Cardiovascular
497 peer-reviewed studies indexed
Adaptive intervention to improve self-management behaviours among hypertensive patients in rural primary care settings: protocol for a Sequential Multiple Assignment Randomised Trial (SMART).
A Sequential Multiple Assignment Randomised Trial (SMART) protocol is designed to evaluate an adaptive, technology-assisted intervention based on physician-patient interaction to improve self-management behaviours among hypertensive patients in rural primary care settings in China.
Factors affecting cost-related medication non-adherence among US population with cardiovascular risk factors.
Adults under 65 with more CVD risk factors and lacking insurance coverage are at higher risk of cost-related medication non-adherence, suggesting that strengthening prescription drug coverage and targeted interventions are necessary to reduce CRMN among those with cardiovascular risk factors.
Financial Burden, Out-of-Pocket Health Spending, and Household Economic Well-Being in Heart Failure Patients in India: A Multicentre Cross-Sectional Survey.
Seven out of 10 HF patients in India lack financial health protection, with out-of-pocket expenditures accounting for over 90% of total health spending and financial burden affecting more than one-third of HF patients.
Urinary tract infections, risk factors and antimicrobial resistance patterns in heart failure patients on sodium-glucose transporter 2 inhibitors: Evidence from Jakaya Kikwete Cardiac Institute in Tanzania.
UTIs are common among HF patients on SGLT2 inhibitors, with E. coli as the predominant pathogen and a concerning resistance to commonly used antibiotics, underscoring the need for routine urine culture and sensitivity testing to guide appropriate therapy and promote antimicrobial stewardship, particularly in resource-constrained settings.
A Gaze-Driven Robotic System for Post-Stroke Active Ankle Rehabilitation Training.
A binocular gaze-driven ankle rehabilitation robot achieved 99.94% selection accuracy with 157.6 ms median end-to-end delay in healthy adults and demonstrated high usability, low workload, and minimal visual fatigue in a pilot post-stroke cohort.
Reduced Pulmonary Function Association with Abnormal Muscle Activation with Knee Osteoarthritis and Increased Cardiovascular Disease Risk.
Individuals with knee osteoarthritis and increased cardiovascular disease risk demonstrated significant reductions in vigorous physical activity and maximal voluntary ventilation, greater biceps femoris muscle activation during stair climbing, and a negative relationship between lower MVV and greater biceps femoris activation compared to those with isolated knee OA.
Hypertension action bundle including training of healthcare professionals to improve the detection of primary aldosteronism: a cohort study.
A hypertension action bundle including a training programme for healthcare professionals resulted in a significant approximately fourfold increase in the annual incidence of primary aldosteronism diagnosis per 1000 consultations over three phases from 2016 to 2024.
[Sleep disorders dynamics in patients with chronic thromboembolic pulmonary hypertension after surgical treatment].
A high prevalence of sleep-disordered breathing in patients with CTEPH persists despite effective pathogenetic treatment of the underlying disease, and nocturnal hypoxemia may be considered a predictor for prescribing timely respiratory support and pulmonary arterial hypertension-specific therapy.
Effects of isometric training based on the entire population on blood pressure regulation: systematic review and meta-analysis of randomized controlled trials.
Isometric exercise, particularly wall squats performed three times weekly for over 8 weeks, is associated with significant reductions in resting blood pressure, with the greatest benefits observed in males and hypertensive individuals.
The blanking interval after atrial fibrillation ablation: time for reassessment with pulsed field energy.
Early recurrences following pulsed field ablation are strongly predictive of long-term arrhythmia recurrence and are unlikely to represent transient inflammatory phenomena, suggesting the conventional blanking interval should be reconsidered after PFA.
[Analysis of lipid-lowering therapy in Chinese patients at high and very high risk of atherosclerotic cardiovascular disease].
Significant clinical inertia and disparities in lipid-lowering therapy exist among Chinese patients at high-risk or very high-risk of ASCVD, characterized by low LDL-C attainment rates and insufficient use of guideline-recommended intensive regimens, especially among the elderly, rural residents, women, and patients with non-coronary ASCVD.
Upadacitinib in refractory ulcerative colitis patients with high thromboembolic risk: two case reports.
Concurrent use of anticoagulation (rivaroxaban) with upadacitinib may represent a safe and valuable strategy for treating refractory UC with high thromboembolic risk.
Guide on Selection of Optimal Motivational Themes for Use in a Clinical Trial Recruiting Black US Adults: Survey Study.
