery who received dietary advice combined with oral nutritional supplements post-hospital discharge exhibited improved overall survival compared to those who received dietary advice alone.
Effects of a novel synbiotic intervention on abdominal visceral fat reductions and gut microbiota in overweight and obese adults: A randomized, double-blind, placebo-controlled trial.
A novel synbiotic formulation comprising four probiotic strains, prebiotics, and Chrysanthemum morifolium extract significantly reduced visceral adipose tissue area compared to placebo over 12 weeks in overweight and obese adults, with effects most pronounced in men and individuals with BMI 24–28.
Efficacy of probiotics (Bifidobacterium bifidum G9-1) in patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation: An exploratory, multicenter, open-label, single-arm study (BIRDIE study).
Bifidobacterium bifidum G9-1 improved stool form, defecation frequency, and quality of life of patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation, without worsening glycemic control and renal function.
Association Between Over-the-Counter Magnesium Supplement Use and Health Outcomes in Veterans with Newly Diagnosed Heart Failure.
Magnesium supplement use was associated with a reduced risk of all-cause mortality or hospitalization among veterans with newly diagnosed heart failure, with a hazard ratio of 0.81 (95% CI: 0.77–0.86) in the primary analysis.
Bottle to body: how multivitamin/mineral supplements shape Canadian nutrient intake.
MVM supplement use in Canada contributes to overall dietary intake but is generally associated with markers of higher socio-economic status and those already consuming a healthy diet, suggesting dietary guidelines should continue to emphasize meeting nutrient requirements from food.
Negligible benefit of oral single-dose sodium bicarbonate on continuous running performance: systematic review with meta-analysis of randomized, double-blind, placebo-controlled trials.
After adjusting for GI-related study withdrawal and publication bias, sodium bicarbonate supplementation has a negligible and non-statistically significant benefit on continuous running performance in a mixed-sex population (SMD=0.18; 95% CI: -0.01, 0.36; p=0.06), though the ergogenic effect may be more pronounced in males.
Effect of protein supplementation on hip bone mineral density, cortical thickness, and bone strength in older adult participants during a caloric restriction and aerobic exercise weight loss intervention: a randomized controlled trial.
Higher protein intake (1.2 g/kg/day for 18 months) had a beneficial effect on hip bone strength in older adults with overweight/obesity undergoing a weight loss intervention over the short-term, with a 3.8% increase versus 0.5% in the recommended protein group at 6 months, but 18-month group differences were non-significant.
Early Supplementation with Branched-Chain Amino Acids Ameliorates Lipid Retention in Aortic Valves of ApoE-Knockout Mice.
Early BCAA supplementation (from 1/3 months of age) significantly reduced lipid retention in the aortic valve of ApoE-knockout mice, while magnesium citrate decreased ionized calcium, with both protective effects being higher in males than females, and dual HSA/MgCit supplementation reduced serum calcification propensity in 68% of myocardial infarction patients.
The Effect of Vitamin B-12 Supplementation During Pregnancy on Early Motor Performance: Secondary Analyses From a Double-Blinded Randomized Controlled Trial.
The negative effect of vitamin B-12 supplementation on infant motor performance cannot be explained by any subgroup specific effects, but the effect appears to be more pronounced in mothers with adequate B-12 status.
Innovative formulation of microencapsulated "spirubiotic sachets" as a synbiotic treatment for metabolic syndrome patients.
Administering a spirubiotic sachet (microencapsulated Spirulina platensis and probiotic bacteria) to metabolic syndrome patients for 3 months effectively reversed the majority of metabolic abnormalities, bringing them closer to normal levels with decreased dietary calories, improved anthropometric measures, altered body composition, and normalized biochemical parameters.
Changes in erythrocyte fatty acid profile after 12 weeks of omega-3 fatty acid (EPA+DHA) supplementation and endurance training in amateur runners.
