Dietary Supplements
470 peer-reviewed studies indexed
Safety and Tolerability of the Gut Bacterium Phascolarctobacterium faecium DSM 32890.
The consumption of P. faecium DSM 32890 did not raise safety concerns and was well tolerated in rats and humans, representing a step forward toward future longer-term studies to explore potential efficacy.
Impact of Curcuma longa L. extract supplementation on the gut microbiota of hemodialysis patients.
Supplementation with 2.5 g of Curcuma longa L. extract three times per week for 12 weeks was inefficient in modulating the gut microbiota of CKD patients undergoing hemodialysis.
Effect of Beetroot Extract Supplementation on Serum Fatty Acid Profiles and Oxidative Stress Markers in Chronic Coronary Artery Disease Patients: A Secondary Analysis of a Randomized Controlled Trial.
Beetroot capsule consumption had favorable effects on serum omega 3 fatty acids as well as TOS and MPO, the oxidant and atherogenesis factors, in chronic coronary artery disease patients over 4 weeks.
Awareness and Risk Behaviors Associated with Tribulus terrestris (Tt), Dietary Supplements, and Anabolic Steroids: Evidence from an Italian Questionnaire-Based Study.
Tribulus terrestris consumption in fitness settings is driven predominantly by performance-oriented expectations rather than demographic characteristics, with individuals reporting performance enhancement as their primary motivation markedly more likely to currently use Tt (adjusted OR ≈ 18.5).
Comparative effectiveness of exercise modalities and nutritional supplementation for sarcopenic obesity in older adults: a network meta-analysis based on randomized controlled trials.
In older adults with sarcopenic obesity, resistance training appears particularly effective for improving muscle strength and reducing adiposity-related measures, whereas multicomponent training shows greater advantages in reducing BMI and percentage body fat, based on a network meta-analysis of 24 RCTs involving 1,298 participants.
Altered gut microbiome function in ADHD: More Prevotella, less vitamin B12 biosynthesis, and beneficial modulation by synbiotic treatment.
Distinct species were differently abundant in adults with ADHD compared to controls, children on psychostimulants had higher Prevotella abundance and lower vitamin B12-synthesis module abundance, and Synbiotic 2000 influenced gut microbiome taxonomy and functionality while increasing plasma SCFA levels towards normal.
Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
Vitamin D replacement therapy guidance significantly reduced ME/CFS symptoms along with improvement of serum 25(OH) vitamin D levels in patients with vitamin D insufficiency or deficiency who developed ME/CFS as PVS or PASC.
Phascolarctobacterium faecium reduces food intake via PYY signaling, contributing to the mitigation of body weight gain in diet-induced obese mice.
Daily administration of Phascolarctobacterium faecium reduced food intake via early overproduction of PYY, attenuated body weight gain in diet-induced obese mice, and also limited adiposity independently of food intake by accelerating gut transit and serum lipid clearance.
The cognitive effects of supplementation with sunflower phosphatidyl serine in healthy children aged 8 to 12 years: a randomized controlled trial.
Supplementation with 100 mg of sunflower-derived phosphatidylserine daily for 12 weeks showed no differences in primary or secondary cognitive outcomes in healthy neurotypical children aged 8-12 years, though a pre-defined subgroup of children with consistently below-median baseline cognitive performance showed benefit on a visuospatial memory task.
Effects of combined dietary fiber and probiotic supplementation on gut microbiota, immune function, and clinical outcomes in patients with advanced colorectal cancer: a retrospective cohort study.
Supplementing conventional therapy with dietary fiber and probiotics in advanced colorectal cancer patients effectively modulates the gut microbiota, enhances systemic immune function, improves nutritional status and quality of life, and is associated with better long-term survival.
Effect of vitamin D as Nutrition Supplement on Patients with Prolonged Ventilation due to Ventilator Associated Pneumonia and Sepsis Followed Severe Traumatic Lung Contusion: A Randomized Controlled Trial.
High-dose vitamin D supplementation (cholecalciferol 100,000 IU/day for 14 days) in ICU patients with severe traumatic lung contusion complicated by VAP and sepsis resulted in significantly faster recovery, shorter mechanical ventilation and ICU stay durations, and lower mortality rate compared to standard enteral nutrition alone.
Systematic high-calorie, high-protein oral nutritional support in hospitalized, moderately hypophagic patients at nutritional risk: A randomized-controlled trial.
In acutely hospitalized adult patients at nutritional risk and without severe hypophagia, the systematic use of ONSs since admission improved body composition, muscle function, and protein-calorie intake, and reduced LOS.