Demographic targeting (age, health status, and geographic location) is more critical than generic motivational messaging in recruiting Black adults to clinical trials.
Remote Patient Monitoring Program Components and Short-Term Hypertension Control: Retrospective Cohort Study.
Both frequency of monitoring and specialized nurse monitoring improve hypertension control within 3 months of RPM program enrollment, with their combination associated with 26%, 17%, and 27% higher prevalence of hypertension control at weeks 4, 8, and 12, respectively.
Association of thyroid nodules with comorbidity burden and prognosis in patients with heart failure, anemia, and hyperuricemia: a retrospective cohort study.
Thyroid nodules are associated with greater cardiovascular comorbidity burden, depression, and poorer prognosis in HFrEF patients with anemia and hyperuricemia.
Early Risk Stratification in Acute Pulmonary Embolism using Inflammatory and Hematologic Biomarkers.
Red blood cell distribution width, white blood cell count, and neutrophil-to-lymphocyte ratio independently predict in-hospital adverse events in acute pulmonary embolism, and their combined use may enhance early risk stratification.
Metabolic syndrome and serum uric acid level in children and adolescents with hypertension.
Metabolic syndrome is common in hypertensive children (14.5% by IDF criteria), particularly those with primary hypertension, and including serum uric acid in metabolic syndrome criteria may enhance prediction of hypertension-mediated organ damage, especially left ventricular hypertrophy.
[Correlation between Serum AGR, LDH Levels and Efficacy of Induction Chemotherapy in Newly Diagnosed Multiple Myeloma Patients].
MM patients exhibit lower serum AGR and higher LDH levels, both of which are closely related to the efficacy of induction chemotherapy and can effectively predict the chemotherapy efficacy in newly diagnosed MM patients.
Dual-layer N-glycoproteomics enhances resolution of serum glycosylation signatures in type 2 diabetes mellitus complicated with coronary heart disease.
An integrated dual-layer N-glycoproteomic strategy combining site-specific N-glycosylation profiling with intact N-glycopeptide analysis revealed extensive glycoproteome remodeling in T2DM complicated with coronary heart disease, characterized by increased microheterogeneity driven by altered sialylation and fucosylation.
Pulmonary hypertension in dialysis patients: clinical insights from tricuspid regurgitation velocity (TRV)-based echocardiographic criteria.
Pulmonary hypertension was common in dialysis patients (prevalence 43.6%) even when applying stricter TRV-based criteria, with longer dialysis vintage, larger LV diastolic dimension, and mitral regurgitation identified as independent predictors, suggesting a predominance of post-capillary mechanisms.
Intention to reduce dietary salt and its influencing factors in middle-aged and older hypertensive patients: a theory of planned behavior-based cross-sectional study.
Perceived behavioral control showed the strongest effect on salt-reducing dietary intentions among middle-aged and older hypertensive patients, while subjective norms did not significantly affect intentions, highlighting the central influence of attitudes and perceived behavioral control within the Theory of Planned Behavior framework.
Exploring Patterns of D-Dimer Assay Ordering at an Australian Rural Referral Hospital: A Retrospective Audit.
Patterns of D-dimer ordering were variably aligned with guideline-recommended pathways, which may limit the clinical usefulness of the test in some cases, with a diagnostic yield of CTPA of only 4.9% among patients who underwent D-dimer testing.
Association between continuity of care and detection of hypertension in Dutch general practice: a 10-year cohort study.
Both GP-COC and team-COC are dose-dependently associated with increased hazard ratios and earlier detection of hypertension in adults without preregistered cardiovascular conditions, with high personal continuity associated with up to 8.3 months earlier detection.
Individual and cumulative effects of social determinants of health on cardiovascular disease: Gender-specific insights from a cross-sectional NHANES study.
Adverse individual and cumulative social determinants of health were independently associated with higher odds of prevalent cardiovascular disease, with unemployment showing the largest association (AOR = 2.27, 95% CI: 2.01-2.57), while sex-stratified analyses showed some larger point estimates in women than men but no statistically significant sex-by-SDoH interactions.
Multidimensional nomogram for prediction of cardiovascular disease risk in cancer survivors.
A nomogram prediction model integrating psychosocial variables with traditional biomedical indicators was constructed to assess CVD risk in cancer survivors, achieving an AUC of 0.734 and demonstrating net clinical benefit across a wide range of thresholds.