Twelve weeks of EPA+DHA supplementation significantly altered erythrocyte fatty acid profiles in amateur runners, increasing EPA, DHA, docosapentaenoic acid, and total PUFAs while decreasing several saturated, monounsaturated, and omega-6 fatty acids, whereas exercise training alone had no effect on RBC fatty acids.
E-health Initiatives for Screening and Management of Anemia in Rural Rajasthan.
Community-based e-health initiatives using an Android app, IFA supplementation, deworming, and pop-up video health education reduced overall anemia prevalence from 46.08% to 14.65% over 9 months in rural Rajasthan.
Meta-analysis of the effects of probiotic supplementation on bone turnover markers in middle-aged and elderly patients with osteoporosis.
Probiotic supplementation is associated with enhanced bone formation and reduced bone resorption in individuals with osteoporosis, with multi-strain formulations and higher dosages yielding the greatest improvements, particularly among postmenopausal women.
Deciphering the role of zinc in prostate health: From mechanism to therapeutic application.
Zinc homeostasis is critical for prostate health, with disturbances closely associated with prostatitis, benign prostatic hyperplasia, and prostate cancer, though the efficacy and safety of zinc supplementation for managing these conditions remains controversial.
Ketone supplementation dose-dependently lowers postprandial blood glucose, lipid and ghrelin levels in individuals with type 2 diabetes: a randomised crossover study.
Pre-meal ketone supplementation reduced postprandial glucose, lipid and ghrelin concentrations in individuals with type 2 diabetes, supporting the therapeutic potential of KE supplementation in the management of type 2 diabetes.
School-Age Neurodevelopmental and Atopy Outcomes in Extremely Preterm Infants: Follow-Up from the Single Versus Triple-Strain Bifidobacterium Randomized Controlled Trial.
Both triple-strain and single-strain Bifidobacterium probiotic formulations were safe, with comparable neurodevelopmental, growth, and atopy-related outcomes at school age in extremely preterm infants.
Impact of amino acid supplementation on cardiovascular and chronic kidney diseases: a systematic review.
Amino acid supplementation shows predominantly preventive effects on cardiovascular and chronic kidney disease comorbidities, with arginine and methionine attributed to the highest number of preventive and adverse effects respectively, though further clinical studies are needed for validation.
Knowledge Related to Blood Donation and Iron, and Willingness to Take Iron Supplements Among Blood Donors in Multiple Countries.
Trust in the blood service and prior supplement use were more strongly associated with willingness to take iron supplements than knowledge or confidence, suggesting that trust-building approaches may be more promising than education-focused strategies for donor iron management.
Dietary and microbial influences on intestinal immune activation in treated people living with HIV and a Th17-deficient mouse model.
Treated PLWH with controlled HIV replication shows lower gut abundance of Akkermansia and Paraprevotella, Mediterranean diet adherence enriches intestinal microbiota diversity, and in Batf-/- mice probiotic supplementation is associated with changes in specific genera implicated in the differentiation of Th17 lymphocytes.
Do the effects of krill oil supplementation on skeletal muscle function and size in older adults differ by sex, age or BMI: A secondary analysis of a randomised controlled trial.
Krill oil supplementation improved muscle strength and size in older adults regardless of age, sex and BMI status, although neuromuscular effects of krill oil on membrane excitability, via the Mwave, may be more pronounced in men.
Lacticaseibacillus rhamnosus alleviates hyperuricemia by restricting intestinal nucleoside absorption.
Lacticaseibacillus rhamnosus alleviates hyperuricemia through a substrate-restriction mechanism whereby intracellular nucleoside hydrolases convert guanosine and inosine into poorly absorbed purine bases, thereby limiting intestinal nucleoside uptake and reducing hepatic substrate supply for urate synthesis.
Omega-3 fatty acids and cardiovascular risk-related metabolic markers in diverse populations: a meta-analysis of randomized trials.
n-3 PUFAs improve cardiovascular-related metabolic markers, potentially benefiting cardiovascular health in patients with cardiovascular disease, PCOS, and kidney disease, especially in older women via reducing TG and HbA1c and increasing HDL and adiponectin.