Clinicopathologic Correlation in a Case of Scurvy.
A case of scurvy in a male patient with sclerosing mesenteritis and chronic dietary restriction presented with bilateral leg purpura, perifollicular hemorrhage, and gingival bleeding, where histopathology revealed classic features and undetectable vitamin C confirmed the diagnosis, with oral supplementation leading to rapid clinical improvement.
[High-dose omega-3 fatty acid supplementation in patients with persistent allergic rhinitis sensitized to perennial allergens: a randomized, placebo-controlled clinical trial].
Supplementation with high doses of EPA and DHA in patients with persistent allergic rhinitis was safe, but there was no evidence of a reduction in severity or improvement in quality of life compared to the placebo group.
Dose-Response Effects of Short-Term Rhodiola rosea (Golden Root Extract) Supplementation on Anaerobic Exercise Performance and Cognitive Function in Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study.
Short-term Rhodiola rosea consumption, regardless of dose or gender, improved resistance performance and significantly enhanced Stroop outcomes, with minimal changes in anaerobic cycling and RPE, and no consistent acute hemodynamic effects.
Baduanjin Exercise, With or Without Vitamin D, Outperforms Vitamin D Alone in Reducing Frailty Among Institutionalized Older Adults: A Cluster-Based Randomized Controlled Trial.
Baduanjin exercise, either alone or combined with vitamin D supplementation, effectively mitigated frailty among older adults residing in long-term care facilities, outperforming vitamin D supplementation alone.
A multicomponent intervention consisting of exercise, proteins and omega-3 supplementation to improve sarcopenia in community-dwelling older adults: Lessons learned from a 5-armed randomized controlled feasibility trial.
A multicomponent intervention combining exercise, proteins, and omega-3 supplementation to treat sarcopenia showed low feasibility, moderate acceptability, and high safety, with preliminary efficacy results suggesting exercise with protein supplementation may improve physical function and that adding omega-3 PUFA might offer further benefits for muscle strength and mass.
Inflammation-responsive DNA hydrogel integrating probiotic outer membrane vesicles for infection monitoring and precision therapy of diabetic wounds.
An inflammation-responsive DNA hydrogel integrating Lactobacillus reuteri-derived outer membrane vesicles with ICG/BHQ3 probes enabled ROS-triggered infection monitoring and on-demand photothermal therapy, markedly accelerating diabetic wound closure through enhanced collagen deposition, neovascularization, and immune resolution.
Effects of personalized vitamin D3 on inflammation in colorectal cancer patients: a randomized trial.
In CRC patients with low vitamin D status, personalized vitamin D3 supplementation reduces serum IL-6, a pro-inflammatory biomarker associated with poor prognosis, but did not significantly reduce IFN-γ or MMP-1.
Preoperative Short-Term Nutrition and Exercise Trial Program for Patients with Esophageal Cancer: A Randomized Clinical Trial: Thoracic Oncology.
A 2-week multimodal prehabilitation program for esophageal cancer patients increased preoperative protein intake and quadriceps strength but did not result in significant differences in anaerobic threshold or physical activity levels compared to controls.
Long-Term Effects of Multiple-Micronutrient Supplementation During Pregnancy, Lactation, and Early Childhood on the Cognitive Development of Children Aged 4-14 Years: A Systematic Review of Randomized Controlled Trials.
Maternal MMN supplementation may modestly enhance specific domains of cognitive development, whereas evidence on the long-term effects of MMN and point-of-use MNPs on cognitive development remain limited, highlighting the necessity for further research.
Effects of Phenolic-Rich Extra Virgin Olive Oil and Prebiotics on Sarcopenia in Older Adults: FOOP-Sarc Project.
Consuming phenolic-rich extra virgin olive oil, alone or combined with prebiotics, improved muscle mass assessed by ultrasound at end-of-intervention and by bioelectrical impedance analysis at 12-week follow-up in older adults with probable sarcopenia.
Vitamin D supplementation and incidence of major depressive disorder - A randomized clinical trial.
Vitamin D3 supplementation did not lower the incidence of major depressive disorder during the 5-year supplementation period among largely vitamin D sufficient aging adults, though there was a borderline indication of benefit during a longer follow-up, possibly suggesting a delayed effect of supplementation.
[Analysis of the market of specialized foodstuffs for nutrition of athletes of child and youth age].
The market for specialized foodstuffs for child and adolescent athletes is represented by only single products, determining broad prospects for development of new products for medical and biological support in youth sports.
