Cardiovascular
497 peer-reviewed studies indexed
Burden of disease for multiple myeloma in China and the Asia-Pacific region, 1990-2021: a systematic analysis of the Global Burden of Disease (GBD) 2021 study.
Between 1990 and 2021, the burden of multiple myeloma grew substantially in China and the Asia-Pacific region, with China's age-standardized incidence increasing 918.69%, driven by population aging, male predominance, and positive correlation with SDI, with future incidence rates predicted to climb especially among the elderly and males.
Molecular epidemiology of the MTHFR C677T polymorphism and its association with type 2 diabetes mellitus at the University of Gondar Comprehensive Specialized Hospital.
The MTHFR C677T polymorphism was associated with T2DM susceptibility, with CT and TT genotypes increasing risk compared to CC, alongside other risk factors including age, hypertension, family history, alcohol use, and smoking.
Small- to medium-sized arteritis diagnosed by F-18 FDG PET/CT: A case report.
F-18 FDG PET/CT revealed linear and branching tree-like patterns of hypermetabolism in small- to medium-sized arteries, facilitating noninvasive diagnosis of arteritis and enabling timely treatment while avoiding unnecessary procedures.
Selenoprotein P Deficiency Is Associated with Early Signs of Kidney Disease and Hospitalization Risk in Heart Failure.
Low selenoprotein P (SELENOP) is associated with selective glomerular hypofiltration syndrome (SGHS) and increased risk of kidney disease hospitalization, especially AKI, in acute heart failure patients, suggesting Se status may influence HF and renal outcomes.
Performance of ChatGPT and Gemini Compared with Emergency Physicians in NSTEMI Cases: A Prospective Cross-sectional Study.
ChatGPT 4.0 and Gemini 2.5 significantly outperformed emergency physicians in NSTEMI-related multiple-choice questions, correctly answering nine of ten questions versus a physician mean of 7.62±1.32 (P<0.001).
Post-infarction left ventricular pseudoaneurysm with septal rupture: a case report.
A 58-year-old man developed a rare combination of left ventricular apical pseudoaneurysm with post-infarction ventricular septal rupture two months after untreated anterior myocardial infarction, successfully treated with aneurysmectomy, septal defect closure, and coronary artery bypass grafting.
Systemic Inflammation Mediates the Association Between Admission Hyperglycemia and Pulmonary Infection or Prognosis in Acute Ischemic Stroke.
Systemic inflammation, measured by SII and SIRI, partially mediated the association between admission hyperglycemia (particularly stress-induced transient hyperglycemia) and clinical outcomes including stroke-associated pneumonia and poor functional outcome at 12 months in acute ischemic stroke patients.
Association between medication adherence and glycaemic control among patients with type 2 diabetes in Luzhou: a retrospective cohort study (2018-2023).
Patients with consistent medication adherence achieved significantly higher glycaemic control rates than intermittent adherents, and poor adherence to medical advice reduced glycaemic control success by 29.4%, while hypertension comorbidity and lifestyle factors moderated this association.
Real-world quality of life in patients with hereditary angioedema receiving lanadelumab or other long-term prophylaxis.
In this real-world study, physicians reported a higher proportion of patients receiving lanadelumab had no chronic pain or fatigue compared with those receiving other LTP, and both physicians and patients reported higher QoL in those receiving lanadelumab.
[Construction and evaluation of a thrombosis risk prediction model in patients with primary immune thrombocytopenia].
This study developed a nomogram prediction model for thrombosis in ITP patients based on age, ITP duration >1 year, comorbid coronary heart disease, and PLT, which can help identify high-risk patients.
Neuroprotective response against the onset of ischemic stroke by upregulation of histone H3Y99 sulfation.
Upregulation of histone H3Y99 sulfation via the SLC26A1-PAPSS1-SULT1B1 axis is a protective cerebral response against ischemic injury that promotes glycolysis and cell survival, and can be boosted by PAPSS1 overexpression or sulfate supplementation to reduce brain injury and improve neurological outcomes.
Associations Between Albumin-Corrected Anion Gap and Mortality in Heart Failure Patients with Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study.
ACAG is closely associated with the risk of mortality in HF patients with COPD and appears to be a potential prognostic predictor for this population, aiding in risk stratification.
Post-Acute Sequelae of COVID-19 Persist Over 3 Years in Acute Lung Injury/Acute Respiratory Distress Syndrome Survivors But Are Not Associated With Persistent Thromboinflammation or Endothelial Dysfunction.