Effects of High-Dose Vitamin D Supplementation and Physical Exercise on Vitamin D Metabolites in Professional Football Players: A Pilot Study.
Football-specific physical activity significantly increased serum concentrations of vitamin D metabolites by up to 25%, and high-dose cholecalciferol supplementation (500,000 IU) combined with exercise further amplified these effects, with 25-(OH)D3 rising by 98% and 3-epi-25-(OH)D3 by 424%.
Adaptogenic Effects of Mushroom Blend Supplementation on Stress, Fatigue, and Sleep: A Randomised, Double-Blind, and Placebo-Controlled Trial.
Restake mushroom blend supplementation over 12 weeks effectively reduced psychological stress, fatigue, and improved sleep quality without adverse effects in a randomised, double-blind, placebo-controlled trial of 50 participants.
Clinical Implementation of Sustainable Functional Foods and Nutraceuticals in Metabolic Health: A Feasibility Study.
Integrating functional foods and nutraceuticals into a Mediterranean-style dietary intervention is feasible, safe, and acceptable in older adults with metabolic risk factors, with high adherence (>80%) and detectable bioavailability of bioactive compounds.
The Role of Omega-3 Polyunsaturated Fatty Acid Supplementation in Postoperative Recovery of Colorectal Cancer: Systematic Review and Meta-Analysis.
Omega-3 PUFA supplementation significantly attenuates postoperative inflammation, enhances immune function, shortens hospitalization, and improves quality of life in CRC patients, with a potentially optimal supplementation range of 0.16–0.30 g/kg/day identified for Chinese CRC populations.
Assessment of a novel functional food modulating the microbiota-inflammation-brain axis in patients with heart failure and/or /atrial fibrillation patients (the AMBROSIA study): Protocol for a randomized controlled trial.
The AMBROSIA study is a single-center, prospective, parallel-group randomized controlled trial protocol designed to explore the response of the microbiota-inflammation-brain axis to a fortified functional food intervention in 120 older adults with atrial fibrillation and/or heart failure.
Beetroot juice supplementation enhances the effects of blood flow restriction training on lower limb strength and vertical jump performance under fatigue in male university students: a randomized, double-blind, placebo-controlled study.
Four weeks of BFR training with or without BRJ supplementation improved knee flexor and extensor strength and bilateral CMJ performance, but BRJ effects were selective rather than broadly superior, mainly enhancing BFR training by reducing fatigue-related declines in vertical jump performance.
The effect of saffron supplementation on indices of oxidative stress, inflammation, mental health, and quality of life in patients with Parkinson's disease: a randomized, triple-blind, placebo-controlled clinical trial.
100 mg per day saffron supplementation for 12 weeks confirmed efficacy as a beneficial adjuvant therapy in the management of Parkinson's disease, improving inflammation, mental health, and quality of life indices.
Marine n-3 fatty acid treatment for carotid plaques in patients with type 2 diabetes.
14-month marine n-3 fatty acid supplementation does not reduce carotid plaque risk in patients with type 2 diabetes but improves lipoprotein profile, with anti-atherosclerotic effects appearing significant only in patients with a low genetic risk of remnant cholesterol.
Amino acid supplementation enhances in vivo efficacy of lipid nanoparticle-mediated mRNA delivery in preclinical models.
Coadministration of an amino acid supplement (methionine, arginine, and serine) with lipid nanoparticles led to a 5- to 20-fold improvement in mRNA expression across various cell types and lipid formulations in vitro, and enhanced in vivo mRNA expression across multiple routes of administration in preclinical models.
Beneficial effects of a compound probiotic in Helicobacter pylori-infected patients aged over 40 years: An open-label randomised clinical trial.
While triple therapy plus probiotics (TTP) was inferior to bismuth quadruple therapy (BQT) in overall H. pylori eradication efficacy, it demonstrated better tolerability and protective effects against gut microbiota dysbiosis, and achieved non-inferior eradication rates in patients aged ≥40 years.