[Transcutaneous electrical acupoint stimulation reduces perioperative arrhythmia risk and improves recovery quality in laparoscopic cholecystectomy: mechanisms involving suppression of repolarization abnormalities induced by CO2 pneumoperitoneum].
TEAS-assisted anesthesia effectively reduces the risk of arrhythmia during CO2 pneumoperitoneum in patients undergoing laparoscopic cholecystectomy, significantly shortens postoperative emergence time, and alleviates pain at early emergence stage.
Retrospective evaluation of choroidal and retinal changes in patients with diabetic peripheral neuropathy but no diabetic retinopathy.
Patients with diabetic peripheral neuropathy but no diabetic retinopathy demonstrated a statistically significant increase in luminal area and total choroidal area, as well as a statistically significant decrease in GCIPL thickness in the inferior and inferonasal sectors, compared to healthy individuals.
Visinin-like protein 1 disrupts calcium homeostasis and promotes atrial fibrillation in human and rodent models.
VILIP-1 is significantly upregulated in AF and promotes atrial fibrillation by augmenting NCX-1 surface abundance via a myristoylation-dependent trafficking mechanism, disrupting Ca2+ homeostasis, and that FDA-approved drugs repaglinide and desloratadine targeting VILIP-1 attenuated AF susceptibility in human and rodent models.
Pericoronary fat attenuation and its association with atherosclerosis in rheumatoid arthritis compared with controls: a cross-sectional study.
Pericoronary adipose tissue attenuation was higher in RA than controls, associated with coronary atherosclerosis in RA but not controls, and differed around plaque-free vessels in RA versus controls only among participants with atherosclerosis elsewhere.
Comparison of drug-coated balloons and plain old balloon angioplasty in hemodialysis patients with Below-The-Knee artery disease.
No significant differences were observed between drug-coated balloons and plain old balloon angioplasty in hemodialysis patients with below-the-knee peripheral artery disease in this small retrospective cohort.
Trends in the mortality of vascular intestinal disorders in the USA: a CDC WONDER analysis.
While VID mortality has decreased overall, this study revealed disproportionately higher mortality among certain demographic groups and geographic areas, with American Indian and Alaska Native patients, rural residents, and Midwest residents experiencing the highest age-adjusted mortality rates.
Coronary Artery Disease and Peripheral Artery Disease Are Associated With Increased Rates of Retear and Postoperative Complications Following Primary Arthroscopic Rotator Cuff Repair.
CAD and PAD significantly increase the risk of rotator cuff retear at 6 months, 1 year, and 4 years in addition to significantly increasing the risk of postoperative complications within 90 days following arthroscopic rotator cuff repair.
TREAT: A Multicentre Cross-sectional TReatment Evaluation of Apparent Resistant hyperTension in Belgium.
Among patients referred to specialized centers for apparent treatment resistant hypertension in Belgium, the prevalence of true resistant hypertension was estimated at 21.9%, with pseudo-resistant hypertension mainly associated with underuse of triple combination therapy and suboptimal dosing.
The "Commando" Procedure in Colombia: Early and Mid-Term Outcomes From the Largest Latin American Series.
The Commando procedure can be performed safely in middle-income settings, with outcomes comparable to high-volume centres in developed countries, and prognosis is driven more by disease severity than by socioeconomic context.
Developing a stroke center in a Brazilian university hospital: implementation, challenges, and outcomes.
Implementation of a stroke center at a Brazilian university hospital proved feasible and effective, achieving outcomes comparable to high-income countries despite operating only during weekday business hours.
Comparative Outcomes of Fractional Flow Reserve and Intravascular Ultrasound Guidance for Percutaneous Coronary Intervention in Intermediate Lesions: A Systematic Review and Meta-Analysis.
FFR and IVUS are both effective for guiding PCI, with similar outcomes in terms of MACE, mortality, MI, TVR and PCI procedures performed.
Prevalence of undiagnosed hypertension and risk assessment using a validated survey in community-based screening in Amman, Jordan.
Community-based screening in Amman, Jordan revealed a high prevalence of undiagnosed hypertension (20.6%) and a validated 9-risk predictor survey showed good screening ability to classify participants' hypertension status, supporting its utility for risk stratification in resource-limited settings.
Monocyte-to-lymphocyte ratio as a predictor of left ventricular aneurysm in acute STEMI patients.