PASC persists for 3 years after acute COVID-19 ALI/ARDS and is associated with frailty, but is not associated with persistently higher levels of inflammatory, endothelial, and complement biomarkers implicated in worse short-term outcomes in acute COVID-19, non-COVID-19 ARDS, and sepsis.
Retinal Characteristics in Eyes With Retinal Vein Occlusion Using Widefield Swept-Source Optical Coherence Tomography Angiography.
65-degree widefield swept-source OCTA imaging allows for precise noninvasive detection of vascular alterations in eyes with retinal vein occlusion, with ghost vessels and collateral vessels serving as indicators of underlying non-perfusion areas.
Intraoperative neurophysiological monitoring in pediatric vascular neurosurgery: a review of the literature and institutional case series.
Despite limited published evidence, institutional experience supports IONM as 'a technically feasible and potentially useful adjunct in pediatric vascular neurosurgery' for AVMs and cavernomas.
Predictors of definite and possible infective endocarditis in children with bacteremia: a reginal cohort study.
The rate of definite IE in pediatric bacteremia was extremely low, and echocardiography should be reserved for children with high-risk cardiac conditions, embolic or immunologic phenomena, or persistent bacteremia particularly Staphylococcus aureus.
Recurrent bowel angioedema in a patient with C1 esterase inhibitor deficiency.
This case underscores the importance of considering hereditary and acquired C1-INH deficiency in the differential diagnosis of recurrent abdominal pain and bowel oedema despite late onset and lack of concomitant facial or peripheral angioedema.
OTUD1 Relieves Coxsackievirus-Induced Ferroptosis and Inflammation in Myocardial Cells by Stabilizing NRF2 and Inhibiting NF-κB Signaling.
OTUD1 relieves CVB3-induced myocardial ferroptosis and inflammation by stabilizing NRF2 expression and inhibiting NF-κB signaling activation, revealing its potential as an intervention target for viral myocarditis treatment.
Clinical outcomes and haemodynamic response after blinded stress assessment of moderate aortic stenosis.
Stress haemodynamic assessment in moderate AS unmasks a subgroup, not identified by conventional metrics, who are at significantly higher risk for AV intervention, with blinded SAVI scores independently predicting the need for clinical aortic valve intervention (hazard ratio 5.7; p=0.007).
Exploratory Mendelian randomization analysis: The genetic susceptibility of CT examination preference and the risk of hypertrophic cardiomyopathy.
This exploratory two-sample Mendelian randomization analysis found a negative correlation between genetic propensity for CT scan and HCM risk using inverse-variance weighting, but MR-Egger and weighted median methods yielded non-significant estimates, reflecting inherent complexity in using broad non-biological exposure indicators.
Emerging trends and disparities in mortality due to coexisting atrial fibrillation and sepsis: A US nationwide observational study (1999-2023).
Deaths involving coexisting atrial fibrillation and sepsis rose substantially over 25 years in the US, with overall AAMR increasing from 2.0 to 7.1 per 100,000, marked by sharp increases in recent years and persistent disparities by age, sex, race/ethnicity, and geography.
Gender differences in clinical profiles, management and outcomes of valvular heart disease in China: insights from a nationwide cohort.
Significant gender differences exist in VHD aetiology and subtypes in China, but intervention improved survival with no gender disparity in 2-year outcomes.
HARMONICS: feasibility of a holistic value-based care hybrid programme that maximises clinical outcomes after stroke.
HARMONICS is a feasible multicentre value-based follow-up model that promotes education, engagement and self-responsibility, with high rates of healthcare satisfaction reported by stroke survivors.
[Impact of cumulative atherogenic index of plasma exposure on the risk of new-onset cardiovascular disease in middle-aged and young populations].
In middle-aged and young populations, a high level of cumulative atherogenic index of plasma is associated with an increased risk of cardiovascular disease, independent of traditional risk factors and significant even among low-risk populations.
Machine learning-extended sPESI for 1-year mortality prediction in pulmonary embolism.
A machine learning extension of the simplified pulmonary embolism severity index using a 10-item hybrid model with continuous physiological variables significantly enhanced prognostic performance compared with conventional 6-item sPESI across all time horizons (30, 180, and 365 days), with XGBoost achieving AUC of 0.796 at 30 days and all ML models outperforming sPESI at 12 months.
Sex-specific short- and long-term outcomes in patients with leadless cardiac pacemakers.