Sodium reduction is the key ingredient in dietary treatment of hypertension - a randomized controlled trial on sodium, potassium and nitrate.
Sodium reduction was the important dietary alteration for lowering blood pressure in hypertensive patients, while beetroot juice with nitrate and potassium chloride supplements did not assist in decreasing BP during this one-week intervention.
Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.
Melatonin supplementation significantly ameliorated multiple cardiometabolic risk factors including hip circumference, systolic blood pressure, fasting blood glucose, LDL cholesterol, total cholesterol, C-reactive protein, malondialdehyde, TNF-alpha, IL-6, and ALT, while increasing HDL cholesterol and total antioxidant capacity.
Amino acid supplementation accelerates resolution of exercise-induced phagocyte infiltration in human skeletal muscle.
Amino acid supplementation accelerates the resolution of inflammation in exercised human skeletal muscle, as evidenced by earlier MPO+ cell infiltration at 0 h post-exercise that diminished by 24 h, compared to placebo where infiltration peaked at 24 h.
Melatonin supplementation for quality of life in older patients with advanced cancer: a randomized controlled trial.
Supplementation with 2 mg melatonin was safe but did not lead to any significant improvement in the global quality of life score on the QLQ-C30 for compliant older cancer patients undergoing systemic treatment.
Effects of a Cranberry, Probiotic, and Vitamin C Supplement on Recurrent Urinary Tract Infections in Children-A Cohort Study.
A multi-component supplement of cranberry, probiotics, and vitamin C effectively reduced recurrent pediatric UTIs, decreased overall infection burden, preserved E. coli as the main pathogen, and was safe and well tolerated, including in children with mild-to-moderate VUR.
Retinal Degeneration in Alzheimer's Disease 5xFAD Mice Fed DHA-Enriched Diets.
DHA supplementation, either from fish oil or DHASCO oil, showed retinal protective effects in 5xFAD Alzheimer's mice, underscoring the potential of retinal biomarkers as non-invasive indicators of cognitive decline and overall brain health.
The effects of Omega-3 supplementation on stress, anxiety, depression, sleep quality, and everyday memory in individuals with psychological distress: A randomized, double-blind, placebo-controlled trial.
Omega-3 supplementation (500 mg EPA + 250 mg DHA daily for three months) resulted in notable psychological and cognitive improvements in stress, anxiety, depression, sleep quality, and everyday memory among individuals with psychological distress.
Experiences and perceptions of a 12-week combined exercise and dietary supplement program for individuals with knee osteoarthritis: a qualitative focus group study.
Participants' tendency to perceive exercise and supplementation as separate components indicates that combined interventions may function as parallel rather than integrated strategies unless explicitly framed and supported as a unified approach.
Are the UK's vitamin C recommendations evidence-based? A critical comment.
The current UK vitamin C recommendation of 40 mg/d should be re-evaluated in light of controlled trial evidence and broader clinical outcomes, as it overlooked key evidence available at the time it was established in 1991.
Gut microbiota-driven dysbiosis of the SCFA-immune axis in pediatric allergic rhinitis-constipation comorbidity: mechanisms and synbiotic remodeling.
Gut dysbiosis in pediatric AR-FC comorbidity is associated with disruption of the microbiota-SCFA-immune axis, and while synbiotic therapy induced taxonomic shifts and improved gastrointestinal function, strain-specific formulations are needed for comprehensive immune and intestinal restoration.
The effects of next generation probiotics on metabolic dysfunction-associated steatotic liver disease: a parallel, double-blind, randomized, placebo-controlled trial.
Eight weeks of next generation probiotics supplementation was associated with changes in the stool microbiome and improvements in the blood biochemical parameters of MASLD.
Proteomic Profile in Retinopathy of Prematurity: A Secondary Analysis of the Mega Donna Mega Randomized Clinical Trial.
A fast rise in FGF-21 levels, a metabolic stress-induced hormone, during the first postnatal days was strongly associated with the development of severe ROP in extremely preterm infants.
Marine ω-3 PUFA Supplementation Enhances FFAR4 Activation and Reduces Inflammatory Markers in PBMC of Subjects with Obesity: A Randomized Controlled Trial (EPICO).
Marine ω-3 PUFA supplementation (EPA+DHA) in the context of a dietary intervention promotes FFAR4 activation, thereby contributing to the modulation of the inflammatory response in human PBMC of subjects with obesity.
Effects of Nutritional Supplements on Explosive Lower Limb Performance in Volleyball Players: A Systematic Review and Network Meta-Analysis.