Effects of combined GABA and L-theanine supplementation on sleep quality: an exploratory study.
Simultaneous intake of GABA (700 mg/day) and L-theanine (200 mg/day) for 4 weeks significantly improved total PSQI scores and sleep recovery scores in adults with sleep problems, though further randomized controlled trials are needed to confirm this finding.
Multidisciplinary Preoperative Immunonutrition Initiative in Colon and Rectal Surgery.
A multidisciplinary preoperative immunonutrition initiative using twice daily supplementation for 7 days before elective colon and rectal surgery did not demonstrate statistically significant reductions in surgical site infections or other postoperative complications compared to a historical unexposed cohort.
Nourishing the Brain or the Mood? Dietary Omega-3s for Psychological, but Not Cognitive Health.
Dietary omega-3 intake was associated with lower depression and stress scores but was not significantly associated with cognitive performance and did not moderate the relationship between mood and memory in healthy adults.
Effect of Vitamin D Supplementation on Cardiometabolic Outcomes in Older Australian Adults-Results from the Randomized Controlled D-Health Trial.
Monthly supplements of vitamin D did not alter the incidence of hypertension, hypercholesterolemia, or type 2 diabetes in older, largely vitamin D-replete Australians.
Bifidobacterium animalis subsp. lactis Bbm-19 ameliorates insomnia by remodeling the gut microbiota and restoring γ-aminobutyric acid and serotonin signaling.
Bifidobacterium animalis subsp. lactis Bbm-19 ameliorates insomnia through coordinated regulation of the gut microbiota, host metabolism, and neuroimmune signaling, highlighting its potential as a targeted psychobiotic intervention for sleep disorders.
Modeling diet-gut microbiome interactions and prebiotic responses in Thai adults.
A novel systems biology pipeline integrating genome-scale metabolic models with Thai dietary intake data revealed inter-individual variability in SCFA profiles, with Bacteroides and Phocaeicola linked to isobutyrate production and Bifidobacterium emerging as a key responder to prebiotic supplementation.
Anti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exercise.
NMN supplementation suppressed exercise-induced inflammatory signaling in human skeletal muscle but also abolished mitochondrial content increases after BFR-exercise, possibly by suppressing mitochondrial replenishment from phagocytes to repairing myofibers.
High-dose vitamin D supplementation and prostate cancer progression: a phase II randomised trial in localised prostate cancer cases with intermediate risk of progression (ProsD).
Vitamin D supplementation did not prevent prostate cancer progression in men on active surveillance, although reduced prevalence of CBMN markers may indicate a benefit of vitamin D supplementation.
Lactiplantibacillus plantarum Lp815 improves sleep and increases urinary GABA in a randomized, double-blind, placebo-controlled study of sleep disturbance.
A daily probiotic containing 5 billion CFU Lp815 significantly improved subjective symptoms of insomnia and anxiety, as well as objective measures of sleep after 6 weeks, with elevation of systemic GABA potentially contributing to these effects.
Tolerability and efficacy of an enteral formula containing partially hydrolyzed guar gum in patients following gastrointestinal surgery: A prospective, multicenter, open-label, randomized controlled study.
A PHGG-enriched enteral nutrition formulation is well-tolerated and non-inferior to a fiber-free formula among patients following GI surgery, with improved GI tolerance and weight preservation benefits when daily intake reaches 800-900 kcal.
The Effect of Short-Term Rhodiola rosea Supplementation on Simulated Game Time, Perceived Fatigue, and Performance in Basketball Players.
Short-term Rhodiola rosea supplementation can improve sprint performance and reduce perceived fatigue in basketball players during simulated games, enhance aerobic work capacity, and delay fatigue.
Beetroot juice or creatine: which yields greater short-term benefits for resistance training capacity, performance and key physiological responses?
CR appeared to preferentially enhance mechanical performance, whereas BJ seemed to provide broader cardiometabolic and autonomic benefits across a ~72 h supplementation period in novice resistance-trained men.