No sex-specific disparities were observed with respect to complications during index stay, in-hospital and all-cause mortality in patients undergoing leadless cardiac pacemaker implantation, though procedure-related complications occurred more frequently in women and indications differed between sexes.
Dynamic suprahyoid muscle ultrasound in acute stroke: a prospective observational study for developing a dysphagia severity score.
A simple scoring system combining ultrasound and clinical parameters showed excellent discriminative performance (AUCs of 0.963 and 0.935 for training and test sets) for early identification of severe dysphagia in acute ischemic stroke patients.
[The Clinical Value of Plasma cfTFEB and miR-1246 in Predicting the Efficacy of Bortezomib Treatment for Patients with Multiple Myeloma].
Plasma cfTFEB and miR-1246 may serve as potential biomarkers for evaluating the efficacy of bortezomib in the treatment of multiple myeloma.
Hypertension and Risk Factors in Nepalese Police in Far Western Region.
The prevalence of hypertension among Nepalese police personnel in the far western region was 14%, lower than the general population, with age, being overweight, and increased waist circumference identified as significant risk factors.
Community health worker-facilitated home visits for hypertension management in urban Nepal: a mixed-methods process evaluation.
CHW-facilitated home visits addressed key individual and family-level barriers to hypertension management, but impact was limited by uneven behaviour uptake and constrained public primary healthcare capacity for medication supply and titration.
Upregulation of Trx alleviated high-glucose-induced Müller cell pyroptosis through ASK-1/Cav-1-mediated endoplasmic reticulum stress and autophagy.
Trx overexpression alleviates high-glucose-induced Müller cell pyroptosis by regulating endoplasmic reticulum stress and autophagy via the ASK-1/Cav-1 pathway, providing a potential therapeutic target for diabetic retinopathy.
Spatial Coefficient of Variation (sCOV) From ASL MRI Reveals Global Cerebrovascular Dysfunction in Long COVID.
Long COVID participants showed significantly higher global gray matter sCOV compared with controls, indicating widespread cerebrovascular dysfunction in the absence of perfusion deficits and not associated with white matter hyperintensities.
Dexmedetomidine Use and Intraoperative Bradycardia During Radiofrequency Rhizotomy for Trigeminal Neuralgia: A Retrospective Observational Study.
Dexmedetomidine use was independently associated with intraoperative bradycardia during radiofrequency rhizotomy for trigeminal neuralgia (OR 5.16), but provided meaningful sedative-sparing effects, and with appropriate monitoring and individualized dosing remains a safe and valuable sedative option.
Holding it all together: Family caregivers' support needs after very early supported discharge post stroke.
Family caregivers following very early supported discharge post stroke felt unprepared, anxious, and overwhelmed, underscoring the need for sustained and comprehensive long-term strategies that include education and mental health support for caregivers in the rehabilitation process after stroke.
Clinical and hemodynamic evaluation of schistosomiasis-associated pulmonary arterial hypertension from Egyptian pulmonary hypertension centers: epidemiology, risk factors, and survival determinants.
Sch-PAH affects primarily older males with significant comorbidities, and ejection fraction percentage emerged as an independent survival predictor with a cutoff below 66% showing high predictive accuracy (AUC = 0.85).
Microcirculatory Dysfunction and Oxidative Stress in Sudden Sensorineural Hearing Loss: Insights From a Case-Control and Experimental Study.
SSNHL is associated with unfavorable perfusion-related surrogate parameters and heightened oxidative stress accompanied by reduced antioxidant defenses, with clinical and experimental findings suggesting microcirculatory dysfunction and oxidative imbalance are interrelated features of SSNHL-associated cochlear injury.
Detection of atrial septal aneurysm on ECG based on Deep Learning algorithm (ANN).
ASA detection by ECG using machine learning is possible, with an ANN model achieving an AUC of 0.8, offering a potential opening for a broader clinical understanding and implications of this cardiac abnormality.
Deciphering the cardiac neuron landscape in heart failure patients.
An integrative cardiac neuron atlas of 11,026 neuronal cells from 75 heart failure patients and 45 healthy donors identified ten distinct neuronal subsets, with N4-ALK neurons significantly enriched in failing hearts and associated with LVAD response, fibroblast crosstalk via PTN-PTPRZ1, and predictive utility for heart failure identification.
Relationship between cerebral perfusion and cognition in white matter hyperintensities of presumed vascular origin: A prospective 3D-pCASL study.