Elevated monocyte-to-lymphocyte ratio (MLR) was independently linked to an increased risk of left ventricular aneurysm development in STEMI patients who received primary PCI, with discriminative ability exceeding that of monocyte and lymphocyte alone.
Integrative genomic and immune landscape analysis of intimal sarcomas for emerging therapeutic targets and immunotherapy strategies.
Intimal sarcomas showed PD-L1 expression, immune cell infiltration, and upregulation of immune response pathways, providing basic evidence for immunotherapy efficacy and identifying potential molecular targets beyond MDM2.
Evaluation of non-ophthalmologist-led and offline AI-assisted models for diabetic retinopathy screening in India: a pragmatic diagnostic accuracy study.
Non-ophthalmologist-led diabetic retinopathy screening at health and wellness centres demonstrated greater accuracy and operational feasibility than offline AI-assisted community screening, though both approaches effectively identified referable cases in rural India.
Prevalence and predictors of hypotension on hospital arrival in traumatic brain injury: a prehospital HEMS cohort study.
Initial hypotension was the strongest predictor of hypotension on hospital arrival in adult TBI patients transported by HEMS (OR 13.82, 95% CI 11.47–16.65), with severe TBI and polytrauma as additional independent predictors.
The Chain Mediating Effect of Instrumental Activities of Daily Living and Regular Exercise in the Relationship Between Physical Performance and Cognitive Function Among Older Adults Comorbid With Diabetes Mellitus and Hypertension.
Physical performance significantly predicts cognitive function among older adults comorbid with diabetes mellitus and hypertension, both directly and indirectly through independent and chain-mediating effects of instrumental activities of daily living and regular exercise.
Heat and socioeconomic deprivation compound to drive coronary heart disease in Los Angeles.
CHD hot spots overlapped with high-deprivation and high-heat areas concentrated in the south and east of Los Angeles County, with socioeconomic deprivation and urban heat each independently associated with higher coronary heart disease prevalence across 2,513 census tracts.
Latent profile analysis and influencing factors of engagement in medication safety among older adults with cardiometabolic multimorbidity: a cross-sectional study.
Latent profile analysis identified three distinct profiles of medication safety engagement among older adults with cardiometabolic multimorbidity—'passive participation' (22.47%), 'moderate participation' (52.53%), and 'active participation' (25.0%)—with occupational status, marital status, medical payment method, daily medication type, and treatment burden as significant independent influencing factors.
Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis at 10 Years.
Among asymptomatic patients with very severe aortic stenosis, early surgery led to a lower risk of a composite of operative mortality or death from cardiovascular causes than conservative care at 10 years.
[Quantitative Assessment of Microvascular Changes in Diabetic Retinopathy and Their Association With Blood-Retinal Barrier Impairment].
OCTA assessment indicators in DR patients are closely related to BRB-related markers, and the area of the non-perfusion zone has the highest predictive value for severe retinal microvascular changes in DR patients.
Atherogenic Lipoprotein Burden, Metabolic Stress and Immune Activation Associated with Coronary Atherosclerosis in Patients with Psoriasis.
Subclinical coronary atherosclerosis in patients with psoriasis is closely associated with an immuno-metabolic risk profile encompassing atherogenic lipoprotein fractions (particularly remnant cholesterol) and immune activation (elevated IgA), underscoring the need for broader cardiovascular risk assessment beyond traditional risk factors.
Mediation of stenosis-induced ischemia by proximal peri-coronary adipose tissue: A cross-sectional study.
Proximal peri-coronary adipose tissue radiomics score partially mediates the relationship between stenosis and coronary ischemia, and combined with stenosis degree in a random forest model achieves high efficacy in identifying FFRCT ≤ 0.75.
Adherence to and Engagement With an mHealth Physical Activity Intervention After Mild Stroke or Transient Ischemic Attack: Secondary Analysis of a Feasibility Randomized Controlled Trial.
Supervised mHealth support was well received with high adherence, while modules for self-management of physical activity faced challenges in engaging participants after mild stroke or TIA.
Unearthing the global, regional, and national epidemiological landscapes of high BMI-driven ischemic heart disease burden in youth: Trends, determinants, and future trajectories.
Geographic distribution and socioeconomic differences in IHD burden attributable to high BMI among 20-49 year-olds show stark disparities, with low-SDI countries exhibiting persistent increases while high-SDI nations show stabilization or decline, driven primarily by epidemiological changes and population growth in less developed regions.