Among volleyball athletes, β-alanine appeared the most promising effective supplement for enhancing key components of explosive lower limb performance, specifically vertical jump height and peak power, though findings are based on low-to-moderate certainty of evidence.
The association between gut microbiota and cognitive decline: A systematic review of the literature.
Gut microbiota modulation represents a promising nonpharmacological strategy to support cognitive health, with early intervention appearing crucial for optimal benefit, though heterogeneity in study design highlights the need for large-scale longitudinal randomized controlled trials.
Impact of Preoperative Calcium and Magnesium Supplementation on Quality of Life and Hypocalcemia Post-Thyroidectomy.
Preoperative calcium and magnesium supplementation might have positive effects on postoperative quality of life, especially in Graves' disease patients, and may reduce hypocalcemia symptoms, though observed effects did not reach statistical significance.
Two-year outcomes of denosumab treatment for osteoporosis comparing the effects of calcium and vitamin D supplementation.
Two-year treatment with denosumab resulted in improvements in BMD that were independent of calcium and vitamin D supplementation.
Assessment of vitamin A, vitamin B2, vitamin B12, vitamin K, folate, and choline status following 4 months of multinutrient supplementation in healthy vegans: a randomised, double-blind, placebo-controlled trial.
A multinutrient supplement containing 82 µg of vitamin B12 per day significantly positively affected vitamin B12 blood biomarkers in healthy vegans, while no significant between-group differences were observed for vitamin A, folate, choline, vitamin K, or most other measured biomarkers after 4 months.
Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation with Cordyceps militaris in Humans-A Narrative Review.
Although some studies reported improvements in selected performance and recovery parameters following Cordyceps militaris supplementation, the findings were inconsistent and the certainty of evidence is limited by small sample sizes, heterogeneity of participants and exercise protocols, and methodological shortcomings.
Beetroot Juice Supplementation as a Healthy Aging Strategy Through Improving Physical Performance and Cognitive Functions: A Systematic Review.
Beetroot supplementation demonstrates strong potential as a natural ergogenic aid for enhancing physical performance, but current evidence on cognitive improvement remains inconclusive, and further research particularly involving female or elite athletes is needed.
Prevalence and Perceptions of Dietary Supplement Use Among Nepalese Gym-Users: An Observational Study.
Among 214 gym users in Lamjung District, Nepal, 32.71% reported consuming dietary supplements, primarily proteins and amino acids for muscle mass enhancement, with peer influence outweighing expert guidance and users perceiving high benefits but low health risks.
Impact of fiber-containing enteral nutrition on microbial community dynamics in critically ill trauma patients: a pilot-randomized trial.
In the dysbiotic gut of critically ill trauma patients, scFOS-EN had context-dependent effects, with prior anaerobic antibiotic exposure appearing to modify the microbial response from beneficial to detrimental, challenging a universal approach to prebiotic therapy in the ICU.
Acute phenylcapsaicin supplementation improves CrossFit® performance: a randomized, triple-blind, placebo-controlled crossover trial.
Acute phenylcapsaicin supplementation (2.5 mg, 45 minutes pre-session) enhances performance and recovery in CrossFit athletes, improving squat performance, attenuating countermovement jump decline, maintaining weightlifting performance over time, and reducing delayed-onset muscle soreness at 24 and 48 hours post-session.
Bioconversion-Based Postbiotics Enhance Muscle Strength and Modulate Gut Microbiota in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial.
KP supplementation produced a modest within-group improvement in grip strength, potentially through gut-muscle axis modulation involving irisin and anti-inflammation pathways, suggesting that kefir-derived postbiotics may have potential relevance for muscle health.
Melatonin Supplementation in Adult Patients With Atopic Dermatitis: A Randomized Clinical Trial.
Melatonin supplementation in adult patients with mild to moderate atopic dermatitis effectively improved disease severity, sleep quality, and quality of life, without any reported adverse effects.
Herba Patriniae with probiotics targets Escherichia fergusonii and the 5-hydroxytryptophan-trimethylamine N-oxide axis in Parkinson's disease.
The Bacteroidaceae enterotype was identified as high-risk for Parkinson's disease, characterized by enrichment of Escherichia fergusonii associated with a 5-HTP-TMAO metabolic axis, and a combination of Herba Patriniae extract with probiotics (F.l-HP) suppressed E. fergusonii activity, reduced 5-HTP consumption and TMAO production, and alleviated neuroinflammation while enhancing intestinal barrier integrity.