More severe WMH may increase perfusion through collateral circulation in certain brain regions, and their CBF is negatively correlated with cognitive function, further unveiling mechanisms behind WMH-related cognitive decline.
Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6ChighLy6Glow monocytes after stroke.
Hypoxia-inducible protein 2 (HIG2/Hilpda) mediates anti-inflammatory properties of Ly6ChighLy6Glow monocyte-derived macrophages in the stroke brain by promoting phosphatidylcholine synthesis via Hif1α-dependent transcriptional regulation of choline kinase α, and intranasal delivery of recombinant HIG2 protein improves neurological outcomes after stroke.
Integrative Proteomic and Transcriptomic Profiling Identifies Candidate Biomarkers for Discriminating Anaphylactic from Cardiac Sudden Death.
Integrative proteomic and transcriptomic profiling identified FN1, GP1BA, and PF4 as candidate biomarkers for forensically distinguishing anaphylactic sudden death from sudden death from coronary heart disease, with FN1 serving as a key differential biomarker across mouse serum and human post-mortem tissues.
Non-invasive cardiac power measurements in decompensated heart failure in elderly adults: A prospective proof-of-concept study.
Non-invasive cardiac power metrics (total, steady, and oscillatory power) predicted short-term all-cause mortality in decompensated heart failure patients, whereas established echocardiographic metrics (LVEF, GLS, and myocardial work indices) did not.
CTA-Based Plaque-RADS to Assess Etiologic Role of Nonstenotic Carotid Plaques in Patients With Embolic Stroke of Undetermined Source.
CTA-based Plaque-RADS can be reliably applied in routine clinical practice to categorize nonstenotic carotid plaques in ESUS, with ipsilateral high-risk plaques strongly associated with the index stroke side, lower prevalence of competing cardioembolic sources, and increased ipsilateral recurrence, supporting their role as a distinct causal mechanism within ESUS.
Stereotactic body radiotherapy plus lenvatinib and sintilimab with and without transarterial embolization for advanced hepatocellular carcinoma with portal vein tumor thrombus: a dual-center, propensity score-matched retrospective analysis.
Adding TAE to SBRT, lenvatinib, and sintilimab prolonged median PFS (11.0 vs. 6.0 months) in patients with advanced HCC and PVTT, with comparable safety profiles between groups.
Associations Between Comorbidities, Medication Use and Dental Outcomes in Clinical Practice in Hail Dental Centre in Saudi Arabia: A Retrospective Study.
This retrospective study of 383 dental patients in Saudi Arabia found high prevalences of diabetes (53.5%), hypertension (49.6%), and hypothyroidism (23.0%), with significant associations between diabetes and active dental caries and between hypertension and increased dental pain.
Cardiologists' attitudes toward psychological care: a national survey on perceptions, collaboration and barriers.
Although 96.3% of cardiologists acknowledged the relevance of psychological factors to CVD management, educational, structural, and cultural barriers—including lack of training and concerns about stigma—limit the integration of psychological interventions into cardiovascular care.
Effects of dietary patterns and sodium intake on blood pressure variability: results from the DASH and DASH-sodium trials.
While the DASH diet and reduced sodium intake lower absolute BP levels, these dietary interventions do not significantly affect blood pressure variability, suggesting their BP-related benefits likely result from reducing absolute BP rather than reducing BPV.
[Clinical characteristics, treatment, and prognosis of double-hit multiple myeloma with concurrent 1q21+ and t (4;14)].
DHMM patients with concurrent 1q21+ and t(4;14) exhibit aggressive clinical features and poor prognosis, and while triple-agent induction therapy (PI+IMiD+CD38Ab) and auto-HSCT are associated with MRD negativity and improved PFS, achieving long-term survival remains challenging for these patients.
Global burden of cardiovascular disease attributable to lead exposure: based on the global burden of disease study 2021.
Despite declining age-standardized rates, lead-attributable cardiovascular disease burden remains substantial (approximately 1.48 million deaths and 30.0 million DALYs in 2021) and increasingly concentrated in lower-SDI populations, driven mainly by population growth and aging.
Neonatal hypoxic-ischemic encephalopathy online registry in Shenzhen: protocol for a multicentre, prospective, open, observational cohort study.
This paper describes the protocol for a multicentre, prospective, open, observational cohort study establishing a neonatal HIE online registry in Shenzhen, China, aiming to clinically characterise HIE, identify risk factors, and document long-term neurodevelopmental outcomes over 3 years.